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The map label for this gene is aspA [H]

Identifier: 167622233

GI number: 167622233

Start: 349416

End: 351221

Strand: Direct

Name: aspA [H]

Synonym: Shal_0292

Alternate gene names: 167622233

Gene position: 349416-351221 (Clockwise)

Preceding gene: 167622231

Following gene: 167622234

Centisome position: 6.68

GC content: 44.57

Gene sequence:

>1806_bases
ATGAAAGGAAACAATATGACGCTTAAATTATCTAAGTGTAGCTTGGCGCTTTTGCCGCTGATGCTATCTACAGTCAGTTA
TGCAGGAGAATCCGACCCCCTGTATAAACACCAATGGCATTTGAAAAATACCGGCCAAGCCGCCTTCTCAGAAAATGGGG
GCAAGGCTGGCAATGATTTAAAAACCAAACAAGCGCATAAAAAGGGGGCCCTTGGGCAGGGGGTTCAAATTTCTGTTGTA
GACACGGGTCTGCAGATTGATCATATCGACTTGGCCGACAATGTTGTACCGGGCTCTATGGATTTGATCACAGGCAGTGA
TTATCCAGAAGATACACACGGCCATGGTACTGCTGTCGGGGGGATTATTGCTGCGGTAGGGTTTAACGGGGAGGGCGTTA
GAGGCATTGCTCCGAAAGCGGGTATTAATGGTTTCAATTTTCTTTTCGAACAGAGCATGAACTCTTGGTTGCTTTCTCAC
GGGTATGGAGAGGGAACTGAAAATACCGAACTATTTAATCAAAGCTATGGTTCACAAGCGTTATTCATTCCTCAATTTGA
TCTTGAAAACGATCCCCAACTGGCTATCGAAAATGCAGTGATGGAGGATGTCGCCAGTAATAGCAATAATGGTCGCGGCG
CTGCATTTGTATCTTCTGCTGGTAACTCTTATAACTATTATGGGTACGCAGGATATTATTTTTTACCCGCCGATTACTTC
GATGTTGAAGCGAGTAACCATGGTCTACCTATGCAAAATAGTAATATGACCAATAGTAAAGCGACTCACTGGAGCACAAC
GGTGAGTGCCATTAACGCAAATGGTGAACGCTCTAGCTACTCGACTGTGGGTGCCAACGTATTTATGGCGGCTACAGGGG
GAGAGTATGGTTCTGAGACGCCTGCTATGGTGACGACCGATCTGATGGGCTGTGATAGTGGTTTTAATGATAGCACTGGT
TTAGGTAAAAACGGTCTTCATGGGGGGACTGCTGATGACCCTAATTGTAATTATACCAGTGTGATGAATGGTACATCATC
TGCTGCACCGAGTATGGTGGGGGCGATCGCGGCTGTTATGTCAGCTAACCCTCAGTTAACGACTCGTGATGCAAAGCATG
TATTAGCGCTAACGGCTAAAAAGACCGATCCTAACAATAAAGGGGTAACGTTAACCTTTACTGATATTAACGGAAATCTA
GTTGAATACCCTGCAATTGATGGTTGGCAGAAAAATGATGCAGGTTTTGATTATCACCTGTTTTACGGTTTAGGCCGTCC
TAATGTTAGCAAGGCGGTTCAGCTTGTAAGGCATGAGTCTGAAGACGATTTAGAAGATATCAAGCTACCGCCTCAGTTAG
TGAGTCAATGGCATGCTAAAGCTGTCAATGTAGAAGTGCCAGACGTCGATCCAAACGGCGGAACAGCTTCTCTGGAAATT
GATTTAGATGATTTTGTTATTGAGGGCGTTGAAGTCTTAGTGACCATAGATCATCCAAGAGTGACGGATTTAGCGATTGA
ACTTATCTCTCCTGAAGGTACCCGTAGTGTGTTAATGACCCCAAGAAATGGTATGTACGGTCAAGCTTTTGGTGGTGATG
CTTACGTGAATAAGCTGTTATCTTCAACGCATTTCTATGGTGAAGAGGCTGAAGGAGATTGGACCTTGAAAGTGGTTGAT
ACCGGTGGTGAAGGTGATGGTGAGTTTATTTGGTATCCAGTAGAAAATGTCACTCAAGCTAACAATGTTAGCCCAGGTAT
TATACAGAATTGGTCAGTACGCTTTATTGGTCACGAGGAGGACTAA

Upstream 100 bases:

>100_bases
ATACAAATTGAAAAAAAATAAATTGTGTGTATTTTGTTAAATCCGCCCTTGATTTAACGTTTTATTAACGTTCGATGGTG
GCTAGGGATAACTAATAAAA

Downstream 100 bases:

>100_bases
ACAATGAAAAAAACAATAATGTTAATGGCAATCTTCGCCATCTCCAGTCAAGCCTTCGCGTCAGTGACGAAAGAGTTACC
TATTGTGGTAACACAAGACT

Product: proprotein convertase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MKGNNMTLKLSKCSLALLPLMLSTVSYAGESDPLYKHQWHLKNTGQAAFSENGGKAGNDLKTKQAHKKGALGQGVQISVV
DTGLQIDHIDLADNVVPGSMDLITGSDYPEDTHGHGTAVGGIIAAVGFNGEGVRGIAPKAGINGFNFLFEQSMNSWLLSH
GYGEGTENTELFNQSYGSQALFIPQFDLENDPQLAIENAVMEDVASNSNNGRGAAFVSSAGNSYNYYGYAGYYFLPADYF
DVEASNHGLPMQNSNMTNSKATHWSTTVSAINANGERSSYSTVGANVFMAATGGEYGSETPAMVTTDLMGCDSGFNDSTG
LGKNGLHGGTADDPNCNYTSVMNGTSSAAPSMVGAIAAVMSANPQLTTRDAKHVLALTAKKTDPNNKGVTLTFTDINGNL
VEYPAIDGWQKNDAGFDYHLFYGLGRPNVSKAVQLVRHESEDDLEDIKLPPQLVSQWHAKAVNVEVPDVDPNGGTASLEI
DLDDFVIEGVEVLVTIDHPRVTDLAIELISPEGTRSVLMTPRNGMYGQAFGGDAYVNKLLSSTHFYGEEAEGDWTLKVVD
TGGEGDGEFIWYPVENVTQANNVSPGIIQNWSVRFIGHEED

Sequences:

>Translated_601_residues
MKGNNMTLKLSKCSLALLPLMLSTVSYAGESDPLYKHQWHLKNTGQAAFSENGGKAGNDLKTKQAHKKGALGQGVQISVV
DTGLQIDHIDLADNVVPGSMDLITGSDYPEDTHGHGTAVGGIIAAVGFNGEGVRGIAPKAGINGFNFLFEQSMNSWLLSH
GYGEGTENTELFNQSYGSQALFIPQFDLENDPQLAIENAVMEDVASNSNNGRGAAFVSSAGNSYNYYGYAGYYFLPADYF
DVEASNHGLPMQNSNMTNSKATHWSTTVSAINANGERSSYSTVGANVFMAATGGEYGSETPAMVTTDLMGCDSGFNDSTG
LGKNGLHGGTADDPNCNYTSVMNGTSSAAPSMVGAIAAVMSANPQLTTRDAKHVLALTAKKTDPNNKGVTLTFTDINGNL
VEYPAIDGWQKNDAGFDYHLFYGLGRPNVSKAVQLVRHESEDDLEDIKLPPQLVSQWHAKAVNVEVPDVDPNGGTASLEI
DLDDFVIEGVEVLVTIDHPRVTDLAIELISPEGTRSVLMTPRNGMYGQAFGGDAYVNKLLSSTHFYGEEAEGDWTLKVVD
TGGEGDGEFIWYPVENVTQANNVSPGIIQNWSVRFIGHEED
>Mature_601_residues
MKGNNMTLKLSKCSLALLPLMLSTVSYAGESDPLYKHQWHLKNTGQAAFSENGGKAGNDLKTKQAHKKGALGQGVQISVV
DTGLQIDHIDLADNVVPGSMDLITGSDYPEDTHGHGTAVGGIIAAVGFNGEGVRGIAPKAGINGFNFLFEQSMNSWLLSH
GYGEGTENTELFNQSYGSQALFIPQFDLENDPQLAIENAVMEDVASNSNNGRGAAFVSSAGNSYNYYGYAGYYFLPADYF
DVEASNHGLPMQNSNMTNSKATHWSTTVSAINANGERSSYSTVGANVFMAATGGEYGSETPAMVTTDLMGCDSGFNDSTG
LGKNGLHGGTADDPNCNYTSVMNGTSSAAPSMVGAIAAVMSANPQLTTRDAKHVLALTAKKTDPNNKGVTLTFTDINGNL
VEYPAIDGWQKNDAGFDYHLFYGLGRPNVSKAVQLVRHESEDDLEDIKLPPQLVSQWHAKAVNVEVPDVDPNGGTASLEI
DLDDFVIEGVEVLVTIDHPRVTDLAIELISPEGTRSVLMTPRNGMYGQAFGGDAYVNKLLSSTHFYGEEAEGDWTLKVVD
TGGEGDGEFIWYPVENVTQANNVSPGIIQNWSVRFIGHEED

Specific function: Agent of furonculosis [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI20336244, Length=546, Percent_Identity=23.4432234432234, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI299523015, Length=586, Percent_Identity=23.7201365187713, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI20336246, Length=585, Percent_Identity=23.7606837606838, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI20336190, Length=591, Percent_Identity=24.8730964467005, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI27894285, Length=590, Percent_Identity=25.5932203389831, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI4505577, Length=549, Percent_Identity=25.1366120218579, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI20336188, Length=549, Percent_Identity=25.1366120218579, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI20336184, Length=549, Percent_Identity=25.1366120218579, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI20336180, Length=549, Percent_Identity=25.1366120218579, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI20336182, Length=549, Percent_Identity=25.1366120218579, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI4505579, Length=549, Percent_Identity=23.8615664845173, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI76443679, Length=550, Percent_Identity=23.8181818181818, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI20336248, Length=555, Percent_Identity=23.963963963964, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI20336242, Length=266, Percent_Identity=27.0676691729323, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI295424143, Length=266, Percent_Identity=27.0676691729323, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI295424145, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20336186, Length=358, Percent_Identity=24.3016759776536, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71987206, Length=551, Percent_Identity=26.1343012704174, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71988312, Length=590, Percent_Identity=25.0847457627119, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988308, Length=590, Percent_Identity=25.0847457627119, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988301, Length=564, Percent_Identity=25.886524822695, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988315, Length=564, Percent_Identity=25.886524822695, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988321, Length=564, Percent_Identity=25.886524822695, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988297, Length=564, Percent_Identity=25.886524822695, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71987215, Length=471, Percent_Identity=24.6284501061571, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25141268, Length=558, Percent_Identity=23.1182795698925, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17136192, Length=545, Percent_Identity=24.0366972477064, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24642488, Length=589, Percent_Identity=25.6366723259762, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642484, Length=589, Percent_Identity=25.6366723259762, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642486, Length=589, Percent_Identity=25.6366723259762, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360987, Length=588, Percent_Identity=25.1700680272109, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24642494, Length=588, Percent_Identity=25.1700680272109, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24642490, Length=588, Percent_Identity=25.1700680272109, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45555723, Length=588, Percent_Identity=25.1700680272109, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24642492, Length=588, Percent_Identity=25.1700680272109, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45553515, Length=583, Percent_Identity=22.4699828473413, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24650058, Length=583, Percent_Identity=22.4699828473413, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24650060, Length=583, Percent_Identity=22.4699828473413, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45553513, Length=583, Percent_Identity=22.4699828473413, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24650056, Length=579, Percent_Identity=23.1433506044905, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17864552, Length=552, Percent_Identity=22.8260869565217, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281360985, Length=202, Percent_Identity=31.1881188118812, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008979
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR002884 [H]

Pfam domain/function: PF01483 P_proprotein; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 64191; Mature: 64191

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGNNMTLKLSKCSLALLPLMLSTVSYAGESDPLYKHQWHLKNTGQAAFSENGGKAGNDL
CCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
KTKQAHKKGALGQGVQISVVDTGLQIDHIDLADNVVPGSMDLITGSDYPEDTHGHGTAVG
HHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCC
GIIAAVGFNGEGVRGIAPKAGINGFNFLFEQSMNSWLLSHGYGEGTENTELFNQSYGSQA
CEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCE
LFIPQFDLENDPQLAIENAVMEDVASNSNNGRGAAFVSSAGNSYNYYGYAGYYFLPADYF
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCEE
DVEASNHGLPMQNSNMTNSKATHWSTTVSAINANGERSSYSTVGANVFMAATGGEYGSET
EEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEECCCEEEEEECCCCCCCCC
PAMVTTDLMGCDSGFNDSTGLGKNGLHGGTADDPNCNYTSVMNGTSSAAPSMVGAIAAVM
CCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
SANPQLTTRDAKHVLALTAKKTDPNNKGVTLTFTDINGNLVEYPAIDGWQKNDAGFDYHL
CCCCCEECCCCCEEEEEEEECCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCEEEE
FYGLGRPNVSKAVQLVRHESEDDLEDIKLPPQLVSQWHAKAVNVEVPDVDPNGGTASLEI
EEECCCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHCCEEEEEECCCCCCCCCEEEEEE
DLDDFVIEGVEVLVTIDHPRVTDLAIELISPEGTRSVLMTPRNGMYGQAFGGDAYVNKLL
EHHHHHCCCEEEEEEECCCCEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHH
SSTHFYGEEAEGDWTLKVVDTGGEGDGEFIWYPVENVTQANNVSPGIIQNWSVRFIGHEE
HHHCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCC
D
C
>Mature Secondary Structure
MKGNNMTLKLSKCSLALLPLMLSTVSYAGESDPLYKHQWHLKNTGQAAFSENGGKAGNDL
CCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
KTKQAHKKGALGQGVQISVVDTGLQIDHIDLADNVVPGSMDLITGSDYPEDTHGHGTAVG
HHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCC
GIIAAVGFNGEGVRGIAPKAGINGFNFLFEQSMNSWLLSHGYGEGTENTELFNQSYGSQA
CEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCE
LFIPQFDLENDPQLAIENAVMEDVASNSNNGRGAAFVSSAGNSYNYYGYAGYYFLPADYF
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCEE
DVEASNHGLPMQNSNMTNSKATHWSTTVSAINANGERSSYSTVGANVFMAATGGEYGSET
EEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEECCCEEEEEECCCCCCCCC
PAMVTTDLMGCDSGFNDSTGLGKNGLHGGTADDPNCNYTSVMNGTSSAAPSMVGAIAAVM
CCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
SANPQLTTRDAKHVLALTAKKTDPNNKGVTLTFTDINGNLVEYPAIDGWQKNDAGFDYHL
CCCCCEECCCCCEEEEEEEECCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCEEEE
FYGLGRPNVSKAVQLVRHESEDDLEDIKLPPQLVSQWHAKAVNVEVPDVDPNGGTASLEI
EEECCCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHCCEEEEEECCCCCCCCCEEEEEE
DLDDFVIEGVEVLVTIDHPRVTDLAIELISPEGTRSVLMTPRNGMYGQAFGGDAYVNKLL
EHHHHHCCCEEEEEEECCCCEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHH
SSTHFYGEEAEGDWTLKVVDTGGEGDGEFIWYPVENVTQANNVSPGIIQNWSVRFIGHEE
HHHCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1468618 [H]