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The map label for this gene is ykgC [H]

Identifier: 16763941

GI number: 16763941

Start: 620328

End: 621653

Strand: Direct

Name: ykgC [H]

Synonym: STM0564

Alternate gene names: 16763941

Gene position: 620328-621653 (Clockwise)

Preceding gene: 16763928

Following gene: 16763942

Centisome position: 12.77

GC content: 52.41

Gene sequence:

>1326_bases
ATGACACAGTATCAGGCGCTCATTATTGGTTTTGGCAAGGCAGGAAAAACGTTGGCGGCAACTCTGGCGAAGACGGGATG
GCGCGTGGCGATTATCGAACAGTCCGCCAGTATGTTCGGCGGAACCTGCATCAACATTGGCTGTATTCCAACGAAAACGC
TGGTGCATGATGCGGAACGTGAGGGCGATTTTTCTGTCGCCATGCAACGTAAAGCGGCGGTCGTAAATTTTTTACGCGAC
AAAAATTTTCATAATCTTGCCGACCTGGACAATGTCGATGTGATTGAGGGAAGGGCGGAGTTTATTGATAACCATACCTT
ACGGGTATTTCAGGCGGACGGCGAGCGGGTGTTACGGGGAGAAAAGATCTTTATTAATACTGGCGCAGAGTCGGTGATCC
CGGCTATTACGGGCTTAACAACGACGGCAGGGGTGTTCGATAGCACCGGGCTACTCAGCCTGAGCCAGCGTCCGGCGCGG
CTGGGGATTTTAGGCGGTGGTTATATTGGCCTTGAATTTGCCTCAATGTTCGCCAACTTTGGTACGAAGGTCACTATCTT
TGAAGCAGCGCCGCAATTCCTGCCTCGTGAAGATCGGGATATCGCGCAGGCAATTACCCGTATTTTACAGGAAAAGGGCG
TCGAGCTGATTTTAAACGCCAACGTACAGGCCGTATCCTCAAAGGAGGGCGCGGTACAAGTAGAAACGCCGGAAGGCGCG
CATCTTGTGGATGCCCTGCTGGTGGCGTCGGGGCGAAAACCGGCGACGGCTGGCTTACAGTTGCAGAACGCCGGCGTGGC
GGTGAACGAACGCGGCGGGATTATCGTGGATGATTACCTGCGTACCACGGCGGACAATATCTGGGCGATGGGCGACGTTA
CCGGTGGGTTGCAGTTTACCTATATTTCACTGGATGATTTTCGTATTGTACGCGACGGGTTATTGGGAGATGGCAAACGC
AGTACCCGCGATCGCCAGAATGTTCCGTATTCCGTCTTTATGACGCCGCCGCTCTCTCGTGTCGGGCTGACGGAAGAACA
AGCGCGGGCAAGCGGCGCAACGGTGCAGGTGGTGACATTACCGGTGGCGGCGATCCCTCGCGCCCGTGTTATGAACGATA
CTCGTGGCGTACTAAAAGCGGTAGTGGACGTGAATACGCAGCGTATTGTAGGGGTGTCATTGTTATGCGTCGATTCTCAT
GAAATGATTAATATCGTTAAAACCGTTATGGATGCAGATTTACCTTATACGGTGTTACGCGACCAGATATTTACCCATCC
TACAATGAGTGAGTCTTTAAACGATCTCTTCTCTCTCATTAAGTAA

Upstream 100 bases:

>100_bases
ACGATAAGACAAAAAATGGCGCGTTGCGGATAACCCTGTCTTTTTTGACGTTATTTATACTTGTCCTGACAAACAGATGG
TGATTTGGCGGAGAAAGAAG

Downstream 100 bases:

>100_bases
AACATAAATAATATAGCCCTGTTAATCAGGGCTTTTTTTTGCCTGTCAGACCATAAAAATACGCCAGGACAAATATGCTG
GCGTCTGAAAGAAAAGGCTT

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVHDAEREGDFSVAMQRKAAVVNFLRD
KNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRGEKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPAR
LGILGGGYIGLEFASMFANFGTKVTIFEAAPQFLPREDRDIAQAITRILQEKGVELILNANVQAVSSKEGAVQVETPEGA
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFTYISLDDFRIVRDGLLGDGKR
STRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTLPVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSH
EMINIVKTVMDADLPYTVLRDQIFTHPTMSESLNDLFSLIK

Sequences:

>Translated_441_residues
MTQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVHDAEREGDFSVAMQRKAAVVNFLRD
KNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRGEKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPAR
LGILGGGYIGLEFASMFANFGTKVTIFEAAPQFLPREDRDIAQAITRILQEKGVELILNANVQAVSSKEGAVQVETPEGA
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFTYISLDDFRIVRDGLLGDGKR
STRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTLPVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSH
EMINIVKTVMDADLPYTVLRDQIFTHPTMSESLNDLFSLIK
>Mature_440_residues
TQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVHDAEREGDFSVAMQRKAAVVNFLRDK
NFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRGEKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPARL
GILGGGYIGLEFASMFANFGTKVTIFEAAPQFLPREDRDIAQAITRILQEKGVELILNANVQAVSSKEGAVQVETPEGAH
LVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFTYISLDDFRIVRDGLLGDGKRS
TRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTLPVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSHE
MINIVKTVMDADLPYTVLRDQIFTHPTMSESLNDLFSLIK

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.2841648590022, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=27.7056277056277, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI291045266, Length=436, Percent_Identity=24.7706422018349, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI22035672, Length=431, Percent_Identity=26.4501160092807, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI291045268, Length=285, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081717, Length=441, Percent_Identity=74.6031746031746, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=28.8546255506608, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=29.5612009237875, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=27.2532188841202, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789065, Length=181, Percent_Identity=30.939226519337, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=28.9130434782609, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71983419, Length=344, Percent_Identity=29.9418604651163, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=344, Percent_Identity=29.9418604651163, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=26.0504201680672, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=441, Percent_Identity=22.6757369614512, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=133, Percent_Identity=38.3458646616541, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=29.3991416309013, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=24.8380129589633, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=489, Percent_Identity=26.7893660531697, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=29.004329004329, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=27.7310924369748, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=27.7310924369748, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=27.7310924369748, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=26.1052631578947, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 47618; Mature: 47487

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVHDAER
CCCEEEEEEEECCCCHHHHHHHHHCCCEEEEEECCHHHCCCEEEEECCCCCHHHHHHCCC
EGDFSVAMQRKAAVVNFLRDKNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCEEEEEECCCCEEECC
EKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPARLGILGGGYIGLEFASMFANF
CEEEEECCCHHHHHHHHCCCHHCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHC
GTKVTIFEAAPQFLPREDRDIAQAITRILQEKGVELILNANVQAVSSKEGAVQVETPEGA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECCCCH
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFT
HHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCEEEHHHHHHHHCCEEEEECCCCCEEEE
YISLDDFRIVRDGLLGDGKRSTRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTL
EEECCCHHHHHHCCCCCCCCCCCHHCCCCEEEEECCCHHHCCCCHHHHHCCCCEEEEEEE
PVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSHEMINIVKTVMDADLPYTVLR
CHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCHHHHH
DQIFTHPTMSESLNDLFSLIK
HHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
TQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVHDAER
CCEEEEEEEECCCCHHHHHHHHHCCCEEEEEECCHHHCCCEEEEECCCCCHHHHHHCCC
EGDFSVAMQRKAAVVNFLRDKNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCEEEEEECCCCEEECC
EKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPARLGILGGGYIGLEFASMFANF
CEEEEECCCHHHHHHHHCCCHHCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHC
GTKVTIFEAAPQFLPREDRDIAQAITRILQEKGVELILNANVQAVSSKEGAVQVETPEGA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECCCCH
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFT
HHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCEEEHHHHHHHHCCEEEEECCCCCEEEE
YISLDDFRIVRDGLLGDGKRSTRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTL
EEECCCHHHHHHCCCCCCCCCCCHHCCCCEEEEECCCHHHCCCCHHHHHCCCCEEEEEEE
PVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSHEMINIVKTVMDADLPYTVLR
CHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCHHHHH
DQIFTHPTMSESLNDLFSLIK
HHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]