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The map label for this gene is pdhR [H]

Identifier: 167622415

GI number: 167622415

Start: 562753

End: 563505

Strand: Direct

Name: pdhR [H]

Synonym: Shal_0475

Alternate gene names: 167622415

Gene position: 562753-563505 (Clockwise)

Preceding gene: 167622414

Following gene: 167622416

Centisome position: 10.77

GC content: 47.28

Gene sequence:

>753_bases
ATGGCTTATAGCAAAATAAACCAGCCAAAAATATCCGACGTCATCATGGGACAGTTAGAACAGATGATCTTGGAAGGCAG
TATTCAACCCGGGCAGAAGCTTCCCCCTGAACGCGAGTTAGCGTTGCAGTTTGAAGTCTCCCGACCTTCTTTGCGGGAAG
CGATCCAAAAGCTTGAAGCAAAAGGTTTGTTGATGCGTCGTCAAGGTGGTGGCACCTATGTAAAAGAACAGCTTTGGCAA
AGTCTTGCCGATCCAATCGTTGAACTTATGCACTCAGACTCTGAAAGTCAGTATGACTTACTGGAGTTTCGTCATGCCAC
TGAAGGCATGATGGCGTACTTTGCAGCACTTCGTGGTACCGATGCTGATATGCAAAATATCAAGCGTACGATCCTTGAGG
TTGAAGCCGCGAAAGATGTCGAAGCGCAAGCTAATGCCATTGTGCGCTTTTACCGTGCAGTCGCAGAAGCATCACATAAC
GTGGCTATGCTGCATCTAGTATTAAGTTTATCTCCAGTGCTGCATAAAAACGTGACACAAAACTTAGAGCTTCTAAGCCG
ACGCGAAGAGGCCTCTACTACGGCAAATGATCACCGGCGAGCACTGCTGGCCGCCATTATTCGTCGAGATCCTGAAGCAG
CACGCGAAGCTTCCAATGAACACTTAAGTTACATTGAAGAAGTCATGTTGTCTGTGAGGGAAGAAGATAGCCGATTGCAA
CGTAGTCTGCGCCGCTTAAAAAGTGGTGTTTAG

Upstream 100 bases:

>100_bases
TGACTTGGATCACTTGCTGGACATCCAAAGTGTGATTTGATAAAGTGCGCCCAGTCAATTAAATTGGTAAGACCAATTTA
CAATAGGAGCTGAGGCCCAT

Downstream 100 bases:

>100_bases
ACCATGGGTTAGCAAAGCTATGACCATTAATTATTACAACTATTGTATATAGGGAAGGACAGCGTCATGTCTGAACATAT
GCTACAAGATTTAGATCCAC

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRTILEVEAAKDVEAQANAIVRFYRAVAEASHN
VAMLHLVLSLSPVLHKNVTQNLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGV

Sequences:

>Translated_250_residues
MAYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRTILEVEAAKDVEAQANAIVRFYRAVAEASHN
VAMLHLVLSLSPVLHKNVTQNLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGV
>Mature_249_residues
AYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQS
LADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRTILEVEAAKDVEAQANAIVRFYRAVAEASHNV
AMLHLVLSLSPVLHKNVTQNLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQR
SLRRLKSGV

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=57.9399141630901, Blast_Score=273, Evalue=6e-75,
Organism=Escherichia coli, GI1790032, Length=239, Percent_Identity=33.8912133891213, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1789353, Length=238, Percent_Identity=26.890756302521, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790780, Length=225, Percent_Identity=30.6666666666667, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994955, Length=217, Percent_Identity=30.8755760368664, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87082208, Length=236, Percent_Identity=27.5423728813559, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28287; Mature: 28156

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRTILEVEAAKDVEAQANAIVRFYRAVAEASHNVAMLHLVLSLSPVLHKNVTQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGV
HHHHHHHCCC
>Mature Secondary Structure 
AYSKINQPKISDVIMGQLEQMILEGSIQPGQKLPPERELALQFEVSRPSLREAIQKLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMHSDSESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRTILEVEAAKDVEAQANAIVRFYRAVAEASHNVAMLHLVLSLSPVLHKNVTQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTTANDHRRALLAAIIRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGV
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]