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The map label for this gene is tdcB [H]

Identifier: 162149111

GI number: 162149111

Start: 3436526

End: 3437722

Strand: Direct

Name: tdcB [H]

Synonym: GDI_3341

Alternate gene names: 162149111

Gene position: 3436526-3437722 (Clockwise)

Preceding gene: 162149110

Following gene: 162149112

Centisome position: 87.13

GC content: 70.18

Gene sequence:

>1197_bases
ATGATCACCCTCAACGACGTTCGCGCCGCCGCCGCGCGGATCGAGGGGCGTGTCCTGCGCACGCCCACCGTTCCCTCGCA
CGCGCTTTCCAGGGCGACGGGGGCGGACATCGTCCTGAAGCTGGACAATCTCCAGGCCGTGGGCTCGTTCAAGGAACGCG
GGGCCGCCAACAAGCTGGCGCTGCTGACGCCCGAGGAACGCGCGCGCGGAGTGATCACCGTATCGGCCGGCAACCACGCC
CAGGGCGTGGCCCGCCATGCCGCGCTGCTGGAAATCGACGCGGTCATCGTCATGCCGCGCTTCACCCCGGCCGCCAAGGT
CACCCGCACCGCCGCCTGGGGCGCGCGCGTGGTGCTGGAAGGCGACAATTTCGCCGAGGCCACGGCCCATGCCAACGCCC
TGTGCGCGCGGGAAGGCCGGGTCTTCGTCCATCCTTACGACGACCCCGAGGTCATGGCCGGCCAGGGCACCTTCGGCCTG
GAACTGTTCGAGGATGCGGGCCCGCTCGACATCTTCGTCGGTCCGATCGGCGGCGGCGGCCTGCTGTCGGGCTGCGCCGT
GGTGGGCCGCGCGCTGCGTCCCGGCATGGACATCATGGGCGTGCAGGTCGAAAGCTATTCCTCGGTGTCCGCTGTCCCGG
GGGACGAGATCATGCCCCCCGGCGGCGCCACGATCGCCGAGGGCATCGCGGTGCTGCAGATCGGGCGGCAGCCGCTGTCG
GTCATTCGCGACCATGTCTCACGCGTGCTGGTGGTGCCGGAACGCGCGGTCGAGGATGCGATCACCCTGATGGCCGAGGG
CGCCAAGCAGGTCAGCGAGGGCGCGGGCGCCAGCGCCCTGGCGGCGGTCCTGACCTATCCCGAACTGTTCCGGGGCAAGC
GGGTGGCGCTGCCGGTGACGGGCGGCAATATCGACAGCCGCATCCTGGCCAACACGCTGCTGCGCTCGCTGCTGCGCGAC
GGGCGGCTGCTGTGCCTGAAGATGGAAATCCCGGACCGGCCGGGCGTGCTGGCCGACATCTCGCGCATGATCGGCGAGGC
CGGCGGAAACATCATCGAGGTCTCGCACCAGCGCCTGTTCACCGCCGCCAGCGTGCAGGCGGCCGAACTGGAAGTGATGA
TCGAAGCCCGCGACCCCACCCACGCGATGGAGATCATGGGGCAACTGGCCAAGACCTACATCGTCCGCCGGGTGTAG

Upstream 100 bases:

>100_bases
CTGATCGGCAAGCGGATCGGCGATTCCGTCTCGGTCCCCGCCCCGGGCGGCGACCGGACGTACGAGATCCTGGCCGTCAC
CTACGGCTAGGCGGGATGCG

Downstream 100 bases:

>100_bases
CCCCTCATATCCTGCCCGCCGGCAGGATTTTGCTGGATCGATATCAAAAATAAAATATGATATCGGTCCTTATGAAGAAG
GGGCTTTCATCATGTCCTCT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MITLNDVRAAAARIEGRVLRTPTVPSHALSRATGADIVLKLDNLQAVGSFKERGAANKLALLTPEERARGVITVSAGNHA
QGVARHAALLEIDAVIVMPRFTPAAKVTRTAAWGARVVLEGDNFAEATAHANALCAREGRVFVHPYDDPEVMAGQGTFGL
ELFEDAGPLDIFVGPIGGGGLLSGCAVVGRALRPGMDIMGVQVESYSSVSAVPGDEIMPPGGATIAEGIAVLQIGRQPLS
VIRDHVSRVLVVPERAVEDAITLMAEGAKQVSEGAGASALAAVLTYPELFRGKRVALPVTGGNIDSRILANTLLRSLLRD
GRLLCLKMEIPDRPGVLADISRMIGEAGGNIIEVSHQRLFTAASVQAAELEVMIEARDPTHAMEIMGQLAKTYIVRRV

Sequences:

>Translated_398_residues
MITLNDVRAAAARIEGRVLRTPTVPSHALSRATGADIVLKLDNLQAVGSFKERGAANKLALLTPEERARGVITVSAGNHA
QGVARHAALLEIDAVIVMPRFTPAAKVTRTAAWGARVVLEGDNFAEATAHANALCAREGRVFVHPYDDPEVMAGQGTFGL
ELFEDAGPLDIFVGPIGGGGLLSGCAVVGRALRPGMDIMGVQVESYSSVSAVPGDEIMPPGGATIAEGIAVLQIGRQPLS
VIRDHVSRVLVVPERAVEDAITLMAEGAKQVSEGAGASALAAVLTYPELFRGKRVALPVTGGNIDSRILANTLLRSLLRD
GRLLCLKMEIPDRPGVLADISRMIGEAGGNIIEVSHQRLFTAASVQAAELEVMIEARDPTHAMEIMGQLAKTYIVRRV
>Mature_398_residues
MITLNDVRAAAARIEGRVLRTPTVPSHALSRATGADIVLKLDNLQAVGSFKERGAANKLALLTPEERARGVITVSAGNHA
QGVARHAALLEIDAVIVMPRFTPAAKVTRTAAWGARVVLEGDNFAEATAHANALCAREGRVFVHPYDDPEVMAGQGTFGL
ELFEDAGPLDIFVGPIGGGGLLSGCAVVGRALRPGMDIMGVQVESYSSVSAVPGDEIMPPGGATIAEGIAVLQIGRQPLS
VIRDHVSRVLVVPERAVEDAITLMAEGAKQVSEGAGASALAAVLTYPELFRGKRVALPVTGGNIDSRILANTLLRSLLRD
GRLLCLKMEIPDRPGVLADISRMIGEAGGNIIEVSHQRLFTAASVQAAELEVMIEARDPTHAMEIMGQLAKTYIVRRV

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=324, Percent_Identity=32.4074074074074, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI33469958, Length=274, Percent_Identity=29.1970802919708, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=39.1025641025641, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1790207, Length=341, Percent_Identity=36.0703812316716, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71991565, Length=396, Percent_Identity=34.5959595959596, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17537387, Length=396, Percent_Identity=32.8282828282828, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17508781, Length=321, Percent_Identity=29.2834890965732, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322631, Length=318, Percent_Identity=38.6792452830189, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320930, Length=328, Percent_Identity=32.9268292682927, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319788, Length=285, Percent_Identity=25.2631578947368, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21355833, Length=395, Percent_Identity=36.9620253164557, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24645328, Length=299, Percent_Identity=34.1137123745819, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 41895; Mature: 41895

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLNDVRAAAARIEGRVLRTPTVPSHALSRATGADIVLKLDNLQAVGSFKERGAANKLA
CEECHHHHHHHHHHCCEEEECCCCCHHHHHHCCCCEEEEEECCCHHHCCHHHCCCCCEEE
LLTPEERARGVITVSAGNHAQGVARHAALLEIDAVIVMPRFTPAAKVTRTAAWGARVVLE
EECCHHHCCEEEEEECCCCHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHCCCEEEEEE
GDNFAEATAHANALCAREGRVFVHPYDDPEVMAGQGTFGLELFEDAGPLDIFVGPIGGGG
CCCCHHHHHHHHHEEECCCEEEEECCCCCCEEECCCCCCEEEECCCCCEEEEEECCCCCH
LLSGCAVVGRALRPGMDIMGVQVESYSSVSAVPGDEIMPPGGATIAEGIAVLQIGRQPLS
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
VIRDHVSRVLVVPERAVEDAITLMAEGAKQVSEGAGASALAAVLTYPELFRGKRVALPVT
HHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHCCCEEEEEEE
GGNIDSRILANTLLRSLLRDGRLLCLKMEIPDRPGVLADISRMIGEAGGNIIEVSHQRLF
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECHHHHH
TAASVQAAELEVMIEARDPTHAMEIMGQLAKTYIVRRV
HHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITLNDVRAAAARIEGRVLRTPTVPSHALSRATGADIVLKLDNLQAVGSFKERGAANKLA
CEECHHHHHHHHHHCCEEEECCCCCHHHHHHCCCCEEEEEECCCHHHCCHHHCCCCCEEE
LLTPEERARGVITVSAGNHAQGVARHAALLEIDAVIVMPRFTPAAKVTRTAAWGARVVLE
EECCHHHCCEEEEEECCCCHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHCCCEEEEEE
GDNFAEATAHANALCAREGRVFVHPYDDPEVMAGQGTFGLELFEDAGPLDIFVGPIGGGG
CCCCHHHHHHHHHEEECCCEEEEECCCCCCEEECCCCCCEEEECCCCCEEEEEECCCCCH
LLSGCAVVGRALRPGMDIMGVQVESYSSVSAVPGDEIMPPGGATIAEGIAVLQIGRQPLS
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
VIRDHVSRVLVVPERAVEDAITLMAEGAKQVSEGAGASALAAVLTYPELFRGKRVALPVT
HHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHCCCEEEEEEE
GGNIDSRILANTLLRSLLRDGRLLCLKMEIPDRPGVLADISRMIGEAGGNIIEVSHQRLF
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECHHHHH
TAASVQAAELEVMIEARDPTHAMEIMGQLAKTYIVRRV
HHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA