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The map label for this gene is 169628948

Identifier: 169628948

GI number: 169628948

Start: 1857758

End: 1858498

Strand: Direct

Name: 169628948

Synonym: MAB_1860

Alternate gene names: NA

Gene position: 1857758-1858498 (Clockwise)

Preceding gene: 169628947

Following gene: 169628950

Centisome position: 36.66

GC content: 63.16

Gene sequence:

>741_bases
ATGATGCCCATAAGGGTGTGGGCCGCGTTCGGCCGCAACGATATTCGTGGCACCTATCGCGATCCGCTGCTGATCATGGT
GGTGCTGGCCCCGATCATCTGGACCACTGGCGTGGCGGTATTGACCCCGCAGGCCACCGACTTGCTGTCTGCTACCAGGG
GATTCGACCTGGTTCCGTACTACCCGTTGGTGCTGACAGCCTTCCTGCTGCTCACCAGCATCATCATCCCCGGAGCGCTG
GCGGCGTTTCTGGTCCTGGATGACGTCGACGCCGGGACGCTGACGGCGCTGCGGGTCACGCCGGTGCCGATGTCGGGGTA
TTTCCTGTACCGGGCCGCCACGGTCGTCGTGATCACCACCGTGTACGTGGTCGCGACCTTGTCCCTGAGTGGCATCTTGG
AGCCCGGCGTGCTACCCGCCCTCATTCCCATCGGGATGCTCTCCGGGCTTTCGGCGGTGGTGACACTGCTCTTGGTGATC
GCCTTTGCCAACAACAAGATTCAGGGACTGGCCGCCGTACGCGCGCTCGGCATGCTGATCGCGGGATTGCCCTGTTTGCC
GTGGTTCATTCACTCCAACTGGGGATACGCCTTTGGCGTGCTGCCCCCGTTCTGGGCGGCGAAGGCCTTTTGGGTGGCCA
GTGCCCACGGCATGTGGTGGCCCTTTGTGCTCATCGGGGTTGCCTACAACCTGCTGATCGCATGGGCGCTGCTCCGGCGT
TTCCTTGCCAAGAATCTCTAG

Upstream 100 bases:

>100_bases
TGTACGCGGTGGGCTATCCCGTGCTGGGCATCGCCGGGCTCTCCTGGCTCTGCAAGATCGCCTTCGGCAAGTACGTCGTG
GCGCAGTCCGGCGGAATGTC

Downstream 100 bases:

>100_bases
TCGAGCACCTTGATGGACAATGTGGGTTTGGGGGCATCTCCTGACTGCACCCGATCCCATGCGGCATCGATGAGCGGCTG
AAGCAGCAGCGCTCCCATCT

Product: antibiotic ABC transporter membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MMPIRVWAAFGRNDIRGTYRDPLLIMVVLAPIIWTTGVAVLTPQATDLLSATRGFDLVPYYPLVLTAFLLLTSIIIPGAL
AAFLVLDDVDAGTLTALRVTPVPMSGYFLYRAATVVVITTVYVVATLSLSGILEPGVLPALIPIGMLSGLSAVVTLLLVI
AFANNKIQGLAAVRALGMLIAGLPCLPWFIHSNWGYAFGVLPPFWAAKAFWVASAHGMWWPFVLIGVAYNLLIAWALLRR
FLAKNL

Sequences:

>Translated_246_residues
MMPIRVWAAFGRNDIRGTYRDPLLIMVVLAPIIWTTGVAVLTPQATDLLSATRGFDLVPYYPLVLTAFLLLTSIIIPGAL
AAFLVLDDVDAGTLTALRVTPVPMSGYFLYRAATVVVITTVYVVATLSLSGILEPGVLPALIPIGMLSGLSAVVTLLLVI
AFANNKIQGLAAVRALGMLIAGLPCLPWFIHSNWGYAFGVLPPFWAAKAFWVASAHGMWWPFVLIGVAYNLLIAWALLRR
FLAKNL
>Mature_246_residues
MMPIRVWAAFGRNDIRGTYRDPLLIMVVLAPIIWTTGVAVLTPQATDLLSATRGFDLVPYYPLVLTAFLLLTSIIIPGAL
AAFLVLDDVDAGTLTALRVTPVPMSGYFLYRAATVVVITTVYVVATLSLSGILEPGVLPALIPIGMLSGLSAVVTLLLVI
AFANNKIQGLAAVRALGMLIAGLPCLPWFIHSNWGYAFGVLPPFWAAKAFWVASAHGMWWPFVLIGVAYNLLIAWALLRR
FLAKNL

Specific function: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the sub

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 26562; Mature: 26562

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPIRVWAAFGRNDIRGTYRDPLLIMVVLAPIIWTTGVAVLTPQATDLLSATRGFDLVPY
CCCEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCCH
YPLVLTAFLLLTSIIIPGALAAFLVLDDVDAGTLTALRVTPVPMSGYFLYRAATVVVITT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
VYVVATLSLSGILEPGVLPALIPIGMLSGLSAVVTLLLVIAFANNKIQGLAAVRALGMLI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AGLPCLPWFIHSNWGYAFGVLPPFWAAKAFWVASAHGMWWPFVLIGVAYNLLIAWALLRR
HCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLAKNL
HHHHCC
>Mature Secondary Structure
MMPIRVWAAFGRNDIRGTYRDPLLIMVVLAPIIWTTGVAVLTPQATDLLSATRGFDLVPY
CCCEEEEEHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCCH
YPLVLTAFLLLTSIIIPGALAAFLVLDDVDAGTLTALRVTPVPMSGYFLYRAATVVVITT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
VYVVATLSLSGILEPGVLPALIPIGMLSGLSAVVTLLLVIAFANNKIQGLAAVRALGMLI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AGLPCLPWFIHSNWGYAFGVLPPFWAAKAFWVASAHGMWWPFVLIGVAYNLLIAWALLRR
HCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLAKNL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]