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The map label for this gene is cvrA [H]

Identifier: 167623807

GI number: 167623807

Start: 2251460

End: 2253319

Strand: Direct

Name: cvrA [H]

Synonym: Shal_1877

Alternate gene names: 167623807

Gene position: 2251460-2253319 (Clockwise)

Preceding gene: 167623806

Following gene: 167623808

Centisome position: 43.07

GC content: 48.12

Gene sequence:

>1860_bases
ATGCTAGAGCAGATCACTGCGATGCTTGCTTTGCTAGGTGTTTTATCATTGTTTTGTCAGTGGATAGGCTGGAAGCTGAG
ACTGCCCGCTATTCTTCCTCTACTCCTGTGTGGTCTATTGCTTGGGCCAGGACTCGGCTTCTTGGATCCTGATGCCATAT
TTGGTGATCTGTTATTTCCGATTATTTCACTCGGCGTCGCGGTGATCTTATTTGAAGGGGCATTAACTCTTAACTTTAAA
GAGATAAAAGAGCATGGCGCCATGGTGACTAGGCTCGTGACCTTAGGCACGGTGATCACCTGGGCCTGTATTACGCTCGC
TACCTTTTCTCTACTGGATTTTGAATGGCCAATGGCCTTGCTATTTGGTGCGTTAGTGGTGGTAACGGGTCCAACGGTAA
TTGTGCCTATGCTCAGAAGCGTACGGCCTAAAACCGAGCTGGCCAGTATTCTGCGCTGGGAGGGGATAGTCATCGACCCT
ATCGGTGCGCTGCTTGCGGTGTTAGTGTTTGAGTATATTGCCGTTGCCGCCGATCCCACCACTCATGTTCTGCACGCATT
AAGTGTCATGTTAGCCGTTGGTTTAGGCTTAGGTGTATTGAGCGGCTATTTAGTGGGCTTAGTGCTGCGTAATAATCTAC
TGCCCCATTATCTGCGTAATACCGCGGTGTTGACATTAATGCTAGCGGTGTTTGTTGGCTCAAACTTGTTACAGGAAGAG
GCGGGCTTACTGTCTGTCACTGTGATGGGAGTGTGGCTGGCGAATATGAAGGGTGTCGATATCGCCGATATTTTGGAGTT
TAAAGAGACCCTTACCGTATTATTGATTTCAGCGCTGTTTATTTTACTTGCGGCAAGACTCAATGCCGATGCGCTTTTAA
GCCTAGGTTGGGAAGGGCTAGCACTGTTAGCTGTCGTCATGTTAATTGCACGGCCATTGAGTATCTGGTGCTGTGGTGTT
GGTACCTCGCTCTCAAGTGGTGATAAGTGGTTTTTAAGCTGGGTAGCACCGAGAGGTATTGTGGCTGCAGCGGTATCGTC
TTTATTTGCCATAAAGCTTGAAGCGAGCGGTATTAAAGGCGCCGAGCTCATCGTGCCACTGGTGTTCTTGATTATTATCG
GCACAGTAGTGATCCAAAGCTTAACCGCAGGTAAGTGGGCCAAAATACTCGGCGTCACCGCCGACTCGTCTCAGGGCTTA
CTTATTTTTGGTGCCTCTAAGTTCCCGCGAGCGCTTGCTAAAACCCTGCAATCAAAAGGCGTGACTGTGCTGCTTGCCGA
TAATAACTGGGACAATATTCGTCTAGCCAGAATGGATAACATCCCCGTATATTTTGGTAATCCGGCCTCCGAGCATGCAG
AAAACCATATGGATATGGCAGGGATTGGCCGAGTCTTGGTGATGTCGCCTTATCGTCAACTCAATCCATTAGTGAGTTTT
TATTTCCAGGACGTGTTTGGCGAGGAAAAAGTGTATGGACTTAATAATGGCGAAACCTCCAGCGCCAGGCACCAGTTGTC
AGAGTCTTATTTGAAACGTCTCTGTCTGTTTGGTGATGCAGCTTCGTACTCAAAACTCGCCAGCTTGATGGCAAAAGGCG
CAACGATAAAAAGTACCCGCCTGACCGAGAGCTTTAATTACGCCATGTTTATGGAGCAATATGCACAAGCTGCGATCCCA
CTTATTTATCTGCAAGAGGGCAAGGTCAGAGTCATTAGTGGTAGCGTCGTTCCTGAACTTTTAACTGGAGTAGAGCTGAT
CAGTTTAATTCCTGCCGATGCGGTTAAGTTGGAACTCACGAGTGACCCCCTTGACGAGGCTAGCACTGTTACTGACGGTA
AGGATGGAATGGTTAGTTAA

Upstream 100 bases:

>100_bases
TTATCGTATTTTACTCATGTTTGGCTATAGTTTTTACACTTGGACGTTTCTTTTAACAAACCAAGATTTCGCTAGAAATG
AGCAGATAAGGAAATAGGCT

Downstream 100 bases:

>100_bases
ACATTTTCGGATGCTTGCTTCCCTATGGGCAGATGTGAAGGAACGATCGCATGTGTAGATATTGCCGTGTCCACACTTGA
TTGTTTCTTTCTTCAATTTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLDPDAIFGDLLFPIISLGVAVILFEGALTLNFK
EIKEHGAMVTRLVTLGTVITWACITLATFSLLDFEWPMALLFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDP
IGALLAVLVFEYIAVAADPTTHVLHALSVMLAVGLGLGVLSGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
AGLLSVTVMGVWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGLALLAVVMLIARPLSIWCCGV
GTSLSSGDKWFLSWVAPRGIVAAAVSSLFAIKLEASGIKGAELIVPLVFLIIIGTVVIQSLTAGKWAKILGVTADSSQGL
LIFGASKFPRALAKTLQSKGVTVLLADNNWDNIRLARMDNIPVYFGNPASEHAENHMDMAGIGRVLVMSPYRQLNPLVSF
YFQDVFGEEKVYGLNNGETSSARHQLSESYLKRLCLFGDAASYSKLASLMAKGATIKSTRLTESFNYAMFMEQYAQAAIP
LIYLQEGKVRVISGSVVPELLTGVELISLIPADAVKLELTSDPLDEASTVTDGKDGMVS

Sequences:

>Translated_619_residues
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLDPDAIFGDLLFPIISLGVAVILFEGALTLNFK
EIKEHGAMVTRLVTLGTVITWACITLATFSLLDFEWPMALLFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDP
IGALLAVLVFEYIAVAADPTTHVLHALSVMLAVGLGLGVLSGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
AGLLSVTVMGVWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGLALLAVVMLIARPLSIWCCGV
GTSLSSGDKWFLSWVAPRGIVAAAVSSLFAIKLEASGIKGAELIVPLVFLIIIGTVVIQSLTAGKWAKILGVTADSSQGL
LIFGASKFPRALAKTLQSKGVTVLLADNNWDNIRLARMDNIPVYFGNPASEHAENHMDMAGIGRVLVMSPYRQLNPLVSF
YFQDVFGEEKVYGLNNGETSSARHQLSESYLKRLCLFGDAASYSKLASLMAKGATIKSTRLTESFNYAMFMEQYAQAAIP
LIYLQEGKVRVISGSVVPELLTGVELISLIPADAVKLELTSDPLDEASTVTDGKDGMVS
>Mature_619_residues
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLDPDAIFGDLLFPIISLGVAVILFEGALTLNFK
EIKEHGAMVTRLVTLGTVITWACITLATFSLLDFEWPMALLFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDP
IGALLAVLVFEYIAVAADPTTHVLHALSVMLAVGLGLGVLSGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
AGLLSVTVMGVWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGLALLAVVMLIARPLSIWCCGV
GTSLSSGDKWFLSWVAPRGIVAAAVSSLFAIKLEASGIKGAELIVPLVFLIIIGTVVIQSLTAGKWAKILGVTADSSQGL
LIFGASKFPRALAKTLQSKGVTVLLADNNWDNIRLARMDNIPVYFGNPASEHAENHMDMAGIGRVLVMSPYRQLNPLVSF
YFQDVFGEEKVYGLNNGETSSARHQLSESYLKRLCLFGDAASYSKLASLMAKGATIKSTRLTESFNYAMFMEQYAQAAIP
LIYLQEGKVRVISGSVVPELLTGVELISLIPADAVKLELTSDPLDEASTVTDGKDGMVS

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 66479; Mature: 66479

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLDPDAIFGDLLFP
CHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IISLGVAVILFEGALTLNFKEIKEHGAMVTRLVTLGTVITWACITLATFSLLDFEWPMAL
HHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDPIGALLAVLVFEYIAVAADPT
HHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHCCCCH
THVLHALSVMLAVGLGLGVLSGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
AGLLSVTVMGVWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHH
ALLAVVMLIARPLSIWCCGVGTSLSSGDKWFLSWVAPRGIVAAAVSSLFAIKLEASGIKG
HHHHHHHHHHCCHHEEEECCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHEEEEECCCCCC
AELIVPLVFLIIIGTVVIQSLTAGKWAKILGVTADSSQGLLIFGASKFPRALAKTLQSKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHCC
VTVLLADNNWDNIRLARMDNIPVYFGNPASEHAENHMDMAGIGRVLVMSPYRQLNPLVSF
CEEEEECCCCCCEEEEEECCCCEEECCCHHHHHHCCCCHHHCCHHEEECCHHHHHHHHHH
YFQDVFGEEKVYGLNNGETSSARHQLSESYLKRLCLFGDAASYSKLASLMAKGATIKSTR
HHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEHHH
LTESFNYAMFMEQYAQAAIPLIYLQEGKVRVISGSVVPELLTGVELISLIPADAVKLELT
HHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEC
SDPLDEASTVTDGKDGMVS
CCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLDPDAIFGDLLFP
CHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IISLGVAVILFEGALTLNFKEIKEHGAMVTRLVTLGTVITWACITLATFSLLDFEWPMAL
HHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDPIGALLAVLVFEYIAVAADPT
HHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHCCCCH
THVLHALSVMLAVGLGLGVLSGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
AGLLSVTVMGVWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHH
ALLAVVMLIARPLSIWCCGVGTSLSSGDKWFLSWVAPRGIVAAAVSSLFAIKLEASGIKG
HHHHHHHHHHCCHHEEEECCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHEEEEECCCCCC
AELIVPLVFLIIIGTVVIQSLTAGKWAKILGVTADSSQGLLIFGASKFPRALAKTLQSKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHCC
VTVLLADNNWDNIRLARMDNIPVYFGNPASEHAENHMDMAGIGRVLVMSPYRQLNPLVSF
CEEEEECCCCCCEEEEEECCCCEEECCCHHHHHHCCCCHHHCCHHEEECCHHHHHHHHHH
YFQDVFGEEKVYGLNNGETSSARHQLSESYLKRLCLFGDAASYSKLASLMAKGATIKSTR
HHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEHHH
LTESFNYAMFMEQYAQAAIPLIYLQEGKVRVISGSVVPELLTGVELISLIPADAVKLELT
HHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEC
SDPLDEASTVTDGKDGMVS
CCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]