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The map label for this gene is hemL [H]

Identifier: 167038988

GI number: 167038988

Start: 336680

End: 338560

Strand: Direct

Name: hemL [H]

Synonym: Teth514_0321

Alternate gene names: 167038988

Gene position: 336680-338560 (Clockwise)

Preceding gene: 167038987

Following gene: 167038989

Centisome position: 13.7

GC content: 37.16

Gene sequence:

>1881_bases
ATGGTTTATTACCCTATAATGCTTAATATAAAAAACAAAAAATGCCTTGTTGTAGGGGGTGGCAAAGTTGCTCTTAGAAA
AATTTTATCTCTTGTTGAAGGAGAAGCTTTAGTTACTGCCATTTCTCCTTCTTTTGATGAGGAAATACTTAAGCTTTCAG
CAAAAGAAAAGGTGGAACTTATAAGACGTGAGTATCAACAAGGGGATGTAAGGGGATTTTTTGTTGCGATTGCTGCTACA
GATGATGAGAAGGTAAATAAACTTGTTGCGTCAGATGGAGAAAAATACAATGTGCTTGTAAATGTGGTTGATGATAAAGA
CCTTTCTTCTTTTATTGTACCTGCCATTGTAAAAAGGGGAGACTTAATTATTTCTATATCTACAAGTGGCAAAAGTCCAC
TTCTTTCGAGAATGATAAAAGAAAAATTGGAGTCAATTTTCAATGACGAGTATGAAAAACTATTACAAAAGCTATACCAG
AAGAGGATAGAATTAAAGGAAAAAGATTTTGCTGAAGAAGAGAAAATGGCTATTTACAGAAAAATTATTGAGAAAAGCGG
GCTGTTAAGAGGTGATTCTGTGAAAACTGATAAATCACAAAAGCTTTTTGAAAAAGCTAAAAAACTTATGCCGGGTGGTG
TCAATAGCCCTGTAAGGGCTTTTAAATCAGTAGGAGCTACTCCTGTTTTTATAAAAAAGGGGCAAGGAAGTCATATATGG
GATGAAGATGGCAATGAATACATAGACTACGTTCTTTCATGGGGACCGCTAATACTTGGGCATTCACATCCACAGGTGGT
AGAAGCTATTAAAAAACAGGCACAACTTGGGACCAGTTTTGGAGCCTGCACAGAGTTAGAAGTTAAGATGGCGGAAAAAG
TAATTGAGGCTGTTCCATCTGTAGAAGTTGTCAGAATGGTAAATTCAGGAACAGAAGCCACCATGAGTGCTATAAGGCTT
GCAAGGGGGTATACGGGCAGAGACATCATTGTAAAATTTGAAGGATGTTATCACGGACATTCTGACAGCTTACTTATAAA
AGCAGGCTCAGGGGCACTTACTTTTGGAATTCCTGATTCAAAGGGCGTGACAAAAGAGGTAGCAAAGGATACAATTATAG
CGAGATACAATGACATCAAAATGGTAGAAGACATTTTTAAAGTTTATGGTGAAAATATTGCTGGTGTCATTGTAGAGCCT
GTTGCCGGAAACATGGGTACTGTTTTGCCTGATGAAGAGTTTTTAAAAGGATTGAGAGAGATTACTACAAAGTATGGGGC
ACTTTTAATTTTTGATGAAGTGATGACAGGTTTTAGAGTGTCTTATTCGGGGGCACAAGGATTTTACAACGTCATGCCTG
ACATTACCACACTTGGGAAAATCATTGGAGGTGGACTTCCTGTCGGTGCCTATGGAGGAAGAGAAGAGATAATGAGGTTG
GTTTCTCCTGATGGGCCTGTGTACCAAGCAGGGACTTTGTCTGGCAATCCTCTTGCAATGGCAGCAGGCTTTGAGACTTT
AAAAATATTATCTGAGGATCCGACCCTTTATGAAGAATTAGATAAAAAAGCAGAAAAACTATGTAATGGGTTAAAAGAGA
GCATGGTTCAAAATGGAATTGATGTTACAATAAATAGAATAGGCAGCATGATGTGTATGTTTTTTAATAAAGAGAGTGTG
CATGACTATGATTCTGCACTAAAATCGAATACTACTTTATACGCTAAATATTTTAGAGAGATGCTTAAAAGAGGAATATA
CATGCCGCCTTCACAATTTGAAACCTTCTTTTTGTCAACTGCTCACACAGATGATGACATTGAAAAAACGATTGAAACAA
GTTTTGAAGTGGCGAAAATTATAAGTCAGCAATTAGAATAA

Upstream 100 bases:

>100_bases
GTTGGATTGATGAAAAATCGGTAGTCTTAGAAATACTCACTTCAATTAAAAGGGCAGGGGCAGACATAGTTATAACCTAC
TTTGCAAAGGATGTTGCAAA

Downstream 100 bases:

>100_bases
AGGCATTTCGGTTTGTGCAAAATGTCAAACTGAATGAGTTATCTACAAAATCTTAGCACAGATAGAATTCTTGCCTTTTA
TTGACAACCTAATTTATAAA

Product: glutamate-1-semialdehyde-2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MVYYPIMLNIKNKKCLVVGGGKVALRKILSLVEGEALVTAISPSFDEEILKLSAKEKVELIRREYQQGDVRGFFVAIAAT
DDEKVNKLVASDGEKYNVLVNVVDDKDLSSFIVPAIVKRGDLIISISTSGKSPLLSRMIKEKLESIFNDEYEKLLQKLYQ
KRIELKEKDFAEEEKMAIYRKIIEKSGLLRGDSVKTDKSQKLFEKAKKLMPGGVNSPVRAFKSVGATPVFIKKGQGSHIW
DEDGNEYIDYVLSWGPLILGHSHPQVVEAIKKQAQLGTSFGACTELEVKMAEKVIEAVPSVEVVRMVNSGTEATMSAIRL
ARGYTGRDIIVKFEGCYHGHSDSLLIKAGSGALTFGIPDSKGVTKEVAKDTIIARYNDIKMVEDIFKVYGENIAGVIVEP
VAGNMGTVLPDEEFLKGLREITTKYGALLIFDEVMTGFRVSYSGAQGFYNVMPDITTLGKIIGGGLPVGAYGGREEIMRL
VSPDGPVYQAGTLSGNPLAMAAGFETLKILSEDPTLYEELDKKAEKLCNGLKESMVQNGIDVTINRIGSMMCMFFNKESV
HDYDSALKSNTTLYAKYFREMLKRGIYMPPSQFETFFLSTAHTDDDIEKTIETSFEVAKIISQQLE

Sequences:

>Translated_626_residues
MVYYPIMLNIKNKKCLVVGGGKVALRKILSLVEGEALVTAISPSFDEEILKLSAKEKVELIRREYQQGDVRGFFVAIAAT
DDEKVNKLVASDGEKYNVLVNVVDDKDLSSFIVPAIVKRGDLIISISTSGKSPLLSRMIKEKLESIFNDEYEKLLQKLYQ
KRIELKEKDFAEEEKMAIYRKIIEKSGLLRGDSVKTDKSQKLFEKAKKLMPGGVNSPVRAFKSVGATPVFIKKGQGSHIW
DEDGNEYIDYVLSWGPLILGHSHPQVVEAIKKQAQLGTSFGACTELEVKMAEKVIEAVPSVEVVRMVNSGTEATMSAIRL
ARGYTGRDIIVKFEGCYHGHSDSLLIKAGSGALTFGIPDSKGVTKEVAKDTIIARYNDIKMVEDIFKVYGENIAGVIVEP
VAGNMGTVLPDEEFLKGLREITTKYGALLIFDEVMTGFRVSYSGAQGFYNVMPDITTLGKIIGGGLPVGAYGGREEIMRL
VSPDGPVYQAGTLSGNPLAMAAGFETLKILSEDPTLYEELDKKAEKLCNGLKESMVQNGIDVTINRIGSMMCMFFNKESV
HDYDSALKSNTTLYAKYFREMLKRGIYMPPSQFETFFLSTAHTDDDIEKTIETSFEVAKIISQQLE
>Mature_626_residues
MVYYPIMLNIKNKKCLVVGGGKVALRKILSLVEGEALVTAISPSFDEEILKLSAKEKVELIRREYQQGDVRGFFVAIAAT
DDEKVNKLVASDGEKYNVLVNVVDDKDLSSFIVPAIVKRGDLIISISTSGKSPLLSRMIKEKLESIFNDEYEKLLQKLYQ
KRIELKEKDFAEEEKMAIYRKIIEKSGLLRGDSVKTDKSQKLFEKAKKLMPGGVNSPVRAFKSVGATPVFIKKGQGSHIW
DEDGNEYIDYVLSWGPLILGHSHPQVVEAIKKQAQLGTSFGACTELEVKMAEKVIEAVPSVEVVRMVNSGTEATMSAIRL
ARGYTGRDIIVKFEGCYHGHSDSLLIKAGSGALTFGIPDSKGVTKEVAKDTIIARYNDIKMVEDIFKVYGENIAGVIVEP
VAGNMGTVLPDEEFLKGLREITTKYGALLIFDEVMTGFRVSYSGAQGFYNVMPDITTLGKIIGGGLPVGAYGGREEIMRL
VSPDGPVYQAGTLSGNPLAMAAGFETLKILSEDPTLYEELDKKAEKLCNGLKESMVQNGIDVTINRIGSMMCMFFNKESV
HDYDSALKSNTTLYAKYFREMLKRGIYMPPSQFETFFLSTAHTDDDIEKTIETSFEVAKIISQQLE

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=349, Percent_Identity=30.3724928366762, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=338, Percent_Identity=29.8816568047337, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI37574042, Length=327, Percent_Identity=29.3577981651376, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI13994255, Length=321, Percent_Identity=28.3489096573209, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI226442705, Length=326, Percent_Identity=27.9141104294479, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI226442709, Length=293, Percent_Identity=30.0341296928328, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI284507298, Length=269, Percent_Identity=30.8550185873606, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1786349, Length=421, Percent_Identity=55.3444180522565, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1788044, Length=294, Percent_Identity=34.6938775510204, Blast_Score=149, Evalue=7e-37,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=35.048231511254, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789016, Length=360, Percent_Identity=30, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI145693181, Length=355, Percent_Identity=28.7323943661972, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1787560, Length=350, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1789768, Length=218, Percent_Identity=27.9816513761468, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786991, Length=301, Percent_Identity=29.2358803986711, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=345, Percent_Identity=31.0144927536232, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71992977, Length=336, Percent_Identity=29.7619047619048, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=324, Percent_Identity=29.6296296296296, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=140, Percent_Identity=40, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=323, Percent_Identity=30.3405572755418, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=322, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357415, Length=320, Percent_Identity=29.0625, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21356575, Length=336, Percent_Identity=29.1666666666667, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 69205; Mature: 69205

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYYPIMLNIKNKKCLVVGGGKVALRKILSLVEGEALVTAISPSFDEEILKLSAKEKVEL
CEEEEEEEEECCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHH
IRREYQQGDVRGFFVAIAATDDEKVNKLVASDGEKYNVLVNVVDDKDLSSFIVPAIVKRG
HHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCC
DLIISISTSGKSPLLSRMIKEKLESIFNDEYEKLLQKLYQKRIELKEKDFAEEEKMAIYR
CEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHH
KIIEKSGLLRGDSVKTDKSQKLFEKAKKLMPGGVNSPVRAFKSVGATPVFIKKGQGSHIW
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
DEDGNEYIDYVLSWGPLILGHSHPQVVEAIKKQAQLGTSFGACTELEVKMAEKVIEAVPS
CCCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
VEVVRMVNSGTEATMSAIRLARGYTGRDIIVKFEGCYHGHSDSLLIKAGSGALTFGIPDS
HHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECEECCCCCCEEEEECCCEEEECCCCC
KGVTKEVAKDTIIARYNDIKMVEDIFKVYGENIAGVIVEPVAGNMGTVLPDEEFLKGLRE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
ITTKYGALLIFDEVMTGFRVSYSGAQGFYNVMPDITTLGKIIGGGLPVGAYGGREEIMRL
HHHHHHHHEEEHHHHHCEEEEECCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
VSPDGPVYQAGTLSGNPLAMAAGFETLKILSEDPTLYEELDKKAEKLCNGLKESMVQNGI
HCCCCCEEECCCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DVTINRIGSMMCMFFNKESVHDYDSALKSNTTLYAKYFREMLKRGIYMPPSQFETFFLST
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHEEEEEE
AHTDDDIEKTIETSFEVAKIISQQLE
CCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVYYPIMLNIKNKKCLVVGGGKVALRKILSLVEGEALVTAISPSFDEEILKLSAKEKVEL
CEEEEEEEEECCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHH
IRREYQQGDVRGFFVAIAATDDEKVNKLVASDGEKYNVLVNVVDDKDLSSFIVPAIVKRG
HHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCC
DLIISISTSGKSPLLSRMIKEKLESIFNDEYEKLLQKLYQKRIELKEKDFAEEEKMAIYR
CEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHH
KIIEKSGLLRGDSVKTDKSQKLFEKAKKLMPGGVNSPVRAFKSVGATPVFIKKGQGSHIW
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
DEDGNEYIDYVLSWGPLILGHSHPQVVEAIKKQAQLGTSFGACTELEVKMAEKVIEAVPS
CCCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
VEVVRMVNSGTEATMSAIRLARGYTGRDIIVKFEGCYHGHSDSLLIKAGSGALTFGIPDS
HHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECEECCCCCCEEEEECCCEEEECCCCC
KGVTKEVAKDTIIARYNDIKMVEDIFKVYGENIAGVIVEPVAGNMGTVLPDEEFLKGLRE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
ITTKYGALLIFDEVMTGFRVSYSGAQGFYNVMPDITTLGKIIGGGLPVGAYGGREEIMRL
HHHHHHHHEEEHHHHHCEEEEECCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
VSPDGPVYQAGTLSGNPLAMAAGFETLKILSEDPTLYEELDKKAEKLCNGLKESMVQNGI
HCCCCCEEECCCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DVTINRIGSMMCMFFNKESVHDYDSALKSNTTLYAKYFREMLKRGIYMPPSQFETFFLST
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHEEEEEE
AHTDDDIEKTIETSFEVAKIISQQLE
CCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA