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The map label for this gene is bioI [H]

Identifier: 169627381

GI number: 169627381

Start: 274574

End: 275803

Strand: Direct

Name: bioI [H]

Synonym: MAB_0276

Alternate gene names: 169627381

Gene position: 274574-275803 (Clockwise)

Preceding gene: 169627380

Following gene: 169627385

Centisome position: 5.42

GC content: 63.09

Gene sequence:

>1230_bases
ATGCCTATTACGACCGACCCGGGCACGCTGTTGCTTCAGGTGCTCGACCCGGCCAACCGCGCGAATCCATACCCCGTGTA
CGGCCAGCTGGTCGAGCAGACGCAGGCCGGTCCGGTGCACCCACCCGGCATGGACGTGAGTGTGCTTGCCACCTTCGCGG
ACTGCAATGCCGTGCTGCGCCACCCGCAGGCGTCGTCGGACCGCCGTAAGTCGAACATCGTCCAGCGGCAGCTTGCGCAG
AATCCCAATCTGATCGCCAGACCCTCTTTCCTGGGGCTGGACGCGCCCGACCACACCCGGTTGCGCAAGTTGGCATCAAA
GGCGTTCGCCCCCAGGGTTATCAATGCGATGGCCGAAGATATCCAGACGTTTGTGGACAAGATGTTGGACGATATCGCCC
TGCGAGGCACCTTCAATCTGGTCACCGAATTTGCCTACCCGCTACCCGTCGCGGTGATCTGTCGCATGCTGGGGGTTCCG
ATCGAAGATGAGCCGGAATTTGGCAGGGCCTCAGCGCTTCTGGGGCAGGGGTTGGACCCGGTGTACGCGTTGACCGGCCA
GTCGCCGGCCAACATGGACGAACGGTTCCAGGCCGCCCGCTGGATGTGGGACTACTTTATCGACCTCATCGCGTCCCGCC
GGCGCAACCTCGGGGACGATCTGCTGTCCGCGCTGATCCAGGTGGAAGAGGCGGGTGATCAGCTGACCGAGGAAGAGATC
ATCTCCACCTGCACCCTGCTGCTCATCGCCGGACACGAGACCACGGTCAATCTGATCGCGAATGCCTCGCTGGCCATGTT
GCGGCATCCGGAACAGTGGAAACTGTTGGGACAGAATGCTGATCGAGCGCCGCTGGTTGTCGAAGAGACGCTGCGTTACG
ATCCGCCGGTGCACATGGTCGCCCGTGTCGCGGACGGAGAGATGGCCATTCGTGACTTCATACTGCCGGACGGGGAGTGG
GTGTTGTTGATGCTTGCTGCCGCGCAACGTGATCCGGACGTCGGACCCGATCTGGACGTCTTCAATCCGGATCGTTCCGA
GATCAAACACCTGGCCTTCGGGCACGGGCCGCACTTTTGCCTGGGAGCTCCGCTGGCCCGCCTGGAGGCCCGGTTGGCGT
TGAGTTCGATTACCGCCCGGTTCCCCGGCGCGCGGTTGATGGACGAACCCACCTACAAGCCGAATGTCACACTGCGCGGG
CTTGCCGAGCTTCCGGTGAGCATCGCCTAG

Upstream 100 bases:

>100_bases
AAGGCTGCTTCCAGGAGCTGCGCGAAGACACCCTGGGCCGCTATTACCGCTGAGCCACGAAGCTCAGGTGCATCTCAGTA
TTTCGGCGCACACTGGACAC

Downstream 100 bases:

>100_bases
ATGCCGCCGACACGCCGTGTTCTGCGCGCGGCTCTCGGCGTTTAGATCGAAACACGGCGTGTCGGCGCTGAAGGGTTAGC
GCGCGACGGATTTCTCCAGA

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MPITTDPGTLLLQVLDPANRANPYPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLRHPQASSDRRKSNIVQRQLAQ
NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAEDIQTFVDKMLDDIALRGTFNLVTEFAYPLPVAVICRMLGVP
IEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGDDLLSALIQVEEAGDQLTEEEI
ISTCTLLLIAGHETTVNLIANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVARVADGEMAIRDFILPDGEW
VLLMLAAAQRDPDVGPDLDVFNPDRSEIKHLAFGHGPHFCLGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRG
LAELPVSIA

Sequences:

>Translated_409_residues
MPITTDPGTLLLQVLDPANRANPYPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLRHPQASSDRRKSNIVQRQLAQ
NPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAEDIQTFVDKMLDDIALRGTFNLVTEFAYPLPVAVICRMLGVP
IEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGDDLLSALIQVEEAGDQLTEEEI
ISTCTLLLIAGHETTVNLIANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVARVADGEMAIRDFILPDGEW
VLLMLAAAQRDPDVGPDLDVFNPDRSEIKHLAFGHGPHFCLGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRG
LAELPVSIA
>Mature_408_residues
PITTDPGTLLLQVLDPANRANPYPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLRHPQASSDRRKSNIVQRQLAQN
PNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAEDIQTFVDKMLDDIALRGTFNLVTEFAYPLPVAVICRMLGVPI
EDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGDDLLSALIQVEEAGDQLTEEEII
STCTLLLIAGHETTVNLIANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVARVADGEMAIRDFILPDGEWV
LLMLAAAQRDPDVGPDLDVFNPDRSEIKHLAFGHGPHFCLGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGL
AELPVSIA

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI119220562, Length=271, Percent_Identity=26.1992619926199, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI13435391, Length=271, Percent_Identity=25.830258302583, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI193083180, Length=229, Percent_Identity=24.8908296943231, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI193083178, Length=229, Percent_Identity=24.8908296943231, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI6005737, Length=251, Percent_Identity=25.0996015936255, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI310125128, Length=207, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI14550409, Length=207, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI310125130, Length=207, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI190570174, Length=207, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI150036266, Length=227, Percent_Identity=24.6696035242291, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4503213, Length=185, Percent_Identity=31.8918918918919, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI261278370, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI195972896, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI195972898, Length=175, Percent_Identity=29.1428571428571, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI261278372, Length=175, Percent_Identity=29.1428571428571, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17552522, Length=205, Percent_Identity=28.780487804878, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17540354, Length=228, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115532670, Length=204, Percent_Identity=27.4509803921569, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982956, Length=189, Percent_Identity=26.4550264550265, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982977, Length=205, Percent_Identity=25.8536585365854, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534628, Length=263, Percent_Identity=24.7148288973384, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355669, Length=377, Percent_Identity=25.7294429708223, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17933518, Length=273, Percent_Identity=24.9084249084249, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24660171, Length=236, Percent_Identity=25.8474576271186, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330299, Length=236, Percent_Identity=25.8474576271186, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358627, Length=213, Percent_Identity=25.8215962441315, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656064, Length=217, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647303, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24582534, Length=204, Percent_Identity=25.4901960784314, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24642101, Length=216, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 44977; Mature: 44846

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITTDPGTLLLQVLDPANRANPYPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLR
CCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHC
HPQASSDRRKSNIVQRQLAQNPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAED
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQTFVDKMLDDIALRGTFNLVTEFAYPLPVAVICRMLGVPIEDEPEFGRASALLGQGLDP
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
VYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGDDLLSALIQVEEAGDQLTEEEI
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ISTCTLLLIAGHETTVNLIANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMV
HHHHHHHEEECCCCEEHHHHCCHHHHHCCCHHHHHHCCCCCCCCCHHHHHHCCCCCHHHH
ARVADGEMAIRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEIKHLAFGHGPHFC
HHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHH
LGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGLAELPVSIA
HCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHCCCCCCC
>Mature Secondary Structure 
PITTDPGTLLLQVLDPANRANPYPVYGQLVEQTQAGPVHPPGMDVSVLATFADCNAVLR
CCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHC
HPQASSDRRKSNIVQRQLAQNPNLIARPSFLGLDAPDHTRLRKLASKAFAPRVINAMAED
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQTFVDKMLDDIALRGTFNLVTEFAYPLPVAVICRMLGVPIEDEPEFGRASALLGQGLDP
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
VYALTGQSPANMDERFQAARWMWDYFIDLIASRRRNLGDDLLSALIQVEEAGDQLTEEEI
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ISTCTLLLIAGHETTVNLIANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMV
HHHHHHHEEECCCCEEHHHHCCHHHHHCCCHHHHHHCCCCCCCCCHHHHHHCCCCCHHHH
ARVADGEMAIRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEIKHLAFGHGPHFC
HHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHH
LGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGLAELPVSIA
HCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]