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The map label for this gene is hom [H]

Identifier: 169824016

GI number: 169824016

Start: 372011

End: 373192

Strand: Direct

Name: hom [H]

Synonym: FMG_0319

Alternate gene names: 169824016

Gene position: 372011-373192 (Clockwise)

Preceding gene: 169824015

Following gene: 169824017

Centisome position: 20.7

GC content: 33.08

Gene sequence:

>1182_bases
GTGAAAATCGCAATAATGGGGTTTGGAACTGTAGGATGCGGTGTAGAAGAAATTCTATACAAAAAAAGAAAATCCCTAAT
AAAAAATAACTTCGACATACAAATAGACAAAATTTTGATAAAAAATACAGATAAACAAAGATTTCCACACCAAAAAGACC
TCGTATTTACTGATGATTTTGATGAGGTTTTAAATTCTGATGTGGACACAGTCATTGATGTTACATCGAGCCTTGAAGAA
ACTCACGAAAGAATTGTGGCGTTGATGAATGCTGGTAAAAATATAGTGACGGCAAACAAGGCTGTTGTTTCCAAATATTT
TGAAGAGTTAAATGAGCTTGCTGTGAAAAACGATGTGTATTTTTCATACGAAGCTTCAGTTGCTGGTGCAATTCCTGTAA
TTCATCCTATCATGGAAGAAATATTTTTCAGCGACATGAATAAAATATATGGGATTTTGAATGGAACTTCCAATTATATT
TTGTCCAAAATGGAAACTGAAGGATTATCTTACGATGAAGTTTTGAAAAAAGCACAAGATTTGGGATACGCTGAGGCTGA
TCCAACTGCGGATGTCGGTGGATTGGATGCTATGAGAAAAATCAGAATCGTCTCCTCGCTTATTTATAATTCTAAGATAA
ATGAAGAAGATATTTTTACATTTGGAATTTCAAATGTGACAAAAACTGATTTTGAATTTGCAAAAAACTTGGGATATTCC
ATCAGACTTCTCGCAAAATGCGCATTAGAAGCTAATAATATAAATATTTCGGTGATTCCTACATTTGTAGCTGATGATTT
CTTTGCGAAAACATTCGAAGGAACAAATGCAATCAAAGTGTGGGGAGAAAACTTCAATTCATACGAATTTAAAGGACCAG
GAGCGGGCAAACTTGAAACAGCCGATGCGATTATGAGAGATCTATTGAGAATTCTTGCAAAAAGAGAAATAAAAACTTTC
TACGATGCGACAAATTCATTTGAAGTTGAAAATAATATTAAACACAAATTCTACATCAGAACAACTGAAGTTACAGATGG
TTTGAAAAATATAATAGATAGGGAAAAAACATCAGGTGAAAATCATATGATAGTTACGAAAAAAGTTAGCTTGGATGAAT
TGACATCAGCAATCGAAAAATTTGACCAAGTATTCATATCGGAAATTGAGGAAGAAAAATGA

Upstream 100 bases:

>100_bases
GTGGATAACGGGCTTAATTTATGGTGTTGTGCTGATAATATCAGAAAAGGTGCTGCAACAAATGCCGTACAAATCGCACT
AAAAGTTTTGGAGGGTTAAT

Downstream 100 bases:

>100_bases
GATATTTATCGACAAGAAATTCTAATTTAAAAGTTTCATCACGTGAAGCAATTCTCAAAGGAATATCAGAAGATGGCGGG
CTTTACGTGCCAGAATCTTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKIAIMGFGTVGCGVEEILYKKRKSLIKNNFDIQIDKILIKNTDKQRFPHQKDLVFTDDFDEVLNSDVDTVIDVTSSLEE
THERIVALMNAGKNIVTANKAVVSKYFEELNELAVKNDVYFSYEASVAGAIPVIHPIMEEIFFSDMNKIYGILNGTSNYI
LSKMETEGLSYDEVLKKAQDLGYAEADPTADVGGLDAMRKIRIVSSLIYNSKINEEDIFTFGISNVTKTDFEFAKNLGYS
IRLLAKCALEANNINISVIPTFVADDFFAKTFEGTNAIKVWGENFNSYEFKGPGAGKLETADAIMRDLLRILAKREIKTF
YDATNSFEVENNIKHKFYIRTTEVTDGLKNIIDREKTSGENHMIVTKKVSLDELTSAIEKFDQVFISEIEEEK

Sequences:

>Translated_393_residues
MKIAIMGFGTVGCGVEEILYKKRKSLIKNNFDIQIDKILIKNTDKQRFPHQKDLVFTDDFDEVLNSDVDTVIDVTSSLEE
THERIVALMNAGKNIVTANKAVVSKYFEELNELAVKNDVYFSYEASVAGAIPVIHPIMEEIFFSDMNKIYGILNGTSNYI
LSKMETEGLSYDEVLKKAQDLGYAEADPTADVGGLDAMRKIRIVSSLIYNSKINEEDIFTFGISNVTKTDFEFAKNLGYS
IRLLAKCALEANNINISVIPTFVADDFFAKTFEGTNAIKVWGENFNSYEFKGPGAGKLETADAIMRDLLRILAKREIKTF
YDATNSFEVENNIKHKFYIRTTEVTDGLKNIIDREKTSGENHMIVTKKVSLDELTSAIEKFDQVFISEIEEEK
>Mature_393_residues
MKIAIMGFGTVGCGVEEILYKKRKSLIKNNFDIQIDKILIKNTDKQRFPHQKDLVFTDDFDEVLNSDVDTVIDVTSSLEE
THERIVALMNAGKNIVTANKAVVSKYFEELNELAVKNDVYFSYEASVAGAIPVIHPIMEEIFFSDMNKIYGILNGTSNYI
LSKMETEGLSYDEVLKKAQDLGYAEADPTADVGGLDAMRKIRIVSSLIYNSKINEEDIFTFGISNVTKTDFEFAKNLGYS
IRLLAKCALEANNINISVIPTFVADDFFAKTFEGTNAIKVWGENFNSYEFKGPGAGKLETADAIMRDLLRILAKREIKTF
YDATNSFEVENNIKHKFYIRTTEVTDGLKNIIDREKTSGENHMIVTKKVSLDELTSAIEKFDQVFISEIEEEK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=270, Percent_Identity=26.2962962962963, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44344; Mature: 44344

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIMGFGTVGCGVEEILYKKRKSLIKNNFDIQIDKILIKNTDKQRFPHQKDLVFTDDF
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHCCCCCCEEEECCH
DEVLNSDVDTVIDVTSSLEETHERIVALMNAGKNIVTANKAVVSKYFEELNELAVKNDVY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCEE
FSYEASVAGAIPVIHPIMEEIFFSDMNKIYGILNGTSNYILSKMETEGLSYDEVLKKAQD
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
LGYAEADPTADVGGLDAMRKIRIVSSLIYNSKINEEDIFTFGISNVTKTDFEFAKNLGYS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHCCCHH
IRLLAKCALEANNINISVIPTFVADDFFAKTFEGTNAIKVWGENFNSYEFKGPGAGKLET
HHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCHH
ADAIMRDLLRILAKREIKTFYDATNSFEVENNIKHKFYIRTTEVTDGLKNIIDREKTSGE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEEHHHHHHHHHHHHHHCCCCC
NHMIVTKKVSLDELTSAIEKFDQVFISEIEEEK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAIMGFGTVGCGVEEILYKKRKSLIKNNFDIQIDKILIKNTDKQRFPHQKDLVFTDDF
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHCCCCCCEEEECCH
DEVLNSDVDTVIDVTSSLEETHERIVALMNAGKNIVTANKAVVSKYFEELNELAVKNDVY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCEE
FSYEASVAGAIPVIHPIMEEIFFSDMNKIYGILNGTSNYILSKMETEGLSYDEVLKKAQD
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
LGYAEADPTADVGGLDAMRKIRIVSSLIYNSKINEEDIFTFGISNVTKTDFEFAKNLGYS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHCCCHH
IRLLAKCALEANNINISVIPTFVADDFFAKTFEGTNAIKVWGENFNSYEFKGPGAGKLET
HHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCHH
ADAIMRDLLRILAKREIKTFYDATNSFEVENNIKHKFYIRTTEVTDGLKNIIDREKTSGE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEEHHHHHHHHHHHHHHCCCCC
NHMIVTKKVSLDELTSAIEKFDQVFISEIEEEK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]