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The map label for this gene is can

Identifier: 16273213

GI number: 16273213

Start: 1380817

End: 1381506

Strand: Reverse

Name: can

Synonym: HI1301

Alternate gene names: 16273213

Gene position: 1381506-1380817 (Counterclockwise)

Preceding gene: 30995440

Following gene: 30995439

Centisome position: 75.49

GC content: 38.41

Gene sequence:

>690_bases
ATGGATAAAATTAAACAACTCTTTGCCAACAATTACAGTTGGGCGCAAAGAATGAAAGAAGAAAACTCTACTTACTTCAA
AGAACTTGCGGATCATCAAACGCCACATTACCTTTGGATTGGTTGCTCTGATAGCCGTGTGCCTGCTGAAAAATTGACAA
ATCTTGAACCGGGCGAACTTTTTGTACACCGTAATGTTGCTAACCAAGTAATTCACACAGATTTTAATTGCCTTTCTGTT
GTGCAATATGCCGTCGATGTGCTTAAAATTGAACATATTATTATCTGTGGTCACACCAACTGCGGGGGGATTCATGCTGC
TATGGCAGATAAAGATTTAGGGCTTATCAACAACTGGCTTCTTCATATTCGTGATATTTGGTTTAAACACGGTCATCTTC
TCGGTAAACTTTCTCCAGAAAAACGTGCCGATATGCTAACTAAAATTAACGTAGCGGAACAGGTTTACAATCTAGGGCGC
ACATCAATTGTAAAAAGTGCTTGGGAACGCGGACAAAAACTCTCATTACACGGCTGGGTATATGATGTAAATGATGGATT
TTTAGTGGATCAAGGCGTAATGGCAACCAGCAGAGAAACCCTTGAAATTTCTTATCGAAACGCTATCGCTCGTTTATCAA
TACTTGATGAAGAAAATATTTTGAAAAAAGATCATCTTGAAAATACATAA

Upstream 100 bases:

>100_bases
CGCACCAAGAAATGCGAATTTCTAATTCAATTTAACTTTAATATTGACCGTACTTACGCCAAAGTGCGGTCAATTTTTTC
AGAATTTTAAGGAAAGTAAA

Downstream 100 bases:

>100_bases
AAAAACGCCCTTTCGGGCGTTATTTTTTTAAGCTTTACCTTCAACCAAATTTTTCTTTTCTTCTAATTCTTCCCAGCGTA
AAAATGCTGTTTCTAATTCG

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase 2

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MDKIKQLFANNYSWAQRMKEENSTYFKELADHQTPHYLWIGCSDSRVPAEKLTNLEPGELFVHRNVANQVIHTDFNCLSV
VQYAVDVLKIEHIIICGHTNCGGIHAAMADKDLGLINNWLLHIRDIWFKHGHLLGKLSPEKRADMLTKINVAEQVYNLGR
TSIVKSAWERGQKLSLHGWVYDVNDGFLVDQGVMATSRETLEISYRNAIARLSILDEENILKKDHLENT

Sequences:

>Translated_229_residues
MDKIKQLFANNYSWAQRMKEENSTYFKELADHQTPHYLWIGCSDSRVPAEKLTNLEPGELFVHRNVANQVIHTDFNCLSV
VQYAVDVLKIEHIIICGHTNCGGIHAAMADKDLGLINNWLLHIRDIWFKHGHLLGKLSPEKRADMLTKINVAEQVYNLGR
TSIVKSAWERGQKLSLHGWVYDVNDGFLVDQGVMATSRETLEISYRNAIARLSILDEENILKKDHLENT
>Mature_229_residues
MDKIKQLFANNYSWAQRMKEENSTYFKELADHQTPHYLWIGCSDSRVPAEKLTNLEPGELFVHRNVANQVIHTDFNCLSV
VQYAVDVLKIEHIIICGHTNCGGIHAAMADKDLGLINNWLLHIRDIWFKHGHLLGKLSPEKRADMLTKINVAEQVYNLGR
TSIVKSAWERGQKLSLHGWVYDVNDGFLVDQGVMATSRETLEISYRNAIARLSILDEENILKKDHLENT

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family

Homologues:

Organism=Escherichia coli, GI1786318, Length=214, Percent_Identity=63.0841121495327, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1786534, Length=167, Percent_Identity=37.7245508982036, Blast_Score=104, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324292, Length=194, Percent_Identity=31.4432989690722, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CAN_HAEIN (P45148)

Other databases:

- EMBL:   L42023
- PIR:   F64170
- RefSeq:   NP_439452.1
- PDB:   2A8C
- PDB:   2A8D
- PDB:   3E1V
- PDB:   3E1W
- PDB:   3E24
- PDB:   3E28
- PDB:   3E2A
- PDB:   3E2W
- PDB:   3E2X
- PDB:   3E31
- PDB:   3E3F
- PDB:   3E3G
- PDB:   3E3I
- PDBsum:   2A8C
- PDBsum:   2A8D
- PDBsum:   3E1V
- PDBsum:   3E1W
- PDBsum:   3E24
- PDBsum:   3E28
- PDBsum:   3E2A
- PDBsum:   3E2W
- PDBsum:   3E2X
- PDBsum:   3E31
- PDBsum:   3E3F
- PDBsum:   3E3G
- PDBsum:   3E3I
- ProteinModelPortal:   P45148
- GeneID:   950229
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1301
- TIGR:   HI_1301
- HOGENOM:   HBG711150
- OMA:   PHRIKEL
- ProtClustDB:   CLSK870162
- BioCyc:   HINF71421:HI_1301-MONOMER
- BRENDA:   4.2.1.1
- InterPro:   IPR001765
- InterPro:   IPR015892
- Gene3D:   G3DSA:3.40.1050.10
- PANTHER:   PTHR11002
- SMART:   SM00947

Pfam domain/function: PF00484 Pro_CA; SSF53056 Prok_plnt_COanhd

EC number: =4.2.1.1

Molecular weight: Translated: 26250; Mature: 26250

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIKQLFANNYSWAQRMKEENSTYFKELADHQTPHYLWIGCSDSRVPAEKLTNLEPGEL
CCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCCCCE
FVHRNVANQVIHTDFNCLSVVQYAVDVLKIEHIIICGHTNCGGIHAAMADKDLGLINNWL
EEECCHHHHHHHCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEHHHCCCCHHHHHHHH
LHIRDIWFKHGHLLGKLSPEKRADMLTKINVAEQVYNLGRTSIVKSAWERGQKLSLHGWV
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEE
YDVNDGFLVDQGVMATSRETLEISYRNAIARLSILDEENILKKDHLENT
EECCCCEEECCCCHHCCCHHEEEHHHHHHHHHEECCCHHHHHHHCCCCC
>Mature Secondary Structure
MDKIKQLFANNYSWAQRMKEENSTYFKELADHQTPHYLWIGCSDSRVPAEKLTNLEPGEL
CCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCCCCE
FVHRNVANQVIHTDFNCLSVVQYAVDVLKIEHIIICGHTNCGGIHAAMADKDLGLINNWL
EEECCHHHHHHHCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEHHHCCCCHHHHHHHH
LHIRDIWFKHGHLLGKLSPEKRADMLTKINVAEQVYNLGRTSIVKSAWERGQKLSLHGWV
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEE
YDVNDGFLVDQGVMATSRETLEISYRNAIARLSILDEENILKKDHLENT
EECCCCEEECCCCHHCCCHHEEEHHHHHHHHHEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800