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The map label for this gene is adrA [H]

Identifier: 16763765

GI number: 16763765

Start: 438129

End: 439241

Strand: Direct

Name: adrA [H]

Synonym: STM0385

Alternate gene names: 16763765

Gene position: 438129-439241 (Clockwise)

Preceding gene: 16763764

Following gene: 16763767

Centisome position: 9.02

GC content: 55.44

Gene sequence:

>1113_bases
ATGTTCCCAAAAATAATGAATGATGAAAATTTTTACCGAAAAGCGGTTGAACAGGCGGTAGCGCCGCCTGACCCTCCTGA
TGATCGTCAGCGCTCCGGGTTGCGCTTCGCCCGGCGCATCAGGCTACCGCGTGCGGTGGGGTTAGGGGGGATGTTTTTAC
CGGTGGCCGCCGTGTTAGTGACGCAACCTGTCTTTGGCGGCTGGTGGCTATTGCTGGTCGGCTGGTCTTTTGTCTGGCCG
CATCTGGCATGGCAGTGGGCGGCGAAAGCCCTTGATCCGCTACGCCAGGAAATTTACAACCTGAAAGTGGATGCGATCCT
CTCCGGCATGTGGATCGCGCTGATGGGCGTCAATATGTTGCCTGCCGCCGCGCTGTTTATGATGATGAGCATGAATCTGA
TGGGCGCTGGCGGGCGGCGGCTATTCACTGTCGGAATGGGCCTTTTGCTGGCGTCATGTCTGGTGACGTTGCAGCTTGCC
GGGCTACCCGTCGCGATGCGAAGCTCGTCGCTGGAAGTCACGCTCTCTTTGCCCGTCATTATGTTGTATCCGCTTCTGTT
CGCCTGGGTAAGTTACCAAACGGCCATTAAATTAGCGGAACATAAGCGACGCTTGCAGGCGATGAGCTCGCGGGATGGCA
TGACCGGCGTCTATAACCGACGCCACTGGGAAATTTTATTACGTAATGAATTCGATCACAGCCGACGCCACCATCGGGAG
GCGACATTGTTGATTATCGATATCGATCATTTTAAGAGCATTAACGACACCTGGGGACATGATGTTGGGGATGAGGCTAT
TATCGCCCTGACGCGTCAATTACAGATAACGCTACGCGGGAGTGATATTATCGGGCGCTTTGGCGGCGACGAATTTGCGG
TGATTATGTGCGGAACGCCGGCAGACAGCGCGATTACCGCCATGTCGCGAGTGCATGAACGGCTAAATACCTTACGCTTG
CCGGGCGCGCCGCAGGTCATGTTACGTATCAGCGTGGGCGTGGCGCCGTTAACGCCACAAATCGGTCATTATCGGGAATG
GCTAAAGTCTGCGGATATGGCGCTTTACAAAGCAAAGAATGCCGGACGTAACCGCACCGAAGTGGCGGCATGA

Upstream 100 bases:

>100_bases
GCGGCGTAGTGCTATCGGGTGAGTCCTGAAAAACACTCACCCGAAATTTCATACTTCCTCCATGCGCTCTGTTTCTATAA
TTTGGGAAAATTGTTTCTAA

Downstream 100 bases:

>100_bases
CGTCCAGCCGGGCTTCAGGATTTACTGAGCGCCTCTGATTTTTCCATACACTTCGTCATCGCTTCTATTACCGCAGCGCG
GAAGCCACGTTCTTCCAGAA

Product: diguanylate cyclase AdrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVFGGWWLLLVGWSFVWP
HLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLA
GLPVAMRSSSLEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAITAMSRVHERLNTLRL
PGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNRTEVAA

Sequences:

>Translated_370_residues
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVFGGWWLLLVGWSFVWP
HLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLA
GLPVAMRSSSLEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAITAMSRVHERLNTLRL
PGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNRTEVAA
>Mature_370_residues
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVFGGWWLLLVGWSFVWP
HLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLA
GLPVAMRSSSLEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAITAMSRVHERLNTLRL
PGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNRTEVAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1786584, Length=371, Percent_Identity=75.2021563342318, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI145693134, Length=161, Percent_Identity=35.4037267080745, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87081881, Length=172, Percent_Identity=35.4651162790698, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787262, Length=174, Percent_Identity=32.7586206896552, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082007, Length=165, Percent_Identity=35.7575757575758, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788381, Length=167, Percent_Identity=31.1377245508982, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787541, Length=167, Percent_Identity=33.5329341317365, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787802, Length=162, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081977, Length=191, Percent_Identity=29.3193717277487, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081974, Length=205, Percent_Identity=29.7560975609756, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788085, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787816, Length=171, Percent_Identity=30.4093567251462, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788956, Length=173, Percent_Identity=27.7456647398844, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR007894 [H]

Pfam domain/function: PF00990 GGDEF; PF05230 MASE2 [H]

EC number: NA

Molecular weight: Translated: 41434; Mature: 41434

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHH
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCHHH
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHCCC
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
EEEEEEEHHHCCCCCCCCCCCCCCHHHHHEEEEEEEEEECCCEEEECCCCCEEEEEECCC
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
AGRNRTEVAA
CCCCCCCCCC
>Mature Secondary Structure
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHH
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCHHH
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHCCC
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
EEEEEEEHHHCCCCCCCCCCCCCCHHHHHEEEEEEEEEECCCEEEECCCCCEEEEEECCC
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
AGRNRTEVAA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]