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The map label for this gene is (rmlA1 [H]

Identifier: 167623418

GI number: 167623418

Start: 1789222

End: 1790109

Strand: Direct

Name: (rmlA1 [H]

Synonym: Shal_1487

Alternate gene names: 167623418

Gene position: 1789222-1790109 (Clockwise)

Preceding gene: 167623417

Following gene: 167623419

Centisome position: 34.23

GC content: 39.98

Gene sequence:

>888_bases
ATGAAAGGTATTGTATTAGCTGGTGGCAGTGGTACTCGTTTATTTCCATTAACTCGTGGTGTATCAAAGCAACTGCTTCC
AATCTACGACAAGCCAATGGTGTTTTATCCTATTTCAACTCTGATGCTGGCGGGCATCAAAGATATTTTAATCATTACTA
CCCCTGAAGATAATGCGGGCTTTAAGCGGCTATTAGGTGACGGCTCAGATTTTGGCATCAACCTTGAGTATGCTATTCAA
CCAAGTCCTGATGGCTTAGCACAAGCGTTTATCATTGGTGAAGAGTTTATTGGTGATGATAGCGTTTGTTTAGTCCTTGG
CGATAACATTTTCTATGGTCAGTCTTTTTCAAATACACTTAAAAATGCAGCATCGCGTGAGTCTGGAGCAACCGTTTTTG
GCTACCAAGTGAAAGATCCTGAGCGTTTTGGTGTGGTTGAGTTCGATGAAGATATGAAAGCGGTATCGATTGAAGAAAAA
CCTGAAACACCAAAATCAAATTATGCAGTTACTGGTCTTTACTTCTACGACAATCGCGTTGTTGAAATGGCAAAACAAGT
TAAACCATCTCATCGTGGTGAGCTTGAAATTACGACACTAAATGAAATGTATTTAAATGATGGATTGTTAAATGTTGAGT
TATTAGGCCGGGGTTTTGCGTGGCTTGATACAGGCACCCATGAAAGCCTTCATGAAGCCTCTTCTTTTGTTCAAACCATT
GAAAATGTTCAAGGCTTAAAGGTTGCCTGCTTAGAAGAAATTGCTTGGCGTAACGGTTGGTTGAGTAACGAGCAGATTTT
GTCTCTAGCCAAGCCTATGATGAAGAACGAATACGGTCAGTATTTAAAACGTTTAGTGAGTGAAAATCAGAAAAAGGTAC
TGACCTAA

Upstream 100 bases:

>100_bases
GGTATTTGACTAACCAAGAGTGGTGTCAACACGTGCAAGATGGGAGTTATCAGCGTGAACGTTTAGGTGTAGTGCCATCT
GCGACGAAGGAAGATGCACA

Downstream 100 bases:

>100_bases
TGCGGGTACTAATTACAGGGTGCAATGGGCAAGTTGGCTGTAGTTTAACTGAGCAATTAGCTAAGGACACAAATACAACA
GTATTAGCGCTTGATAGAGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKGIVLAGGSGTRLFPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAGFKRLLGDGSDFGINLEYAIQ
PSPDGLAQAFIIGEEFIGDDSVCLVLGDNIFYGQSFSNTLKNAASRESGATVFGYQVKDPERFGVVEFDEDMKAVSIEEK
PETPKSNYAVTGLYFYDNRVVEMAKQVKPSHRGELEITTLNEMYLNDGLLNVELLGRGFAWLDTGTHESLHEASSFVQTI
ENVQGLKVACLEEIAWRNGWLSNEQILSLAKPMMKNEYGQYLKRLVSENQKKVLT

Sequences:

>Translated_295_residues
MKGIVLAGGSGTRLFPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAGFKRLLGDGSDFGINLEYAIQ
PSPDGLAQAFIIGEEFIGDDSVCLVLGDNIFYGQSFSNTLKNAASRESGATVFGYQVKDPERFGVVEFDEDMKAVSIEEK
PETPKSNYAVTGLYFYDNRVVEMAKQVKPSHRGELEITTLNEMYLNDGLLNVELLGRGFAWLDTGTHESLHEASSFVQTI
ENVQGLKVACLEEIAWRNGWLSNEQILSLAKPMMKNEYGQYLKRLVSENQKKVLT
>Mature_295_residues
MKGIVLAGGSGTRLFPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAGFKRLLGDGSDFGINLEYAIQ
PSPDGLAQAFIIGEEFIGDDSVCLVLGDNIFYGQSFSNTLKNAASRESGATVFGYQVKDPERFGVVEFDEDMKAVSIEEK
PETPKSNYAVTGLYFYDNRVVEMAKQVKPSHRGELEITTLNEMYLNDGLLNVELLGRGFAWLDTGTHESLHEASSFVQTI
ENVQGLKVACLEEIAWRNGWLSNEQILSLAKPMMKNEYGQYLKRLVSENQKKVLT

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=247, Percent_Identity=23.4817813765182, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI11761621, Length=247, Percent_Identity=23.4817813765182, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790224, Length=292, Percent_Identity=71.2328767123288, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=66.6666666666667, Blast_Score=413, Evalue=1e-117,
Organism=Escherichia coli, GI1787488, Length=240, Percent_Identity=24.5833333333333, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=226, Percent_Identity=24.3362831858407, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=228, Percent_Identity=26.7543859649123, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355443, Length=225, Percent_Identity=24.8888888888889, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644084, Length=225, Percent_Identity=24.8888888888889, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32754; Mature: 32754

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGTRLFPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAG
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCCC
FKRLLGDGSDFGINLEYAIQPSPDGLAQAFIIGEEFIGDDSVCLVLGDNIFYGQSFSNTL
HHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEEECCEEECCCHHHHH
KNAASRESGATVFGYQVKDPERFGVVEFDEDMKAVSIEEKPETPKSNYAVTGLYFYDNRV
HHHHCCCCCCEEEEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
VEMAKQVKPSHRGELEITTLNEMYLNDGLLNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHCCCCCCCEEEEEEEHHHHHCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHH
ENVQGLKVACLEEIAWRNGWLSNEQILSLAKPMMKNEYGQYLKRLVSENQKKVLT
HHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MKGIVLAGGSGTRLFPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAG
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCCC
FKRLLGDGSDFGINLEYAIQPSPDGLAQAFIIGEEFIGDDSVCLVLGDNIFYGQSFSNTL
HHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEEECCEEECCCHHHHH
KNAASRESGATVFGYQVKDPERFGVVEFDEDMKAVSIEEKPETPKSNYAVTGLYFYDNRV
HHHHCCCCCCEEEEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
VEMAKQVKPSHRGELEITTLNEMYLNDGLLNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHCCCCCCCEEEEEEEHHHHHCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHH
ENVQGLKVACLEEIAWRNGWLSNEQILSLAKPMMKNEYGQYLKRLVSENQKKVLT
HHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]