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Identifier: 16519860

GI number: 16519860

Start: 322964

End: 324001

Strand: Direct

Name: Not Available

Synonym: NGR_a02450

Alternate gene names: 16519860

Gene position: 322964-324001 (Clockwise)

Preceding gene: 16519861

Following gene: 16519859

Centisome position: 60.24

GC content: 62.72

Gene sequence:

>1038_bases
ATGAGACGCTCGAAATACGAACGCCCCGCCCATCTGATCGGCAATGCGGAGAGACCCCGATTAACCACGTCGGCGATGAT
CGCTTCCATTGCCGGCGCCGACCAGCCGACACGTCCGGCGCCTTTCGGACATGCGCTTTCCGCCTTGGCGGAAAAGGACG
ACCGTGTCGTCGGTCTTTCGGCCGATCTCGCCAAATACACGGATCTGCATGTCTTCCGGGCGGCCCATCCCGATCGCTTC
TACCAGATGGGCATGGCCGAGCAGTTGCTGATGATGTCGGCTGCCGGGATGGCACGGGAAGGGCTGCAGCCCTGGGTGAC
GACCTATGCCGTCTTCGCATCGCGCCGCGCCTATGACTTCATCTGCCTCGCGATCGCCGAGGAGATGCTTGACGTCAAGG
TCGTCTGCGCGCTGCCGGGACTGACCACAGGCTATGGCCCGAGCCATCAGGCGACCGAGGACATTGCCATGTTCCGCGGC
ATGCCGAACCTCACCATCATCGATCCTTGCGATGCCAGCGAGATCGAGCAGGCGGTCCCGGCCATCGCTGCCCACGAGGG
TCCGGTCTATATGCGGCTTCTGCGCGGCAATGTTCCACTCGTGCTTGAGGAATACGGCTACCGGTTCGAACTGGGCAAGG
CCAAGCTGCTGCGGGATGGCAGGGACACACTGATAATTTCCTCCGGTCTGATGACGATGCGGGCGCTCGAAGCGGCCGAG
GAACTTCGCAAGAACGGCATTGATGCCGGCGTTCTTCATGTTCCGACGATCAAGCCGCTTGACGAGGCAACGATCCTCGC
TGAGTGCGCCAGGCAGGGACGGCTTGTGGTCGTGGCTGAGAACCACACCGTTATCGGTGGCCTCGGCGAAGCGGTCGCCG
CCACCTTGATGCGGTCCGCTGTGCGTCCCGCCGCATTCCGGCAGATCGGACTGCCCGACGCCTTTCTAGAAGCGGGCGCC
CTGCCGACCCTGCACGACATGTACGGCATATCGACCACGAAAATCGTGGCCCAGATCAAGGAGTGGCTCGACGAGTGA

Upstream 100 bases:

>100_bases
GCGTGCCCTTCCTGGAGGCGCGTGAGCGCAACCACTTCCTGCGCGTCGAACCGCAGGAATGGGCCGAGGCGATCCGGATC
ATCGACGCGGGAGTGACGGC

Downstream 100 bases:

>100_bases
CGAAAACGGTCACCCGCGCTGGAGGAGCATCGGGGCCGCAACAGTTTCAAAGTGGAGGAGAGACAATGAAGTACGAGATA
ACCAGACGCCGCTTCCTGGC

Product: transketolase beta-subunit protein

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MRRSKYERPAHLIGNAERPRLTTSAMIASIAGADQPTRPAPFGHALSALAEKDDRVVGLSADLAKYTDLHVFRAAHPDRF
YQMGMAEQLLMMSAAGMAREGLQPWVTTYAVFASRRAYDFICLAIAEEMLDVKVVCALPGLTTGYGPSHQATEDIAMFRG
MPNLTIIDPCDASEIEQAVPAIAAHEGPVYMRLLRGNVPLVLEEYGYRFELGKAKLLRDGRDTLIISSGLMTMRALEAAE
ELRKNGIDAGVLHVPTIKPLDEATILAECARQGRLVVVAENHTVIGGLGEAVAATLMRSAVRPAAFRQIGLPDAFLEAGA
LPTLHDMYGISTTKIVAQIKEWLDE

Sequences:

>Translated_345_residues
MRRSKYERPAHLIGNAERPRLTTSAMIASIAGADQPTRPAPFGHALSALAEKDDRVVGLSADLAKYTDLHVFRAAHPDRF
YQMGMAEQLLMMSAAGMAREGLQPWVTTYAVFASRRAYDFICLAIAEEMLDVKVVCALPGLTTGYGPSHQATEDIAMFRG
MPNLTIIDPCDASEIEQAVPAIAAHEGPVYMRLLRGNVPLVLEEYGYRFELGKAKLLRDGRDTLIISSGLMTMRALEAAE
ELRKNGIDAGVLHVPTIKPLDEATILAECARQGRLVVVAENHTVIGGLGEAVAATLMRSAVRPAAFRQIGLPDAFLEAGA
LPTLHDMYGISTTKIVAQIKEWLDE
>Mature_345_residues
MRRSKYERPAHLIGNAERPRLTTSAMIASIAGADQPTRPAPFGHALSALAEKDDRVVGLSADLAKYTDLHVFRAAHPDRF
YQMGMAEQLLMMSAAGMAREGLQPWVTTYAVFASRRAYDFICLAIAEEMLDVKVVCALPGLTTGYGPSHQATEDIAMFRG
MPNLTIIDPCDASEIEQAVPAIAAHEGPVYMRLLRGNVPLVLEEYGYRFELGKAKLLRDGRDTLIISSGLMTMRALEAAE
ELRKNGIDAGVLHVPTIKPLDEATILAECARQGRLVVVAENHTVIGGLGEAVAATLMRSAVRPAAFRQIGLPDAFLEAGA
LPTLHDMYGISTTKIVAQIKEWLDE

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI225637459, Length=305, Percent_Identity=36.7213114754098, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI225637463, Length=305, Percent_Identity=36.7213114754098, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI225637461, Length=305, Percent_Identity=36.7213114754098, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI133778974, Length=302, Percent_Identity=33.4437086092715, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI205277463, Length=294, Percent_Identity=34.6938775510204, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4507521, Length=294, Percent_Identity=34.6938775510204, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786622, Length=326, Percent_Identity=29.4478527607362, Blast_Score=131, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17539652, Length=319, Percent_Identity=36.3636363636364, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI45551847, Length=308, Percent_Identity=33.7662337662338, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45550715, Length=308, Percent_Identity=33.7662337662338, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24645119, Length=308, Percent_Identity=33.7662337662338, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24666278, Length=305, Percent_Identity=32.7868852459016, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21358145, Length=340, Percent_Identity=26.7647058823529, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650940, Length=340, Percent_Identity=26.7647058823529, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4MN_RHISN (P55573)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443980.1
- ProteinModelPortal:   P55573
- SMR:   P55573
- GeneID:   962370
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a02450
- HOGENOM:   HBG414546
- ProtClustDB:   CLSK2518394
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: 2.2.1.1

Molecular weight: Translated: 37510; Mature: 37510

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSKYERPAHLIGNAERPRLTTSAMIASIAGADQPTRPAPFGHALSALAEKDDRVVGLS
CCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEC
ADLAKYTDLHVFRAAHPDRFYQMGMAEQLLMMSAAGMAREGLQPWVTTYAVFASRRAYDF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHH
ICLAIAEEMLDVKVVCALPGLTTGYGPSHQATEDIAMFRGMPNLTIIDPCDASEIEQAVP
HHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
AIAAHEGPVYMRLLRGNVPLVLEEYGYRFELGKAKLLRDGRDTLIISSGLMTMRALEAAE
HHHCCCCCCEEEECCCCCCEEECCCCCEEECCHHHHHHCCCCEEEEECCHHHHHHHHHHH
ELRKNGIDAGVLHVPTIKPLDEATILAECARQGRLVVVAENHTVIGGLGEAVAATLMRSA
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHHHH
VRPAAFRQIGLPDAFLEAGALPTLHDMYGISTTKIVAQIKEWLDE
HCHHHHHHCCCCHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRSKYERPAHLIGNAERPRLTTSAMIASIAGADQPTRPAPFGHALSALAEKDDRVVGLS
CCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEC
ADLAKYTDLHVFRAAHPDRFYQMGMAEQLLMMSAAGMAREGLQPWVTTYAVFASRRAYDF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHH
ICLAIAEEMLDVKVVCALPGLTTGYGPSHQATEDIAMFRGMPNLTIIDPCDASEIEQAVP
HHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
AIAAHEGPVYMRLLRGNVPLVLEEYGYRFELGKAKLLRDGRDTLIISSGLMTMRALEAAE
HHHCCCCCCEEEECCCCCCEEECCCCCEEECCHHHHHHCCCCEEEEECCHHHHHHHHHHH
ELRKNGIDAGVLHVPTIKPLDEATILAECARQGRLVVVAENHTVIGGLGEAVAATLMRSA
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHHHH
VRPAAFRQIGLPDAFLEAGALPTLHDMYGISTTKIVAQIKEWLDE
HCHHHHHHCCCCHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424