Click here to switch to the map view.

The map label for this gene is mtlA [H]

Identifier: 167038936

GI number: 167038936

Start: 283984

End: 285429

Strand: Direct

Name: mtlA [H]

Synonym: Teth514_0268

Alternate gene names: 167038936

Gene position: 283984-285429 (Clockwise)

Preceding gene: 167038935

Following gene: 167038937

Centisome position: 11.56

GC content: 39.0

Gene sequence:

>1446_bases
ATGCAAAACACTAATGCTCTCATAACTGGTGGCGGAAGTGTGAAAGCGAAGTTGCAAAAGCTTGGTGGCTTCTTGGCTGG
CATGGTAATACCTAATATTGGTGCCTTTATAGCATGGGGACTTATTACTGCTTTCTTTATTCCAACAGGGTGGATTCCAA
ATGAACATTTGGCTAAACTTGTTGGACCTATGATAACGTATCTTTTACCAATTTTAATCGGTTATACAGGTGGTAAACTT
GTATACGATGTAAGAGGTGGAGTAGTAGGAGCCATTGCAACAGCAGGTATCATAATCGGTTCATCTATACCGATGTTTCT
CGGTGCTATGCTGATGGGTCCTTTAGGAGGCTATGTCATTAAAAAATTTGACGAGCTTGTAGAAGGAAAAATCCCAGCAG
GTTTTGAAATGCTTGTCAACAATTTCTCAGCAGGTATTTTAGGTGGTTTATTAGCAATTTTAGCATTTCTTTTCGTTGAA
CCAGTGGTAAATGGCATATCAGTAGGATTAGGTGCAGCAGCTCAATGGGTGACAAACAAAGGCTTATTACCTTTAATAGC
AATTTTTATAGAACCAGGGAAGATATTGTTTTTAAATAACGCTATTAACCACGGTATATTGGCTCCTCTTGGAGTAGCAC
AGGTTAAAGAGCTTGGAAAGTCAATATTCTTCTTACTGGAAACTAATCCAGGTCCAGGTTTGGGGGTTTTACTGGCATAT
TGGCTTTTTGGAAAAGGCGATGCAAAACAATCAGCTCCGGGTGCTATCATAATACACTTTTTTGGCGGAATACATGAAAT
ATATTTTCCCTATGTTTTGATGAATCCATCACTACTCTTGGCAGTTATAGGCGGTGGAATGGCTGCAGACGCGACATTTG
TTTTGACAAAAGCGGGTTTGGTAGCTACACCTTCACCTGGTAGTATATTTGCAGAGATAGCTATGTCACCAAAAGGCGGA
TTACTTCCTGTACTTGCAGGTATTACAGTTGGAGCTGTTGTTTCTTTCCTCATAGCTTCTGTCATTGTAAAAAGGGCAAG
CGAAGAAAGCATGAGTGCAGAAAGCATGACTTTTGCTCGCTCGATCGTTAGTGGACTTAAAGCGCAAAGCAAAGGACAAA
AAGTTGAAGAAGTAAAGCCTAGTGTACAGAAAATAGAGAGTATGCCTAAATTGATTGTTTTTGCTTGCGATGCTGGTATG
GGTTCGTCAGCAATGGGAGAAACTATTTTAAAGAAGAAGTTAAAGGAAGCAGGGCTTAATATTACAGTTAAGCATTCAGC
TGTAAATCAAATACCAAAAGAAGCGGATGTTGTATTTACCCAAGAAAATCTCGCAGAAAGGGCTTCTCAAGTCGTACCAA
ATGCGAAAATCGTTACAGTAAAAAACTTTTTAGATAACACTGTTTACGATGAATTTGTAAAAAGCCTTGTAAAAAATCAA
AAATAA

Upstream 100 bases:

>100_bases
AGAAAACGAATGACAAAACTGATTTTCTTTGAATTGCATAAATGCATATGGGGGTTTACAATAATTATAGAAGAATAAAT
GCAAAAAGGAGGTAAAACTT

Downstream 100 bases:

>100_bases
TTAATGGTGAAAATTATGGATGAGTTAACTGTAAGGCAAAGGTTTATATTAAAAACTTTATTGGAGAAAGGTCCTTCTAA
TATAGAGGACCTTTCCAAGC

Product: PTS system, mannitol-specific IIC subunit

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MQNTNALITGGGSVKAKLQKLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWIPNEHLAKLVGPMITYLLPILIGYTGGKL
VYDVRGGVVGAIATAGIIIGSSIPMFLGAMLMGPLGGYVIKKFDELVEGKIPAGFEMLVNNFSAGILGGLLAILAFLFVE
PVVNGISVGLGAAAQWVTNKGLLPLIAIFIEPGKILFLNNAINHGILAPLGVAQVKELGKSIFFLLETNPGPGLGVLLAY
WLFGKGDAKQSAPGAIIIHFFGGIHEIYFPYVLMNPSLLLAVIGGGMAADATFVLTKAGLVATPSPGSIFAEIAMSPKGG
LLPVLAGITVGAVVSFLIASVIVKRASEESMSAESMTFARSIVSGLKAQSKGQKVEEVKPSVQKIESMPKLIVFACDAGM
GSSAMGETILKKKLKEAGLNITVKHSAVNQIPKEADVVFTQENLAERASQVVPNAKIVTVKNFLDNTVYDEFVKSLVKNQ
K

Sequences:

>Translated_481_residues
MQNTNALITGGGSVKAKLQKLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWIPNEHLAKLVGPMITYLLPILIGYTGGKL
VYDVRGGVVGAIATAGIIIGSSIPMFLGAMLMGPLGGYVIKKFDELVEGKIPAGFEMLVNNFSAGILGGLLAILAFLFVE
PVVNGISVGLGAAAQWVTNKGLLPLIAIFIEPGKILFLNNAINHGILAPLGVAQVKELGKSIFFLLETNPGPGLGVLLAY
WLFGKGDAKQSAPGAIIIHFFGGIHEIYFPYVLMNPSLLLAVIGGGMAADATFVLTKAGLVATPSPGSIFAEIAMSPKGG
LLPVLAGITVGAVVSFLIASVIVKRASEESMSAESMTFARSIVSGLKAQSKGQKVEEVKPSVQKIESMPKLIVFACDAGM
GSSAMGETILKKKLKEAGLNITVKHSAVNQIPKEADVVFTQENLAERASQVVPNAKIVTVKNFLDNTVYDEFVKSLVKNQ
K
>Mature_481_residues
MQNTNALITGGGSVKAKLQKLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWIPNEHLAKLVGPMITYLLPILIGYTGGKL
VYDVRGGVVGAIATAGIIIGSSIPMFLGAMLMGPLGGYVIKKFDELVEGKIPAGFEMLVNNFSAGILGGLLAILAFLFVE
PVVNGISVGLGAAAQWVTNKGLLPLIAIFIEPGKILFLNNAINHGILAPLGVAQVKELGKSIFFLLETNPGPGLGVLLAY
WLFGKGDAKQSAPGAIIIHFFGGIHEIYFPYVLMNPSLLLAVIGGGMAADATFVLTKAGLVATPSPGSIFAEIAMSPKGG
LLPVLAGITVGAVVSFLIASVIVKRASEESMSAESMTFARSIVSGLKAQSKGQKVEEVKPSVQKIESMPKLIVFACDAGM
GSSAMGETILKKKLKEAGLNITVKHSAVNQIPKEADVVFTQENLAERASQVVPNAKIVTVKNFLDNTVYDEFVKSLVKNQ
K

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=472, Percent_Identity=56.5677966101695, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1789301, Length=470, Percent_Identity=52.3404255319149, Blast_Score=469, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 50343; Mature: 50343

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNTNALITGGGSVKAKLQKLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWIPNEHLAKL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VGPMITYLLPILIGYTGGKLVYDVRGGVVGAIATAGIIIGSSIPMFLGAMLMGPLGGYVI
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KKFDELVEGKIPAGFEMLVNNFSAGILGGLLAILAFLFVEPVVNGISVGLGAAAQWVTNK
HHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
GLLPLIAIFIEPGKILFLNNAINHGILAPLGVAQVKELGKSIFFLLETNPGPGLGVLLAY
CHHHHHHHEECCCCEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHH
WLFGKGDAKQSAPGAIIIHFFGGIHEIYFPYVLMNPSLLLAVIGGGMAADATFVLTKAGL
HHHCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHEEHHHCCCCCCCCEEEEEECCE
VATPSPGSIFAEIAMSPKGGLLPVLAGITVGAVVSFLIASVIVKRASEESMSAESMTFAR
EECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
SIVSGLKAQSKGQKVEEVKPSVQKIESMPKLIVFACDAGMGSSAMGETILKKKLKEAGLN
HHHHHHHHHHCCCHHHHHCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
ITVKHSAVNQIPKEADVVFTQENLAERASQVVPNAKIVTVKNFLDNTVYDEFVKSLVKNQ
EEEECHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
K
C
>Mature Secondary Structure
MQNTNALITGGGSVKAKLQKLGGFLAGMVIPNIGAFIAWGLITAFFIPTGWIPNEHLAKL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VGPMITYLLPILIGYTGGKLVYDVRGGVVGAIATAGIIIGSSIPMFLGAMLMGPLGGYVI
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KKFDELVEGKIPAGFEMLVNNFSAGILGGLLAILAFLFVEPVVNGISVGLGAAAQWVTNK
HHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
GLLPLIAIFIEPGKILFLNNAINHGILAPLGVAQVKELGKSIFFLLETNPGPGLGVLLAY
CHHHHHHHEECCCCEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHH
WLFGKGDAKQSAPGAIIIHFFGGIHEIYFPYVLMNPSLLLAVIGGGMAADATFVLTKAGL
HHHCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHEEHHHCCCCCCCCEEEEEECCE
VATPSPGSIFAEIAMSPKGGLLPVLAGITVGAVVSFLIASVIVKRASEESMSAESMTFAR
EECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
SIVSGLKAQSKGQKVEEVKPSVQKIESMPKLIVFACDAGMGSSAMGETILKKKLKEAGLN
HHHHHHHHHHCCCHHHHHCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
ITVKHSAVNQIPKEADVVFTQENLAERASQVVPNAKIVTVKNFLDNTVYDEFVKSLVKNQ
EEEECHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11160802; 11466286 [H]