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The map label for this gene is degS [H]

Identifier: 167040666

GI number: 167040666

Start: 2053224

End: 2054390

Strand: Reverse

Name: degS [H]

Synonym: Teth514_2043

Alternate gene names: 167040666

Gene position: 2054390-2053224 (Counterclockwise)

Preceding gene: 167040667

Following gene: 167040665

Centisome position: 83.6

GC content: 32.65

Gene sequence:

>1167_bases
ATGAATGCCAATGTAGAAGTCACTTATAAAAAACGATTGGATAATATTGTAGAAAAAACAATAGAAGTAATTGAAAGCAG
TAAAGAACAAATTTTTGATATTTTAGAAAAAGCAAAAGAAGAGGCGAGAAGATTAGAAGCGCAATTAGAAGAACTGAAAA
TCCAAGTTATAAATGTCATAAAAGAAGTAGAGCTGTGTGAAAGGAAAGAAAAAAAGTGCAGGCTAAAACTCGCATTTGTA
AGTAAACAATTTGGGCACCTATCTGAACAAGCTATAAGAGAAGCTTATGAAGAGGCAAAAGAGGCTCAAATAGAGTTAGC
GTTAAAAAGGCGGGAGGAAAAAGAATTAATAGAAAAAAGAAACGAACTGGAGAGGAAACTTGTAGACAATAAGGCTATTA
TAGAAAAAGCTGAAAAGCTTGTTTCTCAAATTAATGTAGCTCTCAATTATTTAAATAGGGATTTAAAAAAAATGAATACT
CAATTAGAGCAATTGAAAGACAAACGAGCTTTGAGTGTAAAAATTATTGAAGCACAGGAAGAGGAACGAAAAAGAATTGC
AAGGGAGATTCACGATGGCCCTGCGCAAGCGATGGCAAACGTGTTATCGAAATCTGAACTTTGTGAAAAATTGATAACCA
AAGATATTGAACAGGCGAAAATAGAACTTAAAAATCTAAAAAATATTGTACAACAATCTCTAAAAGAAGTAAGGAAAATA
ATATATGACTTAAGACCTTCTGCTCTTGATGATTTAGGTCTTATTCCAGCACTATCCAGGTATATAAAAAATTTTTCGGA
GGAGACAGGCATATTTGTAGATTTTAGTGTTTTGTCGGATTACAAGAGACTTAGTCCCGAGATTGAAATAACTTGTTTTA
GAGTAGTACAAGAGGCTCTTACAAATATAAAAAAACATTCCAAGGCAAAAAATGCCTCTGTTAAATTTGAGTTTGGCATG
CGATTTATCAGCATAATTATCAAAGACGATGGCATTGGATTTGATAAAGAAAATATTGGGCAAGGATATGGTCTGATGGG
CATGAGGGAAAGAATAGAAATTTTAAACGGTAAATTTGAAATAAGCAGTTTTAAAAATAATGGTACTCAAATTTATATTT
CTATACCTGTAAGGGGTGTTGAGGATGATCAGATTGTTGGTGGCTGA

Upstream 100 bases:

>100_bases
TTTTGCTTTCTTATAACTTAGCAATTTTTTCTTTAAAATGCAGGATTTTTTTGTTTTTTGTCGAATTATTAAAAAGATGG
TGCTCAAAGAGGTGAATTAA

Downstream 100 bases:

>100_bases
TGACCATGCTTTGATAAGAAAAGGGTTAGTCCAGCTTATTGAAATGGAAAAAGATATAAAAGTTATCTCTCAGGCTTCGA
ATGGGGAAGAGGCTTATAAA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNANVEVTYKKRLDNIVEKTIEVIESSKEQIFDILEKAKEEARRLEAQLEELKIQVINVIKEVELCERKEKKCRLKLAFV
SKQFGHLSEQAIREAYEEAKEAQIELALKRREEKELIEKRNELERKLVDNKAIIEKAEKLVSQINVALNYLNRDLKKMNT
QLEQLKDKRALSVKIIEAQEEERKRIAREIHDGPAQAMANVLSKSELCEKLITKDIEQAKIELKNLKNIVQQSLKEVRKI
IYDLRPSALDDLGLIPALSRYIKNFSEETGIFVDFSVLSDYKRLSPEIEITCFRVVQEALTNIKKHSKAKNASVKFEFGM
RFISIIIKDDGIGFDKENIGQGYGLMGMRERIEILNGKFEISSFKNNGTQIYISIPVRGVEDDQIVGG

Sequences:

>Translated_388_residues
MNANVEVTYKKRLDNIVEKTIEVIESSKEQIFDILEKAKEEARRLEAQLEELKIQVINVIKEVELCERKEKKCRLKLAFV
SKQFGHLSEQAIREAYEEAKEAQIELALKRREEKELIEKRNELERKLVDNKAIIEKAEKLVSQINVALNYLNRDLKKMNT
QLEQLKDKRALSVKIIEAQEEERKRIAREIHDGPAQAMANVLSKSELCEKLITKDIEQAKIELKNLKNIVQQSLKEVRKI
IYDLRPSALDDLGLIPALSRYIKNFSEETGIFVDFSVLSDYKRLSPEIEITCFRVVQEALTNIKKHSKAKNASVKFEFGM
RFISIIIKDDGIGFDKENIGQGYGLMGMRERIEILNGKFEISSFKNNGTQIYISIPVRGVEDDQIVGG
>Mature_388_residues
MNANVEVTYKKRLDNIVEKTIEVIESSKEQIFDILEKAKEEARRLEAQLEELKIQVINVIKEVELCERKEKKCRLKLAFV
SKQFGHLSEQAIREAYEEAKEAQIELALKRREEKELIEKRNELERKLVDNKAIIEKAEKLVSQINVALNYLNRDLKKMNT
QLEQLKDKRALSVKIIEAQEEERKRIAREIHDGPAQAMANVLSKSELCEKLITKDIEQAKIELKNLKNIVQQSLKEVRKI
IYDLRPSALDDLGLIPALSRYIKNFSEETGIFVDFSVLSDYKRLSPEIEITCFRVVQEALTNIKKHSKAKNASVKFEFGM
RFISIIIKDDGIGFDKENIGQGYGLMGMRERIEILNGKFEISSFKNNGTQIYISIPVRGVEDDQIVGG

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=230, Percent_Identity=30.8695652173913, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787474, Length=247, Percent_Identity=27.9352226720648, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788812, Length=199, Percent_Identity=26.1306532663317, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44769; Mature: 44769

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANVEVTYKKRLDNIVEKTIEVIESSKEQIFDILEKAKEEARRLEAQLEELKIQVINVI
CCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEVELCERKEKKCRLKLAFVSKQFGHLSEQAIREAYEEAKEAQIELALKRREEKELIEKR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELERKLVDNKAIIEKAEKLVSQINVALNYLNRDLKKMNTQLEQLKDKRALSVKIIEAQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
EERKRIAREIHDGPAQAMANVLSKSELCEKLITKDIEQAKIELKNLKNIVQQSLKEVRKI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYDLRPSALDDLGLIPALSRYIKNFSEETGIFVDFSVLSDYKRLSPEIEITCFRVVQEAL
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHH
TNIKKHSKAKNASVKFEFGMRFISIIIKDDGIGFDKENIGQGYGLMGMRERIEILNGKFE
HHHHHHHCCCCCCEEHHHHHHHHHHHEECCCCCCCHHHCCCCCCCHHHHHHHHHHCCCEE
ISSFKNNGTQIYISIPVRGVEDDQIVGG
EEECCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNANVEVTYKKRLDNIVEKTIEVIESSKEQIFDILEKAKEEARRLEAQLEELKIQVINVI
CCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEVELCERKEKKCRLKLAFVSKQFGHLSEQAIREAYEEAKEAQIELALKRREEKELIEKR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELERKLVDNKAIIEKAEKLVSQINVALNYLNRDLKKMNTQLEQLKDKRALSVKIIEAQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
EERKRIAREIHDGPAQAMANVLSKSELCEKLITKDIEQAKIELKNLKNIVQQSLKEVRKI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYDLRPSALDDLGLIPALSRYIKNFSEETGIFVDFSVLSDYKRLSPEIEITCFRVVQEAL
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHH
TNIKKHSKAKNASVKFEFGMRFISIIIKDDGIGFDKENIGQGYGLMGMRERIEILNGKFE
HHHHHHHCCCCCCEEHHHHHHHHHHHEECCCCCCCHHHCCCCCCCHHHHHHHHHHCCCEE
ISSFKNNGTQIYISIPVRGVEDDQIVGG
EEECCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]