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The map label for this gene is gcvT [H]

Identifier: 169824159

GI number: 169824159

Start: 519479

End: 520579

Strand: Direct

Name: gcvT [H]

Synonym: FMG_0462

Alternate gene names: 169824159

Gene position: 519479-520579 (Clockwise)

Preceding gene: 169824158

Following gene: 169824160

Centisome position: 28.9

GC content: 32.79

Gene sequence:

>1101_bases
ATGCTTATGAGTACAAAAAAAACTCCTCTATATGAGGAACACAAAAAATTAGGTGGAAAAGTTGTTGACTTCGCTGGTTT
TTATTTGCCAGTAGATTATGAAGGTTTACAACAAGAACACGAAGCGGTAAGAAACAGCGTTGGCTTATTTGATGTAAGTC
ACATGGGTGAATTTACTGTTAAAGGCAAAGATGCATTGAAATTTATCAACTATGTTTGCACAAATGATTACTCTAAATGT
GCAGATGGACAAATCCAATATTCTTTATTATTACACGAAGATGGCGGAATGGTTGATGACTTATTAGTTTACAAAAACAA
CGATGAAGACTTTTTAATGGTTCCAAATGCAGCTAATACTGAAAAGGACTTCAAACATATTTCTAAATATGTAGATAAAT
TTGACGTTGAACTTAAAAACATTAGTGATTCAGTAGCTGAAATCGCTATTCAAGGTCCTAAAGCTGAAGAATTATTACAA
AGATTAGTTGATTATGATCTTTCTAAAATCGAATACTATCATTTCGTAAAAGATATTAAATATAAAGAATACGATGTACT
AATTTCTAGAACTGGTTATACTGGTGAAGATGGATTCGAAGTTTATGCAAATGCTGAAGCAATTGTAAAATTATGGGATG
AGTTATTAGAAAAAGGAAAAGACTTAGGTGTTAAACCATGTGGTCTTGGATGTAGAGATACATTGAGATTTGAAGCAGCA
ATGCCTTTATATGGTAACGAACTTTCAGATGAAGTATCTCCATTAGAAGTTGGCTTGAAGTTTGCAGTTAAAATGGATAA
AGACGACTTCGTTGGTAAAGCAAAAACTCAAGAAAAAATTGATGCAGGAATAAACAAGAAACTTATTGGTATCGAAATGC
AAAGCAAACGTATCGCAAGACAAGGTGCTGAAGTTCAAAAAGATGGCAAGACTATCGGTAAAGTAACTACAGGATACCTT
TCACCAACATTTGGCGTATGTTTAGCAAACGCATTTGTAGATAAATCAGCTGTAGCATTAGGTGATGAAGTAGATGTTGT
TATCAGAAATAAACCAGCTAAAGCAACAGTTGTTAAAAGAAAATTTTTGGATAGAAAATAG

Upstream 100 bases:

>100_bases
AAATTCAGGCTTATTTATTCTCACAATTAATAAATTTTGTTACAAAAACTATCAACATTTATGGTACAATAGTTGTGAAA
AGGATTATAAGTAAAAGGAG

Downstream 100 bases:

>100_bases
GGGGAAAAGAAAATGGCAGAAGTAGCAAAAGATTTATTGTACACAAAAGATCATGAATGGATTAAAGTAGACGGAGATGT
TTATGAAATTGGTCTTGCAG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MLMSTKKTPLYEEHKKLGGKVVDFAGFYLPVDYEGLQQEHEAVRNSVGLFDVSHMGEFTVKGKDALKFINYVCTNDYSKC
ADGQIQYSLLLHEDGGMVDDLLVYKNNDEDFLMVPNAANTEKDFKHISKYVDKFDVELKNISDSVAEIAIQGPKAEELLQ
RLVDYDLSKIEYYHFVKDIKYKEYDVLISRTGYTGEDGFEVYANAEAIVKLWDELLEKGKDLGVKPCGLGCRDTLRFEAA
MPLYGNELSDEVSPLEVGLKFAVKMDKDDFVGKAKTQEKIDAGINKKLIGIEMQSKRIARQGAEVQKDGKTIGKVTTGYL
SPTFGVCLANAFVDKSAVALGDEVDVVIRNKPAKATVVKRKFLDRK

Sequences:

>Translated_366_residues
MLMSTKKTPLYEEHKKLGGKVVDFAGFYLPVDYEGLQQEHEAVRNSVGLFDVSHMGEFTVKGKDALKFINYVCTNDYSKC
ADGQIQYSLLLHEDGGMVDDLLVYKNNDEDFLMVPNAANTEKDFKHISKYVDKFDVELKNISDSVAEIAIQGPKAEELLQ
RLVDYDLSKIEYYHFVKDIKYKEYDVLISRTGYTGEDGFEVYANAEAIVKLWDELLEKGKDLGVKPCGLGCRDTLRFEAA
MPLYGNELSDEVSPLEVGLKFAVKMDKDDFVGKAKTQEKIDAGINKKLIGIEMQSKRIARQGAEVQKDGKTIGKVTTGYL
SPTFGVCLANAFVDKSAVALGDEVDVVIRNKPAKATVVKRKFLDRK
>Mature_366_residues
MLMSTKKTPLYEEHKKLGGKVVDFAGFYLPVDYEGLQQEHEAVRNSVGLFDVSHMGEFTVKGKDALKFINYVCTNDYSKC
ADGQIQYSLLLHEDGGMVDDLLVYKNNDEDFLMVPNAANTEKDFKHISKYVDKFDVELKNISDSVAEIAIQGPKAEELLQ
RLVDYDLSKIEYYHFVKDIKYKEYDVLISRTGYTGEDGFEVYANAEAIVKLWDELLEKGKDLGVKPCGLGCRDTLRFEAA
MPLYGNELSDEVSPLEVGLKFAVKMDKDDFVGKAKTQEKIDAGINKKLIGIEMQSKRIARQGAEVQKDGKTIGKVTTGYL
SPTFGVCLANAFVDKSAVALGDEVDVVIRNKPAKATVVKRKFLDRK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=365, Percent_Identity=30.4109589041096, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI257796258, Length=335, Percent_Identity=30.7462686567164, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI24797151, Length=337, Percent_Identity=28.486646884273, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI257796254, Length=362, Percent_Identity=27.0718232044199, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI257796256, Length=310, Percent_Identity=27.741935483871, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI197927446, Length=308, Percent_Identity=25.3246753246753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI21361378, Length=308, Percent_Identity=25.3246753246753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI194306651, Length=331, Percent_Identity=23.8670694864048, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789272, Length=365, Percent_Identity=34.7945205479452, Blast_Score=220, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=34.2245989304813, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71994045, Length=325, Percent_Identity=25.5384615384615, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71994052, Length=325, Percent_Identity=25.5384615384615, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32563613, Length=352, Percent_Identity=23.0113636363636, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320222, Length=381, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=32.620320855615, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28571104, Length=311, Percent_Identity=22.508038585209, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI20130091, Length=344, Percent_Identity=21.5116279069767, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41013; Mature: 41013

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSTKKTPLYEEHKKLGGKVVDFAGFYLPVDYEGLQQEHEAVRNSVGLFDVSHMGEFTV
CCCCCCCCCCHHHHHHHCCEEEEECCEEEECCHHHHHHHHHHHHHCCCEEEECCCCCEEE
KGKDALKFINYVCTNDYSKCADGQIQYSLLLHEDGGMVDDLLVYKNNDEDFLMVPNAANT
CCHHHHHHHHHHHCCCHHHCCCCCEEEEEEEECCCCCEEEEEEEECCCCCEEECCCCCCC
EKDFKHISKYVDKFDVELKNISDSVAEIAIQGPKAEELLQRLVDYDLSKIEYYHFVKDIK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCC
YKEYDVLISRTGYTGEDGFEVYANAEAIVKLWDELLEKGKDLGVKPCGLGCRDTLRFEAA
CCEEEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEE
MPLYGNELSDEVSPLEVGLKFAVKMDKDDFVGKAKTQEKIDAGINKKLIGIEMQSKRIAR
CCCCCCCCCCCCCHHHCCEEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHH
QGAEVQKDGKTIGKVTTGYLSPTFGVCLANAFVDKSAVALGDEVDVVIRNKPAKATVVKR
CCCCHHHCCCHHHHEEECCCCHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHH
KFLDRK
HHCCCC
>Mature Secondary Structure
MLMSTKKTPLYEEHKKLGGKVVDFAGFYLPVDYEGLQQEHEAVRNSVGLFDVSHMGEFTV
CCCCCCCCCCHHHHHHHCCEEEEECCEEEECCHHHHHHHHHHHHHCCCEEEECCCCCEEE
KGKDALKFINYVCTNDYSKCADGQIQYSLLLHEDGGMVDDLLVYKNNDEDFLMVPNAANT
CCHHHHHHHHHHHCCCHHHCCCCCEEEEEEEECCCCCEEEEEEEECCCCCEEECCCCCCC
EKDFKHISKYVDKFDVELKNISDSVAEIAIQGPKAEELLQRLVDYDLSKIEYYHFVKDIK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCC
YKEYDVLISRTGYTGEDGFEVYANAEAIVKLWDELLEKGKDLGVKPCGLGCRDTLRFEAA
CCEEEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEE
MPLYGNELSDEVSPLEVGLKFAVKMDKDDFVGKAKTQEKIDAGINKKLIGIEMQSKRIAR
CCCCCCCCCCCCCHHHCCEEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHH
QGAEVQKDGKTIGKVTTGYLSPTFGVCLANAFVDKSAVALGDEVDVVIRNKPAKATVVKR
CCCCHHHCCCHHHHEEECCCCHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHH
KFLDRK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]