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The map label for this gene is iscS [H]

Identifier: 167040648

GI number: 167040648

Start: 2034626

End: 2035777

Strand: Reverse

Name: iscS [H]

Synonym: Teth514_2025

Alternate gene names: 167040648

Gene position: 2035777-2034626 (Counterclockwise)

Preceding gene: 167040649

Following gene: 167040647

Centisome position: 82.85

GC content: 33.68

Gene sequence:

>1152_bases
ATGGAAGTATATCTCGACAATAGCGCTACTACAAGAGTTAGGAAAGAAGTAATTAAAAAAATGGCTGAAGTTTTAGATAA
AGAATACGGCAATCCCTCTTCTTTACATATGAAAGGCTATCAAGCTGAAAAGTTAATGAAAGAAGCGAGAGAAAATGTAG
CTAACTTAATCAACAGTGAGCCCGAAGGAATAGTTTTTACTTCTGGAGGGACAGAATCAAACAATCTTGCTTTAATAGGG
GTTGCAGAAAGTTTAAAAAAGAAAGGAAATCATATAATATCTTCAAAAATTGAACATCCTTCTGTGCTCAATGTTTTAAA
GTATCTTGAGGAAAATGGCTTTGAAGTAACTTATCTAGATGTGGATAAAACAGGAAAAGTAGATGTAGAGGATTTAAAGA
GGGCGATAACTAATAAAACTATACTTATATCAATTATGGCTGTAAATAATGAGTTAGGAACAATAGAGCCAATAGAGGAA
ATAGCTGATATTGCAGAGAATAAAGACATAGTTTTTCACGTTGATGCTATACAAGCAGTAGGAAAAATAAATATAGATGT
AAAAAAGCATAAAATAAAGATGGTGTCTTTAAGCAGTCATAAAATACACGGTCCTAAAGGAGTAGGAGCCTTATATATTG
ATAAATCAGTAAAGATTAGGCCAATAATTTTTGGAGGGGGACAAGAAAAAAATTTAAGGTCTGGGACAGAAAATATGCCA
GGAATTGTGGGATTTGGTGTGGCTAGCAAATTAGCCAAAGAAAATTTCCACGGTAATGTAAGCAAATTAATGACCTTAAA
GAAGCGACTTTATCAAGGCATAGTTTCTGAAATAAAAGATGTTCATTTAAACGGGCCAAATGTTGAAGAGGGAGCGCCAC
ATATACTCAATATTTCTTTTGCCGGTGTGAGGGGAGAGGTGCTTTTACACGCTCTTGAAGAAAAGGGCATATATGTTTCT
ACGGGATCGGCTTGTTCTTCCAAAAAGAAAGGACAAAGTCATGTTTTAAAAGCGATAGGTCTTAAAGAGGACCTTATTGA
AAGCGCTATAAGATTTTCCATTGGAATTTTTAATACAGAAGAAGAAATTGACTATACTATATCAGTGTTAAAAGAAAAAG
TGAATTTTTTAAGAAAGTATAAACGGAGGTAA

Upstream 100 bases:

>100_bases
ATTAAATTTGCAAAATAATTTAAATTATAAAAGTTTAATAATTATTCACAATATCCAGGAATTTGCTATTATTAAAAATC
TAATTAAAGGGATGATGGCC

Downstream 100 bases:

>100_bases
AATATGCAAGACATATTATTGATTAAATATGGAGAATTAGCTTTAAAAGGAGATAATAGGTCTTTTTTTGAAAATAAATT
GATAAAAAATATAAAACATG

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MEVYLDNSATTRVRKEVIKKMAEVLDKEYGNPSSLHMKGYQAEKLMKEARENVANLINSEPEGIVFTSGGTESNNLALIG
VAESLKKKGNHIISSKIEHPSVLNVLKYLEENGFEVTYLDVDKTGKVDVEDLKRAITNKTILISIMAVNNELGTIEPIEE
IADIAENKDIVFHVDAIQAVGKINIDVKKHKIKMVSLSSHKIHGPKGVGALYIDKSVKIRPIIFGGGQEKNLRSGTENMP
GIVGFGVASKLAKENFHGNVSKLMTLKKRLYQGIVSEIKDVHLNGPNVEEGAPHILNISFAGVRGEVLLHALEEKGIYVS
TGSACSSKKKGQSHVLKAIGLKEDLIESAIRFSIGIFNTEEEIDYTISVLKEKVNFLRKYKRR

Sequences:

>Translated_383_residues
MEVYLDNSATTRVRKEVIKKMAEVLDKEYGNPSSLHMKGYQAEKLMKEARENVANLINSEPEGIVFTSGGTESNNLALIG
VAESLKKKGNHIISSKIEHPSVLNVLKYLEENGFEVTYLDVDKTGKVDVEDLKRAITNKTILISIMAVNNELGTIEPIEE
IADIAENKDIVFHVDAIQAVGKINIDVKKHKIKMVSLSSHKIHGPKGVGALYIDKSVKIRPIIFGGGQEKNLRSGTENMP
GIVGFGVASKLAKENFHGNVSKLMTLKKRLYQGIVSEIKDVHLNGPNVEEGAPHILNISFAGVRGEVLLHALEEKGIYVS
TGSACSSKKKGQSHVLKAIGLKEDLIESAIRFSIGIFNTEEEIDYTISVLKEKVNFLRKYKRR
>Mature_383_residues
MEVYLDNSATTRVRKEVIKKMAEVLDKEYGNPSSLHMKGYQAEKLMKEARENVANLINSEPEGIVFTSGGTESNNLALIG
VAESLKKKGNHIISSKIEHPSVLNVLKYLEENGFEVTYLDVDKTGKVDVEDLKRAITNKTILISIMAVNNELGTIEPIEE
IADIAENKDIVFHVDAIQAVGKINIDVKKHKIKMVSLSSHKIHGPKGVGALYIDKSVKIRPIIFGGGQEKNLRSGTENMP
GIVGFGVASKLAKENFHGNVSKLMTLKKRLYQGIVSEIKDVHLNGPNVEEGAPHILNISFAGVRGEVLLHALEEKGIYVS
TGSACSSKKKGQSHVLKAIGLKEDLIESAIRFSIGIFNTEEEIDYTISVLKEKVNFLRKYKRR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=380, Percent_Identity=45, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI156713448, Length=415, Percent_Identity=34.4578313253012, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI48994898, Length=383, Percent_Identity=46.9973890339426, Blast_Score=343, Evalue=8e-96,
Organism=Escherichia coli, GI1787970, Length=394, Percent_Identity=26.6497461928934, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789175, Length=409, Percent_Identity=24.6943765281174, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=380, Percent_Identity=46.0526315789474, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17533177, Length=310, Percent_Identity=35.1612903225806, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319831, Length=380, Percent_Identity=44.4736842105263, Blast_Score=322, Evalue=6e-89,
Organism=Drosophila melanogaster, GI20129463, Length=380, Percent_Identity=44.7368421052632, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42254; Mature: 42254

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00018 EF_HAND_1 ; PS50222 EF_HAND_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVYLDNSATTRVRKEVIKKMAEVLDKEYGNPSSLHMKGYQAEKLMKEARENVANLINSE
CEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCC
PEGIVFTSGGTESNNLALIGVAESLKKKGNHIISSKIEHPSVLNVLKYLEENGFEVTYLD
CCEEEEECCCCCCCCEEEEEEHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEE
VDKTGKVDVEDLKRAITNKTILISIMAVNNELGTIEPIEEIADIAENKDIVFHVDAIQAV
CCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHC
GKINIDVKKHKIKMVSLSSHKIHGPKGVGALYIDKSVKIRPIIFGGGQEKNLRSGTENMP
CEEEEEEEEEEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
GIVGFGVASKLAKENFHGNVSKLMTLKKRLYQGIVSEIKDVHLNGPNVEEGAPHILNISF
CEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
AGVRGEVLLHALEEKGIYVSTGSACSSKKKGQSHVLKAIGLKEDLIESAIRFSIGIFNTE
CCCHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHEECCCH
EEIDYTISVLKEKVNFLRKYKRR
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEVYLDNSATTRVRKEVIKKMAEVLDKEYGNPSSLHMKGYQAEKLMKEARENVANLINSE
CEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCC
PEGIVFTSGGTESNNLALIGVAESLKKKGNHIISSKIEHPSVLNVLKYLEENGFEVTYLD
CCEEEEECCCCCCCCEEEEEEHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEE
VDKTGKVDVEDLKRAITNKTILISIMAVNNELGTIEPIEEIADIAENKDIVFHVDAIQAV
CCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHC
GKINIDVKKHKIKMVSLSSHKIHGPKGVGALYIDKSVKIRPIIFGGGQEKNLRSGTENMP
CEEEEEEEEEEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
GIVGFGVASKLAKENFHGNVSKLMTLKKRLYQGIVSEIKDVHLNGPNVEEGAPHILNISF
CEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
AGVRGEVLLHALEEKGIYVSTGSACSSKKKGQSHVLKAIGLKEDLIESAIRFSIGIFNTE
CCCHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHEECCCH
EEIDYTISVLKEKVNFLRKYKRR
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA