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The map label for this gene is pheS [H]

Identifier: 167040673

GI number: 167040673

Start: 2063451

End: 2064470

Strand: Reverse

Name: pheS [H]

Synonym: Teth514_2050

Alternate gene names: 167040673

Gene position: 2064470-2063451 (Counterclockwise)

Preceding gene: 167040674

Following gene: 167040672

Centisome position: 84.02

GC content: 35.69

Gene sequence:

>1020_bases
ATGGAGGAATTGTTGCGCAAGCTTTATGAAAATGCACAAAGGGAGATTTTGTCAGCCGATAGTTTACAACAAATTGAAAA
CTTAAGAGTCAAATACTTGGGCAAAAAGGGTGAATTGACACAGATTTTAAGAGGAATGAAAAATTTAAGGCCTGAAGAAA
GACCATTGATTGGTCAAATTGCCAATGAAGTAAGAGAAAAAATTGAGGGATTACTCACAGAAACAAAAAATAAAATTGCC
CAATTAGAAAAAGAAAAGAGAATAAAAAGTGAGTACATAGACATAACTATGCCGGGTAAACCTTATGAGTACGGTCACAA
ACATCCCATGACACAAGTATTGGATGAAATTAAAAAGATATTTTTAGGATTAGGCTTTTCTATTGCAGAAGGGCCAGAAA
TAGAGTTTACTTATTACAACTTTGAGGCATTAAATACTCCAGAGGACCATCCAGCTAGAGACTTACAGGATACCTTTTAT
GTGACTTCTGATATACTTTTGAGGACTCAAACATCCCCGGTACAAGTAAGGACTATGGAGAAAAATAAGCCTCCAATAAG
GGTTATATCTCCTGGAAGGGTTTATAGGTCTGATGAGATAGATGCAACTCACTCCCCAGTGTTTCATCAGATGGAAGGGC
TTGTAGTAGATGAAGGAATAACAATGGGAGATTTAAAAGGAGTTTTAAATATATTTGCGAAAAAGTTTTTTGGAGAAGAC
ACTCAAACCAAATTTAGACCTCATTATTTTCCTTTTACAGAGCCCAGTGCAGAAATGGATGTGAGCTGTTTTGCTTGTGG
TGGAAAAGGTTGTAGAGTTTGCGGATATACTGGTTGGATTGAAATTTTGGGAGCAGGGATGGTACATCCTAATGTCTTGA
GAATGTCTGGTATTGATCCTGAAAAATATAGTGGATTTGCTTTTGGCTTGGGAATAGATAGGATTACAATGCTGAAATAC
GGAATAGATGATTTAAGGTTTCTTTTTGAAAATGATTTAAGGTTTATACAACAGTTTTAA

Upstream 100 bases:

>100_bases
TTTTTATAAAATGCTAATGTAGGTGGTACCGCGGATTCTTCGTCCTATTGACGGAGGATTTTTTATTTTAACTAATACGC
TAAAAGAGGGGTTGAGATAT

Downstream 100 bases:

>100_bases
AGGGGTGGTCGTATGTTAGTATCACTTTTGTGGTTGAAAGAGTTTGTCGATATAGATGAAGATGCGAAAGCTATTGCTGA
AGGCCTTACTATGTCAGGGT

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEELLRKLYENAQREILSADSLQQIENLRVKYLGKKGELTQILRGMKNLRPEERPLIGQIANEVREKIEGLLTETKNKIA
QLEKEKRIKSEYIDITMPGKPYEYGHKHPMTQVLDEIKKIFLGLGFSIAEGPEIEFTYYNFEALNTPEDHPARDLQDTFY
VTSDILLRTQTSPVQVRTMEKNKPPIRVISPGRVYRSDEIDATHSPVFHQMEGLVVDEGITMGDLKGVLNIFAKKFFGED
TQTKFRPHYFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYSGFAFGLGIDRITMLKY
GIDDLRFLFENDLRFIQQF

Sequences:

>Translated_339_residues
MEELLRKLYENAQREILSADSLQQIENLRVKYLGKKGELTQILRGMKNLRPEERPLIGQIANEVREKIEGLLTETKNKIA
QLEKEKRIKSEYIDITMPGKPYEYGHKHPMTQVLDEIKKIFLGLGFSIAEGPEIEFTYYNFEALNTPEDHPARDLQDTFY
VTSDILLRTQTSPVQVRTMEKNKPPIRVISPGRVYRSDEIDATHSPVFHQMEGLVVDEGITMGDLKGVLNIFAKKFFGED
TQTKFRPHYFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYSGFAFGLGIDRITMLKY
GIDDLRFLFENDLRFIQQF
>Mature_339_residues
MEELLRKLYENAQREILSADSLQQIENLRVKYLGKKGELTQILRGMKNLRPEERPLIGQIANEVREKIEGLLTETKNKIA
QLEKEKRIKSEYIDITMPGKPYEYGHKHPMTQVLDEIKKIFLGLGFSIAEGPEIEFTYYNFEALNTPEDHPARDLQDTFY
VTSDILLRTQTSPVQVRTMEKNKPPIRVISPGRVYRSDEIDATHSPVFHQMEGLVVDEGITMGDLKGVLNIFAKKFFGED
TQTKFRPHYFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYSGFAFGLGIDRITMLKY
GIDDLRFLFENDLRFIQQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758340, Length=287, Percent_Identity=34.4947735191638, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI5729820, Length=352, Percent_Identity=26.1363636363636, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1788007, Length=335, Percent_Identity=51.9402985074627, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI32563657, Length=269, Percent_Identity=32.3420074349442, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17508957, Length=269, Percent_Identity=32.3420074349442, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32566635, Length=257, Percent_Identity=33.4630350194552, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321087, Length=285, Percent_Identity=31.5789473684211, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325304, Length=274, Percent_Identity=29.5620437956204, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18858079, Length=288, Percent_Identity=32.9861111111111, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17137424, Length=248, Percent_Identity=29.0322580645161, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 38862; Mature: 38862

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5 ; PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELLRKLYENAQREILSADSLQQIENLRVKYLGKKGELTQILRGMKNLRPEERPLIGQI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHH
ANEVREKIEGLLTETKNKIAQLEKEKRIKSEYIDITMPGKPYEYGHKHPMTQVLDEIKKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHH
FLGLGFSIAEGPEIEFTYYNFEALNTPEDHPARDLQDTFYVTSDILLRTQTSPVQVRTME
HHHCCCEECCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEEECCCCEEEEEEC
KNKPPIRVISPGRVYRSDEIDATHSPVFHQMEGLVVDEGITMGDLKGVLNIFAKKFFGED
CCCCCEEEECCCCEECCCCCCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCC
TQTKFRPHYFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDP
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCC
EKYSGFAFGLGIDRITMLKYGIDDLRFLFENDLRFIQQF
HHHCCEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEELLRKLYENAQREILSADSLQQIENLRVKYLGKKGELTQILRGMKNLRPEERPLIGQI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHH
ANEVREKIEGLLTETKNKIAQLEKEKRIKSEYIDITMPGKPYEYGHKHPMTQVLDEIKKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHH
FLGLGFSIAEGPEIEFTYYNFEALNTPEDHPARDLQDTFYVTSDILLRTQTSPVQVRTME
HHHCCCEECCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEEECCCCEEEEEEC
KNKPPIRVISPGRVYRSDEIDATHSPVFHQMEGLVVDEGITMGDLKGVLNIFAKKFFGED
CCCCCEEEECCCCEECCCCCCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCC
TQTKFRPHYFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDP
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCC
EKYSGFAFGLGIDRITMLKYGIDDLRFLFENDLRFIQQF
HHHCCEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]