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The map label for this gene is tyrR [H]

Identifier: 167623464

GI number: 167623464

Start: 1848208

End: 1849755

Strand: Direct

Name: tyrR [H]

Synonym: Shal_1533

Alternate gene names: 167623464

Gene position: 1848208-1849755 (Clockwise)

Preceding gene: 167623463

Following gene: 167623465

Centisome position: 35.36

GC content: 46.32

Gene sequence:

>1548_bases
ATGCGCTTGGAAGTCAGCTGTTTAGACCGTGTCGGTCTTGCCAAAGATATCTTATTGATCATGGAAGACTACGGGATCAA
TTTGTTTGCCATCGATGCAAGCAACCAAGGTTTTCTCTATCTACAATTTGCTGAAGTTAGTTTTGATATGCTCAGTGAGT
TATTGCCACTTATTCGAAAGGTCGAAGGTGTTCATGATGTTCGTACGGTGTCGTTTATGCCGTCGGAGCAAGAGCATTAC
GCACTTAAGACCTTATTAAAAACCCTACCTGATTCGGTGTTCTCTATCGATGTAAAAGGGCGGATCCGTATTGTTAATGA
ATCGGCACTGCATACGGTGGGTATGGCCGAGCATGAGGTCATTGATGAATCAATAAACCATTGGGTACACGGTTTTAATT
TCAGCCGTTGGCTGAGCGAGTCAACTGTTTTAGCGCAGGCCACACGGGTGAATATTGGTGAAAATGAATACCTTGCGGAA
ATGTTACCCATTTACCTGCCTGATAGCGGCAGTGAAACCCCTATTTTAGCGGGTGCAGTGGTTTCACTTAAGTCACCAGC
ACGCTTAGGTAAACAGTTTAATGCGCTACAAAATCAGTCAAGTGGTTTTGAAAATGTACTCGCGACAAGTGACAAGATGA
AAGAGGTGTTGGTTCAGGCTCGTCGGATGGCGCAGCTTGATGCACCTTTACTCATTACGGGTGAAACAGGCACAGGTAAA
GAGCTGATGTCTCGCGCCTGCCACGATGCCAGTATGCGCCGTGAACACCCTTTCATCGCCATAAACTGTGCAGCCATGCC
TGACAGTGCCGCTGAAGAGGAGCTTTTTGGCTTTGTTAGCAATGGTAACGTGGTCAAACGTGGTTTTATTGAAGAGGCTA
AGGGCGGAACAATCTTTCTCGATGAGATTGCTGAGATGTCTAAGTCGGCTCAGGTTAAGCTATTACGATTCATACAAGAT
GGCACCTTTAGACGTGTTGGCGGCGATGAAGAGATCCGCAGTGATGTGCGGATCATCTGTTCGACCCAAAAGAATCTTGC
CGAATTATGTCAAAGTGGCGAGTTCAGAGAGGATCTCTATTATCGTATCCACGTATTAAGCTTTCATGTGCCCGCCTTGC
GTGAGCGCAAAGTTGATATTATTCCGCTTACTGAGATGTTTTTGGAGCATTACAGCCAGCAACTCTCTATTCCGATACGT
CGTATCTCTGGGGAGTGTCGTGAACATCTTCTCGGTTATGCGTGGCCGGGTAACGTTCGCCAGCTTAAAAATGCCATTTT
TAGAGCGGTATCAATGTGGGATGGCAGTGCAGAGCTAACGGTTGAGCAATTAAAGTTACCCTCTTATGCTGAAGGTTTTG
GATACTTCGACCATCAGTTTGAGGGCAGTTTAGAGGAGGCGATGAAACAGTTTGAAGCGAGCTTATTGCGAAGGCTTTAC
CCCGCCTACCCAAGTACGCGCCAGCTTGCTAAAAAACTGGGGGTATCGCACACCGCGATTGCTAACAAACTGCGCGAATA
TAAGATCAGTAAACAAAAAGCGCTGTAA

Upstream 100 bases:

>100_bases
TGAGTATTGCTTTTCAAGGCTATTTTACTCATCGAGTGACTTGCTTCTGATGATTGTTTTATCCCAATAACGAGTATTTA
AAAAAGGGAACTGCAATAGT

Downstream 100 bases:

>100_bases
AAATGGCTTGCCGCGAGTTGGTGTATTGATAAGCAACTCGCGACTAAAAATTATACTTACGGGCTATTTTTAATAGCCTG
TAAGTATAAGTTTACAATGT

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDMLSELLPLIRKVEGVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDVKGRIRIVNESALHTVGMAEHEVIDESINHWVHGFNFSRWLSESTVLAQATRVNIGENEYLAE
MLPIYLPDSGSETPILAGAVVSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVVKRGFIEEAKGGTIFLDEIAEMSKSAQVKLLRFIQD
GTFRRVGGDEEIRSDVRIICSTQKNLAELCQSGEFREDLYYRIHVLSFHVPALRERKVDIIPLTEMFLEHYSQQLSIPIR
RISGECREHLLGYAWPGNVRQLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEEAMKQFEASLLRRLY
PAYPSTRQLAKKLGVSHTAIANKLREYKISKQKAL

Sequences:

>Translated_515_residues
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDMLSELLPLIRKVEGVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDVKGRIRIVNESALHTVGMAEHEVIDESINHWVHGFNFSRWLSESTVLAQATRVNIGENEYLAE
MLPIYLPDSGSETPILAGAVVSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVVKRGFIEEAKGGTIFLDEIAEMSKSAQVKLLRFIQD
GTFRRVGGDEEIRSDVRIICSTQKNLAELCQSGEFREDLYYRIHVLSFHVPALRERKVDIIPLTEMFLEHYSQQLSIPIR
RISGECREHLLGYAWPGNVRQLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEEAMKQFEASLLRRLY
PAYPSTRQLAKKLGVSHTAIANKLREYKISKQKAL
>Mature_515_residues
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDMLSELLPLIRKVEGVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDVKGRIRIVNESALHTVGMAEHEVIDESINHWVHGFNFSRWLSESTVLAQATRVNIGENEYLAE
MLPIYLPDSGSETPILAGAVVSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVVKRGFIEEAKGGTIFLDEIAEMSKSAQVKLLRFIQD
GTFRRVGGDEEIRSDVRIICSTQKNLAELCQSGEFREDLYYRIHVLSFHVPALRERKVDIIPLTEMFLEHYSQQLSIPIR
RISGECREHLLGYAWPGNVRQLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEEAMKQFEASLLRRLY
PAYPSTRQLAKKLGVSHTAIANKLREYKISKQKAL

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=515, Percent_Identity=47.9611650485437, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1788550, Length=313, Percent_Identity=37.3801916932907, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1788905, Length=288, Percent_Identity=39.9305555555556, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=35.258358662614, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789233, Length=467, Percent_Identity=28.4796573875803, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1790299, Length=327, Percent_Identity=35.474006116208, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1790437, Length=259, Percent_Identity=37.8378378378378, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=35.202492211838, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082152, Length=248, Percent_Identity=42.3387096774194, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786524, Length=270, Percent_Identity=40.3703703703704, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=40.5172413793103, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789828, Length=409, Percent_Identity=26.6503667481663, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081858, Length=367, Percent_Identity=27.5204359673025, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 58002; Mature: 58002

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDMLSELLPLIRK
CEEEHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEHHCCHHHHHHHHHHHHH
VEGVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSIDVKGRIRIVNESALHTVGMAEHEV
HCCHHHHEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEEECHHHHHHCCHHHHH
IDESINHWVHGFNFSRWLSESTVLAQATRVNIGENEYLAEMLPIYLPDSGSETPILAGAV
HHHHHHHHHCCCCHHHHHCCHHHHHHHHEECCCCHHHHHHHCCEEECCCCCCCCEEEHHH
VSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
HHCCCHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVVKRGFIEEAKGGTIFL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHEEECCCCEEECCCHHHCCCCEEEH
DEIAEMSKSAQVKLLRFIQDGTFRRVGGDEEIRSDVRIICSTQKNLAELCQSGEFREDLY
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCHHEEECCHHHHHHHHHCCCCHHHHH
YRIHVLSFHVPALRERKVDIIPLTEMFLEHYSQQLSIPIRRISGECREHLLGYAWPGNVR
EEEEEEEECCCHHHHCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHH
QLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEEAMKQFEASLLRRLY
HHHHHHHHHHHHCCCCCCEEHHHHCCCCHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHC
PAYPSTRQLAKKLGVSHTAIANKLREYKISKQKAL
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLEVSCLDRVGLAKDILLIMEDYGINLFAIDASNQGFLYLQFAEVSFDMLSELLPLIRK
CEEEHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEHHCCHHHHHHHHHHHHH
VEGVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSIDVKGRIRIVNESALHTVGMAEHEV
HCCHHHHEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEEECHHHHHHCCHHHHH
IDESINHWVHGFNFSRWLSESTVLAQATRVNIGENEYLAEMLPIYLPDSGSETPILAGAV
HHHHHHHHHCCCCHHHHHCCHHHHHHHHEECCCCHHHHHHHCCEEECCCCCCCCEEEHHH
VSLKSPARLGKQFNALQNQSSGFENVLATSDKMKEVLVQARRMAQLDAPLLITGETGTGK
HHCCCHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
ELMSRACHDASMRREHPFIAINCAAMPDSAAEEELFGFVSNGNVVKRGFIEEAKGGTIFL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHEEECCCCEEECCCHHHCCCCEEEH
DEIAEMSKSAQVKLLRFIQDGTFRRVGGDEEIRSDVRIICSTQKNLAELCQSGEFREDLY
HHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCHHEEECCHHHHHHHHHCCCCHHHHH
YRIHVLSFHVPALRERKVDIIPLTEMFLEHYSQQLSIPIRRISGECREHLLGYAWPGNVR
EEEEEEEECCCHHHHCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHH
QLKNAIFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDHQFEGSLEEAMKQFEASLLRRLY
HHHHHHHHHHHHCCCCCCEEHHHHCCCCHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHC
PAYPSTRQLAKKLGVSHTAIANKLREYKISKQKAL
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]