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The map label for this gene is nuoH [H]

Identifier: 169629227

GI number: 169629227

Start: 2153503

End: 2154771

Strand: Direct

Name: nuoH [H]

Synonym: MAB_2141

Alternate gene names: 169629227

Gene position: 2153503-2154771 (Clockwise)

Preceding gene: 169629226

Following gene: 169629228

Centisome position: 42.5

GC content: 63.51

Gene sequence:

>1269_bases
GTGACCGGCAGGACCGACCTTTCACAATTCGGGATCGACCCGTTATGGCTGGTCCTTGTGAAATGCGTGGCGGTATTCGC
CTTTCTGGTTCTCACTGTGCTCATCGCCATCCTCGCCGAACGCCGGGTGCTGGCCTGGATGCAGCGCCGCATAGGACCCA
ACAGGGTGGGCCCCTTCGGTCTGTTGCAGAGCCTGGCCGACGGGGTGAAACTCGCTCTCAAAGAGGGCTTGACTCCGGCT
GGCGTCGACAAACCGATTTACCTGCTGGCACCCATCATCTCCGTGGTCCCGGCGATCGTCGCGTACGCGGTCATCCCGTT
CGGGCCGGTCGTCTCTGTTTTCGGGCATCGCACACCTCTGCAACTCACCGATCTACCTGTGGCGATTCTCTTCGTGCTGG
CGGTGACATCGGTCGGGGTGTACGGGATCGTGTTGGGAGGCTGGGCATCCGGATCTACCTACCCGCTGCTCGGAGGGTTG
CGATCTTCCGCGCAGGTGATCTCCTACGAGATCGCGATGGGTCTGACCTTCGCGGCGGTTTTCTTGCTGGCGGGCACCAT
GTCGACATCGGGAATCGTGGCGGCGCAGGAGGGCCGCTGGTACCTGTTTCTGTTGCTGCCCTCGTTCTTGGTCTACGTCA
CCGCGATGGTGGGCGAGACGAACAGGGCGCCTTTCGACCTGCCCGAGGCCGAGGGGGAGCTGGTCGGCGGTTTCCACACC
GAGTACTCCTCGCTTCGTTTCGCCATGTTCATGCTCGCCGAATACATCAACATGGCAACGGTTTCCGGGTTGGCCGCCAC
CATGTTCCTGGGCGGCTGGCACGCACCCTGGCCGCTGAGCCTGATCGACGGGGCCAATACCTCGTGGTTGCCGGCGCTGT
GGTTCGTGGCCAAGGTCTGGGGGTTCATGTTCCTGTTCATGTGGCTGCGCGCTACCTTGCCGCGTCTACGTTATGACCAG
TTCATGCGGTTGGGCTGGGAGGTCCTGATTCCTGTCGCGCTGGTGTGGATCGTCGTCGTCGGCGTGGTGAAGGCCATGGG
GCTGTACGGATATGGGAATCCTTCGATCATCCTTGGGATCACCGGGGTGGCGGTCTCGCTGGGCAGCATCGGCCTGGTCG
GCGTTCTCTCCCGGCGCACACAACCGCCGAAACCCGTGCTGCCCGCACGTTTCGATCCGATGGCCGGCGGATTCCCGGTG
CCGCCGCTGCCGGGACAACGCGTCGACACCGGGGCGCACCCGAGCACCAAGGAGGACGCAGATGCCTGA

Upstream 100 bases:

>100_bases
CGGACCGGGTGGTCTGGGTGCCCATGCGCTCGACGGGGTCGGAGCTTCATCAGCAACTTGGCCCGGCGCTCGGCCAAGTG
GTGAGAATCGAGGTGGCCCC

Downstream 100 bases:

>100_bases
TCTTCTGCGACGTTCGGCCGATGCCATGGCCGGGTTCTGGGTCACGTTCTCGTCCATGTTCAAGAAGCGGCTCACCGAGC
AGTACCCCGAAAAGAAGCAG

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTGRTDLSQFGIDPLWLVLVKCVAVFAFLVLTVLIAILAERRVLAWMQRRIGPNRVGPFGLLQSLADGVKLALKEGLTPA
GVDKPIYLLAPIISVVPAIVAYAVIPFGPVVSVFGHRTPLQLTDLPVAILFVLAVTSVGVYGIVLGGWASGSTYPLLGGL
RSSAQVISYEIAMGLTFAAVFLLAGTMSTSGIVAAQEGRWYLFLLLPSFLVYVTAMVGETNRAPFDLPEAEGELVGGFHT
EYSSLRFAMFMLAEYINMATVSGLAATMFLGGWHAPWPLSLIDGANTSWLPALWFVAKVWGFMFLFMWLRATLPRLRYDQ
FMRLGWEVLIPVALVWIVVVGVVKAMGLYGYGNPSIILGITGVAVSLGSIGLVGVLSRRTQPPKPVLPARFDPMAGGFPV
PPLPGQRVDTGAHPSTKEDADA

Sequences:

>Translated_422_residues
MTGRTDLSQFGIDPLWLVLVKCVAVFAFLVLTVLIAILAERRVLAWMQRRIGPNRVGPFGLLQSLADGVKLALKEGLTPA
GVDKPIYLLAPIISVVPAIVAYAVIPFGPVVSVFGHRTPLQLTDLPVAILFVLAVTSVGVYGIVLGGWASGSTYPLLGGL
RSSAQVISYEIAMGLTFAAVFLLAGTMSTSGIVAAQEGRWYLFLLLPSFLVYVTAMVGETNRAPFDLPEAEGELVGGFHT
EYSSLRFAMFMLAEYINMATVSGLAATMFLGGWHAPWPLSLIDGANTSWLPALWFVAKVWGFMFLFMWLRATLPRLRYDQ
FMRLGWEVLIPVALVWIVVVGVVKAMGLYGYGNPSIILGITGVAVSLGSIGLVGVLSRRTQPPKPVLPARFDPMAGGFPV
PPLPGQRVDTGAHPSTKEDADA
>Mature_421_residues
TGRTDLSQFGIDPLWLVLVKCVAVFAFLVLTVLIAILAERRVLAWMQRRIGPNRVGPFGLLQSLADGVKLALKEGLTPAG
VDKPIYLLAPIISVVPAIVAYAVIPFGPVVSVFGHRTPLQLTDLPVAILFVLAVTSVGVYGIVLGGWASGSTYPLLGGLR
SSAQVISYEIAMGLTFAAVFLLAGTMSTSGIVAAQEGRWYLFLLLPSFLVYVTAMVGETNRAPFDLPEAEGELVGGFHTE
YSSLRFAMFMLAEYINMATVSGLAATMFLGGWHAPWPLSLIDGANTSWLPALWFVAKVWGFMFLFMWLRATLPRLRYDQF
MRLGWEVLIPVALVWIVVVGVVKAMGLYGYGNPSIILGITGVAVSLGSIGLVGVLSRRTQPPKPVLPARFDPMAGGFPVP
PLPGQRVDTGAHPSTKEDADA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=298, Percent_Identity=38.5906040268456, Blast_Score=203, Evalue=3e-52,
Organism=Escherichia coli, GI1788618, Length=327, Percent_Identity=38.2262996941896, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45347; Mature: 45216

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRTDLSQFGIDPLWLVLVKCVAVFAFLVLTVLIAILAERRVLAWMQRRIGPNRVGPFG
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LLQSLADGVKLALKEGLTPAGVDKPIYLLAPIISVVPAIVAYAVIPFGPVVSVFGHRTPL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCC
QLTDLPVAILFVLAVTSVGVYGIVLGGWASGSTYPLLGGLRSSAQVISYEIAMGLTFAAV
EEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
FLLAGTMSTSGIVAAQEGRWYLFLLLPSFLVYVTAMVGETNRAPFDLPEAEGELVGGFHT
HHHHHCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHH
EYSSLRFAMFMLAEYINMATVSGLAATMFLGGWHAPWPLSLIDGANTSWLPALWFVAKVW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHH
GFMFLFMWLRATLPRLRYDQFMRLGWEVLIPVALVWIVVVGVVKAMGLYGYGNPSIILGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
TGVAVSLGSIGLVGVLSRRTQPPKPVLPARFDPMAGGFPVPPLPGQRVDTGAHPSTKEDA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DA
CC
>Mature Secondary Structure 
TGRTDLSQFGIDPLWLVLVKCVAVFAFLVLTVLIAILAERRVLAWMQRRIGPNRVGPFG
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LLQSLADGVKLALKEGLTPAGVDKPIYLLAPIISVVPAIVAYAVIPFGPVVSVFGHRTPL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCC
QLTDLPVAILFVLAVTSVGVYGIVLGGWASGSTYPLLGGLRSSAQVISYEIAMGLTFAAV
EEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
FLLAGTMSTSGIVAAQEGRWYLFLLLPSFLVYVTAMVGETNRAPFDLPEAEGELVGGFHT
HHHHHCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHH
EYSSLRFAMFMLAEYINMATVSGLAATMFLGGWHAPWPLSLIDGANTSWLPALWFVAKVW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHH
GFMFLFMWLRATLPRLRYDQFMRLGWEVLIPVALVWIVVVGVVKAMGLYGYGNPSIILGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
TGVAVSLGSIGLVGVLSRRTQPPKPVLPARFDPMAGGFPVPPLPGQRVDTGAHPSTKEDA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA