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Identifier: 16519667

GI number: 16519667

Start: 25648

End: 27540

Strand: Reverse

Name: Not Available

Synonym: NGR_a00200

Alternate gene names: 16519667

Gene position: 27540-25648 (Counterclockwise)

Preceding gene: 16519666

Following gene: 16519668

Centisome position: 5.14

GC content: 55.41

Gene sequence:

>1893_bases
ATGCTCTCTTCAAGGTTGGGGCTTTTCAATATGTTCAGACTACTTGCGGCGATACTCGTTTTCACGGGACTAGCTTCGGC
GGTGAATGCCGATCTTCTGCAGACTGGGGGTAGCCGATGGGTTGTGCTCGCAAGTACGCGAGATCTCGACAACGCCATTG
GCATCGCGAACCTTTACCAGCATCGCTTTGATGACGTTCGCGTGGCGGAGGCCTCGAACGGTTGGCTCGCAGTGATCGCA
GGACCAGTATCAATCGCCCGAGGAGCGAAGGCGGCACGCGAAGAATTGTGGAGTGCTGGCGGGTTTCCCCCTGACTTGTT
CCTTAGCAATGGGCAAAGCTTGAGACGCACCGTGTGGGAGCCGCCGAAAGGTCGGCCCATTCCCACCTGGTCGTATAAAG
GTGGCCAGCCACTAGTCTTTTCAGCTGGAGGGCTCGAGATTGAAGTGTCTCATCTTGCCGAGGGCAATACTCGGTATCCG
TCTATCACGCTTCGCAGGGCCGGACGTCTGCTCATAAAGGAAGTTCTGAAGGGGTCCGAGTCTTTCGGGGACAACATGAA
TGCTGAAGTGCGGCTCGTTTGGCTCGACCGCGCGGTCGCCGAACCACAGATCATCTTTTCATCTCATTGGAATGGAGCAC
ATTGCTGCACAGTTTCTAAAATACTAACAAAGGTCGGCAACGGCTGGACAAGTATCGAAGGCGCTACGCTCGATGGCGGT
GGGTATCGACTTCAGGACATCGACGGCGATGGCAGCGTGGAATTGCTCAGCGTCGACAATTCCTTCCTTTACACGTTTGC
TCCTTACGTCTTCTCATCAGCTCCGTTGGTAATATCGAAACTCGATGGAGATCGTTTGATTGACATGCGCTGGAATTCTG
CCTTCCGACGCTACTATCGTCGCGAGCTCTTTGGATGGGAGTACCGGGCAAAACTGGAACCAGAGATCTGGCGAAAGAAC
GGTTTTCTGAGCGCTTGGCTGGCATTGAAATCAGTGTTGGGCGAATCAGACCAAGCCTGGACCGTGGTCTTGGAAAATTA
CGATCGTTCAAGCGAATGGCCCTTGACCGTATGTGATGCTCCTCTGAAGGAAGGTGTGTGCCCAGAGGAAGCCACTCGCG
AGGTGAGTTTCCCGGAGGCGCTGCGCGATCACCTTGCGCGTAATGGATACTTGGGTCCGCAAGTGGCGAAAATCGAGGAA
ACTTCAAAGCCCACTGAGCAGCCGTCACCCGCCGATAGCACATCAACGCCTGCGGCACCTGAGAAGGGCGCCGCCTCCAG
TGCAGGAACAGGCTTCTTCATCTCAAAACAAGGCCACCTTGTCACCAATCACCATGTGATCAAGGGTTGCAGCGCCATCG
AAGTGCGCCGCCCCGGCCAGTTGAGGCTTCCGGCAAATATTGTGGCAGTGGACCCCACCAATGATCTAGCTCTACTACGT
GTGGAAAGCGATACGGGCGCATACGCATCTGTCCGGGTAGAAACACGGCTGGGCGAGTCAGTCGCCGTATTTGGCTATCC
GCTTTCTCATGTCTTGGCCAGCGGAGGCAACTTCACCCTCGGCAATGTTACGGCGCTGGCTGGCCTTGGCAACGATACGC
GTTTCATCCAGATATCTGCTCCCGTCCAACCGGGTAATAGTGGCGGCCCGCTAATTGATAGTTATGGCAATGTCATCGGC
GTTGTGACGTCGAAGCTCGACGCACTGGCTGCACTTGCGGTAACAGGGGACATCCCCCAGAATGTAAATTTCGCCCTACG
CGGAGCAAGCCTGTATGCTTTCTTGCTCTCCTACGGGATCTCGCCCGTGGCTGGGTCGAATACACAAAAACTGGACGCGC
CGGAACTCGCTGAACGTGCTTCGTCATTCAGTGTGGCAGTCACCTGTGAATGA

Upstream 100 bases:

>100_bases
CGGCTGTTGGCGCTCAGAAGCGCTCTGCCCCTCGACACAACTCAGACGCCGCAGCGGGCGAATAGTCCGCACGCCCCTGA
CCACATTGCATACTGGTTGG

Downstream 100 bases:

>100_bases
CTTGGCACCGGTCCGCTGCGAACGTGTTACGTGCAGCTCTCTCGCACATGGCCACTACCACTGCAACGTGCAAGTCGGAG
CATACCTCGAGCTCGAGCTC

Product: periplasmic serine protease, DO/DeqQ family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MLSSRLGLFNMFRLLAAILVFTGLASAVNADLLQTGGSRWVVLASTRDLDNAIGIANLYQHRFDDVRVAEASNGWLAVIA
GPVSIARGAKAAREELWSAGGFPPDLFLSNGQSLRRTVWEPPKGRPIPTWSYKGGQPLVFSAGGLEIEVSHLAEGNTRYP
SITLRRAGRLLIKEVLKGSESFGDNMNAEVRLVWLDRAVAEPQIIFSSHWNGAHCCTVSKILTKVGNGWTSIEGATLDGG
GYRLQDIDGDGSVELLSVDNSFLYTFAPYVFSSAPLVISKLDGDRLIDMRWNSAFRRYYRRELFGWEYRAKLEPEIWRKN
GFLSAWLALKSVLGESDQAWTVVLENYDRSSEWPLTVCDAPLKEGVCPEEATREVSFPEALRDHLARNGYLGPQVAKIEE
TSKPTEQPSPADSTSTPAAPEKGAASSAGTGFFISKQGHLVTNHHVIKGCSAIEVRRPGQLRLPANIVAVDPTNDLALLR
VESDTGAYASVRVETRLGESVAVFGYPLSHVLASGGNFTLGNVTALAGLGNDTRFIQISAPVQPGNSGGPLIDSYGNVIG
VVTSKLDALAALAVTGDIPQNVNFALRGASLYAFLLSYGISPVAGSNTQKLDAPELAERASSFSVAVTCE

Sequences:

>Translated_630_residues
MLSSRLGLFNMFRLLAAILVFTGLASAVNADLLQTGGSRWVVLASTRDLDNAIGIANLYQHRFDDVRVAEASNGWLAVIA
GPVSIARGAKAAREELWSAGGFPPDLFLSNGQSLRRTVWEPPKGRPIPTWSYKGGQPLVFSAGGLEIEVSHLAEGNTRYP
SITLRRAGRLLIKEVLKGSESFGDNMNAEVRLVWLDRAVAEPQIIFSSHWNGAHCCTVSKILTKVGNGWTSIEGATLDGG
GYRLQDIDGDGSVELLSVDNSFLYTFAPYVFSSAPLVISKLDGDRLIDMRWNSAFRRYYRRELFGWEYRAKLEPEIWRKN
GFLSAWLALKSVLGESDQAWTVVLENYDRSSEWPLTVCDAPLKEGVCPEEATREVSFPEALRDHLARNGYLGPQVAKIEE
TSKPTEQPSPADSTSTPAAPEKGAASSAGTGFFISKQGHLVTNHHVIKGCSAIEVRRPGQLRLPANIVAVDPTNDLALLR
VESDTGAYASVRVETRLGESVAVFGYPLSHVLASGGNFTLGNVTALAGLGNDTRFIQISAPVQPGNSGGPLIDSYGNVIG
VVTSKLDALAALAVTGDIPQNVNFALRGASLYAFLLSYGISPVAGSNTQKLDAPELAERASSFSVAVTCE
>Mature_630_residues
MLSSRLGLFNMFRLLAAILVFTGLASAVNADLLQTGGSRWVVLASTRDLDNAIGIANLYQHRFDDVRVAEASNGWLAVIA
GPVSIARGAKAAREELWSAGGFPPDLFLSNGQSLRRTVWEPPKGRPIPTWSYKGGQPLVFSAGGLEIEVSHLAEGNTRYP
SITLRRAGRLLIKEVLKGSESFGDNMNAEVRLVWLDRAVAEPQIIFSSHWNGAHCCTVSKILTKVGNGWTSIEGATLDGG
GYRLQDIDGDGSVELLSVDNSFLYTFAPYVFSSAPLVISKLDGDRLIDMRWNSAFRRYYRRELFGWEYRAKLEPEIWRKN
GFLSAWLALKSVLGESDQAWTVVLENYDRSSEWPLTVCDAPLKEGVCPEEATREVSFPEALRDHLARNGYLGPQVAKIEE
TSKPTEQPSPADSTSTPAAPEKGAASSAGTGFFISKQGHLVTNHHVIKGCSAIEVRRPGQLRLPANIVAVDPTNDLALLR
VESDTGAYASVRVETRLGESVAVFGYPLSHVLASGGNFTLGNVTALAGLGNDTRFIQISAPVQPGNSGGPLIDSYGNVIG
VVTSKLDALAALAVTGDIPQNVNFALRGASLYAFLLSYGISPVAGSNTQKLDAPELAERASSFSVAVTCE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S1B family

Homologues:

Organism=Homo sapiens, GI4506141, Length=158, Percent_Identity=32.9113924050633, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786356, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789630, Length=166, Percent_Identity=29.5180722891566, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646839, Length=159, Percent_Identity=33.9622641509434, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4BJ_RHISN (P55377)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443787.1
- ProteinModelPortal:   P55377
- GeneID:   962317
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a00200
- GO:   GO:0006508
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834

Pfam domain/function: PF00089 Trypsin; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.- [C]

Molecular weight: Translated: 67855; Mature: 67855

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb88d38c)-; HASH(0xadb42b0)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSRLGLFNMFRLLAAILVFTGLASAVNADLLQTGGSRWVVLASTRDLDNAIGIANLYQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
HRFDDVRVAEASNGWLAVIAGPVSIARGAKAAREELWSAGGFPPDLFLSNGQSLRRTVWE
HHCCCEEEEECCCCEEEEEECCHHHHHCHHHHHHHHHHCCCCCHHHEECCCCHHHHHHCC
PPKGRPIPTWSYKGGQPLVFSAGGLEIEVSHLAEGNTRYPSITLRRAGRLLIKEVLKGSE
CCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCH
SFGDNMNAEVRLVWLDRAVAEPQIIFSSHWNGAHCCTVSKILTKVGNGWTSIEGATLDGG
HCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCCCCCCEEECCC
GYRLQDIDGDGSVELLSVDNSFLYTFAPYVFSSAPLVISKLDGDRLIDMRWNSAFRRYYR
CEEEEEECCCCCEEEEEECCCEEEEEHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHH
RELFGWEYRAKLEPEIWRKNGFLSAWLALKSVLGESDQAWTVVLENYDRSSEWPLTVCDA
HHHCCCEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEECC
PLKEGVCPEEATREVSFPEALRDHLARNGYLGPQVAKIEETSKPTEQPSPADSTSTPAAP
HHHCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCCCCCCCCCC
EKGAASSAGTGFFISKQGHLVTNHHVIKGCSAIEVRRPGQLRLPANIVAVDPTNDLALLR
CCCCCCCCCCCEEEECCCCEEECCCEECCCCEEEEECCCCEECCCEEEEECCCCCEEEEE
VESDTGAYASVRVETRLGESVAVFGYPLSHVLASGGNFTLGNVTALAGLGNDTRFIQISA
EECCCCCEEEEEEEECCCCEEEEECCCHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEC
PVQPGNSGGPLIDSYGNVIGVVTSKLDALAALAVTGDIPQNVNFALRGASLYAFLLSYGI
CCCCCCCCCCCHHCCCCEEEHHHHHHHHHEEEEEECCCCCCCCEEEEHHHHHHHHHHCCC
SPVAGSNTQKLDAPELAERASSFSVAVTCE
CCCCCCCCCCCCCHHHHHHCCCEEEEEEEH
>Mature Secondary Structure
MLSSRLGLFNMFRLLAAILVFTGLASAVNADLLQTGGSRWVVLASTRDLDNAIGIANLYQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
HRFDDVRVAEASNGWLAVIAGPVSIARGAKAAREELWSAGGFPPDLFLSNGQSLRRTVWE
HHCCCEEEEECCCCEEEEEECCHHHHHCHHHHHHHHHHCCCCCHHHEECCCCHHHHHHCC
PPKGRPIPTWSYKGGQPLVFSAGGLEIEVSHLAEGNTRYPSITLRRAGRLLIKEVLKGSE
CCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCH
SFGDNMNAEVRLVWLDRAVAEPQIIFSSHWNGAHCCTVSKILTKVGNGWTSIEGATLDGG
HCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCCCCCCEEECCC
GYRLQDIDGDGSVELLSVDNSFLYTFAPYVFSSAPLVISKLDGDRLIDMRWNSAFRRYYR
CEEEEEECCCCCEEEEEECCCEEEEEHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHH
RELFGWEYRAKLEPEIWRKNGFLSAWLALKSVLGESDQAWTVVLENYDRSSEWPLTVCDA
HHHCCCEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEECC
PLKEGVCPEEATREVSFPEALRDHLARNGYLGPQVAKIEETSKPTEQPSPADSTSTPAAP
HHHCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCCCCCCCCCC
EKGAASSAGTGFFISKQGHLVTNHHVIKGCSAIEVRRPGQLRLPANIVAVDPTNDLALLR
CCCCCCCCCCCEEEECCCCEEECCCEECCCCEEEEECCCCEECCCEEEEECCCCCEEEEE
VESDTGAYASVRVETRLGESVAVFGYPLSHVLASGGNFTLGNVTALAGLGNDTRFIQISA
EECCCCCEEEEEEEECCCCEEEEECCCHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEC
PVQPGNSGGPLIDSYGNVIGVVTSKLDALAALAVTGDIPQNVNFALRGASLYAFLLSYGI
CCCCCCCCCCCHHCCCCEEEHHHHHHHHHEEEEEECCCCCCCCEEEEHHHHHHHHHHCCC
SPVAGSNTQKLDAPELAERASSFSVAVTCE
CCCCCCCCCCCCCHHHHHHCCCEEEEEEEH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424