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The map label for this gene is cusS [H]

Identifier: 16763938

GI number: 16763938

Start: 618590

End: 618919

Strand: Reverse

Name: cusS [H]

Synonym: STM0561

Alternate gene names: 16763938

Gene position: 618919-618590 (Counterclockwise)

Preceding gene: 16763940

Following gene: 16763937

Centisome position: 12.74

GC content: 49.39

Gene sequence:

>330_bases
ATGCTGCGCAGAGCGATCAGTAATTTACTCTCTAATACGATGCGCTATACGCCGCCGGGTAAAACCATTACTCTTCGGAT
AAAAGAAGCGGACGACCAGATACATATTATTGTTGAAAACCCCGGTACGCCAATCGCGCCGGAACATTTGCCGCTCCTTT
TCGATCGTTTTTATCGCGTTGATCCCTCCCGCCAGCGTAAAGGGGAAGGCAGCGGTATAGGCCTGGCAATTGTAAAATCC
ATCGTCACTGCGCACCGGGGAAAAATTTCTGTCACCTCCGATACACGCGCTACTCGTTTTATTTTGACATTCCCCAAACA
CCTCCGTTGA

Upstream 100 bases:

>100_bases
CCGCCCCGTGGTAAAGCGCCTCATCGAGTTTTTCTGCCGAAAAGGTGTTGGGAGCTTGCGCTTTGAAGGCCGCGCCTGCT
GAATCACCGGCGATCCCATC

Downstream 100 bases:

>100_bases
ACTGTAGCGATAGTGAAAGGCGCTATCACTAGCCAGCAAAATAATCTGATATAATCGTCATTATCCCGTCACGCGCCAGG
CCCAACAACTGTTTTATTAT

Product: sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MLRRAISNLLSNTMRYTPPGKTITLRIKEADDQIHIIVENPGTPIAPEHLPLLFDRFYRVDPSRQRKGEGSGIGLAIVKS
IVTAHRGKISVTSDTRATRFILTFPKHLR

Sequences:

>Translated_109_residues
MLRRAISNLLSNTMRYTPPGKTITLRIKEADDQIHIIVENPGTPIAPEHLPLLFDRFYRVDPSRQRKGEGSGIGLAIVKS
IVTAHRGKISVTSDTRATRFILTFPKHLR
>Mature_109_residues
MLRRAISNLLSNTMRYTPPGKTITLRIKEADDQIHIIVENPGTPIAPEHLPLLFDRFYRVDPSRQRKGEGSGIGLAIVKS
IVTAHRGKISVTSDTRATRFILTFPKHLR

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=105, Percent_Identity=74.2857142857143, Blast_Score=171, Evalue=1e-44,
Organism=Escherichia coli, GI1786600, Length=108, Percent_Identity=45.3703703703704, Blast_Score=93, Evalue=4e-21,
Organism=Escherichia coli, GI1788393, Length=88, Percent_Identity=37.5, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=106, Percent_Identity=37.7358490566038, Blast_Score=71, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=35.2380952380952, Blast_Score=64, Evalue=3e-12,
Organism=Escherichia coli, GI1790346, Length=109, Percent_Identity=31.1926605504587, Blast_Score=63, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 12287; Mature: 12287

Theoretical pI: Translated: 11.50; Mature: 11.50

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRAISNLLSNTMRYTPPGKTITLRIKEADDQIHIIVENPGTPIAPEHLPLLFDRFYRV
CHHHHHHHHHHCCEEECCCCCEEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHCC
DPSRQRKGEGSGIGLAIVKSIVTAHRGKISVTSDTRATRFILTFPKHLR
CCCHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCC
>Mature Secondary Structure
MLRRAISNLLSNTMRYTPPGKTITLRIKEADDQIHIIVENPGTPIAPEHLPLLFDRFYRV
CHHHHHHHHHHCCEEECCCCCEEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHCC
DPSRQRKGEGSGIGLAIVKSIVTAHRGKISVTSDTRATRFILTFPKHLR
CCCHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]