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The map label for this gene is fabF [H]

Identifier: 167623709

GI number: 167623709

Start: 2129985

End: 2131223

Strand: Direct

Name: fabF [H]

Synonym: Shal_1779

Alternate gene names: 167623709

Gene position: 2129985-2131223 (Clockwise)

Preceding gene: 167623708

Following gene: 167623710

Centisome position: 40.75

GC content: 47.86

Gene sequence:

>1239_bases
GTGTCTAAACGTCGAGTAGTCATAACGGGCTTAGGCTTAGTCAGCCCTGTGGGAAATACAGTAGATTCTTCTTGGAAAGC
TTTGGTTTCAGGTAAGAGTGGTATCGCGCCAATAACTAAATTTGATGCTAGCGAGTTTACGACTCGTTTTAGCGGTTCTG
TTAAAGACTTTGATGTCGAGCAGTACATGTCGCGTAAAGACGCGCGTAAGATGGACTTGTTTATTCAATATGGCATGGCT
GCAGGAATTCAAGCCGTGGAAGACTCAGGTCTTGAGATGGATAAGCTTGACCCTGCACGTGTTGGTACGGCTATTGGTGC
TGGTATGGGTGGCTTGCCGTTAATTGAGCAGAACCATTCAGCGCTTTTAAAAGGGGGGCCACGTAAGGTTTCTCCTTTCT
TTGTGCCGAGCACCATTATTAACATGATATCTGGCCACCTTTCTATCAAATACGGTATGACAGGCCCAAATTTTGCTGTG
ACAACGGCTTGTACTACTGGCGTGCATAATATTGGTTTCGCGGCGCGCACGATTGCCTACGGTGATGCCGACGTGATGGT
TGCCGGTGGTGCAGAAGATGCGACTTGCCCATTAGCCGTGGCAGGCTTTGGCTCTGCAAAGGCGCTTTCAACACGTAATG
ACGACCCACAAGCCGCCAGTCGCCCTTGGGATAAAGATCGCGATGGTTTTGTTATCGGTGATGGCGCAGGTGTGATGGTC
GTAGAAGAGTACGAACATGCTAAGGCGCGTGGAGCGACAATTTATGCTGAGCTTGTCGGTTTCGGCATGAGTGGCGATGC
ATTCCATATGACTTCACCACCAAGTGATGGTGCTGGCGCGGCTGCGGCAATGGTTAATGCTATCAATGATGCCAAAGTTG
CAAATGAGTCGATTGGCTATATTAACGCACATGGCACCTCAACACCGGCAGGCGATAAAGCTGAAGCCGCTGCGGTTAAG
TCGGTGTTTGGTGATCACGCTTATGATCTATTGGTTAGCTCGACAAAATCTATGACTGGGCACTTACTCGGCGCCGCAGG
TTCTGTTGAAGCTATTATTACTATTTTAGCGTTAAGAGATCAGGTTGTTCCACCAACGCTTAACTTAGATAATCCTGATG
AAGGTTGTGACTTGGACTTTGTTGCTCACACTGCGCGAGATTATAAGTTCGAATATGGACTATGTAACTCATTTGGTTTT
GGTGGCACCAACGGCTCACTACTTTTCAAAAAAGTGTAG

Upstream 100 bases:

>100_bases
CATTGAATACACACATCACATTGATTGGGTATAGGTATTGGTAGTTCCATTTCTTTGAAGCTATCATCATTATTTATTTT
TAAAGTAAAAAGGTGACCGC

Downstream 100 bases:

>100_bases
TCTGTTTAGGTAATCAAAAAAAGCGCCTCAGGGCGCTTTTTTTATATCTAGAAGGTTCCCAATCTCGGCTACCCAACATA
AGCAAGAAACACGACTCTTT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVEQYMSRKDARKMDLFIQYGMA
AGIQAVEDSGLEMDKLDPARVGTAIGAGMGGLPLIEQNHSALLKGGPRKVSPFFVPSTIINMISGHLSIKYGMTGPNFAV
TTACTTGVHNIGFAARTIAYGDADVMVAGGAEDATCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKVANESIGYINAHGTSTPAGDKAEAAAVK
SVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALRDQVVPPTLNLDNPDEGCDLDFVAHTARDYKFEYGLCNSFGF
GGTNGSLLFKKV

Sequences:

>Translated_412_residues
MSKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVEQYMSRKDARKMDLFIQYGMA
AGIQAVEDSGLEMDKLDPARVGTAIGAGMGGLPLIEQNHSALLKGGPRKVSPFFVPSTIINMISGHLSIKYGMTGPNFAV
TTACTTGVHNIGFAARTIAYGDADVMVAGGAEDATCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKVANESIGYINAHGTSTPAGDKAEAAAVK
SVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALRDQVVPPTLNLDNPDEGCDLDFVAHTARDYKFEYGLCNSFGF
GGTNGSLLFKKV
>Mature_411_residues
SKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVEQYMSRKDARKMDLFIQYGMAA
GIQAVEDSGLEMDKLDPARVGTAIGAGMGGLPLIEQNHSALLKGGPRKVSPFFVPSTIINMISGHLSIKYGMTGPNFAVT
TACTTGVHNIGFAARTIAYGDADVMVAGGAEDATCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMVV
EEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKVANESIGYINAHGTSTPAGDKAEAAAVKS
VFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALRDQVVPPTLNLDNPDEGCDLDFVAHTARDYKFEYGLCNSFGFG
GTNGSLLFKKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=414, Percent_Identity=48.5507246376812, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=53.2544378698225, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI41872631, Length=422, Percent_Identity=24.1706161137441, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=71.1864406779661, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=39.7590361445783, Blast_Score=252, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=41.504854368932, Blast_Score=290, Evalue=8e-79,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=46.5909090909091, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=26.3456090651558, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=351, Percent_Identity=24.5014245014245, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=39.7777777777778, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=43.3734939759036, Blast_Score=338, Evalue=6e-93,
Organism=Drosophila melanogaster, GI24581345, Length=377, Percent_Identity=24.1379310344828, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19920632, Length=374, Percent_Identity=24.5989304812834, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330659, Length=374, Percent_Identity=24.5989304812834, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42868; Mature: 42737

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVE
CCCCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCCCCEECCHHHHHHHHCCCCCCCCHH
QYMSRKDARKMDLFIQYGMAAGIQAVEDSGLEMDKLDPARVGTAIGAGMGGLPLIEQNHS
HHHHHHHHHHHHHHEEHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCC
ALLKGGPRKVSPFFVPSTIINMISGHLSIKYGMTGPNFAVTTACTTGVHNIGFAARTIAY
HHHCCCCCCCCCEECHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCHHCCCEEEEEEE
GDADVMVAGGAEDATCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
CCCCEEEECCCCCCCCCEEEECCCCCCEECCCCCCCCHHCCCCCCCCCCEEEECCCCEEE
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKVANESIGY
EECCHHHHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCE
INAHGTSTPAGDKAEAAAVKSVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALRD
EECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHEEECCCCCHHHHHHHHHHHC
QVVPPTLNLDNPDEGCDLDFVAHTARDYKFEYGLCNSFGFGGTNGSLLFKKV
CCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SKRRVVITGLGLVSPVGNTVDSSWKALVSGKSGIAPITKFDASEFTTRFSGSVKDFDVE
CCCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCCCCEECCHHHHHHHHCCCCCCCCHH
QYMSRKDARKMDLFIQYGMAAGIQAVEDSGLEMDKLDPARVGTAIGAGMGGLPLIEQNHS
HHHHHHHHHHHHHHEEHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCC
ALLKGGPRKVSPFFVPSTIINMISGHLSIKYGMTGPNFAVTTACTTGVHNIGFAARTIAY
HHHCCCCCCCCCEECHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCHHCCCEEEEEEE
GDADVMVAGGAEDATCPLAVAGFGSAKALSTRNDDPQAASRPWDKDRDGFVIGDGAGVMV
CCCCEEEECCCCCCCCCEEEECCCCCCEECCCCCCCCHHCCCCCCCCCCEEEECCCCEEE
VEEYEHAKARGATIYAELVGFGMSGDAFHMTSPPSDGAGAAAAMVNAINDAKVANESIGY
EECCHHHHHCCCEEEEHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCE
INAHGTSTPAGDKAEAAAVKSVFGDHAYDLLVSSTKSMTGHLLGAAGSVEAIITILALRD
EECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHEEECCCCCHHHHHHHHHHHC
QVVPPTLNLDNPDEGCDLDFVAHTARDYKFEYGLCNSFGFGGTNGSLLFKKV
CCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]