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The map label for this gene is fhs

Identifier: 169824158

GI number: 169824158

Start: 517660

End: 519324

Strand: Direct

Name: fhs

Synonym: FMG_0461

Alternate gene names: 169824158

Gene position: 517660-519324 (Clockwise)

Preceding gene: 169824157

Following gene: 169824159

Centisome position: 28.8

GC content: 34.11

Gene sequence:

>1665_bases
ATGTTTATGGCTACAGATGTAGAAATTGCTCAAAAAGCGAAATTAGAAAAAATCAGCGTGATTGCTGAAAAAATGGGATT
AACAGAAGAAGATTATGAACAATATGGTAGATATAAGGCAAAATTAGATTTAAATCTTTTTGAAAAAAATAAAGATAAAA
AAGATGGTAAATTAATTTTGATGACAAGTATTAACCCTACACCAACTGGAGAAGGTAAAACAACTATGAATGTTGGTTTG
GCAATGGGACTTAACAAAATTGGCAAAAACGCTATCTCAGTATTAAGAGAACCATCTTTAGGACCAAACTTTGGTATGAA
AGGTGGAGCTGCGGGTGGTGGATATGCACAAGTAGTTCCAATGGACGAAATCAACATGCACTTCACTGGTGACTTCCATG
CAATCACTACTGCAAACAACTTGATTTGCGCTATGATGGACAACCACATTCACCAAGGTAATGCGTTAAACATCGATCCA
AAACAAATCTTAATTAAAAGATGTATGGATATGAACGAACGTGAATTAAGAGATATAATTATCGGAGTTGGCGCAAAAGG
TAACGGAGTTATGCGTCAAGATGGTTTCGAAATTACTGTTGCAAGTGAAATCATGGCTATTTTATGTCTTGCAAAAGATT
TGAAAGACTTAAAAGAAAGAGTTGGAAATATTCTAATCGCTTTCGATAAAGAAGGTAAACCAGTTTATGCAAGAGACGTT
AAAGCTGATGGTGCAGTAGCATTAGTTATGAAAGAAGCTATCAAACCAAACTTAGTTCAAACATTAGAACACACTCCAGC
AATTATTCACGGTGGACCATTCGCTAACATTGCACATGGTTGTAACTCTTTAATAGCTACTAAATTAGGATTGAAACTTG
GAGATTACGTTGTTACAGAAGCAGGTTTCGGTGCTGACTTAGGAGCAGAAAAATTCTTCGATATTAAATGTAGAAATGAT
TTACATCCAAACATGGTATGTATCGTAGCTACAATAAAAGCATTAAAACATCACGGGGAAGCAGAAGATTTCAAAGTTGA
AAATGTAGAAGCTTTGGAAAAAGGATATGCTAACCTTAAACGTCATATTGAAAATATGAAGAAATACAAAGTTCCAGTAG
TAGTAGCAATCAATAGATTTGCAACTGATACAGATGCAGAAATTAAGAAATTAACTGAATTAGTTGAAGCAGATGGAACA
AGAGCTATTTTCTGTGATGTATGGGCTAAAGGTGGAGAAGGAGCTAAAGAATTAGCAGAATATGTTGTTGAAAATACAAA
AGAAGAAAACGACTTCGAATTCTTATATGACCTTGAATTACCTATCAAAGAAAAAATCGAAAAAATTGCAAAAGAAATTT
ACAGAGCAGACGGCGTAGAATTCAGTGCAAAAGCTAAGAAAAAATTAAAACAAATCAAAGAATTAGGATTAGACAATTAT
CCAGTATGTATGGCTAAGACTCAATACTCATTCTCTGATAATAAAAAATTAATCGGAGCTCCAACTGGATTTACAATCAC
AGTAAGTGATTTCAAAATCTCAAGAGGTGCCGGATTTGTTGTTGCATTATTAGGATCTGTAATGACAATGCCAGGTTTAC
CAAAAGTACCTTCAGCAGAAAATTGCGATGTTTTAGATGATGGTACAGTTGTAGGATTATTCTAG

Upstream 100 bases:

>100_bases
AAAAAAAAGCGTTTTTTAGTGTTATTATTAAATAAAGTTGGGTATAAATTAGGTAGTGGTTATTAGGTTAATAGCTAATT
AAAATAAAAATTTGGAGGTA

Downstream 100 bases:

>100_bases
AAAATTTAAAAGCCTGAATTTGTGTGAATTTAATGCGGTTTATAAAATTTCTATAAATTCAGGCTTATTTATTCTCACAA
TTAATAAATTTTGTTACAAA

Product: formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MFMATDVEIAQKAKLEKISVIAEKMGLTEEDYEQYGRYKAKLDLNLFEKNKDKKDGKLILMTSINPTPTGEGKTTMNVGL
AMGLNKIGKNAISVLREPSLGPNFGMKGGAAGGGYAQVVPMDEINMHFTGDFHAITTANNLICAMMDNHIHQGNALNIDP
KQILIKRCMDMNERELRDIIIGVGAKGNGVMRQDGFEITVASEIMAILCLAKDLKDLKERVGNILIAFDKEGKPVYARDV
KADGAVALVMKEAIKPNLVQTLEHTPAIIHGGPFANIAHGCNSLIATKLGLKLGDYVVTEAGFGADLGAEKFFDIKCRND
LHPNMVCIVATIKALKHHGEAEDFKVENVEALEKGYANLKRHIENMKKYKVPVVVAINRFATDTDAEIKKLTELVEADGT
RAIFCDVWAKGGEGAKELAEYVVENTKEENDFEFLYDLELPIKEKIEKIAKEIYRADGVEFSAKAKKKLKQIKELGLDNY
PVCMAKTQYSFSDNKKLIGAPTGFTITVSDFKISRGAGFVVALLGSVMTMPGLPKVPSAENCDVLDDGTVVGLF

Sequences:

>Translated_554_residues
MFMATDVEIAQKAKLEKISVIAEKMGLTEEDYEQYGRYKAKLDLNLFEKNKDKKDGKLILMTSINPTPTGEGKTTMNVGL
AMGLNKIGKNAISVLREPSLGPNFGMKGGAAGGGYAQVVPMDEINMHFTGDFHAITTANNLICAMMDNHIHQGNALNIDP
KQILIKRCMDMNERELRDIIIGVGAKGNGVMRQDGFEITVASEIMAILCLAKDLKDLKERVGNILIAFDKEGKPVYARDV
KADGAVALVMKEAIKPNLVQTLEHTPAIIHGGPFANIAHGCNSLIATKLGLKLGDYVVTEAGFGADLGAEKFFDIKCRND
LHPNMVCIVATIKALKHHGEAEDFKVENVEALEKGYANLKRHIENMKKYKVPVVVAINRFATDTDAEIKKLTELVEADGT
RAIFCDVWAKGGEGAKELAEYVVENTKEENDFEFLYDLELPIKEKIEKIAKEIYRADGVEFSAKAKKKLKQIKELGLDNY
PVCMAKTQYSFSDNKKLIGAPTGFTITVSDFKISRGAGFVVALLGSVMTMPGLPKVPSAENCDVLDDGTVVGLF
>Mature_554_residues
MFMATDVEIAQKAKLEKISVIAEKMGLTEEDYEQYGRYKAKLDLNLFEKNKDKKDGKLILMTSINPTPTGEGKTTMNVGL
AMGLNKIGKNAISVLREPSLGPNFGMKGGAAGGGYAQVVPMDEINMHFTGDFHAITTANNLICAMMDNHIHQGNALNIDP
KQILIKRCMDMNERELRDIIIGVGAKGNGVMRQDGFEITVASEIMAILCLAKDLKDLKERVGNILIAFDKEGKPVYARDV
KADGAVALVMKEAIKPNLVQTLEHTPAIIHGGPFANIAHGCNSLIATKLGLKLGDYVVTEAGFGADLGAEKFFDIKCRND
LHPNMVCIVATIKALKHHGEAEDFKVENVEALEKGYANLKRHIENMKKYKVPVVVAINRFATDTDAEIKKLTELVEADGT
RAIFCDVWAKGGEGAKELAEYVVENTKEENDFEFLYDLELPIKEKIEKIAKEIYRADGVEFSAKAKKKLKQIKELGLDNY
PVCMAKTQYSFSDNKKLIGAPTGFTITVSDFKISRGAGFVVALLGSVMTMPGLPKVPSAENCDVLDDGTVVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=42.6731078904992, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI36796743, Length=621, Percent_Identity=42.9951690821256, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI310124614, Length=87, Percent_Identity=39.0804597701149, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=606, Percent_Identity=40.7590759075908, Blast_Score=433, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17568739, Length=606, Percent_Identity=40.7590759075908, Blast_Score=433, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=41.28, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=41.2974683544304, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI62472483, Length=623, Percent_Identity=42.0545746388443, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551871, Length=623, Percent_Identity=42.0545746388443, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24645718, Length=623, Percent_Identity=42.0545746388443, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17137370, Length=623, Percent_Identity=42.0545746388443, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_FINM2 (B0S0G1)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691769.1
- ProteinModelPortal:   B0S0G1
- SMR:   B0S0G1
- GeneID:   6020131
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0461
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- BioCyc:   FMAG334413:FMG_0461-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60643; Mature: 60643

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMATDVEIAQKAKLEKISVIAEKMGLTEEDYEQYGRYKAKLDLNLFEKNKDKKDGKLIL
CCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEEEEEHHHCCCCCCCCEEEE
MTSINPTPTGEGKTTMNVGLAMGLNKIGKNAISVLREPSLGPNFGMKGGAAGGGYAQVVP
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
MDEINMHFTGDFHAITTANNLICAMMDNHIHQGNALNIDPKQILIKRCMDMNERELRDII
CCCCCEEECCCEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEEE
IGVGAKGNGVMRQDGFEITVASEIMAILCLAKDLKDLKERVGNILIAFDKEGKPVYARDV
EECCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEECC
KADGAVALVMKEAIKPNLVQTLEHTPAIIHGGPFANIAHGCNSLIATKLGLKLGDYVVTE
CCCCCEEHHHHHHCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCHHCCEEEEC
AGFGADLGAEKFFDIKCRNDLHPNMVCIVATIKALKHHGEAEDFKVENVEALEKGYANLK
CCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHH
RHIENMKKYKVPVVVAINRFATDTDAEIKKLTELVEADGTRAIFCDVWAKGGEGAKELAE
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHH
YVVENTKEENDFEFLYDLELPIKEKIEKIAKEIYRADGVEFSAKAKKKLKQIKELGLDNY
HHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PVCMAKTQYSFSDNKKLIGAPTGFTITVSDFKISRGAGFVVALLGSVMTMPGLPKVPSAE
CEEEEEEECCCCCCCEEEECCCCCEEEEECEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
NCDVLDDGTVVGLF
CCCEECCCCEEEEC
>Mature Secondary Structure
MFMATDVEIAQKAKLEKISVIAEKMGLTEEDYEQYGRYKAKLDLNLFEKNKDKKDGKLIL
CCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEEEEEHHHCCCCCCCCEEEE
MTSINPTPTGEGKTTMNVGLAMGLNKIGKNAISVLREPSLGPNFGMKGGAAGGGYAQVVP
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
MDEINMHFTGDFHAITTANNLICAMMDNHIHQGNALNIDPKQILIKRCMDMNERELRDII
CCCCCEEECCCEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEEE
IGVGAKGNGVMRQDGFEITVASEIMAILCLAKDLKDLKERVGNILIAFDKEGKPVYARDV
EECCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEECC
KADGAVALVMKEAIKPNLVQTLEHTPAIIHGGPFANIAHGCNSLIATKLGLKLGDYVVTE
CCCCCEEHHHHHHCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCHHCCEEEEC
AGFGADLGAEKFFDIKCRNDLHPNMVCIVATIKALKHHGEAEDFKVENVEALEKGYANLK
CCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHH
RHIENMKKYKVPVVVAINRFATDTDAEIKKLTELVEADGTRAIFCDVWAKGGEGAKELAE
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHH
YVVENTKEENDFEFLYDLELPIKEKIEKIAKEIYRADGVEFSAKAKKKLKQIKELGLDNY
HHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PVCMAKTQYSFSDNKKLIGAPTGFTITVSDFKISRGAGFVVALLGSVMTMPGLPKVPSAE
CEEEEEEECCCCCCCEEEECCCCCEEEEECEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
NCDVLDDGTVVGLF
CCCEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA