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The map label for this gene is gip [H]

Identifier: 16763898

GI number: 16763898

Start: 579261

End: 580037

Strand: Direct

Name: gip [H]

Synonym: STM0518

Alternate gene names: 16763898

Gene position: 579261-580037 (Clockwise)

Preceding gene: 16763897

Following gene: 16763899

Centisome position: 11.93

GC content: 45.69

Gene sequence:

>777_bases
ATGTTACGTTTCTCTGCCAATCTTTCTATGCTGTTTACGGAATATGATTTCCTGGAACGCTTTGATAAAGCGGCGTTGTC
GGGATTTCGCGGCGTGGAATTCATGTTTCCCTACGATAACGACATCGAAGTGTTAAAACGTAAGCTCAGGGATAATAATC
TGGAACATACGTTACATAATTTACCTGCTGGCGACTGGGCGGCTGGCGAACGTGGAATTGCCTGTATTCCTGGGCGCGAA
GAAGAGTTTCGCGATGGCGTAGCGGCCGCAATCCGCTATGCACGTGCGTTAGGCAATAAGAAAATAAATTGTCTGGTGGG
TAAAACGCCGTCAGGATTCTCCGCAACGGAGATCCACGACACGTTGGTCGAAAACCTGCGCTATGCGGCAAATATGCTGG
CGAAAGAAGACATTTTATTACTTATCGAACCTATTAATCACTTTGATATGCCGGGATTCCATCTCACCGGCACTCAACAG
GCGTTAGCATTAATTAAGGATATCGGCAGCGATAATATCAAAATTCAGTATGATATTTATCACATGCAACGCATGGAAGG
GGAGTTAACGCAAACCATGACGGCATGGGCCGATAAAATAGGCCATTTACAGATTGCTGATAACCCGCGTCGCGGCGAGC
CGGGGACCGGGGAAATTAATTATGACTTTATTTTTAATGTCATTAAACAGTCTGGTTATGATGGCTGGGTTGGCTGTGAA
TATAAACCACTGACTACCACGGAAGCGGGATTATCGTGGATTAATCAGTACCGTTAA

Upstream 100 bases:

>100_bases
CGAACTGGATAACGTAACCGAGTTTGAAGAGGTTGCGGATAGTGCGAAAGATGCGCCAACAGAAACCTGTTTTATGAAAT
ATGAGTAAGGGAGGTAATCG

Downstream 100 bases:

>100_bases
AACGCAGAATAATTCGGGCAGCGCTTTTTTTTCCACTGTGTTGGAAGGGGATTGTGTTGCCTGAATCTGGAAACACCGAA
AGCAATAAAAGAGGTTGTAT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLRFSANLSMLFTEYDFLERFDKAALSGFRGVEFMFPYDNDIEVLKRKLRDNNLEHTLHNLPAGDWAAGERGIACIPGRE
EEFRDGVAAAIRYARALGNKKINCLVGKTPSGFSATEIHDTLVENLRYAANMLAKEDILLLIEPINHFDMPGFHLTGTQQ
ALALIKDIGSDNIKIQYDIYHMQRMEGELTQTMTAWADKIGHLQIADNPRRGEPGTGEINYDFIFNVIKQSGYDGWVGCE
YKPLTTTEAGLSWINQYR

Sequences:

>Translated_258_residues
MLRFSANLSMLFTEYDFLERFDKAALSGFRGVEFMFPYDNDIEVLKRKLRDNNLEHTLHNLPAGDWAAGERGIACIPGRE
EEFRDGVAAAIRYARALGNKKINCLVGKTPSGFSATEIHDTLVENLRYAANMLAKEDILLLIEPINHFDMPGFHLTGTQQ
ALALIKDIGSDNIKIQYDIYHMQRMEGELTQTMTAWADKIGHLQIADNPRRGEPGTGEINYDFIFNVIKQSGYDGWVGCE
YKPLTTTEAGLSWINQYR
>Mature_258_residues
MLRFSANLSMLFTEYDFLERFDKAALSGFRGVEFMFPYDNDIEVLKRKLRDNNLEHTLHNLPAGDWAAGERGIACIPGRE
EEFRDGVAAAIRYARALGNKKINCLVGKTPSGFSATEIHDTLVENLRYAANMLAKEDILLLIEPINHFDMPGFHLTGTQQ
ALALIKDIGSDNIKIQYDIYHMQRMEGELTQTMTAWADKIGHLQIADNPRRGEPGTGEINYDFIFNVIKQSGYDGWVGCE
YKPLTTTEAGLSWINQYR

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=263, Percent_Identity=42.5855513307985, Blast_Score=207, Evalue=7e-54,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=41.8032786885246, Blast_Score=184, Evalue=6e-47,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=84.1085271317829, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=40.3100775193798, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17552022, Length=253, Percent_Identity=37.9446640316205, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17530883, Length=259, Percent_Identity=35.9073359073359, Blast_Score=173, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29246; Mature: 29246

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00778 HIS_ACID_PHOSPHAT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFSANLSMLFTEYDFLERFDKAALSGFRGVEFMFPYDNDIEVLKRKLRDNNLEHTLHN
CEEECCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHH
LPAGDWAAGERGIACIPGREEEFRDGVAAAIRYARALGNKKINCLVGKTPSGFSATEIHD
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
TLVENLRYAANMLAKEDILLLIEPINHFDMPGFHLTGTQQALALIKDIGSDNIKIQYDIY
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEHH
HMQRMEGELTQTMTAWADKIGHLQIADNPRRGEPGTGEINYDFIFNVIKQSGYDGWVGCE
HHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
YKPLTTTEAGLSWINQYR
CCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLRFSANLSMLFTEYDFLERFDKAALSGFRGVEFMFPYDNDIEVLKRKLRDNNLEHTLHN
CEEECCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHH
LPAGDWAAGERGIACIPGREEEFRDGVAAAIRYARALGNKKINCLVGKTPSGFSATEIHD
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
TLVENLRYAANMLAKEDILLLIEPINHFDMPGFHLTGTQQALALIKDIGSDNIKIQYDIY
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEHH
HMQRMEGELTQTMTAWADKIGHLQIADNPRRGEPGTGEINYDFIFNVIKQSGYDGWVGCE
HHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
YKPLTTTEAGLSWINQYR
CCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]