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The map label for this gene is ddc [H]

Identifier: 167622339

GI number: 167622339

Start: 467410

End: 468852

Strand: Direct

Name: ddc [H]

Synonym: Shal_0399

Alternate gene names: 167622339

Gene position: 467410-468852 (Clockwise)

Preceding gene: 167622338

Following gene: 167622340

Centisome position: 8.94

GC content: 49.0

Gene sequence:

>1443_bases
ATGTCACATCATTTTAAAGATTACCGCGGTTCACTAGAGCGTTCTTTAGATCATGCGGTCTCTTACCTTGAGTCGCTAGA
TGAGCGCCCTGTTGCCAAAGATATCACCTCTGCACAGTTGCGAGATTTGATTGCAGGAGAATTACCACAACAAGGGGTAG
CAGCAGAACAGGTTATCGATGAAATGGCATATGCGCTCGATGCTGGTTTAGTCGCGTCGGGTGGTCCACGATTTTTTGGC
TATGCCATCGGCGGTACTTTTCCTGCGGCATTAGCAGCAGACTGGTTAGTTAGTGCATGGGATCAAAATGTGCCGTACTA
CGTGTCTAGCCCTGCAATGGCGGTAGCCGAAGAAGCTGCAGCAGAATGGATGGTAGAGCTGCTTGGCTTAACCAAAGGTT
CTGCGGTGGGCTTTACTTCAGGCGCTCAAGAGGCGATCTATACCTCGTTAATTACTGCGCGTAATTCTCTGCTAGAAAAT
GCAGGCTGGGATGTGGCTACTAAAGGTCTATATGGCGCGCCGCAAGTGAATGTGGTCGTGAGTGACCAAATTCACTCAAC
CATTAAGCGCGCGCTTTCAATGATAGGTTTGGGGATTGAAACCATCGTTAAAGTGCCAACAGACGATAATCTTCGTCTTA
TTCCTGAGGAGCTTACGCGGGTGTTAGCCGATATAAGCGGGCCAACATTGGTTTGTGCCCAAGCGGGTTGTATCGACTCA
GGGGCTTTCGATCCTTTCGACGAGATAGCTGACGCGGTTGCCAAGCATGGTAACGCTTGGTTGCATGTGGACGGCGCGAT
AGGTCTGTGGGCGGCAGCGAGTGATAAGCAAAAGCATCTGTTGAAAGGCATTGAGCGAGCCGACTCTATCGACACTGACG
GCCATAAGTGGTTCAACATGCCTTATGACTGCGGCATGGTGATAGTGAAAGATCCTGCCAAAATCACCACGGCGGTGGGC
GGCGGCAACATGGGCGATTACCTAAATGATGCCATGGATAAACCGGATCGTAACGCGATTAACTTTGGTATTGCCGCATC
GAGACGCGCCCGTGGTCTGCCTGTCTACGCCGCGTTTAAGTCGCTGGGTAAGCAAGGCATCGTCAATCATTTAGATAACT
GCTGCGCCTTGGCCAAACGCATGGCTGATATTTTGAGAGAAGTGGACGGCGTGACCATTCTTAATGATGTGGTGTCGAAT
CGATTCTCTGCGCAATTTGGCATCGGTGATGTGGAATATCGCAACGAGCTAACAGCAAGAGTTGTGCATAGACTGCAGCA
AGAGGGATATCTTTATCCATCAACATCAGGCTACAAAGGCCTAAAGACCATGCTGTTTTCAGTGCTGAATTATCATACCT
CGATAGAGGATATTGATATTTCAGCAAACAAGATCATTGAAGCGTTTAACATCGAAAAAGCGTTACTGCCTAAGTCGGTT
TAA

Upstream 100 bases:

>100_bases
TGCCAGTGATGACCTTTTGTTTTGACTGTCACCAAATGGCCATTTTATAAAAATATCGCTGGTATATTAGACGGACATTC
CTACTTGAAGAGTATTAACT

Downstream 100 bases:

>100_bases
CGTTATGAATTCAACGAGCAAAGAGAGTGGAGGAAGTATGACTCAGCAACGATTTGTAGGTTATAGCCTAGCCGTATTGG
TTTATTTAACTGTGCTCAAT

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSHHFKDYRGSLERSLDHAVSYLESLDERPVAKDITSAQLRDLIAGELPQQGVAAEQVIDEMAYALDAGLVASGGPRFFG
YAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEEAAAEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLEN
AGWDVATKGLYGAPQVNVVVSDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPEELTRVLADISGPTLVCAQAGCIDS
GAFDPFDEIADAVAKHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNMPYDCGMVIVKDPAKITTAVG
GGNMGDYLNDAMDKPDRNAINFGIAASRRARGLPVYAAFKSLGKQGIVNHLDNCCALAKRMADILREVDGVTILNDVVSN
RFSAQFGIGDVEYRNELTARVVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDISANKIIEAFNIEKALLPKSV

Sequences:

>Translated_480_residues
MSHHFKDYRGSLERSLDHAVSYLESLDERPVAKDITSAQLRDLIAGELPQQGVAAEQVIDEMAYALDAGLVASGGPRFFG
YAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEEAAAEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLEN
AGWDVATKGLYGAPQVNVVVSDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPEELTRVLADISGPTLVCAQAGCIDS
GAFDPFDEIADAVAKHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNMPYDCGMVIVKDPAKITTAVG
GGNMGDYLNDAMDKPDRNAINFGIAASRRARGLPVYAAFKSLGKQGIVNHLDNCCALAKRMADILREVDGVTILNDVVSN
RFSAQFGIGDVEYRNELTARVVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDISANKIIEAFNIEKALLPKSV
>Mature_479_residues
SHHFKDYRGSLERSLDHAVSYLESLDERPVAKDITSAQLRDLIAGELPQQGVAAEQVIDEMAYALDAGLVASGGPRFFGY
AIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEEAAAEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLENA
GWDVATKGLYGAPQVNVVVSDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPEELTRVLADISGPTLVCAQAGCIDSG
AFDPFDEIADAVAKHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNMPYDCGMVIVKDPAKITTAVGG
GNMGDYLNDAMDKPDRNAINFGIAASRRARGLPVYAAFKSLGKQGIVNHLDNCCALAKRMADILREVDGVTILNDVVSNR
FSAQFGIGDVEYRNELTARVVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDISANKIIEAFNIEKALLPKSV

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=445, Percent_Identity=27.6404494382022, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI194294551, Length=365, Percent_Identity=28.2191780821918, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI197276620, Length=355, Percent_Identity=25.6338028169014, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4503875, Length=355, Percent_Identity=25.6338028169014, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI58331246, Length=347, Percent_Identity=28.5302593659942, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI92110055, Length=485, Percent_Identity=25.5670103092783, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4503281, Length=412, Percent_Identity=26.9417475728155, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI132814448, Length=412, Percent_Identity=26.9417475728155, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17534817, Length=484, Percent_Identity=26.4462809917355, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17534819, Length=484, Percent_Identity=26.4462809917355, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71993058, Length=370, Percent_Identity=25.4054054054054, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555682, Length=365, Percent_Identity=25.2054794520548, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71993062, Length=333, Percent_Identity=26.4264264264264, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24652373, Length=503, Percent_Identity=26.2425447316103, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28573972, Length=496, Percent_Identity=25.2016129032258, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221476190, Length=484, Percent_Identity=24.5867768595041, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24585143, Length=484, Percent_Identity=24.5867768595041, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24585139, Length=484, Percent_Identity=24.5867768595041, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24586044, Length=484, Percent_Identity=25.2066115702479, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI17136190, Length=488, Percent_Identity=24.5901639344262, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24657193, Length=354, Percent_Identity=25.1412429378531, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24657185, Length=354, Percent_Identity=25.1412429378531, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24657188, Length=354, Percent_Identity=25.1412429378531, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136594, Length=368, Percent_Identity=25.5434782608696, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24585135, Length=489, Percent_Identity=23.721881390593, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21356415, Length=372, Percent_Identity=22.5806451612903, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 51753; Mature: 51622

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHHFKDYRGSLERSLDHAVSYLESLDERPVAKDITSAQLRDLIAGELPQQGVAAEQVID
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EMAYALDAGLVASGGPRFFGYAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEEAA
HHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
AEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLENAGWDVATKGLYGAPQVNVVV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
SDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPEELTRVLADISGPTLVCAQAGCIDS
CHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCC
GAFDPFDEIADAVAKHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNM
CCCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEECC
PYDCGMVIVKDPAKITTAVGGGNMGDYLNDAMDKPDRNAINFGIAASRRARGLPVYAAFK
CCCCCEEEEECCCCEEEECCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHH
SLGKQGIVNHLDNCCALAKRMADILREVDGVTILNDVVSNRFSAQFGIGDVEYRNELTAR
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDISANKIIEAFNIEKALLPKSV
HHHHHHHCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
SHHFKDYRGSLERSLDHAVSYLESLDERPVAKDITSAQLRDLIAGELPQQGVAAEQVID
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EMAYALDAGLVASGGPRFFGYAIGGTFPAALAADWLVSAWDQNVPYYVSSPAMAVAEEAA
HHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
AEWMVELLGLTKGSAVGFTSGAQEAIYTSLITARNSLLENAGWDVATKGLYGAPQVNVVV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
SDQIHSTIKRALSMIGLGIETIVKVPTDDNLRLIPEELTRVLADISGPTLVCAQAGCIDS
CHHHHHHHHHHHHHHCCCHHHEEECCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCC
GAFDPFDEIADAVAKHGNAWLHVDGAIGLWAAASDKQKHLLKGIERADSIDTDGHKWFNM
CCCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEECC
PYDCGMVIVKDPAKITTAVGGGNMGDYLNDAMDKPDRNAINFGIAASRRARGLPVYAAFK
CCCCCEEEEECCCCEEEECCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHH
SLGKQGIVNHLDNCCALAKRMADILREVDGVTILNDVVSNRFSAQFGIGDVEYRNELTAR
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VVHRLQQEGYLYPSTSGYKGLKTMLFSVLNYHTSIEDIDISANKIIEAFNIEKALLPKSV
HHHHHHHCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]