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The map label for this gene is aceE

Identifier: 16273152

GI number: 16273152

Start: 1303863

End: 1306523

Strand: Reverse

Name: aceE

Synonym: HI1233

Alternate gene names: 16273152

Gene position: 1306523-1303863 (Counterclockwise)

Preceding gene: 16273154

Following gene: 16273151

Centisome position: 71.39

GC content: 40.25

Gene sequence:

>2661_bases
ATGTCTGAGATTTTAAAAAATGACGTTGATCCAATCGAAACACAAGATTGGTTGCAATCATTAGATTCATTAATTCGTGA
AGAGGGCGTTGAGCGTGCTCAATATATTGTTGAGCAAGTTATTGGTCAAGCACGTACAAGTGGTGTTTCATTGCCAACAG
GAGTTACCACTGATTACGTGAATACTATTCCTGTGGCTGAGCAACCTGCTTATCCAGGTGATCACGCTATCGAACGTCGT
ATTCGTTCAGCAGTACGTTGGAATGCGATCGCGATGGTTTTACGCAGTCAGAAGAAAGATCTTGATTTAGGTGGGCATAT
TTCCACTTTCCAATCTGCAGCAACAATGTATGAAGTTTGCTACAACCACTTTTTTAAAGCTGCAACAGAGAAAAACGGTG
GCGATTTAATTTTCTTCCAAGGCCATGCAGCTCCTGGTATGTATGCGCGTGCTTTCTTAGAAGGTCGTTTAACTGAAGAA
CAAATGGATAACTTCCGTCAAGAAGCCTTTACCGACGGTTTATCTTCATATCCACATCCTAAATTAATGCCTGAATTTTG
GCAATTTTCTACGGTTTCTATGGGTTTAGGCCCTGTGAATGCCATCTACCAAGCGCGTTTCTTAAAATATCTCGATAACC
GTGGTTTAAAAGATACCAAAGATCAAAAAGTTTATGCGTTCTTAGGCGATGGCGAGATGGATGAAATTGAGTCTAAAGGT
GCATTAACTTTTGCGGCTCGTGAACACTTAGATAACTTAATCTTCACTATCAGCTGTAACTTACAACGTTTAGATGGACC
TGTGAATGGTAATGGTAAAATCGTTCAAGAGTTAGAAGGGCTATTTACTGGTGCTGGCTGGGAAGTGATTAAAGTTTTAT
GGGGCAGCGATTGGGATAAATTATTCGCGAAAGATACTTCAGGTAAATTAACTCAGTTAATGATGGAAGTGGTTGATGGA
GATTATTTAACCTTTAAATCTAAAGATGGTGCATATATTCGTGAACACTTCTTCGGTCGTTATCCAGAAACTGCTGCATT
AGTTGCTGATATGACCGATGATGAAATCTGGGCATTACGCCGTGGTGCACACGATAGCGAAAAATTATATGCGGCCTATG
CAAAAGCACAAAATGCAACGAAACCAGTTGTGATTTTAGCGCATCAAGTTAAAGGTTATAAAATTCCTGAAGCGGAAAGT
AAAAATACCGCTCACCAATCTAAAAAAATGTCTTACGAAAGCCTTAAAGGTTTCCGTGACTTCTTTGAATTACCATTAAC
CGATGAACAAGTAGAAAAATTAGAATACATTAAATTTGCTGAAGGCACACCTGAGTATGAATACTTACATGGTCACCGTA
AAGCATTAAACGGTTATGTTCCTGCTCGTCGTACTAAATTTGATGTTGAATATAAAGTTCCTGCATTAGAAGAGTTTAAA
GCATTATTAGAAGAACAACCTCGTGGTATTTCAACCACTATGGCGTTTACTCGTGCATTAAACATCTTATTAAAAGATAA
AAACATCGGTAAAACTATCGTTCCAATGATTGCGGATGAAGCACGTACTTTCGGTATGGAAGGTTTATTCCGTCAAGTTG
GTATTTATAACCCACATGGTCAAAACTATATACCTTCAGACCGTGATTTAGTGGCTTACTATCGTGAAGCAAAAGATGGT
CAAGTGCTACAAGAAGGTATCAATGAATTAGGTGCAACCGCATCTTGGTTAGCAGCAGCGAACTCGTACTCTGTCAATAA
CCAACCGATGATTCCATTCTTCATCTATTACTCAATGTTTGGTTTCCAACGTGTGGGCGATATGATGTGGGCTGCAGGCG
ACCAATTAGCTCGTGGCTTTATGGTAGGGGGTACTTCTGGTCGTACAACCTTAAATGGAGAAGGTTTACAACACGAAGAC
GGTCACAGCCATATTCAAGCGGGTATCATTCCTAACTGTATCACTTACGATCCATCATTTGCATTTGAAGTTGCTGTTAT
TATGCAAGACGGTATCAACCGTATGTACGGCGAAAAACAAGAAGATGTGTTCTATTATATGACTACATTAAATGAAGTGA
TGGATCAACCTGCGATGCCTGCTGGTGCGGAAGAAGGTATCCGTAAAGGTTTATATAAATTTGAAACAGTGGAAGGTAAA
AAAGGCAAAGGTCACGTTCAGTTATTAGGTTCTGGTGCGATTATGCGTCACGTTCGTGAAGCGGCACAAATTCTTGCAAA
TGACTACGGTGTGACTTCAGATGTATTTTCTGCGCCTTCATTCAATGAATTAGCACGCGAAGGTCATGATGCAGCACGTT
GGAACTTATTACACCCAACAGAGACACAACGCGTACCATACGTTGCTCAAGTATTAGCTGATTTACCAACCGTTGCTTCA
ACTGACTATGTGAAAGGTTATGCTGATCAAATCCGTGCATTTGTACCAAGTAAGCACTATCATGTATTAGGTACAGACGG
TTTCGGTCGTTCAGATAGCCGTGCAAACTTACGTGAACACTTCGAAGTTGATGCACGTTATGTTGTGGTTGCTGCACTTT
CTCAATTAGCGAAAGAAGGTACAGTATCTAACCAAGTGGTTGCAGATGCGATTGCGAAATTCGGTTTGAATGTAGATCGT
ATCAATCCGCTTTATGCGTAA

Upstream 100 bases:

>100_bases
TTACAAGATTTGTTAAATGTTTGTGAAAAGCAAATATTGCCGTATTCGTGTTTAGCCTTGTCTAAACTAATATTCACTCA
AAACAGATTAAGGAAAACCT

Downstream 100 bases:

>100_bases
TTGATGAAAACTGCGGTCAAAAAACATTGTGTTTTATGACCGCACTTTAAAAGGAACAAAAAATGTCAAAACAAATTCAA
ATTCCTGATATTGGTAGTGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 886; Mature: 885

Protein sequence:

>886_residues
MSEILKNDVDPIETQDWLQSLDSLIREEGVERAQYIVEQVIGQARTSGVSLPTGVTTDYVNTIPVAEQPAYPGDHAIERR
IRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLIFFQGHAAPGMYARAFLEGRLTEE
QMDNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLDNRGLKDTKDQKVYAFLGDGEMDEIESKG
ALTFAAREHLDNLIFTISCNLQRLDGPVNGNGKIVQELEGLFTGAGWEVIKVLWGSDWDKLFAKDTSGKLTQLMMEVVDG
DYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWALRRGAHDSEKLYAAYAKAQNATKPVVILAHQVKGYKIPEAES
KNTAHQSKKMSYESLKGFRDFFELPLTDEQVEKLEYIKFAEGTPEYEYLHGHRKALNGYVPARRTKFDVEYKVPALEEFK
ALLEEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIADEARTFGMEGLFRQVGIYNPHGQNYIPSDRDLVAYYREAKDG
QVLQEGINELGATASWLAAANSYSVNNQPMIPFFIYYSMFGFQRVGDMMWAAGDQLARGFMVGGTSGRTTLNGEGLQHED
GHSHIQAGIIPNCITYDPSFAFEVAVIMQDGINRMYGEKQEDVFYYMTTLNEVMDQPAMPAGAEEGIRKGLYKFETVEGK
KGKGHVQLLGSGAIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGHDAARWNLLHPTETQRVPYVAQVLADLPTVAS
TDYVKGYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVSNQVVADAIAKFGLNVDR
INPLYA

Sequences:

>Translated_886_residues
MSEILKNDVDPIETQDWLQSLDSLIREEGVERAQYIVEQVIGQARTSGVSLPTGVTTDYVNTIPVAEQPAYPGDHAIERR
IRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLIFFQGHAAPGMYARAFLEGRLTEE
QMDNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLDNRGLKDTKDQKVYAFLGDGEMDEIESKG
ALTFAAREHLDNLIFTISCNLQRLDGPVNGNGKIVQELEGLFTGAGWEVIKVLWGSDWDKLFAKDTSGKLTQLMMEVVDG
DYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWALRRGAHDSEKLYAAYAKAQNATKPVVILAHQVKGYKIPEAES
KNTAHQSKKMSYESLKGFRDFFELPLTDEQVEKLEYIKFAEGTPEYEYLHGHRKALNGYVPARRTKFDVEYKVPALEEFK
ALLEEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIADEARTFGMEGLFRQVGIYNPHGQNYIPSDRDLVAYYREAKDG
QVLQEGINELGATASWLAAANSYSVNNQPMIPFFIYYSMFGFQRVGDMMWAAGDQLARGFMVGGTSGRTTLNGEGLQHED
GHSHIQAGIIPNCITYDPSFAFEVAVIMQDGINRMYGEKQEDVFYYMTTLNEVMDQPAMPAGAEEGIRKGLYKFETVEGK
KGKGHVQLLGSGAIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGHDAARWNLLHPTETQRVPYVAQVLADLPTVAS
TDYVKGYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVSNQVVADAIAKFGLNVDR
INPLYA
>Mature_885_residues
SEILKNDVDPIETQDWLQSLDSLIREEGVERAQYIVEQVIGQARTSGVSLPTGVTTDYVNTIPVAEQPAYPGDHAIERRI
RSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLIFFQGHAAPGMYARAFLEGRLTEEQ
MDNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLDNRGLKDTKDQKVYAFLGDGEMDEIESKGA
LTFAAREHLDNLIFTISCNLQRLDGPVNGNGKIVQELEGLFTGAGWEVIKVLWGSDWDKLFAKDTSGKLTQLMMEVVDGD
YLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWALRRGAHDSEKLYAAYAKAQNATKPVVILAHQVKGYKIPEAESK
NTAHQSKKMSYESLKGFRDFFELPLTDEQVEKLEYIKFAEGTPEYEYLHGHRKALNGYVPARRTKFDVEYKVPALEEFKA
LLEEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIADEARTFGMEGLFRQVGIYNPHGQNYIPSDRDLVAYYREAKDGQ
VLQEGINELGATASWLAAANSYSVNNQPMIPFFIYYSMFGFQRVGDMMWAAGDQLARGFMVGGTSGRTTLNGEGLQHEDG
HSHIQAGIIPNCITYDPSFAFEVAVIMQDGINRMYGEKQEDVFYYMTTLNEVMDQPAMPAGAEEGIRKGLYKFETVEGKK
GKGHVQLLGSGAIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGHDAARWNLLHPTETQRVPYVAQVLADLPTVAST
DYVKGYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVSNQVVADAIAKFGLNVDRI
NPLYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=889, Percent_Identity=68.6164229471316, Blast_Score=1319, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ODP1_HAEIN (P45119)

Other databases:

- EMBL:   L42023
- PIR:   A64112
- RefSeq:   NP_439389.1
- ProteinModelPortal:   P45119
- SMR:   P45119
- GeneID:   950116
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1233
- NMPDR:   fig|71421.1.peg.1179
- TIGR:   HI_1233
- HOGENOM:   HBG289271
- OMA:   EVDRHFV
- ProtClustDB:   PRK09405
- BioCyc:   HINF71421:HI_1233-MONOMER
- BRENDA:   1.2.4.1
- GO:   GO:0006096
- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PIRSF:   PIRSF000156
- TIGRFAMs:   TIGR00759

Pfam domain/function: PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =1.2.4.1

Molecular weight: Translated: 99132; Mature: 99001

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEILKNDVDPIETQDWLQSLDSLIREEGVERAQYIVEQVIGQARTSGVSLPTGVTTDYV
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
NTIPVAEQPAYPGDHAIERRIRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
YNHFFKAATEKNGGDLIFFQGHAAPGMYARAFLEGRLTEEQMDNFRQEAFTDGLSSYPHP
HHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
KLMPEFWQFSTVSMGLGPVNAIYQARFLKYLDNRGLKDTKDQKVYAFLGDGEMDEIESKG
CCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCC
ALTFAAREHLDNLIFTISCNLQRLDGPVNGNGKIVQELEGLFTGAGWEVIKVLWGSDWDK
CEEHHHHHHHCCEEEEEEECHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHH
LFAKDTSGKLTQLMMEVVDGDYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWALR
HHHCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHH
RGAHDSEKLYAAYAKAQNATKPVVILAHQVKGYKIPEAESKNTAHQSKKMSYESLKGFRD
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
FFELPLTDEQVEKLEYIKFAEGTPEYEYLHGHRKALNGYVPARRTKFDVEYKVPALEEFK
HHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHH
ALLEEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIADEARTFGMEGLFRQVGIYNPHG
HHHHHCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
QNYIPSDRDLVAYYREAKDGQVLQEGINELGATASWLAAANSYSVNNQPMIPFFIYYSMF
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHH
GFQRVGDMMWAAGDQLARGFMVGGTSGRTTLNGEGLQHEDGHSHIQAGIIPNCITYDPSF
HHHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCCCCCCCCCCCEECCCCCCCEECCCCH
AFEVAVIMQDGINRMYGEKQEDVFYYMTTLNEVMDQPAMPAGAEEGIRKGLYKFETVEGK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHEEECCCC
KGKGHVQLLGSGAIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGHDAARWNLLHPT
CCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHCCCCHHHEECCCCC
ETQRVPYVAQVLADLPTVASTDYVKGYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREH
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHH
FEVDARYVVVAALSQLAKEGTVSNQVVADAIAKFGLNVDRINPLYA
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SEILKNDVDPIETQDWLQSLDSLIREEGVERAQYIVEQVIGQARTSGVSLPTGVTTDYV
CHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
NTIPVAEQPAYPGDHAIERRIRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
YNHFFKAATEKNGGDLIFFQGHAAPGMYARAFLEGRLTEEQMDNFRQEAFTDGLSSYPHP
HHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
KLMPEFWQFSTVSMGLGPVNAIYQARFLKYLDNRGLKDTKDQKVYAFLGDGEMDEIESKG
CCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCC
ALTFAAREHLDNLIFTISCNLQRLDGPVNGNGKIVQELEGLFTGAGWEVIKVLWGSDWDK
CEEHHHHHHHCCEEEEEEECHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHH
LFAKDTSGKLTQLMMEVVDGDYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWALR
HHHCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHH
RGAHDSEKLYAAYAKAQNATKPVVILAHQVKGYKIPEAESKNTAHQSKKMSYESLKGFRD
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
FFELPLTDEQVEKLEYIKFAEGTPEYEYLHGHRKALNGYVPARRTKFDVEYKVPALEEFK
HHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHH
ALLEEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIADEARTFGMEGLFRQVGIYNPHG
HHHHHCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
QNYIPSDRDLVAYYREAKDGQVLQEGINELGATASWLAAANSYSVNNQPMIPFFIYYSMF
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHH
GFQRVGDMMWAAGDQLARGFMVGGTSGRTTLNGEGLQHEDGHSHIQAGIIPNCITYDPSF
HHHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCCCCCCCCCCCEECCCCCCCEECCCCH
AFEVAVIMQDGINRMYGEKQEDVFYYMTTLNEVMDQPAMPAGAEEGIRKGLYKFETVEGK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHEEECCCC
KGKGHVQLLGSGAIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGHDAARWNLLHPT
CCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHCCCCHHHEECCCCC
ETQRVPYVAQVLADLPTVASTDYVKGYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREH
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHH
FEVDARYVVVAALSQLAKEGTVSNQVVADAIAKFGLNVDRINPLYA
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800