Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 167040088

GI number: 167040088

Start: 1483638

End: 1484558

Strand: Direct

Name: cysK [H]

Synonym: Teth514_1448

Alternate gene names: 167040088

Gene position: 1483638-1484558 (Clockwise)

Preceding gene: 167040085

Following gene: 167040089

Centisome position: 60.38

GC content: 36.37

Gene sequence:

>921_bases
ATGATTGCCAACAATGTTTTTGAGCTGATTGGAAAAACGCCAGTTGTTAAGTTAAATAAAATTGTTGAAAAAGAATGGGC
GGAAATTTATTTAAAATTAGAATTTTTTAATCCGGCAGGCAGTGTTAAAGATAGGGTAGCTTTTTCCATGATAGAAAAGG
CAGAAAAAGAAGGAAAATTAAAAAAAGGAAGTGTAATTATTGAACCTACCAGCGGAAATACAGGGATAGGGTTAGCGATG
GTAGGGGCAGCAAAAGGGTATAAGGTAATAATAGTTATGCCCGATACTATGAGTATGGAAAGAAGAATGCTTTTAACGGC
ATATGGGGCAGAAGTAGTTCTTACCCCTGGCAAATTGGGGATGGAAGGCGCTATAAAAAAAGCGGAAGAATTAGTAAGGC
AGAATAAAAACTATTTTATGCCACAACAGTTTGAAAATTTTGCAAATCCGTTAATTCATGAAGAGACTACTGCCAAAGAG
ATAATTGAAGATTTTAACGAAGGACTTGATGTTTTTGTTGCAGGTGTAGGTACGGGAGGAACTATTACAGGAGTAGGAAA
AATATTAAAAAATAAATTTTCTAATATAAAAATTATTGGAGTAGAGCCCTATTCAGCAGCAGTACTTTCTGGTAAAGAGC
CTGGTCCTCATAAGATTCAAGGGATTGGGGCAGGCTTCATTCCTAAGGTGTTAGATAAAAATGTCATAGATGAAGTAATT
GCTGTAAAAGATGAAGATGCCTTTGAGGTGACTCGTCTTTTAGCAAAAAAAGAAGGCATACTTGGAGGAATTTCTACAGG
TGCTTCCTTATGGGCAGCAATTGAAGTTGCTAAGAAATTAGGCAAAGGTAAAAAGGTTTTAGCAATAGCTCCTGACAGTG
GAGAGAGGTATTTAAGCACACAACTTTTTAGAGAGGATTAG

Upstream 100 bases:

>100_bases
TTTTTTCACTAAATTCTTTTGATATTCTAATTTCCATTTGACATGTTTAGCTTAGAAAGTTTAAAATTTTTATAGTAATG
TGCAAATGGAGGTAAATTTT

Downstream 100 bases:

>100_bases
ATTTACAAGCCTTATATTATTGTGTTAAAATATTTTAGACACAGTAAAGGAGGTTTTTTTATGTCAGGGCATTCAAAATG
GGCTAATATAAAACACAAAA

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIANNVFELIGKTPVVKLNKIVEKEWAEIYLKLEFFNPAGSVKDRVAFSMIEKAEKEGKLKKGSVIIEPTSGNTGIGLAM
VGAAKGYKVIIVMPDTMSMERRMLLTAYGAEVVLTPGKLGMEGAIKKAEELVRQNKNYFMPQQFENFANPLIHEETTAKE
IIEDFNEGLDVFVAGVGTGGTITGVGKILKNKFSNIKIIGVEPYSAAVLSGKEPGPHKIQGIGAGFIPKVLDKNVIDEVI
AVKDEDAFEVTRLLAKKEGILGGISTGASLWAAIEVAKKLGKGKKVLAIAPDSGERYLSTQLFRED

Sequences:

>Translated_306_residues
MIANNVFELIGKTPVVKLNKIVEKEWAEIYLKLEFFNPAGSVKDRVAFSMIEKAEKEGKLKKGSVIIEPTSGNTGIGLAM
VGAAKGYKVIIVMPDTMSMERRMLLTAYGAEVVLTPGKLGMEGAIKKAEELVRQNKNYFMPQQFENFANPLIHEETTAKE
IIEDFNEGLDVFVAGVGTGGTITGVGKILKNKFSNIKIIGVEPYSAAVLSGKEPGPHKIQGIGAGFIPKVLDKNVIDEVI
AVKDEDAFEVTRLLAKKEGILGGISTGASLWAAIEVAKKLGKGKKVLAIAPDSGERYLSTQLFRED
>Mature_306_residues
MIANNVFELIGKTPVVKLNKIVEKEWAEIYLKLEFFNPAGSVKDRVAFSMIEKAEKEGKLKKGSVIIEPTSGNTGIGLAM
VGAAKGYKVIIVMPDTMSMERRMLLTAYGAEVVLTPGKLGMEGAIKKAEELVRQNKNYFMPQQFENFANPLIHEETTAKE
IIEDFNEGLDVFVAGVGTGGTITGVGKILKNKFSNIKIIGVEPYSAAVLSGKEPGPHKIQGIGAGFIPKVLDKNVIDEVI
AVKDEDAFEVTRLLAKKEGILGGISTGASLWAAIEVAKKLGKGKKVLAIAPDSGERYLSTQLFRED

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=43.5064935064935, Blast_Score=248, Evalue=4e-66,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=43.5064935064935, Blast_Score=248, Evalue=4e-66,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=43.5064935064935, Blast_Score=248, Evalue=4e-66,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=51.9736842105263, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=41.8060200668896, Blast_Score=228, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=49, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=47.3333333333333, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=48.122866894198, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=46.7320261437908, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=45.2459016393443, Blast_Score=231, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=46.2616822429907, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=37.5776397515528, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25147552, Length=320, Percent_Identity=36.5625, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=44.9152542372881, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=303, Percent_Identity=28.0528052805281, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539800, Length=339, Percent_Identity=26.8436578171091, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539640, Length=336, Percent_Identity=25.5952380952381, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=39.0476190476191, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=36.8098159509202, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=42.5324675324675, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=42.5324675324675, Blast_Score=235, Evalue=3e-62,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33098; Mature: 33098

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIANNVFELIGKTPVVKLNKIVEKEWAEIYLKLEFFNPAGSVKDRVAFSMIEKAEKEGKL
CCCCHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
KKGSVIIEPTSGNTGIGLAMVGAAKGYKVIIVMPDTMSMERRMLLTAYGAEVVLTPGKLG
CCCCEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHEEEEECCEEEECCCCCC
MEGAIKKAEELVRQNKNYFMPQQFENFANPLIHEETTAKEIIEDFNEGLDVFVAGVGTGG
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
TITGVGKILKNKFSNIKIIGVEPYSAAVLSGKEPGPHKIQGIGAGFIPKVLDKNVIDEVI
CHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AVKDEDAFEVTRLLAKKEGILGGISTGASLWAAIEVAKKLGKGKKVLAIAPDSGERYLST
HCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
QLFRED
HHHCCC
>Mature Secondary Structure
MIANNVFELIGKTPVVKLNKIVEKEWAEIYLKLEFFNPAGSVKDRVAFSMIEKAEKEGKL
CCCCHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
KKGSVIIEPTSGNTGIGLAMVGAAKGYKVIIVMPDTMSMERRMLLTAYGAEVVLTPGKLG
CCCCEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHEEEEECCEEEECCCCCC
MEGAIKKAEELVRQNKNYFMPQQFENFANPLIHEETTAKEIIEDFNEGLDVFVAGVGTGG
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
TITGVGKILKNKFSNIKIIGVEPYSAAVLSGKEPGPHKIQGIGAGFIPKVLDKNVIDEVI
CHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AVKDEDAFEVTRLLAKKEGILGGISTGASLWAAIEVAKKLGKGKKVLAIAPDSGERYLST
HCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
QLFRED
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA