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The map label for this gene is hxlA [H]

Identifier: 16766067

GI number: 16766067

Start: 2893685

End: 2894320

Strand: Reverse

Name: hxlA [H]

Synonym: STM2755

Alternate gene names: 16766067

Gene position: 2894320-2893685 (Counterclockwise)

Preceding gene: 16766068

Following gene: 16766060

Centisome position: 59.59

GC content: 53.93

Gene sequence:

>636_bases
ATGAAATTACAGCTTGCCCTGGACGAGTTAACCCTGCCTGAAGCGATGGTATTTATGGATAAGGTGGTTGATGACGTTGA
TATTATTGAAGTGGGAACACCCTTTCTTATTCGGGAAGGCGTGAACGCGATTAAAGCCATTAAAGAAAAATACCCGCATA
AGGAAGTACTGGCGGATGCGAAAATTATGGATGGCGGCCATTTTGAATCGCAGCTGCTTTTCGACGCCGGGGCAGACTAT
GTCACGGTGTTAGGTGTGACCGACGTGCTGACGATCCAGTCGTGCATCCGCGCGGCAAAAGAGGCCGGAAAGCAGGTGGT
GGTGGATATGATCTGCGTCGACGATCTCCCCGCACGAGTCCGCCTGCTGGAGGAGGCGGGGGCAGATATGCTGGCGGTAC
ACACAGGCACCGACCAGCAGGCAGCAGGGCGCAAACCGATTGATGATTTGATAACGATGTTGAAGGTGCGCCGGAAAGCC
CGGATTGCCGTGGCAGGCGGTATCAGTAGCCAGACTGTGAAGGACTACGCACTGTTAGGCCCGGATGTAGTGATTGTGGG
ATCAGCGATCACGCATGCGGCGGATCCGGCAGGTGAAGCGAGGAAGATTTCACAGGTGTTGTTACAGCATCACTGA

Upstream 100 bases:

>100_bases
CCATGATTGTGAATCTGGCGCAGTCGACGGGATATCGCTTAACCAAAGGCTTTGCGCTGCACGCCAACCTCGAATAGTCA
TTCGACACAAGGAAACCAAC

Downstream 100 bases:

>100_bases
GGTGAAGGCGCAGGGGGAACTCTGCGCCTGATTTCACACTTTTAAAGTTATGAGCCGGAGGTTGTCGAAACTATTAAGCA
GGTTCTTCCAGATCGAACCT

Product: hexulose 6 phosphate synthase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase; HUMPS [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKLQLALDELTLPEAMVFMDKVVDDVDIIEVGTPFLIREGVNAIKAIKEKYPHKEVLADAKIMDGGHFESQLLFDAGADY
VTVLGVTDVLTIQSCIRAAKEAGKQVVVDMICVDDLPARVRLLEEAGADMLAVHTGTDQQAAGRKPIDDLITMLKVRRKA
RIAVAGGISSQTVKDYALLGPDVVIVGSAITHAADPAGEARKISQVLLQHH

Sequences:

>Translated_211_residues
MKLQLALDELTLPEAMVFMDKVVDDVDIIEVGTPFLIREGVNAIKAIKEKYPHKEVLADAKIMDGGHFESQLLFDAGADY
VTVLGVTDVLTIQSCIRAAKEAGKQVVVDMICVDDLPARVRLLEEAGADMLAVHTGTDQQAAGRKPIDDLITMLKVRRKA
RIAVAGGISSQTVKDYALLGPDVVIVGSAITHAADPAGEARKISQVLLQHH
>Mature_211_residues
MKLQLALDELTLPEAMVFMDKVVDDVDIIEVGTPFLIREGVNAIKAIKEKYPHKEVLADAKIMDGGHFESQLLFDAGADY
VTVLGVTDVLTIQSCIRAAKEAGKQVVVDMICVDDLPARVRLLEEAGADMLAVHTGTDQQAAGRKPIDDLITMLKVRRKA
RIAVAGGISSQTVKDYALLGPDVVIVGSAITHAADPAGEARKISQVLLQHH

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with hxlB, may act as a formaldehyde detoxification system [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=209, Percent_Identity=33.4928229665072, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790006, Length=200, Percent_Identity=29, Blast_Score=85, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017553
- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 22717; Mature: 22717

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQLALDELTLPEAMVFMDKVVDDVDIIEVGTPFLIREGVNAIKAIKEKYPHKEVLADA
CCEEEEHHHHCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHCC
KIMDGGHFESQLLFDAGADYVTVLGVTDVLTIQSCIRAAKEAGKQVVVDMICVDDLPARV
HHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
RLLEEAGADMLAVHTGTDQQAAGRKPIDDLITMLKVRRKARIAVAGGISSQTVKDYALLG
HHHHHCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCC
PDVVIVGSAITHAADPAGEARKISQVLLQHH
CCEEEECCHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLQLALDELTLPEAMVFMDKVVDDVDIIEVGTPFLIREGVNAIKAIKEKYPHKEVLADA
CCEEEEHHHHCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHCC
KIMDGGHFESQLLFDAGADYVTVLGVTDVLTIQSCIRAAKEAGKQVVVDMICVDDLPARV
HHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
RLLEEAGADMLAVHTGTDQQAAGRKPIDDLITMLKVRRKARIAVAGGISSQTVKDYALLG
HHHHHCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCC
PDVVIVGSAITHAADPAGEARKISQVLLQHH
CCEEEECCHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377 [H]