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The map label for this gene is f1pep1 [H]

Identifier: 167623617

GI number: 167623617

Start: 2021471

End: 2023627

Strand: Direct

Name: f1pep1 [H]

Synonym: Shal_1686

Alternate gene names: 167623617

Gene position: 2021471-2023627 (Clockwise)

Preceding gene: 167623616

Following gene: 167623618

Centisome position: 38.67

GC content: 45.02

Gene sequence:

>2157_bases
ATGCGAATTCACTCGATACTAACTAAAAAGCATTTGTTAGCCATTGGCTTAGGCCTAGCTGTGGTAGGTTGCCAGTCACA
ACCGACAATAGAAGAATCTGCGACTACCGTTAAGAGCAATACTGGCGGCGTAGTGGAAACAATCCATGGCGTAGAGGTTG
CAGACCCTTATCGCTATCTAGAAGTTGAGTCTGAGCAGACCCATAAATGGGTTAGCGAACAGCAGGGCGCTGGTCATGCT
TATCTAGCCAATATTGAAAATAAGCAGGCCATTGTCGAACGTATCACCGAACTTTGGAATTTTGAGAAAATCTCTGCGCC
GTTCGAAAAGGGTGACAATACCTTCTATTATCGAAACGACGGCTTGCAAGCTCAATCTGTACTCTATGTTAAAAGTGGTG
ATGGCGAGGCACGAGTTGTACTCGATCCTAACCGTTTTTCGGATGATGGTACGGTAGCGCTGTCAGGTGTGTCGGTCAGT
GATGATGGCAAAACCTTGGCCTATGGGATCTCTAAGTCAGGCTCAGATTGGCAGGCATGGCACTTTGTTGATGTTGCTAC
GGGGAAGAAACTTAAAGATGAACTTGATTGGATAAAGTTCTCTAGTGCGGTTTGGGATCACGATAACACAGGAGTCTATT
ACGCACGCTATGATGCTCCTGAAGGCGGCAATGCCCTAGCTGATGTGAATTTCAATCAGAAAGTTTACTTTCACAAAATA
GGTACACCGCAAAGTGCAGATACTTTAATTTATGAAAGACCTCAGAATAAAGATTGGGGTTTTGGCATCGAAGTTTCAGA
GAGCGGCGATTATCTATTACTGTATATCTCACAAGGGACAGATAGCCGAAATCGCTTCTTCTATAAGTCACTGAAGGAGC
CGCAAGCTCAAGTTGTCGAGCTTATCCCTGACTTAGAAGCTGAATATAGCTTTATCGGTAACAATAAATCAGTGTTCTAC
TTCAAAACTGATTACAATGCACCGAATGGCAAAGTGATTGCTATTGATGTGAATAATAATGCTAAAGGTAATTGGAAGAC
GGTCATTTCTGAGCTTAATGATCCTATCAGTGACATCGCGATTATTAATGAACACATGGTGGTGAGCTACCTACATGACG
TGTTAGGCAAGTTGACGATTTACAACATGAATGGTGATAAGCGCCAAGATGTCATTTTACCGGGCAAAGGTAAGGTAGCA
GGCCCTTACGGAAAGCGCAGTAAAGATTACTTCTACTATGTTTTCAACAGTTACACTCAGCCTCAAACAACCTACAAGTT
TGATTTTAAAACTGGTGAGTCAACCGTTTACTCTAAGCCTCAAGTCTCTTTTGACCCTAGTAATTATACCTCTGAGCAGG
TTTTTTACACCAGTAAAGACGGTACGAAAGTGCCGATGATGATCTCTTATAAGAAGGGATTAAAGAAAGATAGTCAGAAT
CCAACACTGTTGTACGCCTATGGCGGTTTTGCCATCTCGATGACACCTCGCTTTAGCCCAGCGAATATCGCTTGGATGGA
TATGGGTGGCGTGTATGCTGTGCCAAACCTTCGAGGTGGTGCTGAATACGGTGAAAGCTGGCATCAAGCGGGGATGTTCG
ATAAAAAGCAGAATGTGTTTGATGATTATTACGCGGCGGCGGAGTATTTGATCGAACATGATTATACTAACTCTTCTAAG
TTAGGCGCGTATGGCCGCAGTAACGGTGGTTTGTTGATGGGGGCGACTCTGACTCAACGACCAGAGCTATTTGCGGCTGT
TCTGCCAGCGGTTGGCGTTTTGGATATGCTACGTTTCCAAAAGTTTACCATCGGCTGGGCCTGGACCAGTGAATACGGTA
GCGCCGATAATGCTGAGCAGTTCCCGGCACTTTATGCTTATTCGCCATATCATAACCTTAAAGAGCAAGCGTATCCGGCG
ACGATGGTAATGACAGCCGATCATGACGATCGCGTGGTGCCGCTTCATAGCTTTAAGTTTGGTGCCTTGATGCAAGATAA
GCAGCAGGGTGATGCGCCAGTCATTATGCGTATTGAGTCAAAGGCCGGTCATGGCGCGGGTAAGCCGACCTCGATGAAGA
TTGATGAGTTCGCCGATATCTATAGTTTCCTTTGGCATAACTTTGGCCTTCAGGTACCCGCTAAAATTGGTCAGTAA

Upstream 100 bases:

>100_bases
GGATAAAGCGATAAAAATAAGATTATCTCATTATAAATAACTTAACGATAAAAACAGAAGACTCAATAAATAATAAGAGT
CAGTTAATCAGGGATAAAAA

Downstream 100 bases:

>100_bases
ACCAATTTAAGTTAGGGATAAAAAGGAAGCTTCGGCTTCCTTTTTTTATGGACAAACAGTTTGCTGAAGGCTCCGTGTGC
TGCTTGCTTGAGCGCTTATG

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MRIHSILTKKHLLAIGLGLAVVGCQSQPTIEESATTVKSNTGGVVETIHGVEVADPYRYLEVESEQTHKWVSEQQGAGHA
YLANIENKQAIVERITELWNFEKISAPFEKGDNTFYYRNDGLQAQSVLYVKSGDGEARVVLDPNRFSDDGTVALSGVSVS
DDGKTLAYGISKSGSDWQAWHFVDVATGKKLKDELDWIKFSSAVWDHDNTGVYYARYDAPEGGNALADVNFNQKVYFHKI
GTPQSADTLIYERPQNKDWGFGIEVSESGDYLLLYISQGTDSRNRFFYKSLKEPQAQVVELIPDLEAEYSFIGNNKSVFY
FKTDYNAPNGKVIAIDVNNNAKGNWKTVISELNDPISDIAIINEHMVVSYLHDVLGKLTIYNMNGDKRQDVILPGKGKVA
GPYGKRSKDYFYYVFNSYTQPQTTYKFDFKTGESTVYSKPQVSFDPSNYTSEQVFYTSKDGTKVPMMISYKKGLKKDSQN
PTLLYAYGGFAISMTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVFDDYYAAAEYLIEHDYTNSSK
LGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQKFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKEQAYPA
TMVMTADHDDRVVPLHSFKFGALMQDKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIGQ

Sequences:

>Translated_718_residues
MRIHSILTKKHLLAIGLGLAVVGCQSQPTIEESATTVKSNTGGVVETIHGVEVADPYRYLEVESEQTHKWVSEQQGAGHA
YLANIENKQAIVERITELWNFEKISAPFEKGDNTFYYRNDGLQAQSVLYVKSGDGEARVVLDPNRFSDDGTVALSGVSVS
DDGKTLAYGISKSGSDWQAWHFVDVATGKKLKDELDWIKFSSAVWDHDNTGVYYARYDAPEGGNALADVNFNQKVYFHKI
GTPQSADTLIYERPQNKDWGFGIEVSESGDYLLLYISQGTDSRNRFFYKSLKEPQAQVVELIPDLEAEYSFIGNNKSVFY
FKTDYNAPNGKVIAIDVNNNAKGNWKTVISELNDPISDIAIINEHMVVSYLHDVLGKLTIYNMNGDKRQDVILPGKGKVA
GPYGKRSKDYFYYVFNSYTQPQTTYKFDFKTGESTVYSKPQVSFDPSNYTSEQVFYTSKDGTKVPMMISYKKGLKKDSQN
PTLLYAYGGFAISMTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVFDDYYAAAEYLIEHDYTNSSK
LGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQKFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKEQAYPA
TMVMTADHDDRVVPLHSFKFGALMQDKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIGQ
>Mature_718_residues
MRIHSILTKKHLLAIGLGLAVVGCQSQPTIEESATTVKSNTGGVVETIHGVEVADPYRYLEVESEQTHKWVSEQQGAGHA
YLANIENKQAIVERITELWNFEKISAPFEKGDNTFYYRNDGLQAQSVLYVKSGDGEARVVLDPNRFSDDGTVALSGVSVS
DDGKTLAYGISKSGSDWQAWHFVDVATGKKLKDELDWIKFSSAVWDHDNTGVYYARYDAPEGGNALADVNFNQKVYFHKI
GTPQSADTLIYERPQNKDWGFGIEVSESGDYLLLYISQGTDSRNRFFYKSLKEPQAQVVELIPDLEAEYSFIGNNKSVFY
FKTDYNAPNGKVIAIDVNNNAKGNWKTVISELNDPISDIAIINEHMVVSYLHDVLGKLTIYNMNGDKRQDVILPGKGKVA
GPYGKRSKDYFYYVFNSYTQPQTTYKFDFKTGESTVYSKPQVSFDPSNYTSEQVFYTSKDGTKVPMMISYKKGLKKDSQN
PTLLYAYGGFAISMTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVFDDYYAAAEYLIEHDYTNSSK
LGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQKFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKEQAYPA
TMVMTADHDDRVVPLHSFKFGALMQDKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIGQ

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=685, Percent_Identity=42.3357664233577, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI284172438, Length=355, Percent_Identity=25.0704225352113, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172431, Length=355, Percent_Identity=25.0704225352113, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172420, Length=355, Percent_Identity=25.0704225352113, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172413, Length=355, Percent_Identity=25.0704225352113, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI70778815, Length=355, Percent_Identity=25.0704225352113, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI108860686, Length=214, Percent_Identity=29.9065420560748, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI108860692, Length=201, Percent_Identity=30.3482587064677, Blast_Score=94, Evalue=6e-19,
Organism=Escherichia coli, GI1788150, Length=680, Percent_Identity=25.7352941176471, Blast_Score=202, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24583414, Length=700, Percent_Identity=41.8571428571429, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221510989, Length=691, Percent_Identity=39.7973950795948, Blast_Score=480, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 80221; Mature: 80221

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIHSILTKKHLLAIGLGLAVVGCQSQPTIEESATTVKSNTGGVVETIHGVEVADPYRYL
CCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCEEECCCCCEEEEECCCEECCCEEEE
EVESEQTHKWVSEQQGAGHAYLANIENKQAIVERITELWNFEKISAPFEKGDNTFYYRND
EECCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHCCCHHCCCCEEEEECC
GLQAQSVLYVKSGDGEARVVLDPNRFSDDGTVALSGVSVSDDGKTLAYGISKSGSDWQAW
CCCEEEEEEEECCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCEEE
HFVDVATGKKLKDELDWIKFSSAVWDHDNTGVYYARYDAPEGGNALADVNFNQKVYFHKI
EEEEECCCCHHHHHHHHEEECCEEECCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEC
GTPQSADTLIYERPQNKDWGFGIEVSESGDYLLLYISQGTDSRNRFFYKSLKEPQAQVVE
CCCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCHHHHHHH
LIPDLEAEYSFIGNNKSVFYFKTDYNAPNGKVIAIDVNNNAKGNWKTVISELNDPISDIA
HHCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHE
IINEHMVVSYLHDVLGKLTIYNMNGDKRQDVILPGKGKVAGPYGKRSKDYFYYVFNSYTQ
EHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
PQTTYKFDFKTGESTVYSKPQVSFDPSNYTSEQVFYTSKDGTKVPMMISYKKGLKKDSQN
CCEEEEEEEECCCCEEECCCCEEECCCCCCCCEEEEECCCCCCCCEEEEEHHCCCCCCCC
PTLLYAYGGFAISMTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVF
CEEEEEECCEEEEECCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHH
DDYYAAAEYLIEHDYTNSSKLGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKEQAYPATMVMTADHDDRVVPLHSFKF
EEEEEEEEECCCCCCCCHHHCCEEEEECCCHHHHHHCCCEEEEEEECCCCCEEEECCCCC
GALMQDKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIGQ
CCHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRIHSILTKKHLLAIGLGLAVVGCQSQPTIEESATTVKSNTGGVVETIHGVEVADPYRYL
CCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCEEECCCCCEEEEECCCEECCCEEEE
EVESEQTHKWVSEQQGAGHAYLANIENKQAIVERITELWNFEKISAPFEKGDNTFYYRND
EECCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHCCCHHCCCCEEEEECC
GLQAQSVLYVKSGDGEARVVLDPNRFSDDGTVALSGVSVSDDGKTLAYGISKSGSDWQAW
CCCEEEEEEEECCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCEEE
HFVDVATGKKLKDELDWIKFSSAVWDHDNTGVYYARYDAPEGGNALADVNFNQKVYFHKI
EEEEECCCCHHHHHHHHEEECCEEECCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEC
GTPQSADTLIYERPQNKDWGFGIEVSESGDYLLLYISQGTDSRNRFFYKSLKEPQAQVVE
CCCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCHHHHHHH
LIPDLEAEYSFIGNNKSVFYFKTDYNAPNGKVIAIDVNNNAKGNWKTVISELNDPISDIA
HHCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHE
IINEHMVVSYLHDVLGKLTIYNMNGDKRQDVILPGKGKVAGPYGKRSKDYFYYVFNSYTQ
EHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
PQTTYKFDFKTGESTVYSKPQVSFDPSNYTSEQVFYTSKDGTKVPMMISYKKGLKKDSQN
CCEEEEEEEECCCCEEECCCCEEECCCCCCCCEEEEECCCCCCCCEEEEEHHCCCCCCCC
PTLLYAYGGFAISMTPRFSPANIAWMDMGGVYAVPNLRGGAEYGESWHQAGMFDKKQNVF
CEEEEEECCEEEEECCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHH
DDYYAAAEYLIEHDYTNSSKLGAYGRSNGGLLMGATLTQRPELFAAVLPAVGVLDMLRFQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KFTIGWAWTSEYGSADNAEQFPALYAYSPYHNLKEQAYPATMVMTADHDDRVVPLHSFKF
EEEEEEEEECCCCCCCCHHHCCEEEEECCCHHHHHHCCCEEEEEEECCCCCEEEECCCCC
GALMQDKQQGDAPVIMRIESKAGHGAGKPTSMKIDEFADIYSFLWHNFGLQVPAKIGQ
CCHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]