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The map label for this gene is macA [H]

Identifier: 167038867

GI number: 167038867

Start: 200338

End: 201903

Strand: Direct

Name: macA [H]

Synonym: Teth514_0198

Alternate gene names: 167038867

Gene position: 200338-201903 (Clockwise)

Preceding gene: 167038866

Following gene: 167038868

Centisome position: 8.15

GC content: 35.76

Gene sequence:

>1566_bases
ATGAAGAGGAAATATTTATATGCGATTGTTGCAGTATTAATCATTGGAATTGCCACTTTTTACTTTGTAAACAGGGCAAA
ATCATCACAACCCCAGCAGCTTTCATATGTTACAGTTACTCGTGGTAATATTTCTATGGAAGTCACTGGAACAGGAAACT
TAAGTGGCGATGTAAGAGCAATTACGTTAAAAGGCAGTGGAACAGTAAAGAAAGTGTATTTTAAGGTAGGAGATACTGTA
AAGAAAGGAGACCTATTATACGAAATTGAAGATGACGATTTAAATAATCAGCTTGAAGAAGCCAAATTAAATCTTGATTT
AGCACAGCAGCAATTAAATCAAGAAAAGCAAAATTATAATAATAGCCTTGCTAAGTTGAGTATAACTGCACCTTCTGATG
GAGTTGTACAGGTATTAGTAAAAGAAGGACAGGATGTTACTCCAGGTATGCCTGTTGCAATAATTGGGGATAATTCAAAA
GAGAATGAAACTGCAGAAAATAATGGGCAAACTACTCAAAATTCAGTTAATGTTACAGCACAAATTGCAGGTACAGTAGA
AAAAGTATATGTGTCCCAGGGACAAAATGTAAAAAAAGGCCAACTTTTAATAAAACTATCCTCGAATAATATAAGTGATG
CACAAATAAAAAATGCCGAATTAAAACTGAAGCAAGCACAAAACCAGTACAATCAGATTTTGCAACAAATTGATAACTTA
AAAATTTACTCTCCTATAGATGGGAAGATCCTTAGCCAAAATATAAACGAAGGAGATATACTAGGTACTTCTGTAGCGAG
CACTAACATAAGCAATACAAATAGCCAATCGCAGCAAGCAGGTTTTGTGCCCGTTTTAGATATAACACAATTATCTACTT
ATGAGAGTCAACCAGAAACTGCGGTAATAGTGGGCAATTCTAATTATGTTGTCAATCTTTCTGTTGACGAGACAGACATA
AAAAATATAAAAGTAGGGCAGCAAGCACAGCTTACAACAGATAATTTACCGGGTAAGACTTTTACCGGTACTGTTTCACA
AGTATCACAACTTCCAACAATACAAAACGGAGTAGCTTCTTATAATGTAACTATTGAAGTAGAGCCAAGTGAAGACTTAC
TTTTAGGAATGTCAATGAATGTTTCAATAACTGTTGCAGAAAAACAAGATGCTTTAATACTTCCTATACAAGCTGTTCAG
ACAAACGGTGATAGAAAATACGTAATACTCTACACAAACGATTTAAAAAATCAAAATATCAATAGCACTAACAATAGCAC
TAATAACAGGAACTCTTTCAGGAACAACATGCGATTTGTAGAGACAGGCATATACAACGACAACTTTATAGAAATCGTGA
GCGGTTTACAGGAGGGAGACAAAGTATTAATTCCAACCCTTAATTCTTCAACAAACGCAAATAACAGTAATCTAGGTGGT
TTTGGTGGAATGGGTGGCTTTAGGCCAGGAGGCAATTTCAACGGGAACAGCACAAGCCAAGGTGGTAGTTACCCAGGCGG
AAGCTTTAACAGGACATGGCAAAATAACTCTTCCCAAGGGAGGTAA

Upstream 100 bases:

>100_bases
AAAGTTTAGACTACACAAATTTATCACATATTCTTAATTTTTACATAACAATTTTTTGATATTTTAATTATAACATCAAT
TTTTTAGAAGAGGTGGATTT

Downstream 100 bases:

>100_bases
ATGATGGATAGTGTTTTGATAAAAATAAGGAATTTAACAAAGATTTACAAAATGGGGGAAAATGAAGTAAGAGCGTTAGA
TGGTATAAACCTTGACATTG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MKRKYLYAIVAVLIIGIATFYFVNRAKSSQPQQLSYVTVTRGNISMEVTGTGNLSGDVRAITLKGSGTVKKVYFKVGDTV
KKGDLLYEIEDDDLNNQLEEAKLNLDLAQQQLNQEKQNYNNSLAKLSITAPSDGVVQVLVKEGQDVTPGMPVAIIGDNSK
ENETAENNGQTTQNSVNVTAQIAGTVEKVYVSQGQNVKKGQLLIKLSSNNISDAQIKNAELKLKQAQNQYNQILQQIDNL
KIYSPIDGKILSQNINEGDILGTSVASTNISNTNSQSQQAGFVPVLDITQLSTYESQPETAVIVGNSNYVVNLSVDETDI
KNIKVGQQAQLTTDNLPGKTFTGTVSQVSQLPTIQNGVASYNVTIEVEPSEDLLLGMSMNVSITVAEKQDALILPIQAVQ
TNGDRKYVILYTNDLKNQNINSTNNSTNNRNSFRNNMRFVETGIYNDNFIEIVSGLQEGDKVLIPTLNSSTNANNSNLGG
FGGMGGFRPGGNFNGNSTSQGGSYPGGSFNRTWQNNSSQGR

Sequences:

>Translated_521_residues
MKRKYLYAIVAVLIIGIATFYFVNRAKSSQPQQLSYVTVTRGNISMEVTGTGNLSGDVRAITLKGSGTVKKVYFKVGDTV
KKGDLLYEIEDDDLNNQLEEAKLNLDLAQQQLNQEKQNYNNSLAKLSITAPSDGVVQVLVKEGQDVTPGMPVAIIGDNSK
ENETAENNGQTTQNSVNVTAQIAGTVEKVYVSQGQNVKKGQLLIKLSSNNISDAQIKNAELKLKQAQNQYNQILQQIDNL
KIYSPIDGKILSQNINEGDILGTSVASTNISNTNSQSQQAGFVPVLDITQLSTYESQPETAVIVGNSNYVVNLSVDETDI
KNIKVGQQAQLTTDNLPGKTFTGTVSQVSQLPTIQNGVASYNVTIEVEPSEDLLLGMSMNVSITVAEKQDALILPIQAVQ
TNGDRKYVILYTNDLKNQNINSTNNSTNNRNSFRNNMRFVETGIYNDNFIEIVSGLQEGDKVLIPTLNSSTNANNSNLGG
FGGMGGFRPGGNFNGNSTSQGGSYPGGSFNRTWQNNSSQGR
>Mature_521_residues
MKRKYLYAIVAVLIIGIATFYFVNRAKSSQPQQLSYVTVTRGNISMEVTGTGNLSGDVRAITLKGSGTVKKVYFKVGDTV
KKGDLLYEIEDDDLNNQLEEAKLNLDLAQQQLNQEKQNYNNSLAKLSITAPSDGVVQVLVKEGQDVTPGMPVAIIGDNSK
ENETAENNGQTTQNSVNVTAQIAGTVEKVYVSQGQNVKKGQLLIKLSSNNISDAQIKNAELKLKQAQNQYNQILQQIDNL
KIYSPIDGKILSQNINEGDILGTSVASTNISNTNSQSQQAGFVPVLDITQLSTYESQPETAVIVGNSNYVVNLSVDETDI
KNIKVGQQAQLTTDNLPGKTFTGTVSQVSQLPTIQNGVASYNVTIEVEPSEDLLLGMSMNVSITVAEKQDALILPIQAVQ
TNGDRKYVILYTNDLKNQNINSTNNSTNNRNSFRNNMRFVETGIYNDNFIEIVSGLQEGDKVLIPTLNSSTNANNSNLGG
FGGMGGFRPGGNFNGNSTSQGGSYPGGSFNRTWQNNSSQGR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=328, Percent_Identity=26.5243902439024, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 56424; Mature: 56424

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKYLYAIVAVLIIGIATFYFVNRAKSSQPQQLSYVTVTRGNISMEVTGTGNLSGDVRA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEE
ITLKGSGTVKKVYFKVGDTVKKGDLLYEIEDDDLNNQLEEAKLNLDLAQQQLNQEKQNYN
EEEECCCCEEEEEEEECCCEECCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHCC
NSLAKLSITAPSDGVVQVLVKEGQDVTPGMPVAIIGDNSKENETAENNGQTTQNSVNVTA
CCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEE
QIAGTVEKVYVSQGQNVKKGQLLIKLSSNNISDAQIKNAELKLKQAQNQYNQILQQIDNL
EECCCEEEHHHHCCCCCCCCEEEEEECCCCCCCCEEECCEEHHHHHHHHHHHHHHHHHCE
KIYSPIDGKILSQNINEGDILGTSVASTNISNTNSQSQQAGFVPVLDITQLSTYESQPET
EEECCCCCEEEECCCCCCCEEECEEECCCCCCCCCCHHHCCCEEEEEEEECCCCCCCCCE
AVIVGNSNYVVNLSVDETDIKNIKVGQQAQLTTDNLPGKTFTGTVSQVSQLPTIQNGVAS
EEEEECCCEEEEEEECCCCCCCEECCCCCEEECCCCCCCEEECHHHHHHHCCCHHCCCEE
YNVTIEVEPSEDLLLGMSMNVSITVAEKQDALILPIQAVQTNGDRKYVILYTNDLKNQNI
EEEEEEECCCCCEEEEEECCEEEEEECCCCEEEEEEEEEECCCCEEEEEEEECCCCCCCC
NSTNNSTNNRNSFRNNMRFVETGIYNDNFIEIVSGLQEGDKVLIPTLNSSTNANNSNLGG
CCCCCCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
FGGMGGFRPGGNFNGNSTSQGGSYPGGSFNRTWQNNSSQGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRKYLYAIVAVLIIGIATFYFVNRAKSSQPQQLSYVTVTRGNISMEVTGTGNLSGDVRA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEE
ITLKGSGTVKKVYFKVGDTVKKGDLLYEIEDDDLNNQLEEAKLNLDLAQQQLNQEKQNYN
EEEECCCCEEEEEEEECCCEECCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHCC
NSLAKLSITAPSDGVVQVLVKEGQDVTPGMPVAIIGDNSKENETAENNGQTTQNSVNVTA
CCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEE
QIAGTVEKVYVSQGQNVKKGQLLIKLSSNNISDAQIKNAELKLKQAQNQYNQILQQIDNL
EECCCEEEHHHHCCCCCCCCEEEEEECCCCCCCCEEECCEEHHHHHHHHHHHHHHHHHCE
KIYSPIDGKILSQNINEGDILGTSVASTNISNTNSQSQQAGFVPVLDITQLSTYESQPET
EEECCCCCEEEECCCCCCCEEECEEECCCCCCCCCCHHHCCCEEEEEEEECCCCCCCCCE
AVIVGNSNYVVNLSVDETDIKNIKVGQQAQLTTDNLPGKTFTGTVSQVSQLPTIQNGVAS
EEEEECCCEEEEEEECCCCCCCEECCCCCEEECCCCCCCEEECHHHHHHHCCCHHCCCEE
YNVTIEVEPSEDLLLGMSMNVSITVAEKQDALILPIQAVQTNGDRKYVILYTNDLKNQNI
EEEEEEECCCCCEEEEEECCEEEEEECCCCEEEEEEEEEECCCCEEEEEEEECCCCCCCC
NSTNNSTNNRNSFRNNMRFVETGIYNDNFIEIVSGLQEGDKVLIPTLNSSTNANNSNLGG
CCCCCCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
FGGMGGFRPGGNFNGNSTSQGGSYPGGSFNRTWQNNSSQGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]