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The map label for this gene is paaJ [C]

Identifier: 169628952

GI number: 169628952

Start: 1861159

End: 1862367

Strand: Direct

Name: paaJ [C]

Synonym: MAB_1864

Alternate gene names: 169628952

Gene position: 1861159-1862367 (Clockwise)

Preceding gene: 169628951

Following gene: 169628953

Centisome position: 36.73

GC content: 63.44

Gene sequence:

>1209_bases
ATGAAGCAGCAGAACAAGGTGTTCGTCGTCGGTGTCGGCATGACCAAATTCGAGAAGCCCGGGCGCAGGGAGGGCTGGGA
CTATCCGGCGATGGTCAAGGAAGCCGGCACCAAGGCACTCGAAGACGCCGGGGTTCAGTACCCGGAGATCGAACAGGCCT
TCATCGGAAACGTCTACGGCGACTCGTGCTCCGGCCACCGCGCGCTCTACGAGCTCGGCCACACCGGTATTCCGATCTAT
AACGTCAACAGCAACTGCTCGACCGGTTCCACCGCACTGTTCATGGCGGCCAATGCCATTCGCAGCGGCCAGTCCGATGT
GGTGATGGCCGCGGGATTCGAGAAGATGGAACCCGGCTCGCTGGGCATGAAATTCAGCGATCGTGAGTCGCCCCTGCAAC
CGCACATCATGGCGCTCGGTGAGCTGAGTCAGCCGCAGTTCCCGATGACGGCCTGGATGTTCGCCGCCGCGGCCGAGGAG
TACATGCGTGAATACGGCCTCACCGCAGAACAACTGGCTTGGATCGGTTACAAGAACCACAAGCACTCGGTCAATAACCC
CTACAGCCAGTTCCAGGACGAGTACTCGTTGGAGGACATCCTGAGCTCGCGGACCATCGTGGGCCCGCTGACCAAGCTGC
AGTGCTCACCGACCTCCGATGGGTCCGCCGCCGCGATCGTGGCGAGTGAGGAGTTCGTCGACACGCACGGGTTGGCCGAT
CAGGCGGTGGAGATCGTGGGACAAGCCACCGTCACCGACCGCGAGGACACCTTTGACGGCACCGCCGCCGGCATTGTCGG
TGCGAACATGAACAAGGCCGCCATTGCCAGCGTGTACGCGCAGGCGCAGATCGGTCCGGACGATCTGGATGTGGTGGAGC
TGCATGACTGCTTCTCCGCCAATGAGATCTTGGTCTACGAGGCACTCGGATTCTGCGAACCGGGTGCGGCCGGCAAGCTG
ATCGACAACCAGGACACCACCTTTGGCGGTAAGTGGGTGGTCAATCCGTCGGGCGGGCTGATCTCCAAGGGGCACCCGCT
CGGTGCCACTGGCCTGGCGCAGTGCGCCGAACTGAACTGGCAGCTGCGCGGCAAGGCGGACAAGCGCCAGGTTGCCGGCG
CCGCGACCAAGGACGGCGTGGCCCTGCAACACAACATCGGGCTGGGTGGCTCGGTGGTTGTCACGGCATACCGCCCGGCC
AACCGGTGA

Upstream 100 bases:

>100_bases
CTACGCCGCGGCGCGCGTCAACAAAATCTACGGCGGTACAAGCGAAATCATGAAGGAAATCATCAGCCGGTCCCTGTAGA
CGGCGCGAAGGAGACATGCA

Downstream 100 bases:

>100_bases
CCGGTCCGGCCACGCTCTGCGCGGCGTTCCAGCGCACCGCCGCGCAGCATCCGGACCGCGTCGCGCTGCGCACTGTAGGT
GGCGGTGTGGTGATCACGTG

Product: lipid-transfer protein

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKQQNKVFVVGVGMTKFEKPGRREGWDYPAMVKEAGTKALEDAGVQYPEIEQAFIGNVYGDSCSGHRALYELGHTGIPIY
NVNSNCSTGSTALFMAANAIRSGQSDVVMAAGFEKMEPGSLGMKFSDRESPLQPHIMALGELSQPQFPMTAWMFAAAAEE
YMREYGLTAEQLAWIGYKNHKHSVNNPYSQFQDEYSLEDILSSRTIVGPLTKLQCSPTSDGSAAAIVASEEFVDTHGLAD
QAVEIVGQATVTDREDTFDGTAAGIVGANMNKAAIASVYAQAQIGPDDLDVVELHDCFSANEILVYEALGFCEPGAAGKL
IDNQDTTFGGKWVVNPSGGLISKGHPLGATGLAQCAELNWQLRGKADKRQVAGAATKDGVALQHNIGLGGSVVVTAYRPA
NR

Sequences:

>Translated_402_residues
MKQQNKVFVVGVGMTKFEKPGRREGWDYPAMVKEAGTKALEDAGVQYPEIEQAFIGNVYGDSCSGHRALYELGHTGIPIY
NVNSNCSTGSTALFMAANAIRSGQSDVVMAAGFEKMEPGSLGMKFSDRESPLQPHIMALGELSQPQFPMTAWMFAAAAEE
YMREYGLTAEQLAWIGYKNHKHSVNNPYSQFQDEYSLEDILSSRTIVGPLTKLQCSPTSDGSAAAIVASEEFVDTHGLAD
QAVEIVGQATVTDREDTFDGTAAGIVGANMNKAAIASVYAQAQIGPDDLDVVELHDCFSANEILVYEALGFCEPGAAGKL
IDNQDTTFGGKWVVNPSGGLISKGHPLGATGLAQCAELNWQLRGKADKRQVAGAATKDGVALQHNIGLGGSVVVTAYRPA
NR
>Mature_402_residues
MKQQNKVFVVGVGMTKFEKPGRREGWDYPAMVKEAGTKALEDAGVQYPEIEQAFIGNVYGDSCSGHRALYELGHTGIPIY
NVNSNCSTGSTALFMAANAIRSGQSDVVMAAGFEKMEPGSLGMKFSDRESPLQPHIMALGELSQPQFPMTAWMFAAAAEE
YMREYGLTAEQLAWIGYKNHKHSVNNPYSQFQDEYSLEDILSSRTIVGPLTKLQCSPTSDGSAAAIVASEEFVDTHGLAD
QAVEIVGQATVTDREDTFDGTAAGIVGANMNKAAIASVYAQAQIGPDDLDVVELHDCFSANEILVYEALGFCEPGAAGKL
IDNQDTTFGGKWVVNPSGGLISKGHPLGATGLAQCAELNWQLRGKADKRQVAGAATKDGVALQHNIGLGGSVVVTAYRPA
NR

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=396, Percent_Identity=57.0707070707071, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI302344760, Length=396, Percent_Identity=54.2929292929293, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI302344767, Length=326, Percent_Identity=57.361963190184, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI302344762, Length=396, Percent_Identity=49.7474747474747, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI55956775, Length=354, Percent_Identity=46.6101694915254, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17537653, Length=400, Percent_Identity=50.75, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24585051, Length=398, Percent_Identity=59.2964824120603, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI19921506, Length=398, Percent_Identity=59.0452261306533, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42898; Mature: 42898

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQNKVFVVGVGMTKFEKPGRREGWDYPAMVKEAGTKALEDAGVQYPEIEQAFIGNVYG
CCCCCCEEEEEECHHHCCCCCCCCCCCCHHHHHHHCHHHHHHCCCCCCCHHHHHHCCCCC
DSCSGHRALYELGHTGIPIYNVNSNCSTGSTALFMAANAIRSGQSDVVMAAGFEKMEPGS
CCCCCCHHHHHHCCCCCEEEECCCCCCCCCEEEEEEHHHHHCCCCCEEEECCCCCCCCCC
LGMKFSDRESPLQPHIMALGELSQPQFPMTAWMFAAAAEEYMREYGLTAEQLAWIGYKNH
CCCEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCC
KHSVNNPYSQFQDEYSLEDILSSRTIVGPLTKLQCSPTSDGSAAAIVASEEFVDTHGLAD
CCCCCCCHHHHHHCCCHHHHHHCCCEECCCCEEEECCCCCCCEEEEEECHHHHHHCCCHH
QAVEIVGQATVTDREDTFDGTAAGIVGANMNKAAIASVYAQAQIGPDDLDVVELHDCFSA
HHHHHHHCCEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHCCC
NEILVYEALGFCEPGAAGKLIDNQDTTFGGKWVVNPSGGLISKGHPLGATGLAQCAELNW
CCEEEEEECCCCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCE
QLRGKADKRQVAGAATKDGVALQHNIGLGGSVVVTAYRPANR
EEECCCCHHHHCCCCCCCCEEEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MKQQNKVFVVGVGMTKFEKPGRREGWDYPAMVKEAGTKALEDAGVQYPEIEQAFIGNVYG
CCCCCCEEEEEECHHHCCCCCCCCCCCCHHHHHHHCHHHHHHCCCCCCCHHHHHHCCCCC
DSCSGHRALYELGHTGIPIYNVNSNCSTGSTALFMAANAIRSGQSDVVMAAGFEKMEPGS
CCCCCCHHHHHHCCCCCEEEECCCCCCCCCEEEEEEHHHHHCCCCCEEEECCCCCCCCCC
LGMKFSDRESPLQPHIMALGELSQPQFPMTAWMFAAAAEEYMREYGLTAEQLAWIGYKNH
CCCEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCC
KHSVNNPYSQFQDEYSLEDILSSRTIVGPLTKLQCSPTSDGSAAAIVASEEFVDTHGLAD
CCCCCCCHHHHHHCCCHHHHHHCCCEECCCCEEEECCCCCCCEEEEEECHHHHHHCCCHH
QAVEIVGQATVTDREDTFDGTAAGIVGANMNKAAIASVYAQAQIGPDDLDVVELHDCFSA
HHHHHHHCCEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHCCC
NEILVYEALGFCEPGAAGKLIDNQDTTFGGKWVVNPSGGLISKGHPLGATGLAQCAELNW
CCEEEEEECCCCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCE
QLRGKADKRQVAGAATKDGVALQHNIGLGGSVVVTAYRPANR
EEECCCCHHHHCCCCCCCCEEEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]