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The map label for this gene is guaB [C]

Identifier: 169629498

GI number: 169629498

Start: 2471629

End: 2473065

Strand: Reverse

Name: guaB [C]

Synonym: MAB_2412c

Alternate gene names: 169629498

Gene position: 2473065-2471629 (Counterclockwise)

Preceding gene: 169629499

Following gene: 169629497

Centisome position: 48.81

GC content: 67.36

Gene sequence:

>1437_bases
ATGAAGTTCCTGGACGGGCAGCGGCCGCCGTACGATCTCACGTATGACGACGTCTTCGTGGTGCCCAACCACTCCGACGT
CACCTCGCGGTTCGATGTCGATCTGACCACCGCCGACGGCACCGGCACCACGATTCCCATCGTGGTCGCCAACATGACGG
CGGTGGCAGGGCGGCGGATGGCCGAGACTGTCGCGCGCCGCGGCGGTATCACCGTGTTGCCCCAGGATCTTCCGGTACAG
GCCGTCGCGCAGACCGTCGAGTTCATCAAGAGCCGGGACCTGGTCTACGACACACCGGTGACCCTGGCACCGGACGACTC
GGCCGGCGAGGCAATCGCGCTGATCCACAAGCGCTCACACGGGGCCGCGGTGGTACTCGAACACGGCAAGCCACTCGGAC
TGGTCACCGAGGCGGCATGTACCGGCATCGACAGATTCACCCGGGTGCACGACATCGCGGCCACCGACTTCGTGACGGTG
CCGACGGGGACCGACCCGCGTGCGATCTTCGATCGCCTGTCCGAAGCGCACGTGCCGGTCGCGGTACTGACACGCCCGGA
CGGGACGATGGCCGGCATCCTCACCCGTACCGGTGCGATTCGGGCGGGCCTGTACACCCCGGCCGTCGACGACAACGGAC
GCCTGCGCGTCGCCGGGGCCGTCGGTATCAACGGCGATGTCCGCGCCAAGGCGAGCGCCTTGGTGCAGGCCGGGGTGGAT
CTGCTGGTCATCGACACCGCGCACGGTCATCAACAGAAGATGCTCGACGTACTCGCCGCGGTCGCCGAATTGTCGTTGGG
CGTACCCATTGCCGCCGGCAATGTGGTATCGGCACAGGGCACCCGCGATCTGATTCGGGCCGGTGCGGACATCGTGAAGG
TGGGCGTGGGCCCGGGCGCCATGTGCACGACGCGAATGATGACCGGCGTGGGCCGCCCACAGCTTTCCGCAGTCATCGAA
TGCGCAGCCGCGGCAAGAGAACTCGGCGCTCACGTGTGGGCGGACGGCGGGGTTCGGCATCCCCGCGATGTCGCACTGGC
GCTCGCGGCCGGTGCCGCCAACGTGATGATCGGCTCCTGGTTCGCCGGAACCCACGAGTCCCCTGGCGACCTGCAACTCT
CGCCCACTGGACGGCGCTACAAGGACAGTTTTGGGATGGCCTCCAAACGTGCCGTGGCCGCCCGCACCGCCGGCGACAGC
GCCTTCGACCAGGCGCGCAAAAGCCTGTTCGAGGAAGGTATCTCCACCTCCCGGATCGAATTGGACCCGCAACGTCCCGG
CGTGGAGGATCTCATCGACCACATCATCTCGGGTGTGCGCAGTACCTGCACCTATGTCGGTGCGCGGACGCTGGGCGAGC
TCCATGAACGCGTGGTTCTGGGCGTGCAGTCCGCTGCCGGATTCGCCGAGGGACGCCCCCTTCCCGAAGGTTGGTGA

Upstream 100 bases:

>100_bases
ACCTATGAGCGCATCGACGCCCCCGGCAAGTTCCACACGCTCTGGAGCGGCGACCGCAACGAAGTAGAGGCGTAACGGCC
AGAAGAGTAGGGCGTCACAT

Downstream 100 bases:

>100_bases
CCGGTCGGCACCCTGCCGACCATCTGCACGGTTACCATTGAGCCTCACGATGGTCACCGTGTTTGTTCGAGCGTGACCGC
CCTAAGCCTAAGGGGGCCAG

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKFLDGQRPPYDLTYDDVFVVPNHSDVTSRFDVDLTTADGTGTTIPIVVANMTAVAGRRMAETVARRGGITVLPQDLPVQ
AVAQTVEFIKSRDLVYDTPVTLAPDDSAGEAIALIHKRSHGAAVVLEHGKPLGLVTEAACTGIDRFTRVHDIAATDFVTV
PTGTDPRAIFDRLSEAHVPVAVLTRPDGTMAGILTRTGAIRAGLYTPAVDDNGRLRVAGAVGINGDVRAKASALVQAGVD
LLVIDTAHGHQQKMLDVLAAVAELSLGVPIAAGNVVSAQGTRDLIRAGADIVKVGVGPGAMCTTRMMTGVGRPQLSAVIE
CAAAARELGAHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTHESPGDLQLSPTGRRYKDSFGMASKRAVAARTAGDS
AFDQARKSLFEEGISTSRIELDPQRPGVEDLIDHIISGVRSTCTYVGARTLGELHERVVLGVQSAAGFAEGRPLPEGW

Sequences:

>Translated_478_residues
MKFLDGQRPPYDLTYDDVFVVPNHSDVTSRFDVDLTTADGTGTTIPIVVANMTAVAGRRMAETVARRGGITVLPQDLPVQ
AVAQTVEFIKSRDLVYDTPVTLAPDDSAGEAIALIHKRSHGAAVVLEHGKPLGLVTEAACTGIDRFTRVHDIAATDFVTV
PTGTDPRAIFDRLSEAHVPVAVLTRPDGTMAGILTRTGAIRAGLYTPAVDDNGRLRVAGAVGINGDVRAKASALVQAGVD
LLVIDTAHGHQQKMLDVLAAVAELSLGVPIAAGNVVSAQGTRDLIRAGADIVKVGVGPGAMCTTRMMTGVGRPQLSAVIE
CAAAARELGAHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTHESPGDLQLSPTGRRYKDSFGMASKRAVAARTAGDS
AFDQARKSLFEEGISTSRIELDPQRPGVEDLIDHIISGVRSTCTYVGARTLGELHERVVLGVQSAAGFAEGRPLPEGW
>Mature_478_residues
MKFLDGQRPPYDLTYDDVFVVPNHSDVTSRFDVDLTTADGTGTTIPIVVANMTAVAGRRMAETVARRGGITVLPQDLPVQ
AVAQTVEFIKSRDLVYDTPVTLAPDDSAGEAIALIHKRSHGAAVVLEHGKPLGLVTEAACTGIDRFTRVHDIAATDFVTV
PTGTDPRAIFDRLSEAHVPVAVLTRPDGTMAGILTRTGAIRAGLYTPAVDDNGRLRVAGAVGINGDVRAKASALVQAGVD
LLVIDTAHGHQQKMLDVLAAVAELSLGVPIAAGNVVSAQGTRDLIRAGADIVKVGVGPGAMCTTRMMTGVGRPQLSAVIE
CAAAARELGAHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTHESPGDLQLSPTGRRYKDSFGMASKRAVAARTAGDS
AFDQARKSLFEEGISTSRIELDPQRPGVEDLIDHIISGVRSTCTYVGARTLGELHERVVLGVQSAAGFAEGRPLPEGW

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=460, Percent_Identity=28.4782608695652, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541954, Length=222, Percent_Identity=41.4414414414414, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541952, Length=222, Percent_Identity=41.4414414414414, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541948, Length=222, Percent_Identity=41.4414414414414, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541956, Length=222, Percent_Identity=41.4414414414414, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=28.1115879828326, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=28.1115879828326, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=28.1115879828326, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=28.1115879828326, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI156104880, Length=233, Percent_Identity=39.9141630901288, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI217035148, Length=465, Percent_Identity=27.741935483871, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI217035152, Length=462, Percent_Identity=27.7056277056277, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI217035150, Length=467, Percent_Identity=27.1948608137045, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1788855, Length=469, Percent_Identity=34.1151385927505, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1786293, Length=222, Percent_Identity=41.4414414414414, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560440, Length=222, Percent_Identity=41.8918918918919, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=27.5933609958506, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=28.3333333333333, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322012, Length=467, Percent_Identity=27.6231263383298, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=27.3706896551724, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=26.4642082429501, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319352, Length=366, Percent_Identity=25.1366120218579, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641071, Length=467, Percent_Identity=28.2655246252677, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24641073, Length=467, Percent_Identity=28.2655246252677, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI28571163, Length=426, Percent_Identity=27.9342723004695, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR018529
- InterPro:   IPR001093
- InterPro:   IPR005991 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 50027; Mature: 50027

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDGQRPPYDLTYDDVFVVPNHSDVTSRFDVDLTTADGTGTTIPIVVANMTAVAGRRM
CCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEECHHHHHHHHH
AETVARRGGITVLPQDLPVQAVAQTVEFIKSRDLVYDTPVTLAPDDSAGEAIALIHKRSH
HHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCEEECCEEECCCCCCCCEEEEEEECCC
GAAVVLEHGKPLGLVTEAACTGIDRFTRVHDIAATDFVTVPTGTDPRAIFDRLSEAHVPV
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCE
AVLTRPDGTMAGILTRTGAIRAGLYTPAVDDNGRLRVAGAVGINGDVRAKASALVQAGVD
EEEECCCCCEEHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCC
LLVIDTAHGHQQKMLDVLAAVAELSLGVPIAAGNVVSAQGTRDLIRAGADIVKVGVGPGA
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHCCCCEEEECCCCCH
MCTTRMMTGVGRPQLSAVIECAAAARELGAHVWADGGVRHPRDVALALAAGAANVMIGSW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEE
FAGTHESPGDLQLSPTGRRYKDSFGMASKRAVAARTAGDSAFDQARKSLFEEGISTSRIE
ECCCCCCCCCEEECCCCCCHHHHCCCCHHHHHEEECCCCHHHHHHHHHHHHCCCCCCEEE
LDPQRPGVEDLIDHIISGVRSTCTYVGARTLGELHERVVLGVQSAAGFAEGRPLPEGW
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKFLDGQRPPYDLTYDDVFVVPNHSDVTSRFDVDLTTADGTGTTIPIVVANMTAVAGRRM
CCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEECHHHHHHHHH
AETVARRGGITVLPQDLPVQAVAQTVEFIKSRDLVYDTPVTLAPDDSAGEAIALIHKRSH
HHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCEEECCEEECCCCCCCCEEEEEEECCC
GAAVVLEHGKPLGLVTEAACTGIDRFTRVHDIAATDFVTVPTGTDPRAIFDRLSEAHVPV
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCE
AVLTRPDGTMAGILTRTGAIRAGLYTPAVDDNGRLRVAGAVGINGDVRAKASALVQAGVD
EEEECCCCCEEHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCC
LLVIDTAHGHQQKMLDVLAAVAELSLGVPIAAGNVVSAQGTRDLIRAGADIVKVGVGPGA
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHCCCCEEEECCCCCH
MCTTRMMTGVGRPQLSAVIECAAAARELGAHVWADGGVRHPRDVALALAAGAANVMIGSW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEE
FAGTHESPGDLQLSPTGRRYKDSFGMASKRAVAARTAGDSAFDQARKSLFEEGISTSRIE
ECCCCCCCCCEEECCCCCCHHHHCCCCHHHHHEEECCCCHHHHHHHHHHHHCCCCCCEEE
LDPQRPGVEDLIDHIISGVRSTCTYVGARTLGELHERVVLGVQSAAGFAEGRPLPEGW
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]