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The map label for this gene is thrC [H]

Identifier: 169824017

GI number: 169824017

Start: 373189

End: 375483

Strand: Direct

Name: thrC [H]

Synonym: FMG_0320

Alternate gene names: 169824017

Gene position: 373189-375483 (Clockwise)

Preceding gene: 169824016

Following gene: 169824018

Centisome position: 20.76

GC content: 34.99

Gene sequence:

>2295_bases
ATGAGATATTTATCGACAAGAAATTCTAATTTAAAAGTTTCATCACGTGAAGCAATTCTCAAAGGAATATCAGAAGATGG
CGGGCTTTACGTGCCAGAATCTTTTCCAAAATTTGATATACTAGATCACTTGGATCTTTCGTATACACAACTTTGTCACG
CAATCCTATCTCTTTATCTGACAGATTTTGTTAGCGACGAATTACTAGAAATAATCGAAAAATCATACGCAAGCTTCGAG
CAAGACATCTGCAAAGTAGCTTATCATAAAGATTATTATTTGGAGCTTTACCATGGAAGAACATCTGCATTCAAAGATTT
CGCACTTTGTTTGCTTCCAAATCTTATGATTTATGCGAAAAAATCTTTGGGAATAAATGAAAAGACGTTGATATTGACGG
CGACATCTGGAGATACAGGAAAAGCTGCTCTCGAAGGATTTTACAACACAGAAAATATCGACATCTTGGTTTTGTATCCG
ACAGAAGGAGTAAGCTGTATCCAAAAAGCACAAATGGATACGACATCATCGCTCAACTCAAAAGTAATATCGATTGATGG
GAATTTTGATGATGCACAAACGGCGGCCAAGAAGATTTTTAACGACAAAGATATAAAAGAAGAATTGAAAAATCAAAATA
TTTGTTTGTCATCAGCAAACTCCATTAATATTGGAAGATTGTTGCCGCAAATCGTCTACTACTTCTACGCATACCAAGAT
TTGGTAAATAACAAAAAAATTTCTGCCGGAGACAAAATATCATTCTGTGTACCTACAGGAAATTTTGGAGATATCTTGGC
TGGATACTACGCAAAAGAAATGGGGCTTCCAATTGAAAAACTCGTCATCGCATCCAATGACAACAACGTGTTGACAGATT
TTTTCACGACTGGAACTTACGATGCAAACAGAGATTTGGTCAAGACAATCTCTCCTTCGATGGATATTTTGGTTTCATCA
AATCTTGAAAGATTGATTTACCACAAATCATCAGATGAAATCGTAAAACAAAAGATGACAGAATTGAATGAGTCGAAAAT
TTTCACATTTGAAGGAGATTTCCATGAGTTTAAATGTGGATATGCAACTGAAAATGAAACGAGAAATACTATCAAGGAAG
TTTTCGAAGACGAAGGGTATTTGATAGACACTCACACTGCGGTTGCAAAAAATATTACAGACAAACTTGGCCTCGATAAA
ACAGTTATATTGTCGACTGCAAGCCCGTACAAATTCTCTTCCACGGTTTTGAGTGCATTGGGAGAAAATATCTCGTCAGA
TGAATTTGAAAATATTGATCTTCTATACGAGAAAACTGGAGCGAAAATTCCTACTGAAATCAAAAAATTACATTCCAAGA
AGATAATTCATAAAACAAAAATTACAAAAGATAAAATAGAAGATGAAGTATTAAAATTTGCAAAGCGAGGCAAGAGAATT
TCCGTTCCCGCAACGTCTGCAAACATTGGCCCTGGGTTTGATGCACTTGGGGTTGCGCTGGATTTGGCAAACACATGTGA
ATTTAAGTTGACAGATGATGAAAATACATTTGAAAAAAATGTAGAATCTAATTTGATATATAAATCATACAAGTATACAT
TTGATTTTTACGGAGAAAAAATAGTTCCTGTGGAATTTGACCTCGATACTAATATTCCAATGTCACGAGGACTCGGATCG
TCTGCAGCTTGTATCGTAATGGGAATAATGGCGGCATTTTCAGTCATGGGAAAAAATCCTGACGAAAAAGAAATATTGAA
AATAGCAACTCAAATCGAAGGCCATCCCGACAACGTCGCACCAGCGATTTTCGCAGATGCAGTTGCGTCAATATTAAAAG
ACGATGAAGTTTTTGTGGAAAAATTTGAAATATCAGACAAATTTAAATTCCTAGCGATAATTTCAGATTTTGAGCTTTCA
ACACAAAAAGCAAGAGAAGTACTGCCGGAAAATTATACAAAAAACGATGCGGTGTTCAATATTTCGAGAGTTTCGATGCT
AGTATTGTCATTAATTTCTGGAAATGAGGATAATCTGAAAATCGCACTTGAAGATAAAATTCACGAGCCTTACAGATTAC
AACTAATTCCTGAAATAGAGAAAATCGACGAAATTATCGAAAACTCTGATGCAATCGGACATTATTTGAGTGGAGCAGGC
TCAACGATTATGATAATTTTAAAATCAGATGACACTACATCAGAATCAGAAATTAGAAATAAACTGAACAAATTATCCAA
TTCTTATGAAGTTATGCAGCTTGATATCGACAAAAAAGGCGCGTTTATAATTTAA

Upstream 100 bases:

>100_bases
AAAATCATATGATAGTTACGAAAAAAGTTAGCTTGGATGAATTGACATCAGCAATCGAAAAATTTGACCAAGTATTCATA
TCGGAAATTGAGGAAGAAAA

Downstream 100 bases:

>100_bases
AAATTTTAAGAATACAAAATGAAATATTTTTAATACCAGAGATTTATTTCTCTGGTATTTTTATTTGAAAATAATCAATA
TAATATATTGAAATTAAACA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MRYLSTRNSNLKVSSREAILKGISEDGGLYVPESFPKFDILDHLDLSYTQLCHAILSLYLTDFVSDELLEIIEKSYASFE
QDICKVAYHKDYYLELYHGRTSAFKDFALCLLPNLMIYAKKSLGINEKTLILTATSGDTGKAALEGFYNTENIDILVLYP
TEGVSCIQKAQMDTTSSLNSKVISIDGNFDDAQTAAKKIFNDKDIKEELKNQNICLSSANSINIGRLLPQIVYYFYAYQD
LVNNKKISAGDKISFCVPTGNFGDILAGYYAKEMGLPIEKLVIASNDNNVLTDFFTTGTYDANRDLVKTISPSMDILVSS
NLERLIYHKSSDEIVKQKMTELNESKIFTFEGDFHEFKCGYATENETRNTIKEVFEDEGYLIDTHTAVAKNITDKLGLDK
TVILSTASPYKFSSTVLSALGENISSDEFENIDLLYEKTGAKIPTEIKKLHSKKIIHKTKITKDKIEDEVLKFAKRGKRI
SVPATSANIGPGFDALGVALDLANTCEFKLTDDENTFEKNVESNLIYKSYKYTFDFYGEKIVPVEFDLDTNIPMSRGLGS
SAACIVMGIMAAFSVMGKNPDEKEILKIATQIEGHPDNVAPAIFADAVASILKDDEVFVEKFEISDKFKFLAIISDFELS
TQKAREVLPENYTKNDAVFNISRVSMLVLSLISGNEDNLKIALEDKIHEPYRLQLIPEIEKIDEIIENSDAIGHYLSGAG
STIMIILKSDDTTSESEIRNKLNKLSNSYEVMQLDIDKKGAFII

Sequences:

>Translated_764_residues
MRYLSTRNSNLKVSSREAILKGISEDGGLYVPESFPKFDILDHLDLSYTQLCHAILSLYLTDFVSDELLEIIEKSYASFE
QDICKVAYHKDYYLELYHGRTSAFKDFALCLLPNLMIYAKKSLGINEKTLILTATSGDTGKAALEGFYNTENIDILVLYP
TEGVSCIQKAQMDTTSSLNSKVISIDGNFDDAQTAAKKIFNDKDIKEELKNQNICLSSANSINIGRLLPQIVYYFYAYQD
LVNNKKISAGDKISFCVPTGNFGDILAGYYAKEMGLPIEKLVIASNDNNVLTDFFTTGTYDANRDLVKTISPSMDILVSS
NLERLIYHKSSDEIVKQKMTELNESKIFTFEGDFHEFKCGYATENETRNTIKEVFEDEGYLIDTHTAVAKNITDKLGLDK
TVILSTASPYKFSSTVLSALGENISSDEFENIDLLYEKTGAKIPTEIKKLHSKKIIHKTKITKDKIEDEVLKFAKRGKRI
SVPATSANIGPGFDALGVALDLANTCEFKLTDDENTFEKNVESNLIYKSYKYTFDFYGEKIVPVEFDLDTNIPMSRGLGS
SAACIVMGIMAAFSVMGKNPDEKEILKIATQIEGHPDNVAPAIFADAVASILKDDEVFVEKFEISDKFKFLAIISDFELS
TQKAREVLPENYTKNDAVFNISRVSMLVLSLISGNEDNLKIALEDKIHEPYRLQLIPEIEKIDEIIENSDAIGHYLSGAG
STIMIILKSDDTTSESEIRNKLNKLSNSYEVMQLDIDKKGAFII
>Mature_764_residues
MRYLSTRNSNLKVSSREAILKGISEDGGLYVPESFPKFDILDHLDLSYTQLCHAILSLYLTDFVSDELLEIIEKSYASFE
QDICKVAYHKDYYLELYHGRTSAFKDFALCLLPNLMIYAKKSLGINEKTLILTATSGDTGKAALEGFYNTENIDILVLYP
TEGVSCIQKAQMDTTSSLNSKVISIDGNFDDAQTAAKKIFNDKDIKEELKNQNICLSSANSINIGRLLPQIVYYFYAYQD
LVNNKKISAGDKISFCVPTGNFGDILAGYYAKEMGLPIEKLVIASNDNNVLTDFFTTGTYDANRDLVKTISPSMDILVSS
NLERLIYHKSSDEIVKQKMTELNESKIFTFEGDFHEFKCGYATENETRNTIKEVFEDEGYLIDTHTAVAKNITDKLGLDK
TVILSTASPYKFSSTVLSALGENISSDEFENIDLLYEKTGAKIPTEIKKLHSKKIIHKTKITKDKIEDEVLKFAKRGKRI
SVPATSANIGPGFDALGVALDLANTCEFKLTDDENTFEKNVESNLIYKSYKYTFDFYGEKIVPVEFDLDTNIPMSRGLGS
SAACIVMGIMAAFSVMGKNPDEKEILKIATQIEGHPDNVAPAIFADAVASILKDDEVFVEKFEISDKFKFLAIISDFELS
TQKAREVLPENYTKNDAVFNISRVSMLVLSLISGNEDNLKIALEDKIHEPYRLQLIPEIEKIDEIIENSDAIGHYLSGAG
STIMIILKSDDTTSESEIRNKLNKLSNSYEVMQLDIDKKGAFII

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=39.2935982339956, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI149193323, Length=440, Percent_Identity=29.7727272727273, Blast_Score=187, Evalue=4e-47,
Organism=Escherichia coli, GI1786185, Length=432, Percent_Identity=32.1759259259259, Blast_Score=202, Evalue=8e-53,
Organism=Escherichia coli, GI1786184, Length=308, Percent_Identity=24.6753246753247, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319901, Length=464, Percent_Identity=37.9310344827586, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6321814, Length=348, Percent_Identity=29.3103448275862, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 85449; Mature: 85449

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00627 GHMP_KINASES_ATP ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLSTRNSNLKVSSREAILKGISEDGGLYVPESFPKFDILDHLDLSYTQLCHAILSLYL
CCCCCCCCCCEEECHHHHHHHCCCCCCCEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHH
TDFVSDELLEIIEKSYASFEQDICKVAYHKDYYLELYHGRTSAFKDFALCLLPNLMIYAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCHHHEEEH
KSLGINEKTLILTATSGDTGKAALEGFYNTENIDILVLYPTEGVSCIQKAQMDTTSSLNS
HCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCC
KVISIDGNFDDAQTAAKKIFNDKDIKEELKNQNICLSSANSINIGRLLPQIVYYFYAYQD
EEEEEECCCCHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LVNNKKISAGDKISFCVPTGNFGDILAGYYAKEMGLPIEKLVIASNDNNVLTDFFTTGTY
HHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCEEEEEEECCCC
DANRDLVKTISPSMDILVSSNLERLIYHKSSDEIVKQKMTELNESKIFTFEGDFHEFKCG
CCCCHHHHHCCCCCEEEECCCCHHHEEECCHHHHHHHHHHHCCCCEEEEEECCCCEEECC
YATENETRNTIKEVFEDEGYLIDTHTAVAKNITDKLGLDKTVILSTASPYKFSSTVLSAL
CCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
GENISSDEFENIDLLYEKTGAKIPTEIKKLHSKKIIHKTKITKDKIEDEVLKFAKRGKRI
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
SVPATSANIGPGFDALGVALDLANTCEFKLTDDENTFEKNVESNLIYKSYKYTFDFYGEK
ECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCEEEEEEEEEEEECCCE
IVPVEFDLDTNIPMSRGLGSSAACIVMGIMAAFSVMGKNPDEKEILKIATQIEGHPDNVA
EEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
PAIFADAVASILKDDEVFVEKFEISDKFKFLAIISDFELSTQKAREVLPENYTKNDAVFN
HHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEE
ISRVSMLVLSLISGNEDNLKIALEDKIHEPYRLQLIPEIEKIDEIIENSDAIGHYLSGAG
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHCCCC
STIMIILKSDDTTSESEIRNKLNKLSNSYEVMQLDIDKKGAFII
CEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MRYLSTRNSNLKVSSREAILKGISEDGGLYVPESFPKFDILDHLDLSYTQLCHAILSLYL
CCCCCCCCCCEEECHHHHHHHCCCCCCCEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHH
TDFVSDELLEIIEKSYASFEQDICKVAYHKDYYLELYHGRTSAFKDFALCLLPNLMIYAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCHHHEEEH
KSLGINEKTLILTATSGDTGKAALEGFYNTENIDILVLYPTEGVSCIQKAQMDTTSSLNS
HCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCC
KVISIDGNFDDAQTAAKKIFNDKDIKEELKNQNICLSSANSINIGRLLPQIVYYFYAYQD
EEEEEECCCCHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LVNNKKISAGDKISFCVPTGNFGDILAGYYAKEMGLPIEKLVIASNDNNVLTDFFTTGTY
HHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCEEEEEEECCCC
DANRDLVKTISPSMDILVSSNLERLIYHKSSDEIVKQKMTELNESKIFTFEGDFHEFKCG
CCCCHHHHHCCCCCEEEECCCCHHHEEECCHHHHHHHHHHHCCCCEEEEEECCCCEEECC
YATENETRNTIKEVFEDEGYLIDTHTAVAKNITDKLGLDKTVILSTASPYKFSSTVLSAL
CCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
GENISSDEFENIDLLYEKTGAKIPTEIKKLHSKKIIHKTKITKDKIEDEVLKFAKRGKRI
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
SVPATSANIGPGFDALGVALDLANTCEFKLTDDENTFEKNVESNLIYKSYKYTFDFYGEK
ECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCEEEEEEEEEEEECCCE
IVPVEFDLDTNIPMSRGLGSSAACIVMGIMAAFSVMGKNPDEKEILKIATQIEGHPDNVA
EEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
PAIFADAVASILKDDEVFVEKFEISDKFKFLAIISDFELSTQKAREVLPENYTKNDAVFN
HHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEE
ISRVSMLVLSLISGNEDNLKIALEDKIHEPYRLQLIPEIEKIDEIIENSDAIGHYLSGAG
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHCCCC
STIMIILKSDDTTSESEIRNKLNKLSNSYEVMQLDIDKKGAFII
CEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]