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The map label for this gene is nagB [H]

Identifier: 167040073

GI number: 167040073

Start: 1467467

End: 1468228

Strand: Direct

Name: nagB [H]

Synonym: Teth514_1433

Alternate gene names: 167040073

Gene position: 1467467-1468228 (Clockwise)

Preceding gene: 167040072

Following gene: 167040074

Centisome position: 59.72

GC content: 31.5

Gene sequence:

>762_bases
ATGAAAGTAATTATAACTGTAAATTATGAGGAAATGAGTAAAAAGGCAGCAGAAATTGTGAAAAAGCAAATCAAAGAAAA
ACCTAATACGGTTTTAGGGCTTGCTACAGGTTCTACGCCTCTGGGGATGTATAAACATTTAATTGAGATGTATAAAAGAG
GGGAAATAGATTTTTCTAATGTCATTACTTTTAATTTAGACGAATACATTGGTTTATCTCCAGACCATCCTCAAAGCTAT
CATTATTTTATGTTCCACAATTTTTTCAATCATATTAACATTAAAAAAGAAAATGTTCATATTCCAAATGGTATAGCCGA
GGATTTAGAAGAAGAATGTAGAAAATATGAAGAAGAAATAGAAAAAGCAGGAGGAATTGATTTACAGATATTAGGAATTG
GTATAAATGGACATATAGGGTTTAATGAGCCAGATGAAAGTATAGAGACAAAAACACATGTGGTTACTTTGACTGAAAAG
ACGATAAATGCTAATAAGAGATTTTTTAAAAGCGCAGAGGAAGTGCCAAGAAAGGCGATTACTATGGGACTTGGAAGTAT
CATGAAAGCAAAGAAAATTGTCCTTTTGGCATCTGGAAAAAATAAAGCAGAGGCAATAAAAGAAACTATAAAAGGACAAT
TGACTACTAAAGTGCCTGCTACTGTTTTAGCTTTACATCACGATGTAACTATAATAATTGATAAGGAGGCTGCTTCACTT
ATACCCGATGAAGATTTAAAAGAAATAGAAGTAATTGTTTAA

Upstream 100 bases:

>100_bases
TAAAGTAGCTCAACTTGGTGAAGATGCTTCTGCTATTGGGGCGGTAGCCGATGTGCTTTTAAATACAAATAATTTAATTT
TACTATAAGGAGGCCATAAG

Downstream 100 bases:

>100_bases
TAGGCGAAAGCCTGTTTTTTTATATTTTCAAAAGATAACTGTATAATTTATAATGTAAGGAAAAAATGGTTATAGATAGG
TAAAAACATGAATAGCGGTG

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKVIITVNYEEMSKKAAEIVKKQIKEKPNTVLGLATGSTPLGMYKHLIEMYKRGEIDFSNVITFNLDEYIGLSPDHPQSY
HYFMFHNFFNHINIKKENVHIPNGIAEDLEEECRKYEEEIEKAGGIDLQILGIGINGHIGFNEPDESIETKTHVVTLTEK
TINANKRFFKSAEEVPRKAITMGLGSIMKAKKIVLLASGKNKAEAIKETIKGQLTTKVPATVLALHHDVTIIIDKEAASL
IPDEDLKEIEVIV

Sequences:

>Translated_253_residues
MKVIITVNYEEMSKKAAEIVKKQIKEKPNTVLGLATGSTPLGMYKHLIEMYKRGEIDFSNVITFNLDEYIGLSPDHPQSY
HYFMFHNFFNHINIKKENVHIPNGIAEDLEEECRKYEEEIEKAGGIDLQILGIGINGHIGFNEPDESIETKTHVVTLTEK
TINANKRFFKSAEEVPRKAITMGLGSIMKAKKIVLLASGKNKAEAIKETIKGQLTTKVPATVLALHHDVTIIIDKEAASL
IPDEDLKEIEVIV
>Mature_253_residues
MKVIITVNYEEMSKKAAEIVKKQIKEKPNTVLGLATGSTPLGMYKHLIEMYKRGEIDFSNVITFNLDEYIGLSPDHPQSY
HYFMFHNFFNHINIKKENVHIPNGIAEDLEEECRKYEEEIEKAGGIDLQILGIGINGHIGFNEPDESIETKTHVVTLTEK
TINANKRFFKSAEEVPRKAITMGLGSIMKAKKIVLLASGKNKAEAIKETIKGQLTTKVPATVLALHHDVTIIIDKEAASL
IPDEDLKEIEVIV

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=244, Percent_Identity=45.4918032786885, Blast_Score=211, Evalue=5e-55,
Organism=Homo sapiens, GI19923881, Length=243, Percent_Identity=42.3868312757202, Blast_Score=201, Evalue=5e-52,
Organism=Escherichia coli, GI1786893, Length=243, Percent_Identity=40.3292181069959, Blast_Score=201, Evalue=3e-53,
Organism=Escherichia coli, GI1789530, Length=227, Percent_Identity=32.15859030837, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI48994958, Length=236, Percent_Identity=31.7796610169492, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17554876, Length=242, Percent_Identity=45.0413223140496, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24581960, Length=243, Percent_Identity=44.8559670781893, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI19920764, Length=243, Percent_Identity=44.8559670781893, Blast_Score=221, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 28412; Mature: 28412

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIITVNYEEMSKKAAEIVKKQIKEKPNTVLGLATGSTPLGMYKHLIEMYKRGEIDFSN
CEEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
VITFNLDEYIGLSPDHPQSYHYFMFHNFFNHINIKKENVHIPNGIAEDLEEECRKYEEEI
EEEEECHHHCCCCCCCCCCEEEHHHHHHHHHCEEEECCEECCCCHHHHHHHHHHHHHHHH
EKAGGIDLQILGIGINGHIGFNEPDESIETKTHVVTLTEKTINANKRFFKSAEEVPRKAI
HHCCCCEEEEEEEEEECCCCCCCCCHHHCCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHH
TMGLGSIMKAKKIVLLASGKNKAEAIKETIKGQLTTKVPATVLALHHDVTIIIDKEAASL
HHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCEECCCCHHEEEEECCEEEEEECCHHHC
IPDEDLKEIEVIV
CCCCCCCCEEEEC
>Mature Secondary Structure
MKVIITVNYEEMSKKAAEIVKKQIKEKPNTVLGLATGSTPLGMYKHLIEMYKRGEIDFSN
CEEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
VITFNLDEYIGLSPDHPQSYHYFMFHNFFNHINIKKENVHIPNGIAEDLEEECRKYEEEI
EEEEECHHHCCCCCCCCCCEEEHHHHHHHHHCEEEECCEECCCCHHHHHHHHHHHHHHHH
EKAGGIDLQILGIGINGHIGFNEPDESIETKTHVVTLTEKTINANKRFFKSAEEVPRKAI
HHCCCCEEEEEEEEEECCCCCCCCCHHHCCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHH
TMGLGSIMKAKKIVLLASGKNKAEAIKETIKGQLTTKVPATVLALHHDVTIIIDKEAASL
HHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCEECCCCHHEEEEECCEEEEEECCHHHC
IPDEDLKEIEVIV
CCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA