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The map label for this gene is apt [H]

Identifier: 167040106

GI number: 167040106

Start: 1500533

End: 1501054

Strand: Direct

Name: apt [H]

Synonym: Teth514_1466

Alternate gene names: 167040106

Gene position: 1500533-1501054 (Clockwise)

Preceding gene: 167040105

Following gene: 167040107

Centisome position: 61.07

GC content: 35.25

Gene sequence:

>522_bases
ATGACGCTGGAAGAAATCAAAATGATGATTAGAGAAATACCTGACTTCCCTAAAAAAGGAATAAAATTTAAAGATATTAC
ACCTGTTTTAAAAGATGCGCAAGCTTTCAATTATTCCATAGAAATGCTGGCTAAGGCTTTAGAGGGTAGAAAATTTGACC
TTATTGCAGCGCCAGAAGCAAGAGGATTTTTGTTTGGAGCCCCACTAGCTTATAGATTGGGAGTAGGATTTGTCCCTGTC
AGGAAACCTGGAAAATTACCTGCTGAAACTTTAAGCTATGAGTATGAACTGGAATATGGGACAGATTCTCTTGAAATACA
CAAAGATGCTGTTTTAGAGGGACAAAGAGTTGTGATAGTTGATGACTTACTGGCTACAGGTGGGACAATTTACGCTTCTG
CAAAACTTGTTGAAAAATTGGGTGGAATAGTAGACTCTATTATTTTCTTGAGTGAGTTAACTTTTTTAGATGGTAGAAAA
AAACTTGACGGATATGATATAATTTCATTAATAAAGTTTTAA

Upstream 100 bases:

>100_bases
GAACAAGCTCGAATAATGCAACAGATACTCTCAGCTAAAAAAGAGTTTATTGAATTTGCCAAGTTCATTGTCAGCCAGAA
AATTTAAGGAGGTTTTTGTA

Downstream 100 bases:

>100_bases
TCTATTAAGTGGCTTTAAGCCACTTTAATTATAAGGTGTGGTAAATATGTTGGACAAAGTGATAAATAGGATAAAAAAAT
ATATGGGTGATGATGCAAAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MTLEEIKMMIREIPDFPKKGIKFKDITPVLKDAQAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAYRLGVGFVPV
RKPGKLPAETLSYEYELEYGTDSLEIHKDAVLEGQRVVIVDDLLATGGTIYASAKLVEKLGGIVDSIIFLSELTFLDGRK
KLDGYDIISLIKF

Sequences:

>Translated_173_residues
MTLEEIKMMIREIPDFPKKGIKFKDITPVLKDAQAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAYRLGVGFVPV
RKPGKLPAETLSYEYELEYGTDSLEIHKDAVLEGQRVVIVDDLLATGGTIYASAKLVEKLGGIVDSIIFLSELTFLDGRK
KLDGYDIISLIKF
>Mature_172_residues
TLEEIKMMIREIPDFPKKGIKFKDITPVLKDAQAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAYRLGVGFVPVR
KPGKLPAETLSYEYELEYGTDSLEIHKDAVLEGQRVVIVDDLLATGGTIYASAKLVEKLGGIVDSIIFLSELTFLDGRKK
LDGYDIISLIKF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=50, Blast_Score=157, Evalue=3e-39,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=54.6875, Blast_Score=131, Evalue=3e-31,
Organism=Escherichia coli, GI1786675, Length=167, Percent_Identity=52.6946107784431, Blast_Score=169, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=45.6140350877193, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=165, Percent_Identity=45.4545454545455, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=165, Percent_Identity=38.7878787878788, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=45.0867052023121, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19234; Mature: 19103

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEEIKMMIREIPDFPKKGIKFKDITPVLKDAQAFNYSIEMLAKALEGRKFDLIAAPEA
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
RGFLFGAPLAYRLGVGFVPVRKPGKLPAETLSYEYELEYGTDSLEIHKDAVLEGQRVVIV
CCEEECCCHHHHHCCCCEECCCCCCCCHHHCCEEEEEECCCCCEEECHHHHHCCCEEEEE
DDLLATGGTIYASAKLVEKLGGIVDSIIFLSELTFLDGRKKLDGYDIISLIKF
ECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TLEEIKMMIREIPDFPKKGIKFKDITPVLKDAQAFNYSIEMLAKALEGRKFDLIAAPEA
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
RGFLFGAPLAYRLGVGFVPVRKPGKLPAETLSYEYELEYGTDSLEIHKDAVLEGQRVVIV
CCEEECCCHHHHHCCCCEECCCCCCCCHHHCCEEEEEECCCCCEEECHHHHHCCCEEEEE
DDLLATGGTIYASAKLVEKLGGIVDSIIFLSELTFLDGRKKLDGYDIISLIKF
ECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA