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The map label for this gene is adhB [H]

Identifier: 169629170

GI number: 169629170

Start: 2084542

End: 2085648

Strand: Direct

Name: adhB [H]

Synonym: MAB_2084

Alternate gene names: 169629170

Gene position: 2084542-2085648 (Clockwise)

Preceding gene: 169629169

Following gene: 169629171

Centisome position: 41.14

GC content: 61.43

Gene sequence:

>1107_bases
ATGAAGACACGTGCGGCTGTTTTGTGGGGCTTGGAGCAGAAGTGGGAGGTCGAAGAAGTCGATTTGGATCCGCCAGGTCC
CGGGGAGGTCCTCGTGCGGCTGGCGGCCACCGGCTTGTGCCATTCCGACGAACATCTGGTGACCGGCGACCTCCCGATCC
CATTGCCGGTAGTGGGGGGTCATGAGGGTGCTGGCACAGTCGTGGAGTGCGGCGAAGGGGTCGAGGATCTGTCCGAAGGT
GATTCTGTCATCTTGACCTTCCTTCCCTCGTGTGGGCGCTGCTCGTACTGCGCGCGCGGCATGGGCAATCTCTGTGAGTT
GGGAGCGGCGCTCATGATGGGACCGCAGATCGACGGCACCTATCGCTTTCACGCACGAGGCGAGGACGTCGGGCAGATGT
GTTTGCTCGGAACGTTTTCCGAGTACACAGTGGTGCCGCAGGCATCCGTGGTCAAGATTGACGGCGGAATCCCTCTGGAT
CGGGCAGCCTTGATCGGGTGCGGCGTCACGACCGGCTACGGATCTGCGGTGCGGACTGGGGAGGTGCGCGCCGGGGACAC
CGTCGTGGTAGTGGGAGCAGGCGGAATCGGAATGAATGCGATTCAGGGTGCGCGAATCGCGGGTGCGCTAGCAATTGTGG
CGGTCGATCCGGTGAACTTCAAGCGAGAGCAAGCGAGCGGGTTCGGCGCGACGCATACCGCCGCCTCGATGGATGAAGCT
TGGTCGCTGGTCAGCGATATGACGCGGGGCAAGCTGGCCGATGTCTGCATCCTCACCACTGATGTAGCTGAGGGCTCTTA
TACCGCCGAAGCGCTGGCCTTGGTCGGAAAGCGCGGACGCGTCGTGGTTACGGCCATCGGGCATCCCGACGAGTCGTCGA
TCTCAGGGTCACTGCTGGAGATGACGCTTTACGAGAAGCAGATTCGTGGCGCTTTGTATGGCTCATCCAATGCGCCACAC
GATATTCCGCGGCTGGTCGAGCTTTACTCCGCCGGGCTGTTGAAGCTCGACGAGTTGGTCACCCGCGAATACTCCCTCGA
CCAAATCAATGAGGGCTACCAGGATATGCGTTCAGGAAGAAACATTCGAGGGCTCGTCCGGTTCTGA

Upstream 100 bases:

>100_bases
GGGCGATGTGCCCGGAGATCATCCAGGACAGTTCGCGCGACCACCGTGCGCGGTCGGGACAACTACTTCAGAAGCGTCAT
TAGATAGAAGGGACTTCAAC

Downstream 100 bases:

>100_bases
AGAGAACCATGCTCCACTGCTCGTGTTCATGTCCTTGCGCCGCTGCAGATTACACGCCGCCGGACCGCTTAGGCTGCCGC
GCGTCGCGTCCTCGTTTCCC

Product: zinc-type alcohol dehydrogenase AdhD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIPLPVVGGHEGAGTVVECGEGVEDLSEG
DSVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLD
RAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEA
WSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPH
DIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF

Sequences:

>Translated_368_residues
MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIPLPVVGGHEGAGTVVECGEGVEDLSEG
DSVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLD
RAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEA
WSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPH
DIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF
>Mature_368_residues
MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIPLPVVGGHEGAGTVVECGEGVEDLSEG
DSVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLD
RAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEA
WSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPH
DIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=377, Percent_Identity=37.6657824933687, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI34577061, Length=377, Percent_Identity=37.6657824933687, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=35.230352303523, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=35.230352303523, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4501929, Length=376, Percent_Identity=36.1702127659575, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=35.2, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=34.9462365591398, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=34.9726775956284, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=32.6259946949602, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI156627571, Length=360, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786552, Length=383, Percent_Identity=34.4647519582245, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=26.3707571801567, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=25.5192878338279, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1786825, Length=374, Percent_Identity=27.807486631016, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=26.4880952380952, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=359, Percent_Identity=27.8551532033426, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=27.536231884058, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786518, Length=378, Percent_Identity=28.3068783068783, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788073, Length=376, Percent_Identity=23.936170212766, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=29.2035398230088, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=24.1758241758242, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=385, Percent_Identity=31.6883116883117, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71997431, Length=387, Percent_Identity=31.5245478036176, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17565904, Length=355, Percent_Identity=31.830985915493, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71988145, Length=363, Percent_Identity=28.9256198347107, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=352, Percent_Identity=28.6931818181818, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=371, Percent_Identity=27.4932614555256, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=374, Percent_Identity=29.144385026738, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=370, Percent_Identity=27.027027027027, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=378, Percent_Identity=35.4497354497354, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=28.1524926686217, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=26.2536873156342, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=362, Percent_Identity=27.0718232044199, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=345, Percent_Identity=27.8260869565217, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=209, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=353, Percent_Identity=25.4957507082153, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=228, Percent_Identity=30.2631578947368, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=228, Percent_Identity=30.2631578947368, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=371, Percent_Identity=23.989218328841, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737895, Length=380, Percent_Identity=35, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17137530, Length=367, Percent_Identity=26.158038147139, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737897, Length=362, Percent_Identity=26.2430939226519, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38670; Mature: 38670

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIPLPVVGG
CCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEECC
HEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGT
CCCCCCCEECCCCHHHHHCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCE
YRFHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTG
EEEEECCCCCCCEEEEECCCCEEECCCCEEEEECCCCCCCHHHEEECCCCCCCCCCEECC
EVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEA
CCCCCCEEEEEECCCCCCHHHCCCHHEEEEEEEEECCCCCCHHHCCCCCCCCHHHHHHHH
WSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLE
HHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHH
MTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSGR
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCHHHHHCCC
NIRGLVRF
CCEEEECC
>Mature Secondary Structure
MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIPLPVVGG
CCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEECC
HEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGT
CCCCCCCEECCCCHHHHHCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCE
YRFHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTG
EEEEECCCCCCCEEEEECCCCEEECCCCEEEEECCCCCCCHHHEEECCCCCCCCCCEECC
EVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEA
CCCCCCEEEEEECCCCCCHHHCCCHHEEEEEEEEECCCCCCHHHCCCCCCCCHHHHHHHH
WSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLE
HHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHH
MTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSGR
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCHHHHHCCC
NIRGLVRF
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]