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The map label for this gene is csdA [C]

Identifier: 16273252

GI number: 16273252

Start: 1418131

End: 1418847

Strand: Reverse

Name: csdA [C]

Synonym: HI1343

Alternate gene names: 16273252

Gene position: 1418847-1418131 (Counterclockwise)

Preceding gene: 16273254

Following gene: 16273251

Centisome position: 77.53

GC content: 39.33

Gene sequence:

>717_bases
ATGCGTGTTGCCATTTTGCGAATAACAGAACGGTCATGGGAAATAAATACAATGCTACCTTGGAAATCCAGTAAGAAATT
TTCCAACCATTCAATAGCTTCCACATCCAAGTGGTTGGTTCATCAAGTTGCTAATTTTGTCACTTGGCATGAAACGGCGA
AAAAGTGCGGTGCAAAAATTCGAGTTTTACCGATTTTAGATAATTGGCTAATTGATGAAAATGTGCTTATTTCTACCCTT
TCTGAAAAAACAAAACTCGTTGCGCTGAATTTTGTTTCAAATGTCACTGGCACAGAACAGCCGATTAAACGCCTGATTCA
ACTTATTAGAAAACATAGTCATGCGTTGGTTTTAGTGGATGCAGCACAAGCGATTAGTCATATTAAAATTGATTTACAAG
ATTTAGATGCCGATTTCCTCGCATTTTCTGCCCATAAAATTTATGGCCCAAATGGACTTGGCGTTTTAACAGGAAAATTG
ACCGCACTTTCTCAACTTCAACCGCTCTTTTTTGGCGGAAAAATGGTTGAACGTGTGTCAAATAATCGTATTACTTTTGC
CGAATTGCCTTATCGTTTAGAAGCTGGCACACCCAATATTGCTGGGGTTATAGGCTTTAATGCTGTGCTGGATTGGCTAC
AAAAATGGGATTTTACCGCAGCAGAACAGCACGCTATATCCTTGGCTGAATCCGTCAAAGTGCGGCGTAATTTTTGA

Upstream 100 bases:

>100_bases
ATTCTGCAAGGCTTCAACGCGTAGATTTTCTTCTTTCGTGGTTAAATATAAATCGTAATTGCCTAGATAAGACTGCAATT
GACCGCGATCTAAATCCACA

Downstream 100 bases:

>100_bases
TGGTTTTCAACTTGTGGGCGATGATTTCAATTCAGATCAAACGGCTGAAAATACATCGCCAGCTTGGCAAGTGCTTTACA
CAACCCATTTACAAAGTTGC

Product: hypothetical protein

Products: @ALAN01txt*L-Alanine! [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRVAILRITERSWEINTMLPWKSSKKFSNHSIASTSKWLVHQVANFVTWHETAKKCGAKIRVLPILDNWLIDENVLISTL
SEKTKLVALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKL
TALSQLQPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRRNF

Sequences:

>Translated_238_residues
MRVAILRITERSWEINTMLPWKSSKKFSNHSIASTSKWLVHQVANFVTWHETAKKCGAKIRVLPILDNWLIDENVLISTL
SEKTKLVALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKL
TALSQLQPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRRNF
>Mature_238_residues
MRVAILRITERSWEINTMLPWKSSKKFSNHSIASTSKWLVHQVANFVTWHETAKKCGAKIRVLPILDNWLIDENVLISTL
SEKTKLVALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKL
TALSQLQPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRRNF

Specific function: Catalyzes The Removal Of Elemental Sulfur And Selenium Atoms From L-Cysteine, L-Cystine, L-Selenocysteine, And L- Selenocystine To Produce L-Alanine. L-Cysteine Sulfinic Acid Is The Best Substrate. Functions As A Selenium Delivery Protein In The Pathway F

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=117, Percent_Identity=32.4786324786325, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1789175, Length=187, Percent_Identity=44.3850267379679, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1787970, Length=171, Percent_Identity=42.6900584795322, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI48994898, Length=120, Percent_Identity=30.8333333333333, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=157, Percent_Identity=29.9363057324841, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=119, Percent_Identity=36.9747899159664, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20129463, Length=117, Percent_Identity=35.8974358974359, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1343_HAEIN (P71379)

Other databases:

- EMBL:   L42023
- PIR:   G64117
- RefSeq:   NP_439493.1
- ProteinModelPortal:   P71379
- SMR:   P71379
- GeneID:   949643
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1343
- NMPDR:   fig|71421.1.peg.1278
- TIGR:   HI_1343
- BioCyc:   HINF71421:HI_1343-MONOMER
- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 4.4.1.- [C]

Molecular weight: Translated: 26720; Mature: 26720

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAILRITERSWEINTMLPWKSSKKFSNHSIASTSKWLVHQVANFVTWHETAKKCGAKI
CEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
RVLPILDNWLIDENVLISTLSEKTKLVALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVD
EEEEEECCEECCCCHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHCCCEEEEEE
AAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQPLFFGGKMVERVS
HHHHHHHEEEEHHHCCCHHHEEEHHEEECCCCCEEEEHHHHHHHHCCHHHHCHHHHHHHC
NNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRRNF
CCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVAILRITERSWEINTMLPWKSSKKFSNHSIASTSKWLVHQVANFVTWHETAKKCGAKI
CEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
RVLPILDNWLIDENVLISTLSEKTKLVALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVD
EEEEEECCEECCCCHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHCCCEEEEEE
AAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQPLFFGGKMVERVS
HHHHHHHEEEEHHHCCCHHHEEEHHEEECCCCCEEEEHHHHHHHHCCHHHHCHHHHHHHC
NNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRRNF
CCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-cystine; L-selenocystine [C]

Specific reaction: Catalyzes the removal of elemental sulfur and selenium atoms from l-cysteine, l-cystine, l-selenocysteine, and l- selenocystine to produce @ALAN01.txt*l-Alanine! [C]

General reaction: Remove sulfur and selenium atoms [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800