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The map label for this gene is moeA [H]

Identifier: 167622086

GI number: 167622086

Start: 163354

End: 165153

Strand: Reverse

Name: moeA [H]

Synonym: Shal_0145

Alternate gene names: 167622086

Gene position: 165153-163354 (Counterclockwise)

Preceding gene: 167622087

Following gene: 167622085

Centisome position: 3.16

GC content: 50.06

Gene sequence:

>1800_bases
ATGAGCATACCTTTTACTAATCCGTTACCTATTCCTGTACTCGGATTCTGTGCTTATAGCGGTACAGGCAAGACCACATT
ATTAAAGCAATTAATCCCGGAACTTAATCGCCGCGGTGTGCGACTCGCAGTCATTAAGCATGCTCATCATAATTTCGATG
TCGATATCCCCGGTAAAGATAGCTATGAAATGCGCAAAGCCGGCGCAAAGCAGATGTTAGTTGCTTCCCATGTGCGCTGG
GCATTGATGACGGAAGATGCAATAGACTCAGACCCAGAGCTACCTCACCTGCTGAAACAGATTGAAGCCGACAAGGTCGA
TATCGTCCTCGTCGAAGGATTTAAAAAGCTCGAACTGCCCAAGATTGAACTTCACCGCGCCGCTCACGGCAAACCTTTCA
TCCATACCCATGATGACAATATCCAAGCTATTGCCTGCTGTGATGACACCCAGCTACCAAGTGAGCTGCGCCGTCTAGAT
ATCAACAATATCGCTCAAATCGCGGATTACGTTAGCGAGTACATTGCCGCGTGGAAACCTTGCCCAATCGACCTACCAAT
GGCACCAACCTGTGGCTGTGAGCTAGATAACAGCAGCACACTGTCTGTGCGCCAAGGTATCGATAGGATCCTATCTTATG
TAACGCCTTTAACTGCCACTGAATCTGTTGAACTTGATGAGCTAGAGAGCCGTATACTAGCCAGTGATGCAATCTCACCA
ATAAATGTGCCACAACATATCAACTCGGCGATGGACGGTTACGCCTTTAAGCTAAATGACGAGCCAAACGCATCTTACAA
GATGGTTGGCGAAGTGATGGCAGGCTATGCCTATGATGGCACACTCCAAGCGGGTGAAGCGGTACGCATCATGACAGGCG
CGCCACTACCAGCCGGAGCCGATACGGTTCAGCTGCGTGAGCTTGCCAATGAGCAAGACGGCGAAGTACGCTTTGAAGGC
AAAATGAGCCTAGGGCAACATATTCGCCAAGCGGGCGAAGATATTGCACAAGGTGCAACCGCTCTTGCTGCTCACACCCG
CCTACACGCTGCAGAGCAAGGTCTATTGGCTTCATTAGGCTTTGGCGAGTTACCGGTATTTAGACGTCCTAAAGTTGCCG
TATTCTCTACAGGCGATGAAGTTTGCCAACCGGGCGAGCCGCTGAAAGCTAACTGCATATTCGATTCAAACCGCTACACC
ATCAAGTCGATGGCGAAAAAGCTGGGTTGTGAAGTGATCGATTTAGGGATCATCCAAGATTCAGAAGCGGCGCTCGCTCA
GGCGCTAAAAGATGGCGCAGCGCAAGCCGATATCGTGATCAGCTCTGGTGGTGTGTCGGTCGGTGATGCCGATTATATTA
AGACGGTACTTGAGCAAGTTGGACAGATTAACTTCTGGCGTATCAATATGCGCCCGGGGCGTCCACTCGCTTTCGGTCAG
ATTGACGACTCGCTGTTCTTCGGTTTACCGGGTAATCCGGTTGCCGTGATGGTATCTTTCCTGCAGTTTGTGCAGCCAGC
GATCCGTAAGCTTGCTGGTGAGCAAAACTGGGCACCGACTATGGTGCCAGCCATTACCGATAAACCACTGCGCAGCCGTA
CAGGTCGTACAGAGTTTACCCGCGGTATCTATCACTTAGCTGCCAATGGCAAGTTACATGTAACCACAAGCGGTGCTCAG
GGCTCAGGGATGCTTAGCTCTATGGTAAAAGGAAACTGTCTCATCGTGATTGGCGAGAAAGATGAACAGTTAAATCCAGG
TGACACAGTTTACATTCAACCTTTTGCCGACCTCCTTTAG

Upstream 100 bases:

>100_bases
TTTCAGATCAGCCAAATGCATTCGTAAACGTAAATACGCCAGAACAAAAACAGCAGCTTGGCGAAGCCATAGCTAATGAG
AAAAATTACTAGAGGTGTAA

Downstream 100 bases:

>100_bases
GGGTCATGTAGGTAGTTAGTATGAGTTTAATCGTTGACACTTTTGGTCGCACGGTAGAATACCTGCGGCTATCCGTCACA
GACCGCTGCGACTTTCGCTG

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MSIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKDSYEMRKAGAKQMLVASHVRW
ALMTEDAIDSDPELPHLLKQIEADKVDIVLVEGFKKLELPKIELHRAAHGKPFIHTHDDNIQAIACCDDTQLPSELRRLD
INNIAQIADYVSEYIAAWKPCPIDLPMAPTCGCELDNSSTLSVRQGIDRILSYVTPLTATESVELDELESRILASDAISP
INVPQHINSAMDGYAFKLNDEPNASYKMVGEVMAGYAYDGTLQAGEAVRIMTGAPLPAGADTVQLRELANEQDGEVRFEG
KMSLGQHIRQAGEDIAQGATALAAHTRLHAAEQGLLASLGFGELPVFRRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYT
IKSMAKKLGCEVIDLGIIQDSEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
IDDSLFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFTRGIYHLAANGKLHVTTSGAQ
GSGMLSSMVKGNCLIVIGEKDEQLNPGDTVYIQPFADLL

Sequences:

>Translated_599_residues
MSIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKDSYEMRKAGAKQMLVASHVRW
ALMTEDAIDSDPELPHLLKQIEADKVDIVLVEGFKKLELPKIELHRAAHGKPFIHTHDDNIQAIACCDDTQLPSELRRLD
INNIAQIADYVSEYIAAWKPCPIDLPMAPTCGCELDNSSTLSVRQGIDRILSYVTPLTATESVELDELESRILASDAISP
INVPQHINSAMDGYAFKLNDEPNASYKMVGEVMAGYAYDGTLQAGEAVRIMTGAPLPAGADTVQLRELANEQDGEVRFEG
KMSLGQHIRQAGEDIAQGATALAAHTRLHAAEQGLLASLGFGELPVFRRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYT
IKSMAKKLGCEVIDLGIIQDSEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
IDDSLFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFTRGIYHLAANGKLHVTTSGAQ
GSGMLSSMVKGNCLIVIGEKDEQLNPGDTVYIQPFADLL
>Mature_598_residues
SIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKDSYEMRKAGAKQMLVASHVRWA
LMTEDAIDSDPELPHLLKQIEADKVDIVLVEGFKKLELPKIELHRAAHGKPFIHTHDDNIQAIACCDDTQLPSELRRLDI
NNIAQIADYVSEYIAAWKPCPIDLPMAPTCGCELDNSSTLSVRQGIDRILSYVTPLTATESVELDELESRILASDAISPI
NVPQHINSAMDGYAFKLNDEPNASYKMVGEVMAGYAYDGTLQAGEAVRIMTGAPLPAGADTVQLRELANEQDGEVRFEGK
MSLGQHIRQAGEDIAQGATALAAHTRLHAAEQGLLASLGFGELPVFRRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYTI
KSMAKKLGCEVIDLGIIQDSEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQI
DDSLFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFTRGIYHLAANGKLHVTTSGAQG
SGMLSSMVKGNCLIVIGEKDEQLNPGDTVYIQPFADLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=36.7758186397985, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=36.7758186397985, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1787049, Length=388, Percent_Identity=46.9072164948454, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=50, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=310, Percent_Identity=30.9677419354839, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=321, Percent_Identity=26.1682242990654, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=350, Percent_Identity=33.7142857142857, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24638841, Length=350, Percent_Identity=33.7142857142857, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 64982; Mature: 64851

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKD
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCCC
SYEMRKAGAKQMLVASHVRWALMTEDAIDSDPELPHLLKQIEADKVDIVLVEGFKKLELP
CHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCC
KIELHRAAHGKPFIHTHDDNIQAIACCDDTQLPSELRRLDINNIAQIADYVSEYIAAWKP
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCC
CPIDLPMAPTCGCELDNSSTLSVRQGIDRILSYVTPLTATESVELDELESRILASDAISP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
INVPQHINSAMDGYAFKLNDEPNASYKMVGEVMAGYAYDGTLQAGEAVRIMTGAPLPAGA
CCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
DTVQLRELANEQDGEVRFEGKMSLGQHIRQAGEDIAQGATALAAHTRLHAAEQGLLASLG
CHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
FGELPVFRRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYTIKSMAKKLGCEVIDLGIIQD
CCCCCCCCCCCEEEEECCHHHCCCCCCCEEEEEECCCCEEHHHHHHHHCCEEEEEEEECC
SEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
CHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEC
IDDSLFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFT
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHHH
RGIYHLAANGKLHVTTSGAQGSGMLSSMVKGNCLIVIGEKDEQLNPGDTVYIQPFADLL
HHHEEEECCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCHHHCC
>Mature Secondary Structure 
SIPFTNPLPIPVLGFCAYSGTGKTTLLKQLIPELNRRGVRLAVIKHAHHNFDVDIPGKD
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCCC
SYEMRKAGAKQMLVASHVRWALMTEDAIDSDPELPHLLKQIEADKVDIVLVEGFKKLELP
CHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCC
KIELHRAAHGKPFIHTHDDNIQAIACCDDTQLPSELRRLDINNIAQIADYVSEYIAAWKP
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCC
CPIDLPMAPTCGCELDNSSTLSVRQGIDRILSYVTPLTATESVELDELESRILASDAISP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
INVPQHINSAMDGYAFKLNDEPNASYKMVGEVMAGYAYDGTLQAGEAVRIMTGAPLPAGA
CCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
DTVQLRELANEQDGEVRFEGKMSLGQHIRQAGEDIAQGATALAAHTRLHAAEQGLLASLG
CHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
FGELPVFRRPKVAVFSTGDEVCQPGEPLKANCIFDSNRYTIKSMAKKLGCEVIDLGIIQD
CCCCCCCCCCCEEEEECCHHHCCCCCCCEEEEEECCCCEEHHHHHHHHCCEEEEEEEECC
SEAALAQALKDGAAQADIVISSGGVSVGDADYIKTVLEQVGQINFWRINMRPGRPLAFGQ
CHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEC
IDDSLFFGLPGNPVAVMVSFLQFVQPAIRKLAGEQNWAPTMVPAITDKPLRSRTGRTEFT
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHHH
RGIYHLAANGKLHVTTSGAQGSGMLSSMVKGNCLIVIGEKDEQLNPGDTVYIQPFADLL
HHHEEEECCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]