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The map label for this gene is phoR [H]

Identifier: 167040619

GI number: 167040619

Start: 2005973

End: 2007343

Strand: Reverse

Name: phoR [H]

Synonym: Teth514_1996

Alternate gene names: 167040619

Gene position: 2007343-2005973 (Counterclockwise)

Preceding gene: 167040620

Following gene: 167040618

Centisome position: 81.69

GC content: 27.94

Gene sequence:

>1371_bases
ATGTTGAAAAAATCCTATTGTAAATTGTTTTTTATAAACCTACTTGGAATTTTAATAGTCGCCATATTTTTTTTAGGCTA
TGTTCCAATGACTAAATTTATTTTTGCTATTTTATTAGGAATTTTAGTAACATTTTTTTTAAGTTATAGATTTATAAAAA
ATATAGTAGAGCCTATAAAAGAGATAACTGAAATCACAAAGGATATTGCAAAGGGGATATACAGTCATAGGCTTGAAAGC
GATTCTATTGATGAAATAAAAGAACTTTCTCTTGCAGTAGATTCTATGTCTTATAAATTAAAAGAAACAATAGAGGAATT
AAATGATAGAAACGCAAAATTAGAAGCCATTTTAAAAAGCATAGTAAATGGGGTTATCGCTTTTGATAATAATGAGAAGA
TATTACTTATAAATGACGCTGCGAGGAAAATTCTAAATATAAAAGAGAAAGATTTAATTGGAAGACATATCTTAGAAATT
GTAAGAAATAGTAAATTACATGACTTTTTTGAAGATGTTAAGAAAAATAAAAATTCCCCTTCCAAAAGTTTAGAACTAAA
TGTTTTCAACAAACACCTCAAAGTGTATACTAGTCCAATTCTTCATCCAATTTCCCATCAAAATTTAGGTTTTGTGTTAA
TAATAGATGATATTACAGAAATGAGAAGATTGGAAAAAATAAGAAGCGAATTTGTTGCAAATGTGTCCCATGAGCTGAGA
ACTCCTTTGACTTCTATTAGAGGCTTTATTGAAACTTTAAGAAATGGTGCTATTGACAATCCGCAGGCAAGAGATAAATT
TTTAGATATAATTGATTTTGAGTCTGAAAGACTTACAAGACTTATAAACGATATACTCACTCTTTCTGAAATAGAAAATG
TTAAAGAAGGTTATCCTAAAGAAGAAATAGAATTAGATAATGAGATAGAGGATATATTATATATAATGGACAAGGTCGCG
AGAAATAAAAATATAACGTTGAAAAAAGATTTAAATTGTACAGATTTAGTGATAAAAACTAATAAAGATAGATTTCATCA
AATGATGATTAATTTAATAGATAATGGTATAAAATACACTCCAGAGGGAGGATTTGTAAAGGTATCTACCAGAGAAGAGG
GGGATAAAATAATTATTACAGTTGAAGACAACGGTATAGGAATTTCGAAAGAAAATATTCCTAGGCTTTTTGAGAGATTT
TATCGAGTTGACAAAAGTCGCTCAAGAAAATTAGGTGGTACAGGATTGGGACTTGCTATAGTTAAACATATTGTGGAATC
TATGAAAGGAGAAATTTTTGTAGAAAGTGAAGTAGGGAGAGGTACAAAATTTATTATAAAATTCAACAAAACTGATTTAA
CAAAGACTTAA

Upstream 100 bases:

>100_bases
GGCATTTAAGAAAGAAAATAGAAGACGATGATAAATCCCCTGTATATATTGAAACTGTAAGAGGAATTGGGTATAAGTTA
AATGATAAAGGTGAAGCGTA

Downstream 100 bases:

>100_bases
CAATATCTTAATATTGAATTTACAATAGACTGTTACAATGTACTTGTACAAAAAAATTTAAGGAATTTTGGAGGTGCTTT
AATGTTAAAGAGTCGATTTG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLKKSYCKLFFINLLGILIVAIFFLGYVPMTKFIFAILLGILVTFFLSYRFIKNIVEPIKEITEITKDIAKGIYSHRLES
DSIDEIKELSLAVDSMSYKLKETIEELNDRNAKLEAILKSIVNGVIAFDNNEKILLINDAARKILNIKEKDLIGRHILEI
VRNSKLHDFFEDVKKNKNSPSKSLELNVFNKHLKVYTSPILHPISHQNLGFVLIIDDITEMRRLEKIRSEFVANVSHELR
TPLTSIRGFIETLRNGAIDNPQARDKFLDIIDFESERLTRLINDILTLSEIENVKEGYPKEEIELDNEIEDILYIMDKVA
RNKNITLKKDLNCTDLVIKTNKDRFHQMMINLIDNGIKYTPEGGFVKVSTREEGDKIIITVEDNGIGISKENIPRLFERF
YRVDKSRSRKLGGTGLGLAIVKHIVESMKGEIFVESEVGRGTKFIIKFNKTDLTKT

Sequences:

>Translated_456_residues
MLKKSYCKLFFINLLGILIVAIFFLGYVPMTKFIFAILLGILVTFFLSYRFIKNIVEPIKEITEITKDIAKGIYSHRLES
DSIDEIKELSLAVDSMSYKLKETIEELNDRNAKLEAILKSIVNGVIAFDNNEKILLINDAARKILNIKEKDLIGRHILEI
VRNSKLHDFFEDVKKNKNSPSKSLELNVFNKHLKVYTSPILHPISHQNLGFVLIIDDITEMRRLEKIRSEFVANVSHELR
TPLTSIRGFIETLRNGAIDNPQARDKFLDIIDFESERLTRLINDILTLSEIENVKEGYPKEEIELDNEIEDILYIMDKVA
RNKNITLKKDLNCTDLVIKTNKDRFHQMMINLIDNGIKYTPEGGFVKVSTREEGDKIIITVEDNGIGISKENIPRLFERF
YRVDKSRSRKLGGTGLGLAIVKHIVESMKGEIFVESEVGRGTKFIIKFNKTDLTKT
>Mature_456_residues
MLKKSYCKLFFINLLGILIVAIFFLGYVPMTKFIFAILLGILVTFFLSYRFIKNIVEPIKEITEITKDIAKGIYSHRLES
DSIDEIKELSLAVDSMSYKLKETIEELNDRNAKLEAILKSIVNGVIAFDNNEKILLINDAARKILNIKEKDLIGRHILEI
VRNSKLHDFFEDVKKNKNSPSKSLELNVFNKHLKVYTSPILHPISHQNLGFVLIIDDITEMRRLEKIRSEFVANVSHELR
TPLTSIRGFIETLRNGAIDNPQARDKFLDIIDFESERLTRLINDILTLSEIENVKEGYPKEEIELDNEIEDILYIMDKVA
RNKNITLKKDLNCTDLVIKTNKDRFHQMMINLIDNGIKYTPEGGFVKVSTREEGDKIIITVEDNGIGISKENIPRLFERF
YRVDKSRSRKLGGTGLGLAIVKHIVESMKGEIFVESEVGRGTKFIIKFNKTDLTKT

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=432, Percent_Identity=30.787037037037, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786783, Length=268, Percent_Identity=31.3432835820896, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=33.7719298245614, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788549, Length=376, Percent_Identity=24.7340425531915, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788713, Length=263, Percent_Identity=30.0380228136882, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788393, Length=209, Percent_Identity=32.0574162679426, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=33.8842975206612, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=30.8333333333333, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=30.1310043668122, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=31.5126050420168, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1790346, Length=229, Percent_Identity=28.82096069869, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790861, Length=208, Percent_Identity=28.3653846153846, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=30.5309734513274, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789403, Length=196, Percent_Identity=31.6326530612245, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=27.3504273504274, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=211, Percent_Identity=29.8578199052133, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790551, Length=225, Percent_Identity=25.7777777777778, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789808, Length=221, Percent_Identity=28.9592760180996, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787374, Length=232, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788279, Length=203, Percent_Identity=28.0788177339901, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=357, Percent_Identity=23.5294117647059, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52453; Mature: 52453

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKSYCKLFFINLLGILIVAIFFLGYVPMTKFIFAILLGILVTFFLSYRFIKNIVEPIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EITEITKDIAKGIYSHRLESDSIDEIKELSLAVDSMSYKLKETIEELNDRNAKLEAILKS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IVNGVIAFDNNEKILLINDAARKILNIKEKDLIGRHILEIVRNSKLHDFFEDVKKNKNSP
HHCCEEEECCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
SKSLELNVFNKHLKVYTSPILHPISHQNLGFVLIIDDITEMRRLEKIRSEFVANVSHELR
CCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
TPLTSIRGFIETLRNGAIDNPQARDKFLDIIDFESERLTRLINDILTLSEIENVKEGYPK
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
EEIELDNEIEDILYIMDKVARNKNITLKKDLNCTDLVIKTNKDRFHQMMINLIDNGIKYT
HHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCEEC
PEGGFVKVSTREEGDKIIITVEDNGIGISKENIPRLFERFYRVDKSRSRKLGGTGLGLAI
CCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHH
VKHIVESMKGEIFVESEVGRGTKFIIKFNKTDLTKT
HHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MLKKSYCKLFFINLLGILIVAIFFLGYVPMTKFIFAILLGILVTFFLSYRFIKNIVEPIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EITEITKDIAKGIYSHRLESDSIDEIKELSLAVDSMSYKLKETIEELNDRNAKLEAILKS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IVNGVIAFDNNEKILLINDAARKILNIKEKDLIGRHILEIVRNSKLHDFFEDVKKNKNSP
HHCCEEEECCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
SKSLELNVFNKHLKVYTSPILHPISHQNLGFVLIIDDITEMRRLEKIRSEFVANVSHELR
CCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
TPLTSIRGFIETLRNGAIDNPQARDKFLDIIDFESERLTRLINDILTLSEIENVKEGYPK
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
EEIELDNEIEDILYIMDKVARNKNITLKKDLNCTDLVIKTNKDRFHQMMINLIDNGIKYT
HHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCEEC
PEGGFVKVSTREEGDKIIITVEDNGIGISKENIPRLFERFYRVDKSRSRKLGGTGLGLAI
CCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHH
VKHIVESMKGEIFVESEVGRGTKFIIKFNKTDLTKT
HHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]