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The map label for this gene is icd2 [H]

Identifier: 167623649

GI number: 167623649

Start: 2061266

End: 2063488

Strand: Direct

Name: icd2 [H]

Synonym: Shal_1718

Alternate gene names: 167623649

Gene position: 2061266-2063488 (Clockwise)

Preceding gene: 167623643

Following gene: 167623651

Centisome position: 39.44

GC content: 45.3

Gene sequence:

>2223_bases
ATGAACGATAAGACATCAACGATCATCTATACCGAAACAGATGAAGCACCAGCATTAGCAACATTATCTTTATTACCTAT
TATACAAAAGTTCACTCAGACTGCAGGTGTTGACGTAGAAACTCGCGATATTTCTCTTTCTGGTCGTGTGATTGCAAATT
TCCCTGAGAAACTAACAGCAGAGCAGCGTATTGGTGATGCACTTGCTGAACTCGGTGAGCTGGCGAAAAAGCCTGAAGCT
AACATTATCAAACTGCCGAATATCAGTGCATCAATCCCGCAACTTAAAGCTTGTATCCTTGAATTACAGAATAAAGGATA
TGACATACCAAACTATCCTGATGAGCCGCAAAATGACGTAGAAAAAGAGATCCAATCTCGTTACGACAAGATTAAAGGCA
GTGCCGTAAACCCAGTGCTGCGTGAAGGTAACTCTGACCGCCGCGCGCCGGGATCAGTGAAGAAGTTTGCTCAGAAAAAC
CCACATTCGATGGGTAAATGGTTAGCCGACTCTAAGTCGCACGTTGCGCATATGAACGAAGGTGATTTTTACGCGAGTGA
AAAATCAGTAACCGTTGCCGATGCGGGCAGCGTATCCATTGTCTTGAATAAGGTTGATGGTTCTGAGCAAGTATTGCGTA
ATGCCATTGCACTGCAAGCGGGTGAGGTGATTGACTCGGCAGTGATGAGCAAAAAAGCCCTAGTTGAGTTTTACGAGCGT
GAAACCAACCTAGCTAAAGAGCAGGATGTTTTATTGTCCTTGCACTTAAAAGCGACAATGATGAAAGTGTCTGATCCAAT
TCTTTTTGGTCATGCAGTAAAAGTTTATTACAAAGACGTTTTTGCTGAGCACGGTGAATTGTTTGAACAGCTAGGTGTTG
ATGTTAACAATGGATTGGGCGATGTTTACGCTAAAATAGCGACATTGCCAAGCGATCAAAAAGCGGCAATCGAAGCCGAT
CTTGCAGCGGTATACACTCACCGTGCAGAGCTCGCCATGGTCGATTCCGATAGAGGGATCACCAACCTACATGTACCAAG
TGATGTGATTATTGATGCGTCAATGCCTGCAGCTATCCGAACTTCAGGTAAAATGTGGGGTCCAGATGGCCAACTAAAAG
ATATGAAAGCAATGATCCCAGATCGTTGTTATGCAGGTGTTTACCAAGAGACAATTGATTTTTGTATCAACAATGGTGCG
TTCGACCCAAGCACTATGGGCAGCGTACCAAACGTGGGCCTTATGGCACAAAAAGCGGAAGAGTACGGTAGCCACGATAA
GACGTTTGAAATTGCAGCGGCTGGCACCGTTAACGTCGTTGACCAAAACGGCAACGTATTAATGTCGCACGATGTCGAAG
CGGGCGATATTTTCAGAATGTGTCAGGTTAAAGACGCACCCATTCGTGATTGGGTGAAACTTGCCGTTAATCGCTCTCGT
TTATCTGCAACTCCTGCTGTTTTTTGGCTAGACGCAGCTCGTGCTCATGATGCTGAAATCATCAAGAAAGTTGAGCTTTA
CCTACAAGATCACGATACAAATGGTCTTGAGCTTTACATTATGCCACCCGTTGAAGCGACTCGTTTCACACTGGAGCGTG
TCAAAGCTGGTAAAGATACTATTTCAGTAACCGGTAACGTGTTACGTGATTATTTAACGGATCTATTCCCTATTCTTGAG
TTAGGTACGAGCGCGAAAATGCTTTCAATTGTGCCACTGATGAATGGCGGCGGGTTATTTGAGACTGGCGCGGGTGGTAG
TGCACCTAAGCACGTTCAGCAGGTTGAGAAAGAAGGTCACCTGCGTTGGGATTCATTAGGTGAGTTCCTGGCACTAGGGG
CGTCTTTAGAGCACCTAAGCCAAACCACGGGTAACAGCAAAGCACAAGTACTGGCAGACACGCTTGATATCGCAATTGGT
CAATTTCTAGATCTCAACAAGTCGCCATCACGCCGTGTGGGTGAACTTGATAACCGAGGTAGTCATTTCTATCTAGCAAT
GTACTGGGCGCAGGCACTTGTTGCACAAACTGCAGATATCCAATTACAGGCTGAATTTAGTGGATTGGCAGAGTCATTAA
CTAACAATGAAGACCAGATTGTGAGCGAACTAAACGGTGTTCAAGGTCCAGCTGTTGATTTAGGCGGCTACTACCGTCTA
GATGCAGTGAAAGCTGAAACAGCAATGCGCCCAAGCGCCACACTAAATAGCATTGTGGGTTAA

Upstream 100 bases:

>100_bases
AATCAAAATGATAGGATTAGGTTACAACTGATTTTTAATCTAAGAAAAACACAATAATTATTATAAAAAATCATAAATTC
AAATCAAAGTAGGACACAAA

Downstream 100 bases:

>100_bases
TACATTTTAAAAATGTTTAAGCACAAAGGCCTGCATCAATGCAGGCCTTTTTTATTTGCAAAATTTTTACTAGATTTTAG
GCAATAAAAAAGCAGAGTAG

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH-II; IDP-2; NADP+-specific ICDH 2; Oxalosuccinate decarboxylase 2 [H]

Number of amino acids: Translated: 740; Mature: 740

Protein sequence:

>740_residues
MNDKTSTIIYTETDEAPALATLSLLPIIQKFTQTAGVDVETRDISLSGRVIANFPEKLTAEQRIGDALAELGELAKKPEA
NIIKLPNISASIPQLKACILELQNKGYDIPNYPDEPQNDVEKEIQSRYDKIKGSAVNPVLREGNSDRRAPGSVKKFAQKN
PHSMGKWLADSKSHVAHMNEGDFYASEKSVTVADAGSVSIVLNKVDGSEQVLRNAIALQAGEVIDSAVMSKKALVEFYER
ETNLAKEQDVLLSLHLKATMMKVSDPILFGHAVKVYYKDVFAEHGELFEQLGVDVNNGLGDVYAKIATLPSDQKAAIEAD
LAAVYTHRAELAMVDSDRGITNLHVPSDVIIDASMPAAIRTSGKMWGPDGQLKDMKAMIPDRCYAGVYQETIDFCINNGA
FDPSTMGSVPNVGLMAQKAEEYGSHDKTFEIAAAGTVNVVDQNGNVLMSHDVEAGDIFRMCQVKDAPIRDWVKLAVNRSR
LSATPAVFWLDAARAHDAEIIKKVELYLQDHDTNGLELYIMPPVEATRFTLERVKAGKDTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKEGHLRWDSLGEFLALGASLEHLSQTTGNSKAQVLADTLDIAIG
QFLDLNKSPSRRVGELDNRGSHFYLAMYWAQALVAQTADIQLQAEFSGLAESLTNNEDQIVSELNGVQGPAVDLGGYYRL
DAVKAETAMRPSATLNSIVG

Sequences:

>Translated_740_residues
MNDKTSTIIYTETDEAPALATLSLLPIIQKFTQTAGVDVETRDISLSGRVIANFPEKLTAEQRIGDALAELGELAKKPEA
NIIKLPNISASIPQLKACILELQNKGYDIPNYPDEPQNDVEKEIQSRYDKIKGSAVNPVLREGNSDRRAPGSVKKFAQKN
PHSMGKWLADSKSHVAHMNEGDFYASEKSVTVADAGSVSIVLNKVDGSEQVLRNAIALQAGEVIDSAVMSKKALVEFYER
ETNLAKEQDVLLSLHLKATMMKVSDPILFGHAVKVYYKDVFAEHGELFEQLGVDVNNGLGDVYAKIATLPSDQKAAIEAD
LAAVYTHRAELAMVDSDRGITNLHVPSDVIIDASMPAAIRTSGKMWGPDGQLKDMKAMIPDRCYAGVYQETIDFCINNGA
FDPSTMGSVPNVGLMAQKAEEYGSHDKTFEIAAAGTVNVVDQNGNVLMSHDVEAGDIFRMCQVKDAPIRDWVKLAVNRSR
LSATPAVFWLDAARAHDAEIIKKVELYLQDHDTNGLELYIMPPVEATRFTLERVKAGKDTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKEGHLRWDSLGEFLALGASLEHLSQTTGNSKAQVLADTLDIAIG
QFLDLNKSPSRRVGELDNRGSHFYLAMYWAQALVAQTADIQLQAEFSGLAESLTNNEDQIVSELNGVQGPAVDLGGYYRL
DAVKAETAMRPSATLNSIVG
>Mature_740_residues
MNDKTSTIIYTETDEAPALATLSLLPIIQKFTQTAGVDVETRDISLSGRVIANFPEKLTAEQRIGDALAELGELAKKPEA
NIIKLPNISASIPQLKACILELQNKGYDIPNYPDEPQNDVEKEIQSRYDKIKGSAVNPVLREGNSDRRAPGSVKKFAQKN
PHSMGKWLADSKSHVAHMNEGDFYASEKSVTVADAGSVSIVLNKVDGSEQVLRNAIALQAGEVIDSAVMSKKALVEFYER
ETNLAKEQDVLLSLHLKATMMKVSDPILFGHAVKVYYKDVFAEHGELFEQLGVDVNNGLGDVYAKIATLPSDQKAAIEAD
LAAVYTHRAELAMVDSDRGITNLHVPSDVIIDASMPAAIRTSGKMWGPDGQLKDMKAMIPDRCYAGVYQETIDFCINNGA
FDPSTMGSVPNVGLMAQKAEEYGSHDKTFEIAAAGTVNVVDQNGNVLMSHDVEAGDIFRMCQVKDAPIRDWVKLAVNRSR
LSATPAVFWLDAARAHDAEIIKKVELYLQDHDTNGLELYIMPPVEATRFTLERVKAGKDTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKEGHLRWDSLGEFLALGASLEHLSQTTGNSKAQVLADTLDIAIG
QFLDLNKSPSRRVGELDNRGSHFYLAMYWAQALVAQTADIQLQAEFSGLAESLTNNEDQIVSELNGVQGPAVDLGGYYRL
DAVKAETAMRPSATLNSIVG

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 80419; Mature: 80419

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKTSTIIYTETDEAPALATLSLLPIIQKFTQTAGVDVETRDISLSGRVIANFPEKLTA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECEEEECCCEEECCCHHHHH
EQRIGDALAELGELAKKPEANIIKLPNISASIPQLKACILELQNKGYDIPNYPDEPQNDV
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
EKEIQSRYDKIKGSAVNPVLREGNSDRRAPGSVKKFAQKNPHSMGKWLADSKSHVAHMNE
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCHHEEECCC
GDFYASEKSVTVADAGSVSIVLNKVDGSEQVLRNAIALQAGEVIDSAVMSKKALVEFYER
CCEEECCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETNLAKEQDVLLSLHLKATMMKVSDPILFGHAVKVYYKDVFAEHGELFEQLGVDVNNGLG
HHCCCHHHHHEEEEHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVYAKIATLPSDQKAAIEADLAAVYTHRAELAMVDSDRGITNLHVPSDVIIDASMPAAIR
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCEEEECCCCHHHH
TSGKMWGPDGQLKDMKAMIPDRCYAGVYQETIDFCINNGAFDPSTMGSVPNVGLMAQKAE
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHH
EYGSHDKTFEIAAAGTVNVVDQNGNVLMSHDVEAGDIFRMCQVKDAPIRDWVKLAVNRSR
HHCCCCCEEEEEECCEEEEEECCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSATPAVFWLDAARAHDAEIIKKVELYLQDHDTNGLELYIMPPVEATRFTLERVKAGKDT
HCCCCEEEEEECHHCCHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHHHHHHCCCCE
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKEGH
EEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCC
LRWDSLGEFLALGASLEHLSQTTGNSKAQVLADTLDIAIGQFLDLNKSPSRRVGELDNRG
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
SHFYLAMYWAQALVAQTADIQLQAEFSGLAESLTNNEDQIVSELNGVQGPAVDLGGYYRL
CEEEHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEE
DAVKAETAMRPSATLNSIVG
EHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MNDKTSTIIYTETDEAPALATLSLLPIIQKFTQTAGVDVETRDISLSGRVIANFPEKLTA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECEEEECCCEEECCCHHHHH
EQRIGDALAELGELAKKPEANIIKLPNISASIPQLKACILELQNKGYDIPNYPDEPQNDV
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
EKEIQSRYDKIKGSAVNPVLREGNSDRRAPGSVKKFAQKNPHSMGKWLADSKSHVAHMNE
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCHHEEECCC
GDFYASEKSVTVADAGSVSIVLNKVDGSEQVLRNAIALQAGEVIDSAVMSKKALVEFYER
CCEEECCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETNLAKEQDVLLSLHLKATMMKVSDPILFGHAVKVYYKDVFAEHGELFEQLGVDVNNGLG
HHCCCHHHHHEEEEHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVYAKIATLPSDQKAAIEADLAAVYTHRAELAMVDSDRGITNLHVPSDVIIDASMPAAIR
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCEEEECCCCHHHH
TSGKMWGPDGQLKDMKAMIPDRCYAGVYQETIDFCINNGAFDPSTMGSVPNVGLMAQKAE
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHH
EYGSHDKTFEIAAAGTVNVVDQNGNVLMSHDVEAGDIFRMCQVKDAPIRDWVKLAVNRSR
HHCCCCCEEEEEECCEEEEEECCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSATPAVFWLDAARAHDAEIIKKVELYLQDHDTNGLELYIMPPVEATRFTLERVKAGKDT
HCCCCEEEEEECHHCCHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHHHHHHCCCCE
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKEGH
EEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCC
LRWDSLGEFLALGASLEHLSQTTGNSKAQVLADTLDIAIGQFLDLNKSPSRRVGELDNRG
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
SHFYLAMYWAQALVAQTADIQLQAEFSGLAESLTNNEDQIVSELNGVQGPAVDLGGYYRL
CEEEHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEE
DAVKAETAMRPSATLNSIVG
EHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226630; 1295895 [H]