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The map label for this gene is fumB [H]

Identifier: 16764126

GI number: 16764126

Start: 824918

End: 825463

Strand: Reverse

Name: fumB [H]

Synonym: STM0761

Alternate gene names: 16764126

Gene position: 825463-824918 (Counterclockwise)

Preceding gene: 16764127

Following gene: 16764124

Centisome position: 16.99

GC content: 42.49

Gene sequence:

>546_bases
ATGATGGAATTAACATTACCATTGACTAAAGAGAAAGCGAAAACTCTTAAGGTCGGCGATATATTATTTCTCACTGGATT
TGCTTACACCTGCCGTGACGCCGCGCATAAAAAAATCGAAGTAGCGCTTAGTAACGGAGAAAAATCACCAGTCGATTTTC
AAAACCAAACAATTTACTATGCTGGCCCCTGCCCTGCCAGACCTGGTTTACCTATTGGCTCCAACGGTCCTACAACGGCC
GCGCGTATGGACCCATTTGTAGAAATGATGTTTCAACAAGGGGCAACTGCGTTTCTTGGCAAAGGCGATCGTGCTGATTA
TGTCGCTGAGCTTTGTAAAAAATACGGTGGGGTTTCGCTACTCGGGATTGGAGGAGCGTCTGCAATTAATACAAAACATG
TTAAATCAGTAGAAATTGTTGCCTACGAAGAATTAGGAACAGAATCCATTAAGAAGTTATATTTTGACCGCTATAGAGTC
ATTGTAGGAATTGATTCGGAAGGAAATACTCTCCAGAAGCAGGAAGTACCTAAGTACGCCAAATAA

Upstream 100 bases:

>100_bases
ATTACTATCCTTGCCATATCACTGCACTGCCAGTCGCAATCAATTTCCAATGTAATGCAAGCCGCCACGCTAGTGAAATC
ATTTAATACCTGGAGAAGCT

Downstream 100 bases:

>100_bases
TAATACATTAATATTGGTAATACCGGTCCGGTAGGCTGTTACCGGACCAATATGTTTTCTATCCTGCACTTCACTACAGG
ATAGAAACTAAACTTAGCCG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MMELTLPLTKEKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIYYAGPCPARPGLPIGSNGPTTA
ARMDPFVEMMFQQGATAFLGKGDRADYVAELCKKYGGVSLLGIGGASAINTKHVKSVEIVAYEELGTESIKKLYFDRYRV
IVGIDSEGNTLQKQEVPKYAK

Sequences:

>Translated_181_residues
MMELTLPLTKEKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIYYAGPCPARPGLPIGSNGPTTA
ARMDPFVEMMFQQGATAFLGKGDRADYVAELCKKYGGVSLLGIGGASAINTKHVKSVEIVAYEELGTESIKKLYFDRYRV
IVGIDSEGNTLQKQEVPKYAK
>Mature_181_residues
MMELTLPLTKEKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIYYAGPCPARPGLPIGSNGPTTA
ARMDPFVEMMFQQGATAFLGKGDRADYVAELCKKYGGVSLLGIGGASAINTKHVKSVEIVAYEELGTESIKKLYFDRYRV
IVGIDSEGNTLQKQEVPKYAK

Specific function: It functions in the generation of fumarate for use as an anaerobic electron acceptor [H]

COG id: COG1838

COG function: function code C; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1790564, Length=159, Percent_Identity=38.9937106918239, Blast_Score=110, Evalue=4e-26,
Organism=Escherichia coli, GI1787897, Length=155, Percent_Identity=40, Blast_Score=109, Evalue=8e-26,
Organism=Escherichia coli, GI1789443, Length=175, Percent_Identity=31.4285714285714, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167
- InterPro:   IPR020557 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 19720; Mature: 19720

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMELTLPLTKEKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIYY
CEEEECCCCCHHHCEEECCCEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEE
AGPCPARPGLPIGSNGPTTAARMDPFVEMMFQQGATAFLGKGDRADYVAELCKKYGGVSL
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCEEE
LGIGGASAINTKHVKSVEIVAYEELGTESIKKLYFDRYRVIVGIDSEGNTLQKQEVPKYA
EECCCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHHCCEEEEEEECCCCCCCCHHCCCCCC
K
C
>Mature Secondary Structure
MMELTLPLTKEKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIYY
CEEEECCCCCHHHCEEECCCEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEE
AGPCPARPGLPIGSNGPTTAARMDPFVEMMFQQGATAFLGKGDRADYVAELCKKYGGVSL
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCEEE
LGIGGASAINTKHVKSVEIVAYEELGTESIKKLYFDRYRVIVGIDSEGNTLQKQEVPKYA
EECCCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHHCCEEEEEEECCCCCCCCHHCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2656658; 7610040; 9278503 [H]