Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 167040178

GI number: 167040178

Start: 1562455

End: 1564317

Strand: Direct

Name: dxs [H]

Synonym: Teth514_1540

Alternate gene names: 167040178

Gene position: 1562455-1564317 (Clockwise)

Preceding gene: 167040177

Following gene: 167040179

Centisome position: 63.59

GC content: 35.05

Gene sequence:

>1863_bases
ATGCTGGAACAAATTGATAGCCCTTATGACTTGAAAAAATTAGACAAAAAGGACTTTCCGCTGATTTGTGAAGAAATACG
CCAGTTTTTAATAGAAAAAGTGTCTAAAACAGGTGGGCATTTAGCATCAAACCTTGGAATCGTTGAACTTACAATTGCAC
TTCATTATGTTTTTAATTCGCCAGTTGACAAAATAATCTGGGATGTAGGACATCAGTGTTATGTACATAAAATGCTTACA
GGTAGGAAAGACCAGTTTGATACTTTGAGGAAATTCAATGGCCTTTCTGGTTATACTAAAAGAACGGAAAGTGTGCATGA
TATATTTGGAGCAGGACACAGTAGTACCTCTATATCTGCAGCATTGGGCATTGCCAAGGCAAGAGATTTAAAGGGCGAGA
AATATTCTGTTGTAGCGGTAATTGGGGATGGAGCTTTAACTGGTGGCATGGCTTTTGAAGCATTAAATAATGCAGGAAGG
TCTAAAACAGATTTGATTGTCGTGCTAAATCACAATGAGATGTCTATTTCGGAAAACGTAGGTAGTTTATCTTTGTATTT
AAGTAAACTTAGAACTGACCCTACTTACAACAAATTAAAACAAGAGGTTGATAATTTACTCAATATTGTACCTCCAATAG
GAAAAAGCCTTCATAAATACATTGAAAGAATTAAGGATTCTGTAAAACAGTTAGTAGTGTCAGGAATGTTTTTTGAAGAG
ATGGGTTTTACATATTTAGGACCTATTGACGGACATGACGTTGGTAGCCTTATAGAGGTTTTAGAAAGAGCGAAGAAAAT
AAAAGGACCTATTTTAGTACATGTTATCACAAAAAAAGGCAAAGGTTACAAATTTGCAGAAAAATTTCCTGATAAATTTC
ATTCTGCAGCTCCTTTTGACATACAAACAGGTAAGTTTGTAAATGAGGGGCAGGCGACTTATTCTGATGTATTTGGGAAG
ACTCTTACTGAAATGGCCTTGCAAGATGACAAAATTGTTGCAATAACTGCTGCCATGCCAGAGGGAACAGGGCTTATTCA
TTTTGCAAAATTGATTCCTGAAAGATTTTTTGATGTAGGAATAGCAGAGCAGCATGCTACTACCTTTGCAGCAGGAATGG
CAGTACAAGGATACAAACCTTATTTTGCAGTGTATTCTACCTTTTTACAAAGAGCTTATGACCAGCTTATACACGATGTA
TGTATACAAAAATTACCTGTTGTTTTTGCAATTGATAGAGCAGGAATTGTAGGAGAGGATGGAGAAACCCATCAAGGAGT
TTTTGATTTGTCTTATTTAAGGCCAATTCCTAATATAACGATTATGTCTCCAAAAGACGCAAATGAATTAGTTGAAATGG
TTAAATTATCAAGAAATCTTGAGTTCCCTGTTGCCATAAGGTATCCAAGAGGAAAAGCAGGAGAATTCGATATTACAAGA
GAATGCAGTATAGAGTTTGGAAAGGCAGAGTTAGTTACTGAAGGAAAAGAAATAGCAATTTTTGCATTAGGAAGAATGGT
AGGAAAGGTGTTAGAAGCAAAGGAAATTTTAAAAGTTTCTGATTTGCAACCCTTTATTGTCAATTTGAGATTTGTTAAAC
CTTTAGATGAAGAGCTAATTTTGGATATCTCAAACAAAGTCAAATTTATTGTTACAGTAGAAGACAATGTCATAGCTGGT
GGCGTTGGAAGCGCTATATTAGAACTTTTAAATTCTAACGGAATTTATAAGCCAGTTTTGCGTTTGGGGTTTCCCGATAA
ATTTATTGAACACGGAGATGTGGAAAACTTGTTTAAAAAATACAATTTAGATGCTGAGTCTATCGCAAATACTATACTAC
AAAAATATAAGGAAATGAGGTAA

Upstream 100 bases:

>100_bases
CTGGCTTGGATAGAAAAAAACACGGGTATAAAGATTTTGCCAGATTATAAGAATAATAATAAGAATAATAAAAGGAAGAA
AAGAAAGTGAGGGTATTTAA

Downstream 100 bases:

>100_bases
ATATGGCTTCAAAAAAAGAAAGATTGGATGTTTTGCTTGTTCAAAAAGGTTTTTTCTCCTCAAGAGAAAAAGCAAAAGCT
TCTATTATGGCAGGAGAAGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MLEQIDSPYDLKKLDKKDFPLICEEIRQFLIEKVSKTGGHLASNLGIVELTIALHYVFNSPVDKIIWDVGHQCYVHKMLT
GRKDQFDTLRKFNGLSGYTKRTESVHDIFGAGHSSTSISAALGIAKARDLKGEKYSVVAVIGDGALTGGMAFEALNNAGR
SKTDLIVVLNHNEMSISENVGSLSLYLSKLRTDPTYNKLKQEVDNLLNIVPPIGKSLHKYIERIKDSVKQLVVSGMFFEE
MGFTYLGPIDGHDVGSLIEVLERAKKIKGPILVHVITKKGKGYKFAEKFPDKFHSAAPFDIQTGKFVNEGQATYSDVFGK
TLTEMALQDDKIVAITAAMPEGTGLIHFAKLIPERFFDVGIAEQHATTFAAGMAVQGYKPYFAVYSTFLQRAYDQLIHDV
CIQKLPVVFAIDRAGIVGEDGETHQGVFDLSYLRPIPNITIMSPKDANELVEMVKLSRNLEFPVAIRYPRGKAGEFDITR
ECSIEFGKAELVTEGKEIAIFALGRMVGKVLEAKEILKVSDLQPFIVNLRFVKPLDEELILDISNKVKFIVTVEDNVIAG
GVGSAILELLNSNGIYKPVLRLGFPDKFIEHGDVENLFKKYNLDAESIANTILQKYKEMR

Sequences:

>Translated_620_residues
MLEQIDSPYDLKKLDKKDFPLICEEIRQFLIEKVSKTGGHLASNLGIVELTIALHYVFNSPVDKIIWDVGHQCYVHKMLT
GRKDQFDTLRKFNGLSGYTKRTESVHDIFGAGHSSTSISAALGIAKARDLKGEKYSVVAVIGDGALTGGMAFEALNNAGR
SKTDLIVVLNHNEMSISENVGSLSLYLSKLRTDPTYNKLKQEVDNLLNIVPPIGKSLHKYIERIKDSVKQLVVSGMFFEE
MGFTYLGPIDGHDVGSLIEVLERAKKIKGPILVHVITKKGKGYKFAEKFPDKFHSAAPFDIQTGKFVNEGQATYSDVFGK
TLTEMALQDDKIVAITAAMPEGTGLIHFAKLIPERFFDVGIAEQHATTFAAGMAVQGYKPYFAVYSTFLQRAYDQLIHDV
CIQKLPVVFAIDRAGIVGEDGETHQGVFDLSYLRPIPNITIMSPKDANELVEMVKLSRNLEFPVAIRYPRGKAGEFDITR
ECSIEFGKAELVTEGKEIAIFALGRMVGKVLEAKEILKVSDLQPFIVNLRFVKPLDEELILDISNKVKFIVTVEDNVIAG
GVGSAILELLNSNGIYKPVLRLGFPDKFIEHGDVENLFKKYNLDAESIANTILQKYKEMR
>Mature_620_residues
MLEQIDSPYDLKKLDKKDFPLICEEIRQFLIEKVSKTGGHLASNLGIVELTIALHYVFNSPVDKIIWDVGHQCYVHKMLT
GRKDQFDTLRKFNGLSGYTKRTESVHDIFGAGHSSTSISAALGIAKARDLKGEKYSVVAVIGDGALTGGMAFEALNNAGR
SKTDLIVVLNHNEMSISENVGSLSLYLSKLRTDPTYNKLKQEVDNLLNIVPPIGKSLHKYIERIKDSVKQLVVSGMFFEE
MGFTYLGPIDGHDVGSLIEVLERAKKIKGPILVHVITKKGKGYKFAEKFPDKFHSAAPFDIQTGKFVNEGQATYSDVFGK
TLTEMALQDDKIVAITAAMPEGTGLIHFAKLIPERFFDVGIAEQHATTFAAGMAVQGYKPYFAVYSTFLQRAYDQLIHDV
CIQKLPVVFAIDRAGIVGEDGETHQGVFDLSYLRPIPNITIMSPKDANELVEMVKLSRNLEFPVAIRYPRGKAGEFDITR
ECSIEFGKAELVTEGKEIAIFALGRMVGKVLEAKEILKVSDLQPFIVNLRFVKPLDEELILDISNKVKFIVTVEDNVIAG
GVGSAILELLNSNGIYKPVLRLGFPDKFIEHGDVENLFKKYNLDAESIANTILQKYKEMR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=537, Percent_Identity=23.463687150838, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4507521, Length=537, Percent_Identity=23.463687150838, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI225637463, Length=424, Percent_Identity=25, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI225637459, Length=424, Percent_Identity=25, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI225637461, Length=424, Percent_Identity=25, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI133778974, Length=373, Percent_Identity=23.5924932975871, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI156564403, Length=301, Percent_Identity=24.2524916943522, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1786622, Length=614, Percent_Identity=48.2084690553746, Blast_Score=598, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17539652, Length=619, Percent_Identity=22.2940226171244, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319698, Length=283, Percent_Identity=28.2685512367491, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666278, Length=591, Percent_Identity=24.8730964467005, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24645119, Length=546, Percent_Identity=24.7252747252747, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45551847, Length=594, Percent_Identity=24.9158249158249, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45550715, Length=594, Percent_Identity=24.9158249158249, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68907; Mature: 68907

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQIDSPYDLKKLDKKDFPLICEEIRQFLIEKVSKTGGHLASNLGIVELTIALHYVFNS
CCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHHHCC
PVDKIIWDVGHQCYVHKMLTGRKDQFDTLRKFNGLSGYTKRTESVHDIFGAGHSSTSISA
CHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHH
ALGIAKARDLKGEKYSVVAVIGDGALTGGMAFEALNNAGRSKTDLIVVLNHNEMSISENV
HHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEEHHCCC
GSLSLYLSKLRTDPTYNKLKQEVDNLLNIVPPIGKSLHKYIERIKDSVKQLVVSGMFFEE
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MGFTYLGPIDGHDVGSLIEVLERAKKIKGPILVHVITKKGKGYKFAEKFPDKFHSAAPFD
CCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCHHHCCCCCCC
IQTGKFVNEGQATYSDVFGKTLTEMALQDDKIVAITAAMPEGTGLIHFAKLIPERFFDVG
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCC
IAEQHATTFAAGMAVQGYKPYFAVYSTFLQRAYDQLIHDVCIQKLPVVFAIDRAGIVGED
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
GETHQGVFDLSYLRPIPNITIMSPKDANELVEMVKLSRNLEFPVAIRYPRGKAGEFDITR
CCCCCCEEEHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
ECSIEFGKAELVTEGKEIAIFALGRMVGKVLEAKEILKVSDLQPFIVNLRFVKPLDEELI
CCCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHH
LDISNKVKFIVTVEDNVIAGGVGSAILELLNSNGIYKPVLRLGFPDKFIEHGDVENLFKK
EEECCCEEEEEEECCCEEECCHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCHHHHHHH
YNLDAESIANTILQKYKEMR
HCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLEQIDSPYDLKKLDKKDFPLICEEIRQFLIEKVSKTGGHLASNLGIVELTIALHYVFNS
CCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHHHCC
PVDKIIWDVGHQCYVHKMLTGRKDQFDTLRKFNGLSGYTKRTESVHDIFGAGHSSTSISA
CHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHH
ALGIAKARDLKGEKYSVVAVIGDGALTGGMAFEALNNAGRSKTDLIVVLNHNEMSISENV
HHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEEHHCCC
GSLSLYLSKLRTDPTYNKLKQEVDNLLNIVPPIGKSLHKYIERIKDSVKQLVVSGMFFEE
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MGFTYLGPIDGHDVGSLIEVLERAKKIKGPILVHVITKKGKGYKFAEKFPDKFHSAAPFD
CCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCHHHCCCCCCC
IQTGKFVNEGQATYSDVFGKTLTEMALQDDKIVAITAAMPEGTGLIHFAKLIPERFFDVG
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCC
IAEQHATTFAAGMAVQGYKPYFAVYSTFLQRAYDQLIHDVCIQKLPVVFAIDRAGIVGED
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
GETHQGVFDLSYLRPIPNITIMSPKDANELVEMVKLSRNLEFPVAIRYPRGKAGEFDITR
CCCCCCEEEHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
ECSIEFGKAELVTEGKEIAIFALGRMVGKVLEAKEILKVSDLQPFIVNLRFVKPLDEELI
CCCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHH
LDISNKVKFIVTVEDNVIAGGVGSAILELLNSNGIYKPVLRLGFPDKFIEHGDVENLFKK
EEECCCEEEEEEECCCEEECCHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCHHHHHHH
YNLDAESIANTILQKYKEMR
HCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]