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The map label for this gene is aceE [H]

Identifier: 167622416

GI number: 167622416

Start: 563572

End: 566235

Strand: Direct

Name: aceE [H]

Synonym: Shal_0476

Alternate gene names: 167622416

Gene position: 563572-566235 (Clockwise)

Preceding gene: 167622415

Following gene: 167622417

Centisome position: 10.78

GC content: 47.45

Gene sequence:

>2664_bases
ATGTCTGAACATATGCTACAAGATTTAGATCCACTAGAAACTCAGGAATGGGTAGATTCACTGCAAGCGGTATTAGAGCA
AGAAGGCCCTGAGCGCGCGCACTACCTACTGGAGAAGTTGATTGATAAAGCACGTCGTAATGGTACTCACCTACCTTATA
AAGCGACGACCGCTTACTTAAACACAATCCCTGCGGGCCAAGAGCCACATATGCCTGGCAACCAAGAGATGGAGCGTCGT
ATTCGCGCTATCGTTCGTTGGAATGCCTTGGCTATGGTTTTGCGTGGTTCTAAGAAAGATCTAGAGCTAGGTGGTCACAT
CTCAAGCTTTGCATCGAGTGCAACCATTTATGACGTCTGTTTTAACCATTTCTTCCGCGGTCCAAATGAAAAAGATGGCG
GCGACTTGGTTTACTTCCAAGGACATATTGCTCCGGGGATCTACTCTCGCTCTTTCCTTGAGGGGCGTATCACCGAAGAC
CAGATGAACAACTTCCGTCAAGAGGTCGATGGTAAAGGTCTATCATCATACCCACACCCTAAGTTGATGCCAGATTACTG
GCAGTTCCCTACGGTATCTATGGGTCTGGGTCCGATACAAGCTATCTATCAAGCACGCTTCCTTAAGTACCTGACTGACC
GTGGGATCAAAGATTGCTCTGAGCAAACGGTTTACTGCTTCTTAGGCGACGGTGAGTGTGATGAGCCTGAAGCCTTAGGC
GCAATCGGCCTTGCAGCACGTGAAGAGCTAGATAACCTTTGCTTCATCGTTAACTGTAACTTACAGCGTCTTGACGGTCC
GGTACGTGGTAACGGTAAGATTATTCAAGAGCTTGAAGGCGAATTCCGCGGCGCAGGCTGGGAAGCGGTTAAAGTGATTT
GGGGTCGTTACTGGGATCCACTACTTGCTCGCGACACTAGCGGTAAGTTACTGCAGTTGATGGAAGAAACCGTCGATGGT
GAATACCAAAACTGTAAGGCTAAGGGCGGCGCTTATACTCGTGAGCACTTCTTTGGTAAGTACCCAGAAACGGCTGAGAT
GGTTGCCAATATGTCAGATGATGACATCTGGCGTCTAAACCGTGGCGGTCACGATCCTGTTAAGATCTTTGCGGCACTTC
AGCATGCTAAGAACACTAAAGGTCGTCCAACGGTTATCCTCGCTAAAACGGTAAAAGGTTATGGCATGGGGGATGCGGGT
GAGGGCAAGAACATCGCTCACAACGTGAAGAAGATGGGCATTGAGTCACTTAGATACTTCCGCGATCGTTTCAATATCCC
AATTAGTGATGAACAGTTAGAAGATATTCCTTTCTATCATCCAGGTGCAGACTCGGAAGAGGTGCAGTACCTTAAGGCTC
GCCGTGCAGAGTTACACGGCATGATACCTGCTCGTCGTGCAAAGTTCTCACAAGAGCTTGAAGTTCCATCACTGAAGATC
TTTGATTCAATACTCAAGGGCTCAAATGGTCGTGAGATCTCAAGTACAATGGCGTTTGTGCGTATTCTTACCGCATTGCT
AAAAGACAAGAAGATTGGCAAACAGATTGTACCTATTATCCCGGATGAGGCGCGTACCTTTGGTATGGAAGGCTTATTCC
GCCAAGTGGGGATCTATGCCCATGAAGGACAAAAGTACGTACCACAAGATTCAGATCAGGTCGCTTACTATCGCGAAGAT
AAGAGTGGTCAGGTTCTGCAAGAAGGTATCAACGAGCTAGGCGCAATGTCATCCTGGGTTGCTGCGGCAACTAGTTATTC
AGTTAACGACACGCCGATGATCCCGTTTTATATCTACTACTCAATGTTTGGTTTCCAGCGTATTGGCGATATGGCTTGGG
CCGCTGGCGATATGCGTGCTCGCGGCTTTATGGTTGGTGGTACTTCAGGTCGTACAACGTTGAACGGTGAAGGTCTGCAG
CATCAAGATGGTCACAGTCATATTTTGGCTAACACCATTCCAAACTGTATCTCTTACGACCCCACTTACGGCTACGAAAT
TGCCGTTGTAGTTCAAGACGGTATTCGTCGTATGTACGGTGAGCAGGAAGATGTTTTCTACTACCTAACAACGATGAATG
AGAACTACGAACAACCCGCAATGCCTGAAGGGGCTGAAGAGGGTATCGTTAAAGGTATCTACAAGCTTGAAACCCTTAAA
GGTAGTGGTAAAGGCTCGGTACAGCTAATGGGTAGCGGTACGATTTTAGAGCAAGTTCGTAAGGCTGCGGTTGCACTGTC
TAAAGACTTTGGCATTACCGCAGATGTTTACAGTGTAACCAGCTTTAACGAGTTAACGCGTGACGGCCAAGCGGCAGAGC
GTTACAACATGTTACACCCAACTGAAACAGCAAAAGTACCTTATATTACCCAAGTGCTTGCTAGCGATGCGCCAGCGATT
GTTGCAACAGACTACATGAAGATTTACGGCGAGCAGCTACGTGCCTACGTACCCACTGACTATAAAGTACTAGGTACTGA
TGGTTTCGGTCGTTCAGACAGCCGCGAGAACCTACGTCATCACTTTGAGGTTGACGCTAAGTTTATCGTTATCGCTTCAC
TTAAAGCCCTTGTTGATCGTAACGAGCTACCTGTTGATGTGCTAACTAAAGCTATCAAAGAGTATGGTATCGACGTTGAC
AAGATCAACCCACAGTACGCGTAA

Upstream 100 bases:

>100_bases
ACGTAGTCTGCGCCGCTTAAAAAGTGGTGTTTAGACCATGGGTTAGCAAAGCTATGACCATTAATTATTACAACTATTGT
ATATAGGGAAGGACAGCGTC

Downstream 100 bases:

>100_bases
AGGGGAAACAAAATGGCTGAATTAAAAGAAGTTTTGATTCCTGATATCGGTGGCGATGAAGTTCAGGTTATTGAGATCTG
TGCTGCGGTCGGCGACACGC

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSEHMLQDLDPLETQEWVDSLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYKATTAYLNTIPAGQEPHMPGNQEMERR
IRAIVRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRGPNEKDGGDLVYFQGHIAPGIYSRSFLEGRITED
QMNNFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALG
AIGLAAREELDNLCFIVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWEAVKVIWGRYWDPLLARDTSGKLLQLMEETVDG
EYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIFAALQHAKNTKGRPTVILAKTVKGYGMGDAG
EGKNIAHNVKKMGIESLRYFRDRFNIPISDEQLEDIPFYHPGADSEEVQYLKARRAELHGMIPARRAKFSQELEVPSLKI
FDSILKGSNGREISSTMAFVRILTALLKDKKIGKQIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYRED
KSGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFMVGGTSGRTTLNGEGLQ
HQDGHSHILANTIPNCISYDPTYGYEIAVVVQDGIRRMYGEQEDVFYYLTTMNENYEQPAMPEGAEEGIVKGIYKLETLK
GSGKGSVQLMGSGTILEQVRKAAVALSKDFGITADVYSVTSFNELTRDGQAAERYNMLHPTETAKVPYITQVLASDAPAI
VATDYMKIYGEQLRAYVPTDYKVLGTDGFGRSDSRENLRHHFEVDAKFIVIASLKALVDRNELPVDVLTKAIKEYGIDVD
KINPQYA

Sequences:

>Translated_887_residues
MSEHMLQDLDPLETQEWVDSLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYKATTAYLNTIPAGQEPHMPGNQEMERR
IRAIVRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRGPNEKDGGDLVYFQGHIAPGIYSRSFLEGRITED
QMNNFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALG
AIGLAAREELDNLCFIVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWEAVKVIWGRYWDPLLARDTSGKLLQLMEETVDG
EYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIFAALQHAKNTKGRPTVILAKTVKGYGMGDAG
EGKNIAHNVKKMGIESLRYFRDRFNIPISDEQLEDIPFYHPGADSEEVQYLKARRAELHGMIPARRAKFSQELEVPSLKI
FDSILKGSNGREISSTMAFVRILTALLKDKKIGKQIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYRED
KSGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFMVGGTSGRTTLNGEGLQ
HQDGHSHILANTIPNCISYDPTYGYEIAVVVQDGIRRMYGEQEDVFYYLTTMNENYEQPAMPEGAEEGIVKGIYKLETLK
GSGKGSVQLMGSGTILEQVRKAAVALSKDFGITADVYSVTSFNELTRDGQAAERYNMLHPTETAKVPYITQVLASDAPAI
VATDYMKIYGEQLRAYVPTDYKVLGTDGFGRSDSRENLRHHFEVDAKFIVIASLKALVDRNELPVDVLTKAIKEYGIDVD
KINPQYA
>Mature_886_residues
SEHMLQDLDPLETQEWVDSLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYKATTAYLNTIPAGQEPHMPGNQEMERRI
RAIVRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRGPNEKDGGDLVYFQGHIAPGIYSRSFLEGRITEDQ
MNNFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALGA
IGLAAREELDNLCFIVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWEAVKVIWGRYWDPLLARDTSGKLLQLMEETVDGE
YQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKIFAALQHAKNTKGRPTVILAKTVKGYGMGDAGE
GKNIAHNVKKMGIESLRYFRDRFNIPISDEQLEDIPFYHPGADSEEVQYLKARRAELHGMIPARRAKFSQELEVPSLKIF
DSILKGSNGREISSTMAFVRILTALLKDKKIGKQIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYREDK
SGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFMVGGTSGRTTLNGEGLQH
QDGHSHILANTIPNCISYDPTYGYEIAVVVQDGIRRMYGEQEDVFYYLTTMNENYEQPAMPEGAEEGIVKGIYKLETLKG
SGKGSVQLMGSGTILEQVRKAAVALSKDFGITADVYSVTSFNELTRDGQAAERYNMLHPTETAKVPYITQVLASDAPAIV
ATDYMKIYGEQLRAYVPTDYKVLGTDGFGRSDSRENLRHHFEVDAKFIVIASLKALVDRNELPVDVLTKAIKEYGIDVDK
INPQYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=890, Percent_Identity=66.0674157303371, Blast_Score=1271, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99376; Mature: 99245

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHMLQDLDPLETQEWVDSLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYKATTAYL
CCCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
NTIPAGQEPHMPGNQEMERRIRAIVRWNALAMVLRGSKKDLELGGHISSFASSATIYDVC
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHH
FNHFFRGPNEKDGGDLVYFQGHIAPGIYSRSFLEGRITEDQMNNFRQEVDGKGLSSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHH
AIGLAAREELDNLCFIVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWEAVKVIWGRYWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
LLARDTSGKLLQLMEETVDGEYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLN
HHHCCCCHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCEEECC
RGGHDPVKIFAALQHAKNTKGRPTVILAKTVKGYGMGDAGEGKNIAHNVKKMGIESLRYF
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RDRFNIPISDEQLEDIPFYHPGADSEEVQYLKARRAELHGMIPARRAKFSQELEVPSLKI
HHHCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
FDSILKGSNGREISSTMAFVRILTALLKDKKIGKQIVPIIPDEARTFGMEGLFRQVGIYA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCEEE
HEGQKYVPQDSDQVAYYREDKSGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYY
ECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWAAGDMRARGFMVGGTSGRTTLNGEGLQHQDGHSHILANTIPNCISYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEHHHHCCHHHCCC
PTYGYEIAVVVQDGIRRMYGEQEDVFYYLTTMNENYEQPAMPEGAEEGIVKGIYKLETLK
CCCCEEEEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEC
GSGKGSVQLMGSGTILEQVRKAAVALSKDFGITADVYSVTSFNELTRDGQAAERYNMLHP
CCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHCCCCC
TETAKVPYITQVLASDAPAIVATDYMKIYGEQLRAYVPTDYKVLGTDGFGRSDSRENLRH
CCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCHHHHHH
HFEVDAKFIVIASLKALVDRNELPVDVLTKAIKEYGIDVDKINPQYA
HHCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEHMLQDLDPLETQEWVDSLQAVLEQEGPERAHYLLEKLIDKARRNGTHLPYKATTAYL
CCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
NTIPAGQEPHMPGNQEMERRIRAIVRWNALAMVLRGSKKDLELGGHISSFASSATIYDVC
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHH
FNHFFRGPNEKDGGDLVYFQGHIAPGIYSRSFLEGRITEDQMNNFRQEVDGKGLSSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGIKDCSEQTVYCFLGDGECDEPEALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHH
AIGLAAREELDNLCFIVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWEAVKVIWGRYWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
LLARDTSGKLLQLMEETVDGEYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLN
HHHCCCCHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCEEECC
RGGHDPVKIFAALQHAKNTKGRPTVILAKTVKGYGMGDAGEGKNIAHNVKKMGIESLRYF
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RDRFNIPISDEQLEDIPFYHPGADSEEVQYLKARRAELHGMIPARRAKFSQELEVPSLKI
HHHCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
FDSILKGSNGREISSTMAFVRILTALLKDKKIGKQIVPIIPDEARTFGMEGLFRQVGIYA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCEEE
HEGQKYVPQDSDQVAYYREDKSGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYY
ECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWAAGDMRARGFMVGGTSGRTTLNGEGLQHQDGHSHILANTIPNCISYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEHHHHCCHHHCCC
PTYGYEIAVVVQDGIRRMYGEQEDVFYYLTTMNENYEQPAMPEGAEEGIVKGIYKLETLK
CCCCEEEEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEC
GSGKGSVQLMGSGTILEQVRKAAVALSKDFGITADVYSVTSFNELTRDGQAAERYNMLHP
CCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHCCCCC
TETAKVPYITQVLASDAPAIVATDYMKIYGEQLRAYVPTDYKVLGTDGFGRSDSRENLRH
CCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCHHHHHH
HFEVDAKFIVIASLKALVDRNELPVDVLTKAIKEYGIDVDKINPQYA
HHCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]