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The map label for this gene is manC [H]

Identifier: 162146657

GI number: 162146657

Start: 855140

End: 856603

Strand: Reverse

Name: manC [H]

Synonym: GDI_0835

Alternate gene names: 162146657

Gene position: 856603-855140 (Counterclockwise)

Preceding gene: 162146658

Following gene: 162146656

Centisome position: 21.72

GC content: 63.93

Gene sequence:

>1464_bases
ATGTCTGACACCACCTTCCCGGTGATCGGCACCAAGGCTGCCAACACGACCCGTATCGTTCCCGTCATCCTGTCCGGCGG
AACCGGCAGCCGGCTTTGGCCGCTCTCGCGGGCCAGCTATCCCAAACAGCTCTGGTCCCTGGTCAGCGAGAAGACGATGC
TGCAGGAAACGGCGCTGCGCGGCTGCGGGGAAACGTTCGACGCGCCGATCGTCATCTGCAACAACGAACATCGATTCCTG
ATCGCCGAGCAACTGCGCGAGGCCGGTATCGAGAATGCGCGGATCGTGCTGGAACCCGCCGGACGCAATTCCGCCCCGGC
CATCGCCGCCGCCGCCCTGCTGGCCGCCGAGACGAACCCGGATGCGGTGCTGTGGATCATGGCCGCCGATGCCGTCATCA
CGCGCCCGGAAACACTGGAGCACCTGATGCCCGCGGCGGCGGCGGCGGCGCAGCGCGGCCATATCGTCGTCTTCGGCATG
CACCCCACGCGGCCCGAGACCGGATACGGCTACATCGAGGCCGGCAAGCCGCTTGCCAAGCTGCCCGAGGCCAACGCGGT
CGCCTGCTTCATCGAAAAGCCGGATGCCGCGACGGCGGCCGAGCTGATCGCGTCGGGCAAGTATATGTGGAATTCGGGCA
TGTTCGTCTTCACCGCCCGTACCCTGCTGAAGGAAATGGAGACCTACGCCCCGGCCGTACTGAACCCCGTACGCCAGGCC
GTCGAACGCCGCACCAGCGACCTGGTGTTCCAGCGCCTGGACCCGCAATCCTTCCTGTCCACGCCCGATATCTCGTTCGA
TTATGCCGTCATGGAACATACCGACCAGGCGGCGGTGATCGCCGGCGATTTCGGATGGACCGATATCGGCAGCTGGGACG
CGCTGTGGGACATCAGCAGGAAGGATGACAGCGGCAATGTCGCCGAAGGCCAGGTTTTTCTGGAATCGGTCCATGGCAGC
TATGTCCGGTCGGACGAGATCCTGACCGCCGTCGTCGGCGTCGACGACGTGATCGTGGTCGCGACCCGCGACGCGGTGCT
GGTGACGCAGCAGAGCAAGGCGCAGGACGTCAAGAAGATCGTCACCCGCCTGCAGGCCGCGGGACGCCAGGAGGCCAAGG
CGCATAACCGCTGCTATCGTCCCTGGGGTTTCTATGAAAGCCTGATCCAGGACCAGCGCTTCCAGGTCAAGCGCATCGTC
GTGATGCCGGGCGAAAAACTGTCGCTGCAGAAGCACTACCATCGCGCCGAACACTGGATCGTCGTCAGCGGCGTGGCGCT
GGTGACCCGCAATGCGGAACTGATTACCGTCCATGAGAACGAGAGCATCTACCTGCCGCAGGAATGCACCCACCGGATGG
AAAATCCCGGCAAGATTCCGCTGGTGCTGATCGAGATCCAGACCGGATCCTATCTGGGCGAGGACGATATCATCCGGTTC
GAGGATAACTACAACCGCAGCTGA

Upstream 100 bases:

>100_bases
GGTCCGGGCGACTATCGGCGTTTCGTCGCGTAATCGCATTGTTTCCCATGCATACTGATGCATCGCTCCGCATAACCCAT
GGACCAGAGAGGACCGTGAC

Downstream 100 bases:

>100_bases
TGCCTCATCTCCGAAATTCGATCGGCGGATTTCGGAGGTCGGCAGCCTCCGGGAGAGGATCATGACGACACGATCACGCT
TTCTGGTCACGGGCGGCGCG

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyl transferase; GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSDTTFPVIGTKAANTTRIVPVILSGGTGSRLWPLSRASYPKQLWSLVSEKTMLQETALRGCGETFDAPIVICNNEHRFL
IAEQLREAGIENARIVLEPAGRNSAPAIAAAALLAAETNPDAVLWIMAADAVITRPETLEHLMPAAAAAAQRGHIVVFGM
HPTRPETGYGYIEAGKPLAKLPEANAVACFIEKPDAATAAELIASGKYMWNSGMFVFTARTLLKEMETYAPAVLNPVRQA
VERRTSDLVFQRLDPQSFLSTPDISFDYAVMEHTDQAAVIAGDFGWTDIGSWDALWDISRKDDSGNVAEGQVFLESVHGS
YVRSDEILTAVVGVDDVIVVATRDAVLVTQQSKAQDVKKIVTRLQAAGRQEAKAHNRCYRPWGFYESLIQDQRFQVKRIV
VMPGEKLSLQKHYHRAEHWIVVSGVALVTRNAELITVHENESIYLPQECTHRMENPGKIPLVLIEIQTGSYLGEDDIIRF
EDNYNRS

Sequences:

>Translated_487_residues
MSDTTFPVIGTKAANTTRIVPVILSGGTGSRLWPLSRASYPKQLWSLVSEKTMLQETALRGCGETFDAPIVICNNEHRFL
IAEQLREAGIENARIVLEPAGRNSAPAIAAAALLAAETNPDAVLWIMAADAVITRPETLEHLMPAAAAAAQRGHIVVFGM
HPTRPETGYGYIEAGKPLAKLPEANAVACFIEKPDAATAAELIASGKYMWNSGMFVFTARTLLKEMETYAPAVLNPVRQA
VERRTSDLVFQRLDPQSFLSTPDISFDYAVMEHTDQAAVIAGDFGWTDIGSWDALWDISRKDDSGNVAEGQVFLESVHGS
YVRSDEILTAVVGVDDVIVVATRDAVLVTQQSKAQDVKKIVTRLQAAGRQEAKAHNRCYRPWGFYESLIQDQRFQVKRIV
VMPGEKLSLQKHYHRAEHWIVVSGVALVTRNAELITVHENESIYLPQECTHRMENPGKIPLVLIEIQTGSYLGEDDIIRF
EDNYNRS
>Mature_486_residues
SDTTFPVIGTKAANTTRIVPVILSGGTGSRLWPLSRASYPKQLWSLVSEKTMLQETALRGCGETFDAPIVICNNEHRFLI
AEQLREAGIENARIVLEPAGRNSAPAIAAAALLAAETNPDAVLWIMAADAVITRPETLEHLMPAAAAAAQRGHIVVFGMH
PTRPETGYGYIEAGKPLAKLPEANAVACFIEKPDAATAAELIASGKYMWNSGMFVFTARTLLKEMETYAPAVLNPVRQAV
ERRTSDLVFQRLDPQSFLSTPDISFDYAVMEHTDQAAVIAGDFGWTDIGSWDALWDISRKDDSGNVAEGQVFLESVHGSY
VRSDEILTAVVGVDDVIVVATRDAVLVTQQSKAQDVKKIVTRLQAAGRQEAKAHNRCYRPWGFYESLIQDQRFQVKRIVV
MPGEKLSLQKHYHRAEHWIVVSGVALVTRNAELITVHENESIYLPQECTHRMENPGKIPLVLIEIQTGSYLGEDDIIRFE
DNYNRS

Specific function: Involved in xanthan production [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=474, Percent_Identity=48.7341772151899, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53755; Mature: 53624

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTTFPVIGTKAANTTRIVPVILSGGTGSRLWPLSRASYPKQLWSLVSEKTMLQETALR
CCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GCGETFDAPIVICNNEHRFLIAEQLREAGIENARIVLEPAGRNSAPAIAAAALLAAETNP
HCCCCCCCCEEEECCCCCEEEHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
DAVLWIMAADAVITRPETLEHLMPAAAAAAQRGHIVVFGMHPTRPETGYGYIEAGKPLAK
CEEEEEEECCEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCHHH
LPEANAVACFIEKPDAATAAELIASGKYMWNSGMFVFTARTLLKEMETYAPAVLNPVRQA
CCCCCEEEEEEECCCCHHHHHHHHCCCEEECCCEEEEHHHHHHHHHHHHCHHHHHHHHHH
VERRTSDLVFQRLDPQSFLSTPDISFDYAVMEHTDQAAVIAGDFGWTDIGSWDALWDISR
HHHHHHHHHHHHCCHHHHCCCCCCCEEEHEEECCCCEEEEEECCCCCCCCCCCCEEECCC
KDDSGNVAEGQVFLESVHGSYVRSDEILTAVVGVDDVIVVATRDAVLVTQQSKAQDVKKI
CCCCCCEEHHHHHEEHHCCCCEECCHHEEEEECCCCEEEEEECCEEEEECCHHHHHHHHH
VTRLQAAGRQEAKAHNRCYRPWGFYESLIQDQRFQVKRIVVMPGEKLSLQKHYHRAEHWI
HHHHHHCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCEE
VVSGVALVTRNAELITVHENESIYLPQECTHRMENPGKIPLVLIEIQTGSYLGEDDIIRF
EEECEEEEECCCEEEEEECCCCEECCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEE
EDNYNRS
CCCCCCC
>Mature Secondary Structure 
SDTTFPVIGTKAANTTRIVPVILSGGTGSRLWPLSRASYPKQLWSLVSEKTMLQETALR
CCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GCGETFDAPIVICNNEHRFLIAEQLREAGIENARIVLEPAGRNSAPAIAAAALLAAETNP
HCCCCCCCCEEEECCCCCEEEHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
DAVLWIMAADAVITRPETLEHLMPAAAAAAQRGHIVVFGMHPTRPETGYGYIEAGKPLAK
CEEEEEEECCEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCHHH
LPEANAVACFIEKPDAATAAELIASGKYMWNSGMFVFTARTLLKEMETYAPAVLNPVRQA
CCCCCEEEEEEECCCCHHHHHHHHCCCEEECCCEEEEHHHHHHHHHHHHCHHHHHHHHHH
VERRTSDLVFQRLDPQSFLSTPDISFDYAVMEHTDQAAVIAGDFGWTDIGSWDALWDISR
HHHHHHHHHHHHCCHHHHCCCCCCCEEEHEEECCCCEEEEEECCCCCCCCCCCCEEECCC
KDDSGNVAEGQVFLESVHGSYVRSDEILTAVVGVDDVIVVATRDAVLVTQQSKAQDVKKI
CCCCCCEEHHHHHEEHHCCCCEECCHHEEEEECCCCEEEEEECCEEEEECCHHHHHHHHH
VTRLQAAGRQEAKAHNRCYRPWGFYESLIQDQRFQVKRIVVMPGEKLSLQKHYHRAEHWI
HHHHHHCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCEE
VVSGVALVTRNAELITVHENESIYLPQECTHRMENPGKIPLVLIEIQTGSYLGEDDIIRF
EEECEEEEECCCEEEEEECCCCEECCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEE
EDNYNRS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1370280; 11589581 [H]