Click here to switch to the map view.

The map label for this gene is yhcA [H]

Identifier: 16766217

GI number: 16766217

Start: 3053279

End: 3054487

Strand: Reverse

Name: yhcA [H]

Synonym: STM2911

Alternate gene names: 16766217

Gene position: 3054487-3053279 (Counterclockwise)

Preceding gene: 16766219

Following gene: 16766216

Centisome position: 62.88

GC content: 54.43

Gene sequence:

>1209_bases
ATGACGTATCGCAGTAAAGTGGCAGTGGTTTACCTGCTCGGCTTCTTTCTTGATCTGATTAATCTGTTTATTGCCAGCGT
GGCTTTTCCTGCGATGTCCGTGGATCTGCATACGTCCATATCGGCGCTGGCATGGGTGAGTAACGGTTATATCGCAGGAT
TAACGCTGATCGTTCCGTTTAGCGCGTTTCTTTCGCGTTATCTCGGCGCACGACGGCTGATCATATTTTCGCTCATTCTG
TTTAGCGTTGCCGCCGCTGCCGCAGGTTTTGCCGATTCATTACACAGCCTTGTTTTCTGGCGTATTGTGCAGGGGGCGGG
CGGTGGCTTATTGATCCCGGTTGGTCAGGCGTTAACCTGGCAACAGTTTAAACCGCATGAACGCGCTGGCGTGTCATCGG
TTGTCATGATGGTGGCGCTACTGGCGCCGGCATGTTCGCCTGCGATTGGCGGGCTGCTGGTGGAAACGTGCGGCTGGCGC
TGGATATTCTTTGCCACGCTGCCGGTGGCCGTTCTCACCTTATTGCTCGCTTATCGTTGGCTGAATGTCGCGTCGACGAC
AATGGCGTCAGCAAGATTGCTCCATCTGCCGTTGTTGACGGACAGGCTGCTGCGTTTTGCCATGATCGTCTATCTGTGTG
TGCCGGGTATGTTCATTGGTATCAGCGTGGTCGGGATGTTTTATCTACAGAACGTCGCGCAGCTATCGCCTGCGGCGGCG
GGGTCGCTGATGATCCCCTGGTCGATCGCTTCATTTGTCGCCATTATGCTTACCGGACGTTACTTCAATCGGCTTGGGCC
GCGTCCGCTGATTATCGTCGGCTGTCTTCTTCAGGCCGCAGGGATACTGCTTTTAACTAACGTTACGCCTGCGACATCGC
ACCGTGTACTGATGATGATATTCGCCTTAATGGGCGCTGGCGGCAGTTTGTGCAGCAGTACCGCGCAGAGTGGCGCTTTC
CTGACTATTGCTCGCCGGGACATGCCTGACGCCAGCGCGCTATGGAATCTTAATCGTCAGATCAGCTTTTTCCTTGGCGC
GACGCTGTTGACGCTGCTGTTAAATGCGCTCCAGCGCGTTATGTCGCTTGAGGTTGCTTATCGCTGGACCTTTATTGCCG
CCGCCGGTATCACCCTGCTGCCCCTTATTTACGCTGTCTGTCTAAACAATAGACAGGCGCTTCTGTGCCTGAAAAAGGAA
AGATCATGA

Upstream 100 bases:

>100_bases
CCTTTACTGTCAAAATTATTTTGACAGTATATCGTTGAAGCGCGGACTTATCTGGCTTTCTCCGGACGGCTACATTAGCG
CCTCTGACGGAGGATGCATA

Downstream 100 bases:

>100_bases
ATCCATATAAAGAAGAAATTATTCATGCCCATGCGGCGATTGAGAACTGGCTTAGTAAGGGGGTGGGTAGCCTGGAGGCG
TTGATAGCGCGTTTCGCTGC

Product: permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTYRSKVAVVYLLGFFLDLINLFIASVAFPAMSVDLHTSISALAWVSNGYIAGLTLIVPFSAFLSRYLGARRLIIFSLIL
FSVAAAAAGFADSLHSLVFWRIVQGAGGGLLIPVGQALTWQQFKPHERAGVSSVVMMVALLAPACSPAIGGLLVETCGWR
WIFFATLPVAVLTLLLAYRWLNVASTTMASARLLHLPLLTDRLLRFAMIVYLCVPGMFIGISVVGMFYLQNVAQLSPAAA
GSLMIPWSIASFVAIMLTGRYFNRLGPRPLIIVGCLLQAAGILLLTNVTPATSHRVLMMIFALMGAGGSLCSSTAQSGAF
LTIARRDMPDASALWNLNRQISFFLGATLLTLLLNALQRVMSLEVAYRWTFIAAAGITLLPLIYAVCLNNRQALLCLKKE
RS

Sequences:

>Translated_402_residues
MTYRSKVAVVYLLGFFLDLINLFIASVAFPAMSVDLHTSISALAWVSNGYIAGLTLIVPFSAFLSRYLGARRLIIFSLIL
FSVAAAAAGFADSLHSLVFWRIVQGAGGGLLIPVGQALTWQQFKPHERAGVSSVVMMVALLAPACSPAIGGLLVETCGWR
WIFFATLPVAVLTLLLAYRWLNVASTTMASARLLHLPLLTDRLLRFAMIVYLCVPGMFIGISVVGMFYLQNVAQLSPAAA
GSLMIPWSIASFVAIMLTGRYFNRLGPRPLIIVGCLLQAAGILLLTNVTPATSHRVLMMIFALMGAGGSLCSSTAQSGAF
LTIARRDMPDASALWNLNRQISFFLGATLLTLLLNALQRVMSLEVAYRWTFIAAAGITLLPLIYAVCLNNRQALLCLKKE
RS
>Mature_401_residues
TYRSKVAVVYLLGFFLDLINLFIASVAFPAMSVDLHTSISALAWVSNGYIAGLTLIVPFSAFLSRYLGARRLIIFSLILF
SVAAAAAGFADSLHSLVFWRIVQGAGGGLLIPVGQALTWQQFKPHERAGVSSVVMMVALLAPACSPAIGGLLVETCGWRW
IFFATLPVAVLTLLLAYRWLNVASTTMASARLLHLPLLTDRLLRFAMIVYLCVPGMFIGISVVGMFYLQNVAQLSPAAAG
SLMIPWSIASFVAIMLTGRYFNRLGPRPLIIVGCLLQAAGILLLTNVTPATSHRVLMMIFALMGAGGSLCSSTAQSGAFL
TIARRDMPDASALWNLNRQISFFLGATLLTLLLNALQRVMSLEVAYRWTFIAAAGITLLPLIYAVCLNNRQALLCLKKER
S

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=167, Percent_Identity=31.1377245508982, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788710, Length=194, Percent_Identity=28.3505154639175, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790195, Length=200, Percent_Identity=27.5, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081983, Length=418, Percent_Identity=24.8803827751196, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788392, Length=160, Percent_Identity=30, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43484; Mature: 43353

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRSKVAVVYLLGFFLDLINLFIASVAFPAMSVDLHTSISALAWVSNGYIAGLTLIVPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCCCHHHHHHHHHHH
SAFLSRYLGARRLIIFSLILFSVAAAAAGFADSLHSLVFWRIVQGAGGGLLIPVGQALTW
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
QQFKPHERAGVSSVVMMVALLAPACSPAIGGLLVETCGWRWIFFATLPVAVLTLLLAYRW
HHCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LNVASTTMASARLLHLPLLTDRLLRFAMIVYLCVPGMFIGISVVGMFYLQNVAQLSPAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSLMIPWSIASFVAIMLTGRYFNRLGPRPLIIVGCLLQAAGILLLTNVTPATSHRVLMMI
CCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHH
FALMGAGGSLCSSTAQSGAFLTIARRDMPDASALWNLNRQISFFLGATLLTLLLNALQRV
HHHHCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MSLEVAYRWTFIAAAGITLLPLIYAVCLNNRQALLCLKKERS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure 
TYRSKVAVVYLLGFFLDLINLFIASVAFPAMSVDLHTSISALAWVSNGYIAGLTLIVPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCCCHHHHHHHHHHH
SAFLSRYLGARRLIIFSLILFSVAAAAAGFADSLHSLVFWRIVQGAGGGLLIPVGQALTW
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
QQFKPHERAGVSSVVMMVALLAPACSPAIGGLLVETCGWRWIFFATLPVAVLTLLLAYRW
HHCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LNVASTTMASARLLHLPLLTDRLLRFAMIVYLCVPGMFIGISVVGMFYLQNVAQLSPAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GSLMIPWSIASFVAIMLTGRYFNRLGPRPLIIVGCLLQAAGILLLTNVTPATSHRVLMMI
CCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHH
FALMGAGGSLCSSTAQSGAFLTIARRDMPDASALWNLNRQISFFLGATLLTLLLNALQRV
HHHHCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MSLEVAYRWTFIAAAGITLLPLIYAVCLNNRQALLCLKKERS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]