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The map label for this gene is guaA

Identifier: 169824011

GI number: 169824011

Start: 362851

End: 364383

Strand: Direct

Name: guaA

Synonym: FMG_0314

Alternate gene names: 169824011

Gene position: 362851-364383 (Clockwise)

Preceding gene: 169824010

Following gene: 169824012

Centisome position: 20.19

GC content: 36.73

Gene sequence:

>1533_bases
ATGAAACATCAATTAGTTATTGTAGTAGATTTTGGAGGACAATATAATCAACTAATCGCTCGTCGTGTCAGAGATTTGAA
CGTGTACTGCGAAGTTGTTCCTTACAAAAAAGCATTGGATGTTATCAAAGAAAAACAACCAATCGGGATAATCTTCACAG
GCGGACCAAACAGCGTTTATGAAGAAAATTCTCCACAAATCGAAAAAGAAATTTTTGAATTAAATATTCCTATTTTGGGA
ATGTGCTACGGAATGCAACTTATCTCCAAAGATTTTGGTGGAGTTGTTGAAAAAGCAAAAAATCGTGAATTTGGTAAAAC
AAACGCCAAAATCTCAAATCAAAGCTCTATATTAAAAGGAATGAGTGACGAAAGTATCGTGTGGATGAGCCACACTGATT
TCGTATCAGAAAAACCAGAAGGATTTGATATTATCCAAACAACGGATTCTTGTCCTGTAGCAGCAATTGCAAACGAAGAC
AAGAAGATATTCGCTGTACAATATCACCCAGAAGTTAACCACACAGTTGAAGGTAAAACATTAATCAAAAACTTCCTTTA
TGAAATCTGTAAAGCAGACGGAGATTGGACAATGGAAAATTTCTTGGAAGAACAAATCCAAAAAATCAGAAAAACTGTCG
GCGACAAAAAAGTTTTGTTGGCATTATCTGGTGGGGTAGACAGTTCTGTGTGTGCAGCACTTTTATCCAGAGCAATCGGC
AAAAACTTGACATGCGTATTCGTTGACCATGGTTTGATGAGAAAAAATGAAGGCGACGAAGTTGAAGCTGCATTCAAAAA
TGACGAATTAAACTTCGTAAGAGTAAATGCAAAAGACAGATTCTTAAATAAATTAAAAGGCGTATCAGATCCAGAACAAA
AGAGAAAAATCATCGGAGAAGAATTCATCAGAGTATTTGAAGATGAAGCGAAAAAAATCGGATCTGTGGATTTCTTAGCA
CAAGGAACAATCTATCCAGACGTAATAGAATCTGGACAAGGCGATGCATCAGTTATCAAATCTCACCACAACGTTGGTGG
ACTTCCTGATGTAGTTGATTTCAAAGATTTAATCGAACCACTTCGCGATTTATTCAAAGACGAAGTCAGAAGATTGGGAT
TAGAATTAGAAATGCCAGAATATTTGGTATATCGTCAACCATTCCCAGGACCAGGACTTGGAATAAGAGTAATGGGGGAA
ATAACAGAAGAAAAATTAGAAGTGTTGCGTGAAGCAGACTTCATATTCAGAGACGAAGTTGCAAAAGCAGGAATCGACAA
AGACATCAACCAATACTTCGCAGTAATCACTAATAACAGAACAGTCGGAGTAATGGGAGATTTCAGAACTTACGACTACA
CATTAGCACTAAGAGCCGTAACAACAACAGACTTCATGACAGCAGATTGGGCAAGAATCCCATACGAAGTATTAGATAAA
ACTTCAGTAAGAATAATTAACGAAGTAGACCACATCAATAGAATAGTCTATGATATCACAAGCAAACCACCAGCAACAAT
TGAATGGGAATAA

Upstream 100 bases:

>100_bases
ATAGAATTATTGAAATATTTGATGACGGAACTTATCGTGACGTATCAATGAATTACGAAGACTATATAGAAAAATATTTA
ACTAATAATTAGGAGTAGAA

Downstream 100 bases:

>100_bases
ATTTTTGGTAAAAATGGCGTATTAAACTTGATTCGTTGCCTCACAACCTCGACGTACTAATTGTACGACTCGGCTGCGAG
GCTCCTCATCGGCGTCTAAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKHQLVIVVDFGGQYNQLIARRVRDLNVYCEVVPYKKALDVIKEKQPIGIIFTGGPNSVYEENSPQIEKEIFELNIPILG
MCYGMQLISKDFGGVVEKAKNREFGKTNAKISNQSSILKGMSDESIVWMSHTDFVSEKPEGFDIIQTTDSCPVAAIANED
KKIFAVQYHPEVNHTVEGKTLIKNFLYEICKADGDWTMENFLEEQIQKIRKTVGDKKVLLALSGGVDSSVCAALLSRAIG
KNLTCVFVDHGLMRKNEGDEVEAAFKNDELNFVRVNAKDRFLNKLKGVSDPEQKRKIIGEEFIRVFEDEAKKIGSVDFLA
QGTIYPDVIESGQGDASVIKSHHNVGGLPDVVDFKDLIEPLRDLFKDEVRRLGLELEMPEYLVYRQPFPGPGLGIRVMGE
ITEEKLEVLREADFIFRDEVAKAGIDKDINQYFAVITNNRTVGVMGDFRTYDYTLALRAVTTTDFMTADWARIPYEVLDK
TSVRIINEVDHINRIVYDITSKPPATIEWE

Sequences:

>Translated_510_residues
MKHQLVIVVDFGGQYNQLIARRVRDLNVYCEVVPYKKALDVIKEKQPIGIIFTGGPNSVYEENSPQIEKEIFELNIPILG
MCYGMQLISKDFGGVVEKAKNREFGKTNAKISNQSSILKGMSDESIVWMSHTDFVSEKPEGFDIIQTTDSCPVAAIANED
KKIFAVQYHPEVNHTVEGKTLIKNFLYEICKADGDWTMENFLEEQIQKIRKTVGDKKVLLALSGGVDSSVCAALLSRAIG
KNLTCVFVDHGLMRKNEGDEVEAAFKNDELNFVRVNAKDRFLNKLKGVSDPEQKRKIIGEEFIRVFEDEAKKIGSVDFLA
QGTIYPDVIESGQGDASVIKSHHNVGGLPDVVDFKDLIEPLRDLFKDEVRRLGLELEMPEYLVYRQPFPGPGLGIRVMGE
ITEEKLEVLREADFIFRDEVAKAGIDKDINQYFAVITNNRTVGVMGDFRTYDYTLALRAVTTTDFMTADWARIPYEVLDK
TSVRIINEVDHINRIVYDITSKPPATIEWE
>Mature_510_residues
MKHQLVIVVDFGGQYNQLIARRVRDLNVYCEVVPYKKALDVIKEKQPIGIIFTGGPNSVYEENSPQIEKEIFELNIPILG
MCYGMQLISKDFGGVVEKAKNREFGKTNAKISNQSSILKGMSDESIVWMSHTDFVSEKPEGFDIIQTTDSCPVAAIANED
KKIFAVQYHPEVNHTVEGKTLIKNFLYEICKADGDWTMENFLEEQIQKIRKTVGDKKVLLALSGGVDSSVCAALLSRAIG
KNLTCVFVDHGLMRKNEGDEVEAAFKNDELNFVRVNAKDRFLNKLKGVSDPEQKRKIIGEEFIRVFEDEAKKIGSVDFLA
QGTIYPDVIESGQGDASVIKSHHNVGGLPDVVDFKDLIEPLRDLFKDEVRRLGLELEMPEYLVYRQPFPGPGLGIRVMGE
ITEEKLEVLREADFIFRDEVAKAGIDKDINQYFAVITNNRTVGVMGDFRTYDYTLALRAVTTTDFMTADWARIPYEVLDK
TSVRIINEVDHINRIVYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=37.4321880650995, Blast_Score=326, Evalue=3e-89,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=51.8234165067178, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI133901714, Length=565, Percent_Identity=35.7522123893805, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992717, Length=565, Percent_Identity=35.7522123893805, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=565, Percent_Identity=35.7522123893805, Blast_Score=312, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=50.0970873786408, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=37.2262773722628, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_FINM2 (B0S0S7)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691622.1
- ProteinModelPortal:   B0S0S7
- SMR:   B0S0S7
- GeneID:   6020194
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0314
- HOGENOM:   HBG391775
- OMA:   PSTIEPC
- ProtClustDB:   CLSK2799215
- BioCyc:   FMAG334413:FMG_0314-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57611; Mature: 57611

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 82-82 ACT_SITE 169-169 ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHQLVIVVDFGGQYNQLIARRVRDLNVYCEVVPYKKALDVIKEKQPIGIIFTGGPNSVY
CCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEECHHHHHHHHHCCCCEEEEEECCCCCCC
EENSPQIEKEIFELNIPILGMCYGMQLISKDFGGVVEKAKNREFGKTNAKISNQSSILKG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHC
MSDESIVWMSHTDFVSEKPEGFDIIQTTDSCPVAAIANEDKKIFAVQYHPEVNHTVEGKT
CCCCCEEEEECCCHHCCCCCCCEEEEECCCCCEEEEECCCCEEEEEEECCCCCCCCCHHH
LIKNFLYEICKADGDWTMENFLEEQIQKIRKTVGDKKVLLALSGGVDSSVCAALLSRAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHC
KNLTCVFVDHGLMRKNEGDEVEAAFKNDELNFVRVNAKDRFLNKLKGVSDPEQKRKIIGE
CCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHH
EFIRVFEDEAKKIGSVDFLAQGTIYPDVIESGQGDASVIKSHHNVGGLPDVVDFKDLIEP
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
LRDLFKDEVRRLGLELEMPEYLVYRQPFPGPGLGIRVMGEITEEKLEVLREADFIFRDEV
HHHHHHHHHHHCCCCCCCCHHHEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
AKAGIDKDINQYFAVITNNRTVGVMGDFRTYDYTLALRAVTTTDFMTADWARIPYEVLDK
HHCCCCCCCCCEEEEEECCCEEEEEECCCEEEEEEEEEEEEECCCCCCCHHHCCHHHHCC
TSVRIINEVDHINRIVYDITSKPPATIEWE
CHHHHHHHHHHHHHHHEEECCCCCCEEECC
>Mature Secondary Structure
MKHQLVIVVDFGGQYNQLIARRVRDLNVYCEVVPYKKALDVIKEKQPIGIIFTGGPNSVY
CCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEECHHHHHHHHHCCCCEEEEEECCCCCCC
EENSPQIEKEIFELNIPILGMCYGMQLISKDFGGVVEKAKNREFGKTNAKISNQSSILKG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHC
MSDESIVWMSHTDFVSEKPEGFDIIQTTDSCPVAAIANEDKKIFAVQYHPEVNHTVEGKT
CCCCCEEEEECCCHHCCCCCCCEEEEECCCCCEEEEECCCCEEEEEEECCCCCCCCCHHH
LIKNFLYEICKADGDWTMENFLEEQIQKIRKTVGDKKVLLALSGGVDSSVCAALLSRAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHC
KNLTCVFVDHGLMRKNEGDEVEAAFKNDELNFVRVNAKDRFLNKLKGVSDPEQKRKIIGE
CCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHH
EFIRVFEDEAKKIGSVDFLAQGTIYPDVIESGQGDASVIKSHHNVGGLPDVVDFKDLIEP
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
LRDLFKDEVRRLGLELEMPEYLVYRQPFPGPGLGIRVMGEITEEKLEVLREADFIFRDEV
HHHHHHHHHHHCCCCCCCCHHHEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
AKAGIDKDINQYFAVITNNRTVGVMGDFRTYDYTLALRAVTTTDFMTADWARIPYEVLDK
HHCCCCCCCCCEEEEEECCCEEEEEECCCEEEEEEEEEEEEECCCCCCCHHHCCHHHHCC
TSVRIINEVDHINRIVYDITSKPPATIEWE
CHHHHHHHHHHHHHHHEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA