Click here to switch to the map view.

The map label for this gene is nudH

Identifier: 162149120

GI number: 162149120

Start: 3444387

End: 3444890

Strand: Direct

Name: nudH

Synonym: GDI_3350

Alternate gene names: 162149120

Gene position: 3444387-3444890 (Clockwise)

Preceding gene: 162149119

Following gene: 162149127

Centisome position: 87.33

GC content: 70.44

Gene sequence:

>504_bases
ATGACTGACGCGGCGGACCTGCCCTATCGCCGCAATGTCGGTGCCATGCTGTTCAACGCCCAGGGCAGGATCCTGATCGG
CCGCCGCACCGACCAGCCGGGCGCCGGCGGCCCGCTGGATGGCGGCGTCTGGCAGTGCCCGCAGGGCGGCATCGACGCCG
ACGAGGACCCGGAAGAGGCGGTGCTGCGCGAACTGCGCGAGGAAATCGGCACCGACCGGGCCGTCATCATGGGCGCGCGG
CCGGACTGGCTGACCTACGACCTGCCCGCCGCGCTGATCGGCCGGGCGCTGGGCGGGCGCTATCGCGGCCAGACGCAGAA
ATGGTTCGCCCTGCGCTTCACCGGGCAGGATTCGGATATCCGCCTGGACGACCAGCAGCCGCCGGAATTCGATGCCTGGC
AGTGGATCGACCTGCCCAGCCTGCCGGAGCGCAATGTCGGCTTCAAGCGCGACATCTACCGGACCCTGGTCCGCGACTTC
GCCCGCTTCAGCCAGCCTGCCTGA

Upstream 100 bases:

>100_bases
CCGGCCACCGACTTCCAGTTGCAGGAAGGGCTGAAGATCGTCCGCGCGATGGGAACGGGGCCGCGTTCGGCCGCCGCCGC
CGTCCCCGCGGCGCCGCGTC

Downstream 100 bases:

>100_bases
GGGCGGGCAGCACGTGCAGGCGCAGCAGCGGCGCCAGCACGGCCTCCCCATGGGATGCGCGCAGGTCGAACCACAGCATC
TGCGCGATTTCCGCGCGGAT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTDAADLPYRRNVGAMLFNAQGRILIGRRTDQPGAGGPLDGGVWQCPQGGIDADEDPEEAVLRELREEIGTDRAVIMGAR
PDWLTYDLPAALIGRALGGRYRGQTQKWFALRFTGQDSDIRLDDQQPPEFDAWQWIDLPSLPERNVGFKRDIYRTLVRDF
ARFSQPA

Sequences:

>Translated_167_residues
MTDAADLPYRRNVGAMLFNAQGRILIGRRTDQPGAGGPLDGGVWQCPQGGIDADEDPEEAVLRELREEIGTDRAVIMGAR
PDWLTYDLPAALIGRALGGRYRGQTQKWFALRFTGQDSDIRLDDQQPPEFDAWQWIDLPSLPERNVGFKRDIYRTLVRDF
ARFSQPA
>Mature_166_residues
TDAADLPYRRNVGAMLFNAQGRILIGRRTDQPGAGGPLDGGVWQCPQGGIDADEDPEEAVLRELREEIGTDRAVIMGARP
DWLTYDLPAALIGRALGGRYRGQTQKWFALRFTGQDSDIRLDDQQPPEFDAWQWIDLPSLPERNVGFKRDIYRTLVRDFA
RFSQPA

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=155, Percent_Identity=38.0645161290323, Blast_Score=109, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_GLUDA (A9H3A6)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001603581.1
- RefSeq:   YP_002277365.1
- ProteinModelPortal:   A9H3A6
- SMR:   A9H3A6
- GeneID:   5790771
- GeneID:   6976454
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_3020
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18818; Mature: 18687

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAADLPYRRNVGAMLFNAQGRILIGRRTDQPGAGGPLDGGVWQCPQGGIDADEDPEEA
CCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCHHHH
VLRELREEIGTDRAVIMGARPDWLTYDLPAALIGRALGGRYRGQTQKWFALRFTGQDSDI
HHHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCE
RLDDQQPPEFDAWQWIDLPSLPERNVGFKRDIYRTLVRDFARFSQPA
EECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDAADLPYRRNVGAMLFNAQGRILIGRRTDQPGAGGPLDGGVWQCPQGGIDADEDPEEA
CCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCHHHH
VLRELREEIGTDRAVIMGARPDWLTYDLPAALIGRALGGRYRGQTQKWFALRFTGQDSDI
HHHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCE
RLDDQQPPEFDAWQWIDLPSLPERNVGFKRDIYRTLVRDFARFSQPA
EECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA