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The map label for this gene is fes [H]

Identifier: 16763963

GI number: 16763963

Start: 644002

End: 645216

Strand: Direct

Name: fes [H]

Synonym: STM0586

Alternate gene names: 16763963

Gene position: 644002-645216 (Clockwise)

Preceding gene: 16763958

Following gene: 16763964

Centisome position: 13.26

GC content: 60.08

Gene sequence:

>1215_bases
ATGAAAGAGGCGCTGGCAACGGGAAGTGAGGCCTGGTGGAGGACGAAAACCGGGCCGGAATGGATACGGGAAAAAGACGG
AAATTATCGGGTCACTTTTTGGTGGCGCGACCCGCAGGGAAACGAAACACACTCCCCGATACGGCGTGTCTGGGTCTACA
TCACTGGCGTAACCGATCATCATCAAAACGCGCAGCCTCAGACGATGGCGCGTATTGCCGGAACGGATGTCTGGCGCTGG
AGCACGGCGCTTAGCGCTAACTGGCGCGGCAGCTACTGTTTTATTCCTACCGAGCGCGATGACGTTTTTGCCGCTTTTGC
GCCGGGCGAAACGCCCGATCGGAACGTGCTGCGTGAAGGCTGGCGACAGCTATTACCGCAGGCGATTGCCGACCCGCTTA
ATTCGCAAAGCTGGCGGGGAGGACGTGGTCATGCGGTTTCAGCGCTGGAAATGCCGGATGCGCCCCTTCAGCCGGGATGG
GATCGTCCTGAAACGCCGTACTCGCCGCCTTTGATGATGCAGTGGCATAGCGAACGTCTGGGTAACTCCCGCCGCGTATG
GATATTGACGACCGGAGACGAGGCGCCGGAGGAAAGACCGTTGGCTATTCTGCTGGACGGTCAATTCTGGGCGGAAAATA
TGCCCGTCTGGCCCGCGCTCGCCTCGCTGACTCATCAACGCCTGCTTCCCGGTGCCGTCTATCTGCTGATTGACGCGATT
GATACTCAACACCGCAGCCAGGAGTTGCCCTGCAATGCCGACTTCTGGCTGGCGGTGCAGCAGGAACTGTTGCCGCAAGT
CAGAGCCGTGACGCCTTTTAGCGATGATGCCGGACGAACGGTGGTCGCCGGACAGAGCTTTGGCGGCCTGTCGGCGCTGT
ATGCCGGCCTGAACTGGCCGACGCGTTTTGGCTGTGTACTGAGCCAGTCAGGATCGTTCTGGTGGCCCCATCGCATCACC
CCGCCGGAGGGGGAAGTCATTACCCGGCTGAAAACCGGCGCATTATGCGCGCGCGGACTGCGTATCGTACTGGAAGCCGG
CGTGCGTGAGCCGATCGTGTTTCAGGCGAATCAGGCGCTTTATGCCCAACTGAATACTTCGCAGCAGTCCATTTTCTGGC
GTCAGGTTGACGGCGGACACGATGCGCTTTGCTGGCGCGGCGGGCTAACGCAAGGGCTGATGCTGCTTTGGCAGCCGCTT
ATCGACACGCTTTAA

Upstream 100 bases:

>100_bases
AGCGCGACAATACGCTATTGCAAATGCAAATAGTTATCAATAATATTATCAATATATTTCACCTTTTATATACAAAATTC
ATAATAAACACAGGGTTATA

Downstream 100 bases:

>100_bases
CCGGGCACATGTCCATGACAGGAGTTGAGTATGGAATTCAGTAATCCCTTCGATAATCCGCAGGGACAGTTTTACATCCT
GCAAAATGCGCAGCGTCAAT

Product: enterobactin/ferric enterobactin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDHHQNAQPQTMARIAGTDVWRW
STALSANWRGSYCFIPTERDDVFAAFAPGETPDRNVLREGWRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPLQPGW
DRPETPYSPPLMMQWHSERLGNSRRVWILTTGDEAPEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
DTQHRSQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRIT
PPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPL
IDTL

Sequences:

>Translated_404_residues
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDHHQNAQPQTMARIAGTDVWRW
STALSANWRGSYCFIPTERDDVFAAFAPGETPDRNVLREGWRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPLQPGW
DRPETPYSPPLMMQWHSERLGNSRRVWILTTGDEAPEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
DTQHRSQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRIT
PPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPL
IDTL
>Mature_404_residues
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDHHQNAQPQTMARIAGTDVWRW
STALSANWRGSYCFIPTERDDVFAAFAPGETPDRNVLREGWRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPLQPGW
DRPETPYSPPLMMQWHSERLGNSRRVWILTTGDEAPEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
DTQHRSQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRIT
PPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPL
IDTL

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=373, Percent_Identity=73.7265415549598, Blast_Score=573, Evalue=1e-165,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 45617; Mature: 45617

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDH
CCCCCCCCCCCEEECCCCHHHHHCCCCCEEEEEEEECCCCCCCHHHHEEEEEEEEECCCC
HQNAQPQTMARIAGTDVWRWSTALSANWRGSYCFIPTERDDVFAAFAPGETPDRNVLREG
CCCCCHHHHHHHHCCCEEEEEHEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
WRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPLQPGWDRPETPYSPPLMMQWHSERL
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECHHHC
GNSRRVWILTTGDEAPEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
CCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHH
DTQHRSQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCC
TRFGCVLSQSGSFWWPHRITPPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQAL
CCCCEEEECCCCEECCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEE
YAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPLIDTL
EEEECCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDH
CCCCCCCCCCCEEECCCCHHHHHCCCCCEEEEEEEECCCCCCCHHHHEEEEEEEEECCCC
HQNAQPQTMARIAGTDVWRWSTALSANWRGSYCFIPTERDDVFAAFAPGETPDRNVLREG
CCCCCHHHHHHHHCCCEEEEEHEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
WRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPLQPGWDRPETPYSPPLMMQWHSERL
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECHHHC
GNSRRVWILTTGDEAPEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
CCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHH
DTQHRSQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCC
TRFGCVLSQSGSFWWPHRITPPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQAL
CCCCEEEECCCCEECCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEE
YAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPLIDTL
EEEECCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]