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The map label for this gene is ubiB [C]

Identifier: 167040104

GI number: 167040104

Start: 1496396

End: 1498063

Strand: Direct

Name: ubiB [C]

Synonym: Teth514_1464

Alternate gene names: 167040104

Gene position: 1496396-1498063 (Clockwise)

Preceding gene: 167040103

Following gene: 167040105

Centisome position: 60.9

GC content: 31.35

Gene sequence:

>1668_bases
ATGAATTTGCCTTTTATTTTTAGAAATAAAAATATTACCAGAAGATATAAAGAGATATTAAAGATTTTAACTAAAAATGG
TTTTGGTTTTATTTCTGATATTTTATTAAAAGGTGGACATATACCTTTTCATATACTGAAAAGTCATGATTACATGGGAG
CAGGAGAGAGGATTCGGAAAACATTAGAGGAATTAGGTCCTACTTTTATAAAAATGGGACAGCTTTTAAGTACAAGAGGG
GACCTTATTCCCCATGATATTTTATTGGAACTTGCTAAACTTCAAGATGATGTAGAACCAGAAGACTTTGTAACTATAAA
GAATATTTTAGAAAGTGAATTAAAAGGCAAAATATCGGATTTTTTCATTTATTTTGATGAAACTCCTATTGCTTCAGCTT
CTATTGGACAAGTTTATAGGGCAAAAATTAAAGAAGGGAAAGATGTCGTTGTTAAAGTACAGCGTCCAGAAGTATCCCAA
AAGATAAATGCTGATATAATAATTCTAAAGAATATTGCTAAAATTTTGAATGAGCGTATAGTTGATGCTCCTTTGGATTT
TGTAGAAATTGTTGATGAATTAGCCGAATCTCTTCTCAATGAATTGGATTACACACAAGAAGGGAATAATGCCGAACGCT
TTAGAGAAAATTTTGAAAAGGAAAGTTATATCTACATACCTAAAGTATATTGGGGATACACTACAAAGCGCGTTCTTACA
ATGGAGTACGTAGAAGGTATAAGTGTAAAAAATAGAGATTTACTTGTTAAAAAAGGCTTTGATTTAAAGAAAATTGCAAG
AGAGGGAGCATGGGCTATATTTTTACAAGTTTATGAATTTGGTCTTTTCCACGGAGATCCCCATCCTGGCAATATCTTAA
TTACAAATGATGGCAAAATTTCATATATAGATTTTGGAATTGTAGGCTACCTTGATAAATCCTCAAGGGAAATGATAATT
GACCTTTTTAAAGCTTTTGCTGAGAATGATATTGAGGAAGTAATAGAAGTTTTGTCGGACATGGGTGCCATAAGGCCTGA
TACTAACCTTAGAACTCTTAAGTCTGATTTGAGCCATATAATAAATTATTTTTACAATACTCCTCTAAAAAATATCAGTG
TGAATGATTCAATGAGGAAAATAATGTCAACTGTTTATAAGCATAAGCTGATTTTACCTCCAGGGTTTACTTTACTTCTC
AAGTCCTTAGCTACAGTAGAAGGTGTAGGCAGAAGCTTAGATCCCGATTTTAGCATTTCTAGTGTAGCAAAAGATTTTAT
AAAAGAGGTATATTTGAGAAACATCAGTTTAACTAAAATATTAAAAGAAAACTCGAAGGATTTACATAAGGCAATAATAG
TATTGAGAAAACTTCCTTCCAAAATCCAAAGTATAATGACAAAGCTTATAAAAGACGATATAAAAGTTAGAATAAACCTT
GATGAAAGTGAAAGCTTACGCTATGACTTAAATATTATGGTGAATAAAGTTATTATAAGTATCATAGCATCAGCATTAAT
TGTAGCTTCTTCATTGGTTTTGACATTTCAAGGGGGATATAAAATTTTCGGCTACAATGCATTGGGGCTTTTTGGCTATG
TGGTTGCTTTACTTCTGTGCTTATGGGTCTTTTATCGAATCTTTATAATTGAGAGGAGAAAAAAATAG

Upstream 100 bases:

>100_bases
AAACCTATAAAAGCCTAAGTTTTAAATAAATACAAAAAATCTAGTGGCATAATATCTCTTTTTAGAGATAATGCTACTAG
ATTTTTATTGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GAGAATTTGTGGGTGATTTGATGTCCAAAATTTACAGGTGGATTTTGAAGGAGAATAAAGATTCTCGATTGTCTGAAGAA
GTACAAAAAACTTATGGGTT

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MNLPFIFRNKNITRRYKEILKILTKNGFGFISDILLKGGHIPFHILKSHDYMGAGERIRKTLEELGPTFIKMGQLLSTRG
DLIPHDILLELAKLQDDVEPEDFVTIKNILESELKGKISDFFIYFDETPIASASIGQVYRAKIKEGKDVVVKVQRPEVSQ
KINADIIILKNIAKILNERIVDAPLDFVEIVDELAESLLNELDYTQEGNNAERFRENFEKESYIYIPKVYWGYTTKRVLT
MEYVEGISVKNRDLLVKKGFDLKKIAREGAWAIFLQVYEFGLFHGDPHPGNILITNDGKISYIDFGIVGYLDKSSREMII
DLFKAFAENDIEEVIEVLSDMGAIRPDTNLRTLKSDLSHIINYFYNTPLKNISVNDSMRKIMSTVYKHKLILPPGFTLLL
KSLATVEGVGRSLDPDFSISSVAKDFIKEVYLRNISLTKILKENSKDLHKAIIVLRKLPSKIQSIMTKLIKDDIKVRINL
DESESLRYDLNIMVNKVIISIIASALIVASSLVLTFQGGYKIFGYNALGLFGYVVALLLCLWVFYRIFIIERRKK

Sequences:

>Translated_555_residues
MNLPFIFRNKNITRRYKEILKILTKNGFGFISDILLKGGHIPFHILKSHDYMGAGERIRKTLEELGPTFIKMGQLLSTRG
DLIPHDILLELAKLQDDVEPEDFVTIKNILESELKGKISDFFIYFDETPIASASIGQVYRAKIKEGKDVVVKVQRPEVSQ
KINADIIILKNIAKILNERIVDAPLDFVEIVDELAESLLNELDYTQEGNNAERFRENFEKESYIYIPKVYWGYTTKRVLT
MEYVEGISVKNRDLLVKKGFDLKKIAREGAWAIFLQVYEFGLFHGDPHPGNILITNDGKISYIDFGIVGYLDKSSREMII
DLFKAFAENDIEEVIEVLSDMGAIRPDTNLRTLKSDLSHIINYFYNTPLKNISVNDSMRKIMSTVYKHKLILPPGFTLLL
KSLATVEGVGRSLDPDFSISSVAKDFIKEVYLRNISLTKILKENSKDLHKAIIVLRKLPSKIQSIMTKLIKDDIKVRINL
DESESLRYDLNIMVNKVIISIIASALIVASSLVLTFQGGYKIFGYNALGLFGYVVALLLCLWVFYRIFIIERRKK
>Mature_555_residues
MNLPFIFRNKNITRRYKEILKILTKNGFGFISDILLKGGHIPFHILKSHDYMGAGERIRKTLEELGPTFIKMGQLLSTRG
DLIPHDILLELAKLQDDVEPEDFVTIKNILESELKGKISDFFIYFDETPIASASIGQVYRAKIKEGKDVVVKVQRPEVSQ
KINADIIILKNIAKILNERIVDAPLDFVEIVDELAESLLNELDYTQEGNNAERFRENFEKESYIYIPKVYWGYTTKRVLT
MEYVEGISVKNRDLLVKKGFDLKKIAREGAWAIFLQVYEFGLFHGDPHPGNILITNDGKISYIDFGIVGYLDKSSREMII
DLFKAFAENDIEEVIEVLSDMGAIRPDTNLRTLKSDLSHIINYFYNTPLKNISVNDSMRKIMSTVYKHKLILPPGFTLLL
KSLATVEGVGRSLDPDFSISSVAKDFIKEVYLRNISLTKILKENSKDLHKAIIVLRKLPSKIQSIMTKLIKDDIKVRINL
DESESLRYDLNIMVNKVIISIIASALIVASSLVLTFQGGYKIFGYNALGLFGYVVALLLCLWVFYRIFIIERRKK

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=303, Percent_Identity=29.3729372937294, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI217035081, Length=236, Percent_Identity=31.7796610169492, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI41393593, Length=264, Percent_Identity=29.9242424242424, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI34147522, Length=292, Percent_Identity=30.1369863013699, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI27363457, Length=363, Percent_Identity=24.7933884297521, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI217416386, Length=308, Percent_Identity=24.6753246753247, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI32261307, Length=315, Percent_Identity=23.4920634920635, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI2367309, Length=508, Percent_Identity=32.2834645669291, Blast_Score=238, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=34.6153846153846, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32565180, Length=367, Percent_Identity=25.6130790190736, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17555620, Length=478, Percent_Identity=25.3138075313808, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325148, Length=434, Percent_Identity=27.1889400921659, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=246, Percent_Identity=30.8943089430894, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321319, Length=254, Percent_Identity=26.3779527559055, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24662575, Length=294, Percent_Identity=30.2721088435374, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI22024280, Length=293, Percent_Identity=29.0102389078498, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18859849, Length=364, Percent_Identity=27.1978021978022, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63482; Mature: 63482

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50011 PROTEIN_KINASE_DOM ; PS50290 PI3_4_KINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPFIFRNKNITRRYKEILKILTKNGFGFISDILLKGGHIPFHILKSHDYMGAGERIRK
CCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TLEELGPTFIKMGQLLSTRGDLIPHDILLELAKLQDDVEPEDFVTIKNILESELKGKISD
HHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEE
FFIYFDETPIASASIGQVYRAKIKEGKDVVVKVQRPEVSQKINADIIILKNIAKILNERI
EEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCEEEHHHHHHHHHHHH
VDAPLDFVEIVDELAESLLNELDYTQEGNNAERFRENFEKESYIYIPKVYWGYTTKRVLT
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEECCCEECCCHHHEEE
MEYVEGISVKNRDLLVKKGFDLKKIAREGAWAIFLQVYEFGLFHGDPHPGNILITNDGKI
HHHHCCCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEE
SYIDFGIVGYLDKSSREMIIDLFKAFAENDIEEVIEVLSDMGAIRPDTNLRTLKSDLSHI
EEEEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
INYFYNTPLKNISVNDSMRKIMSTVYKHKLILPPGFTLLLKSLATVEGVGRSLDPDFSIS
HHHHHCCCCCCCCCCHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHH
SVAKDFIKEVYLRNISLTKILKENSKDLHKAIIVLRKLPSKIQSIMTKLIKDDIKVRINL
HHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
DESESLRYDLNIMVNKVIISIIASALIVASSLVLTFQGGYKIFGYNALGLFGYVVALLLC
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHH
LWVFYRIFIIERRKK
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLPFIFRNKNITRRYKEILKILTKNGFGFISDILLKGGHIPFHILKSHDYMGAGERIRK
CCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TLEELGPTFIKMGQLLSTRGDLIPHDILLELAKLQDDVEPEDFVTIKNILESELKGKISD
HHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEE
FFIYFDETPIASASIGQVYRAKIKEGKDVVVKVQRPEVSQKINADIIILKNIAKILNERI
EEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCEEEHHHHHHHHHHHH
VDAPLDFVEIVDELAESLLNELDYTQEGNNAERFRENFEKESYIYIPKVYWGYTTKRVLT
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEECCCEECCCHHHEEE
MEYVEGISVKNRDLLVKKGFDLKKIAREGAWAIFLQVYEFGLFHGDPHPGNILITNDGKI
HHHHCCCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEE
SYIDFGIVGYLDKSSREMIIDLFKAFAENDIEEVIEVLSDMGAIRPDTNLRTLKSDLSHI
EEEEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
INYFYNTPLKNISVNDSMRKIMSTVYKHKLILPPGFTLLLKSLATVEGVGRSLDPDFSIS
HHHHHCCCCCCCCCCHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHH
SVAKDFIKEVYLRNISLTKILKENSKDLHKAIIVLRKLPSKIQSIMTKLIKDDIKVRINL
HHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
DESESLRYDLNIMVNKVIISIIASALIVASSLVLTFQGGYKIFGYNALGLFGYVVALLLC
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHH
LWVFYRIFIIERRKK
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA